EKS-MOD-00156

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00156

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	360.2	8.0E-108	65	326	262

Status

Unreviewed

Ensembl Protein

ENSMODP00000009452

UniProt Accession

F7C5A4;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000007615	ENSMODP00000009452	ENSMODT00000009638

Organism

Monodelphis domestica

Functional Description

Protein Length

476

Protein Sequence
(FASTA)

MAAVFDIDLE TEEGSEGDGE PELSPADADL DLRTAGLEPA GHYEEVELSE ASVNQSPERI 60

GPHCFELLRV LGKGGYGKVF QVRKVQGTNV GKIFAMKVLR KAKIMRNAKD TAHTRAERSI 120

LEAVRHPFIV ELVYAFQTRG KLYLILECLS GGELFMQLER EGIFMEDTAC FYLGEITLAL 180

GHLHSQGIIY RDLKPENIML SSQGHIKLTD FGLCKESIHE GSVTHTFCGT IEYMAPEILT 240

RSGHNRAVDW WSLGALMYDM LTGSPPFTAE NRKKTIDKIL RAKLALPAYL TPDARDLLKK 300

FLKRNPSQRL GGGPGDVADV QKHPFFRHIN WEDLLARQVD PPFRPCLQSE EDVSQFDTRF 360

TRQTPVDSPD DMSLSDSANQ AFLGFTYVAP SVLEGIKEGF SFQPKLRSPR RLNSSPRTPI 420

SPLKFSPFEG FRASAGPAES MELPPPPPPP PVSSAPLPIR TPTGKKSKKG RGRSGR 476

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTTGACAT CGACCTGGAG ACGGAAGAGG GCAGCGAGGG AGACGGCGAG 60

CCGGAACTCA GCCCCGCGGA TGCCGACCTG GACTTGAGGA CGGCCGGCTT GGAGCCTGCC 120

GGACACTATG AGGAAGTGGA GTTGTCCGAG GCCTCTGTGA ATCAGAGCCC CGAGCGCATC 180

GGCCCGCACT GCTTTGAGCT GCTCCGAGTC CTGGGCAAAG GAGGCTACGG CAAGGTTTTC 240

CAGGTCCGGA AGGTACAGGG CACCAATGTG GGGAAAATAT TCGCCATGAA AGTGCTGAGA 300

AAAGCAAAAA TTATGCGCAA CGCCAAGGAC ACAGCCCACA CGCGGGCAGA GCGGAGCATC 360

CTGGAGGCTG TGAGGCACCC CTTCATCGTG GAGCTGGTGT ATGCCTTCCA GACCCGCGGC 420

AAGCTCTATC TCATTCTGGA GTGCCTCAGT GGAGGAGAGC TCTTCATGCA GCTGGAGCGC 480

GAGGGGATCT TCATGGAGGA CACGGCCTGT TTCTACCTGG GGGAGATCAC CCTGGCCCTG 540

GGCCACCTGC ACTCCCAGGG CATCATCTAC CGGGACCTGA AGCCTGAAAA CATCATGTTG 600

AGCAGCCAAG GCCACATCAA GTTGACAGAT TTCGGCCTGT GTAAGGAGTC CATCCATGAG 660

GGCTCCGTCA CTCACACGTT CTGCGGCACC ATCGAGTACA TGGCCCCAGA GATCCTCACC 720

CGCAGTGGCC ACAACCGGGC AGTGGACTGG TGGAGCCTGG GCGCCCTGAT GTATGACATG 780

CTCACTGGAT CGCCGCCCTT CACTGCAGAG AATCGAAAGA AAACCATTGA CAAGATCCTC 840

AGGGCAAAGC TGGCACTGCC AGCCTACCTC ACCCCAGATG CACGGGACCT CCTCAAGAAG 900

TTTTTGAAGC GAAATCCCAG CCAGCGGCTT GGGGGTGGGC CTGGGGATGT AGCTGATGTG 960

CAGAAACACC CTTTCTTCCG CCATATCAAT TGGGAAGACC TCTTGGCCCG ACAAGTAGAC 1020

CCCCCCTTCC GGCCCTGCTT GCAGTCTGAA GAGGACGTGA GCCAGTTTGA CACCCGTTTC 1080

ACGAGGCAGA CGCCCGTGGA CAGCCCCGAT GACATGTCCC TCAGTGACAG CGCCAACCAG 1140

GCTTTCTTGG GCTTCACCTA CGTGGCCCCC TCTGTCCTGG AGGGCATCAA GGAAGGCTTC 1200

TCGTTCCAAC CCAAACTGCG CTCCCCCCGA CGCCTCAACA GCAGTCCTCG GACCCCCATC 1260

AGCCCCTTGA AATTCTCACC CTTTGAAGGG TTTCGAGCCA GCGCTGGCCC AGCAGAGTCC 1320

ATGGAGCTAC CCCCTCCTCC ACCTCCACCT CCCGTCAGCT CGGCCCCCCT GCCCATCCGG 1380

ACTCCCACTG GCAAGAAGTC CAAGAAGGGC CGGGGGCGTT CTGGACGCTA G 1431

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk++a+Kvl+ka++++  k++++t++er+iLe+v

Q: 65    FELLRVLGKGGYGKVFQVRKVQGTNVGKIFAMKVLRKAKIMRnaKDTAHTRAERSILEAV  124

         89**************************************9999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l++afq++ klyl+le+l+GgeL+++l+++++f+e++a+f+l e++lal +lH

Q: 125   RHPFIVELVYAFQTRGKLYLILECLSGGELFMQLEREGIFMEDTACFYLGEITLALGHLH  184

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 185   SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGSVTHTFCGTIEYMAPEILTRSG  243

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++il++k  l lpa+  l+++a+dl+k

Q: 244   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTIDKILRAK--LALPAY--LTPDARDLLK  299

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++Rlg    +++++++h+f+

Q: 300   KFLKRNPSQRLGGgpgDVADVQKHPFF  326

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNVGKIF AMKVLRKAKI MRNAKDTAHT RAERSILEAV 60

RHPFIVELVY AFQTRGKLYL ILECLSGGEL FMQLEREGIF MEDTACFYLG EITLALGHLH 120

SQGIIYRDLK PENIMLSSQG HIKLTDFGLC KESIHEGSVT HTFCGTIEYM APEILTRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TIDKILRAKL ALPAYLTPDA RDLLKKFLKR 240

NPSQRLGGGP GDVADVQKHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013