EKS-MOD-00271

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00271

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	374.9	3.9E-112	11	347	337

Status

Unreviewed

Ensembl Protein

ENSMODP00000009537

UniProt Accession

F7FNF8;

Protein Name

Protein Synonyms/Alias

Gene Name

HIPK4

Gene Synonyms/Alias

HIPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000007678	ENSMODP00000009537	ENSMODT00000009725

Organism

Monodelphis domestica

Functional Description

Protein Length

617

Protein Sequence
(FASTA)

MATIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR IIKNELKLLR 60

CMRGLDPDEA HIIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLAA RHIRTVTLQV 120

LRALARLKEL AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF 180

YRAPEILLGL PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQIRYICET QGLPKAHLLH 240

AARKAHHFFK RNPHPEASNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAA 300

GKLAFPDRET LAEYADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ QLRSAHEGTR 360

YYQLSLRGCR LSLQLEGRAP TDEGPPYYRL AEEEEGSGGG GTYYREEKAP GVQRAIDQLD 420

DLSLQEPGRL WGEGRAGAYG APEPPPDTMV LPKGVTRRGR EPGPEPILAF YGSRLSGRHK 480

SRKHPAGSKS DPNFGNLIRL GQASPDEGGP GRGGGWEEGE RRGASADPPA VPQLDGDGPD 540

ERPGAKELTL AAERAGPELY DAGAPPLPPC PGEWLSDPDW SLEGGGGARG QAPPPRHPHP 600

HGPPRVTGFL QHVGGHH 617

Nucleotide Sequence
(FASTA)

ATGGCCACCA TCCAGTCTGA AACCGACTGC TATGACATCA TCGAGGTCCT AGGTAAGGGG 60

ACCTTTGGTG AGGTGGCCAA GGGCTGGCGA CGGAGCACGG GCGAGATGGT GGCCATCAAA 120

ATCCTCAAGA ATGATGCGTA CCGTAACCGC ATCATCAAGA ACGAGCTCAA ACTCCTTCGC 180

TGCATGCGGG GCCTGGACCC GGACGAGGCT CACATCATCC GCTTCCTCGA GTTCTTCCAC 240

GATGCCCTCA AGTTTTACCT GGTCTTTGAG CTTCTGGAGC AGAACCTTTT CGAGTTCCAA 300

AAGGAGAACA ATTTTGCGCC CCTCGCGGCC CGTCACATCC GCACCGTGAC GCTGCAGGTG 360

CTCCGGGCCT TGGCCCGGCT CAAGGAACTG GCCATCATCC ACGCTGACCT CAAACCGGAG 420

AACATCATGC TGGTCGACCA GACCCGTTGT CCCTTCAGGG TCAAGGTGAT TGACTTTGGC 480

TCAGCCAGCA TCTTCAGTGA GGTGCGTTAT GTCAAAGAAC CCTACATCCA GTCCCGTTTT 540

TACCGGGCCC CCGAGATCCT CCTGGGCCTG CCCTTCTGCG AGAAGGTGGA CGTCTGGTCA 600

CTGGGGTGCG TGATGGCCGA GCTTCACCTG GGCTGGCCTC TCTACCCAGG CAACAATGAA 660

TACGACCAGA TCCGCTACAT CTGTGAGACC CAGGGCCTGC CGAAGGCCCA CCTCCTCCAT 720

GCCGCCCGTA AGGCCCACCA TTTCTTCAAA CGCAACCCCC ATCCAGAGGC CTCCAACCCT 780

TGGCAGCTCA AGTCTTCGGC CGACTACTTG GCGGAGACCA AGGTCCGCCC CCTGGAGCGG 840

CGTAAATACA TGCTCAAGTC TCTGGACCAG ATCGAGACCG TGAATGGCGG CGGGGCAGCG 900

GGCAAGCTGG CGTTCCCAGA CCGCGAGACG CTGGCCGAGT ACGCAGACCT CAAGAGCATG 960

GTGGAGCTTA TCAAGCGGAT GCTGACCTGG GAGTCCCATG AGCGCATCAG CCCCAGCGCT 1020

GCTCTCCGCC ACCCCTTCGT GTCGATGCAG CAGCTGCGCA GCGCCCACGA GGGCACCCGC 1080

TACTACCAGC TGTCCCTGCG CGGCTGCCGC CTCTCGCTGC AGCTGGAGGG CCGGGCGCCC 1140

ACGGACGAGG GGCCCCCCTA CTACCGCCTG GCGGAGGAGG AAGAGGGCAG CGGCGGAGGC 1200

GGCACCTACT ACCGGGAGGA GAAGGCCCCC GGCGTGCAGA GGGCCATCGA CCAGCTGGAT 1260

GACCTGAGCC TGCAGGAGCC CGGAAGGCTG TGGGGGGAAG GCCGGGCTGG GGCCTACGGT 1320

GCCCCCGAGC CACCCCCGGA TACCATGGTG CTGCCCAAGG GGGTTACCCG GCGGGGCCGT 1380

GAGCCCGGGC CCGAGCCGAT CTTGGCCTTC TACGGCAGCC GTCTCTCCGG GCGTCACAAG 1440

TCCCGCAAGC ACCCTGCCGG CTCCAAGTCC GACCCTAACT TTGGCAACCT TATCCGGCTG 1500

GGCCAGGCTT CGCCCGACGA GGGTGGGCCT GGCCGGGGCG GCGGCTGGGA GGAGGGGGAG 1560

CGGCGTGGGG CCTCTGCGGA CCCCCCGGCC GTCCCGCAGC TAGATGGGGA TGGGCCCGAC 1620

GAGCGGCCTG GGGCCAAGGA GCTGACACTA GCAGCTGAGA GGGCTGGCCC GGAGCTGTAC 1680

GACGCAGGTG CACCCCCCCT ACCCCCCTGC CCGGGGGAGT GGCTAAGCGA CCCTGACTGG 1740

AGCTTGGAGG GCGGTGGTGG GGCCCGGGGC CAGGCCCCCC CGCCCCGCCA CCCCCACCCC 1800

CACGGGCCTC CCCGGGTCAC TGGCTTCCTC CAGCACGTCG GCGGGCATCA CTGA 1854

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         y+++ev+gkG+fg+V+k+++++t e+vaiki+kn++  +r +++E+++L++++  d++e+

Q: 11    YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLRCMRGLDPDEA  70

         99*******************************************************988

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

          +++r+le+f+   +++lvfell+qnL+e+ k+n+f++l+ +++r+++ q+l+aL+ Lke

Q: 71    -HIIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLAARHIRTVTLQVLRALARLKE  129

         .9**********************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqk..eiytyiqsrfYraPEiilg  176

         l+iiHaDlKPeNi+lv+++r++  vkviDFGs+s +s+   + ++yiqsrfYraPEi+lg

Q: 130   LAIIHADLKPENIMLVDQTRCPfrVKVIDFGSASIFSEVryVKEPYIQSRFYRAPEILLG  189

         *********************999**********99987447899***************

S: 177   lkydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff  236

         l+++e++D+WSlGcv+aEl++G+pL+pG+ne+dq+++i+e++glp+++ll++a+ka++ff

Q: 190   LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQIRYICETQGLPKAHLLHAARKAHHFF  249

         ************************************************************

S: 237   tkkeapkyilktk.............ksdrkkklvlnvkkaakkrkaplsk.....elge  278

         +++ +p+    ++                +++k++l+  +++++++  +++       +e

Q: 250   KRNPHPEASNPWQlkssadylaetkvRPLERRKYMLKSLDQIETVNGGGAAgklafPDRE  309

         888888776666666779999988886667778888888888777654443111115578

S: 279   alkekedkl.fkdllkrmleldpakRitpkealkhpfv  315

         +l+e++d + +++l+krml++++++Ri+p++al+hpfv

Q: 310   TLAEYADLKsMVELIKRMLTWESHERISPSAALRHPFV  347

         8899999888***************************7

Domain Sequence
(FASTA)

YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR IIKNELKLLR CMRGLDPDEA 60

HIIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLAA RHIRTVTLQV LRALARLKEL 120

AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF YRAPEILLGL 180

PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQIRYICET QGLPKAHLLH AARKAHHFFK 240

RNPHPEASNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAA GKLAFPDRET 300

LAEYADLKSM VELIKRMLTW ESHERISPSA ALRHPFV 337

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013