EKS-MOD-00336

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00336

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	348.2	3.8E-104	170	581	412

Status

Unreviewed

Ensembl Protein

ENSMODP00000010072

UniProt Accession

F7G5W1;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK1

Gene Synonyms/Alias

EIF2AK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000008099	ENSMODP00000010072	ENSMODT00000010266

Organism

Monodelphis domestica

Functional Description

Protein Length

630

Protein Sequence
(FASTA)

MRAMLEDDSE SQECEAKGAG ATGLPPPPAI DFPQEGSDIR YDESDVPAEL QAVRGPLPHS 60

TFPSAVANQL LLVSLLEHLS HVHESDPRRS RQVFTLLCQT FTKMGLLSSF ACSEEFSSLR 120

LHHNKAITEL MRIAKQRVLE AQHEEYPHIR KVRAKEVIFE AQTSRYLNEF EEVAVLGKGG 180

YGKVYKVKNK LDRQFYAIKK ILIKKATRKD CMKVLREVKV LAGLQHPNIV GYHTAWIEHV 240

HSAQPQDKRL SMVKLPSLQL VSDETEDREQ YPVQSDESSS SSIIFADLNS EKEKSLAETW 300

VDNQNNKLVN YTDLITRDGS EYESSENCLV NASTTSLVNH HVLQENNSYL EENFTSSEES 360

CEENIALLGQ TEVRYHLMLH IQMQLCEISL WDWITDRNKN KGSSVDEPSC PYIMSSVATK 420

IFQELLEGVC YIHNMGVVHR DLKPRNIFLQ GPDHHVRIGD FGLACTDLIQ KDTEWTSRNR 480

KRLTHTSGVG TSLYASPEQL QGSEYDAKSD MYSLGVILLE LFQPFGTEME RAEVLTGLRN 540

GHIPESLSQR CPVQAKYIKQ LTRSNSSQRP SAAELLESEL FQSPGNVNCI LQKKVVEQEK 600

EIEKLKETIR LLSLEKGMKE DLKECGDSPV 630

Nucleotide Sequence
(FASTA)

ATGCGGGCGA TGCTCGAGGA CGATTCTGAA TCCCAGGAAT GTGAGGCAAA GGGCGCTGGA 60

GCTACGGGGT TACCACCGCC ACCTGCCATA GACTTCCCCC AGGAGGGATC GGACATCCGA 120

TATGATGAAT CTGATGTTCC TGCAGAACTC CAGGCTGTGA GAGGACCTCT ACCACACTCG 180

ACTTTTCCCT CTGCAGTTGC AAACCAACTA TTGCTTGTTT CTTTGTTAGA ACACTTGAGC 240

CATGTTCATG AATCAGACCC CCGTCGTTCA AGACAAGTGT TCACATTACT TTGCCAGACT 300

TTTACCAAAA TGGGACTGTT GTCTTCTTTT GCCTGCAGTG AAGAATTTAG TTCTTTGAGG 360

CTGCATCATA ACAAGGCTAT TACTGAATTA ATGAGAATAG CTAAGCAGAG AGTTCTTGAG 420

GCTCAGCATG AAGAATACCC TCATATTCGT AAAGTTAGAG CAAAAGAGGT GATCTTTGAA 480

GCACAGACAT CTCGTTATTT AAATGAATTT GAGGAAGTTG CTGTCCTAGG AAAGGGCGGG 540

TATGGGAAAG TATATAAGGT CAAGAACAAA TTAGATAGGC AGTTTTATGC AATAAAAAAA 600

ATTCTGATCA AGAAAGCCAC TAGAAAGGAT TGTATGAAGG TACTGCGGGA GGTGAAGGTG 660

CTGGCGGGTC TGCAACATCC TAACATTGTA GGTTATCACA CAGCTTGGAT AGAGCATGTT 720

CATTCAGCCC AGCCACAAGA TAAGAGACTT TCTATGGTCA AGTTGCCATC TCTCCAGCTG 780

GTATCTGATG AGACAGAGGA CAGAGAGCAG TATCCTGTTC AAAGTGATGA AAGTAGTAGC 840

TCATCCATTA TTTTTGCTGA TTTAAACTCA GAAAAAGAAA AATCCCTTGC AGAAACTTGG 900

GTTGACAATC AGAATAACAA ATTAGTAAAC TATACTGATT TGATCACAAG AGATGGCAGT 960

GAATATGAAT CATCAGAAAA TTGCTTAGTT AATGCATCTA CTACATCACT TGTTAACCAT 1020

CATGTGCTAC AAGAGAATAA TTCATACCTG GAGGAGAACT TTACATCCTC TGAAGAATCT 1080

TGTGAAGAAA ATATAGCCTT GCTTGGGCAG ACTGAGGTGA GATATCATCT GATGCTCCAT 1140

ATACAGATGC AACTATGTGA AATCTCCCTT TGGGACTGGA TTACTGATCG AAATAAAAAT 1200

AAGGGCTCAT CTGTAGATGA ACCTTCCTGT CCTTATATTA TGAGCAGTGT TGCAACAAAA 1260

ATTTTTCAAG AGTTATTGGA AGGTGTATGC TATATACATA ACATGGGAGT GGTACACAGA 1320

GATCTCAAGC CCAGAAATAT TTTTCTTCAA GGCCCTGACC ATCATGTAAG AATAGGAGAT 1380

TTTGGCCTAG CCTGTACAGA CCTCATTCAG AAAGACACAG AATGGACCAG TAGAAATAGA 1440

AAAAGACTTA CACATACTTC TGGAGTGGGT ACTAGTCTGT ATGCTTCACC AGAACAGCTG 1500

CAAGGATCTG AATATGATGC CAAGTCAGAC ATGTATAGTT TGGGTGTGAT TCTTCTAGAG 1560

CTCTTTCAGC CATTTGGAAC AGAAATGGAA AGAGCAGAAG TTCTGACAGG CTTAAGAAAT 1620

GGTCATATTC CAGAATCGCT TAGCCAAAGA TGTCCAGTAC AAGCTAAATA CATAAAACAA 1680

TTAACCAGGA GTAATTCTTC ACAGCGACCA TCTGCTGCAG AGCTACTGGA AAGTGAACTT 1740

TTTCAAAGTC CTGGAAATGT GAATTGTATC CTACAGAAGA AAGTAGTTGA ACAAGAAAAA 1800

GAAATTGAAA AGCTCAAGGA AACTATAAGA CTGCTTTCTC TGGAAAAAGG CATGAAGGAA 1860

GACTTGAAAG AATGTGGGGA CTCTCCAGTC TGA 1893

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59

         fee++vlGkGg+g+V+k+knkld++ yaik+i ++ka+++ ++kv+revk+La l+hpni

Q: 170   FEEVAVLGKGGYGKVYKVKNKLDRQFYAIKKILIKKATRKdCMKVLREVKVLAGLQHPNI  229

         899*********************************************************

S: 60    vrYfaawleekeesl..................................tdsseveaeae  85

         v Y++aw+e+ ++ +                                  ++ss ++a+ +

Q: 230   VGYHTAWIEHVHSAQpqdkrlsmvklpslqlvsdetedreqypvqsdesSSSSIIFADLN  289

         ************99999**********998887777777777777777433666666666

S: 86    leesesseesdtk...............................................  98

         +e+++s  e+ ++

Q: 290   SEKEKSLAETWVDnqnnklvnytdlitrdgseyessenclvnasttslvnhhvlqennsy  349

         666666665555588999999999999999999999999999999999999999999999

S: 99    ............................llyiqmelceketLkdwiderk......lles  124

                                     +l+iqm+lce  +L+dwi++r+      ++e

Q: 350   leenftsseesceeniallgqtevryhlMLHIQMQLCE-ISLWDWITDRNknkgssVDEP  408

         99999999******************************.********9998888888888

S: 125   rselvm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLatala  178

         ++ ++m     ++f++lleg+ y+H++g++HrdLkp+niFl+  d++v+igDFgLa+++

Q: 409   SCPYIMssvatKIFQELLEGVCYIHNMGVVHRDLKPRNIFLQgPDHHVRIGDFGLACTDL  468

         89999899999*******************************9999**************

S: 179   ealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfst  238

          ++ +++++++ ++  +ht+ vgt+ly+sPeql++s+Y++k+D++sLG+il+eL++pf t

Q: 469   IQKDTEWTSRNRKRL-THTSGVGTSLYASPEQLQGSEYDAKSDMYSLGVILLELFQPFGT  527

         999999**9998888.********************************************

S: 239   emervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292

         emer+e+lt lr+g+ipe++++++p+++k++++l++ ++++Rpsa ell+sel+

Q: 528   EMERAEVLTGLRNGHIPESLSQRCPVQAKYIKQLTRSNSSQRPSAAELLESELF  581

         ***************************************************986

Domain Sequence
(FASTA)

FEEVAVLGKG GYGKVYKVKN KLDRQFYAIK KILIKKATRK DCMKVLREVK VLAGLQHPNI 60

VGYHTAWIEH VHSAQPQDKR LSMVKLPSLQ LVSDETEDRE QYPVQSDESS SSSIIFADLN 120

SEKEKSLAET WVDNQNNKLV NYTDLITRDG SEYESSENCL VNASTTSLVN HHVLQENNSY 180

LEENFTSSEE SCEENIALLG QTEVRYHLML HIQMQLCEIS LWDWITDRNK NKGSSVDEPS 240

CPYIMSSVAT KIFQELLEGV CYIHNMGVVH RDLKPRNIFL QGPDHHVRIG DFGLACTDLI 300

QKDTEWTSRN RKRLTHTSGV GTSLYASPEQ LQGSEYDAKS DMYSLGVILL ELFQPFGTEM 360

ERAEVLTGLR NGHIPESLSQ RCPVQAKYIK QLTRSNSSQR PSAAELLESE LF 412

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006950	; P:response to stress

KEGG

InterPros

IPR015516	; Haem-reg_EIF2A_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013