EKS-MOD-00307

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00307

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	353.5	7.4E-106	24	274	251

Status

Unreviewed

Ensembl Protein

ENSMODP00000010412

UniProt Accession

F7CDT9;

Protein Name

Protein Synonyms/Alias

Gene Name

STK24

Gene Synonyms/Alias

STK24;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000008378	ENSMODP00000010412	ENSMODT00000010614

Organism

Monodelphis domestica

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

TMQVTALSSF SLKQNLKADP EELFTKLEKI GKGSFGEVFK GIDNRTQKVV AIKIIDLEEA 60

EDEIEDIQQE ITVLSQCDSP YVTKYYGSYL KDTKLWIIME YLGGGSALDL LEPGALDETQ 120

IATILREILK GLDYLHSEKK IHRDIKAANV LLSEQGEVKL ADFGVAGQLT DTQIKRNTFV 180

GTPFWMAPEV IKQSAYDSKA DIWSLGITAI ELAKGEPPHS ELHPMKVLFL IPKNNPPTLE 240

GNYSKPLKEF VEACLNKEPS FRPTAKELLK HKFILRNAKK TSYLTELIDR YKRWKAEQSQ 300

DDSSSEDSDA ETDGQASGGS DSGDWIFTIR EKDPKNLENG AVQPQELERN KVKDIPKRPL 360

SQCLSTVISP LFAELKEKSQ ASGGNMGSIE ELRGAIYLAE EACPGISDTM VSQLVQRLQR 420

YSLSGGGPSS H 431

Nucleotide Sequence
(FASTA)

ACGATGCAAG TAACTGCCCT CTCCTCTTTT TCTTTAAAAC AGAATCTAAA AGCAGATCCA 60

GAAGAGCTTT TTACAAAGCT AGAAAAAATT GGAAAAGGTT CCTTTGGTGA AGTATTTAAA 120

GGCATTGACA ATCGGACTCA GAAAGTAGTA GCCATAAAAA TCATTGATTT AGAAGAAGCA 180

GAAGATGAAA TAGAAGACAT TCAGCAAGAA ATCACAGTGC TGAGTCAGTG CGACAGTCCA 240

TATGTCACAA AATATTATGG ATCTTATCTC AAGGATACCA AATTGTGGAT AATAATGGAA 300

TATCTTGGTG GAGGCTCTGC ACTAGATCTG TTAGAACCTG GTGCTCTAGA TGAAACTCAG 360

ATTGCTACTA TATTAAGAGA AATCCTGAAA GGACTCGATT ATTTGCATTC AGAAAAGAAA 420

ATTCACCGAG ATATCAAAGC TGCAAATGTT CTGCTCTCTG AACAAGGGGA AGTGAAACTT 480

GCTGATTTTG GAGTAGCTGG GCAGCTGACA GATACCCAAA TAAAAAGAAA CACCTTTGTG 540

GGCACCCCAT TTTGGATGGC ACCTGAAGTC ATTAAGCAAT CTGCCTATGA TTCAAAGGCA 600

GATATCTGGT CTCTGGGCAT AACAGCAATA GAGCTGGCTA AAGGCGAACC TCCTCATTCA 660

GAGCTACACC CAATGAAGGT GTTATTCCTC ATTCCAAAGA ACAATCCACC AACGCTGGAA 720

GGGAACTACA GCAAACCCCT CAAAGAGTTT GTGGAGGCCT GTCTAAACAA GGAACCAAGC 780

TTTAGACCGA CAGCAAAGGA GTTGTTGAAA CACAAGTTTA TATTAAGAAA TGCAAAGAAA 840

ACATCTTACT TGACAGAACT GATTGACAGG TACAAGAGAT GGAAGGCTGA ACAGAGCCAA 900

GATGACTCTA GTTCAGAAGA CTCAGATGCA GAAACAGATG GTCAGGCATC AGGCGGCAGT 960

GACTCAGGAG ACTGGATCTT TACAATCAGA GAAAAAGATC CCAAGAACCT GGAGAATGGA 1020

GCAGTTCAGC CACAAGAACT GGAAAGAAAT AAGGTGAAAG ATATCCCAAA GAGGCCTTTG 1080

TCTCAGTGTT TATCTACAGT TATTTCTCCC CTATTTGCAG AGTTGAAAGA GAAAAGCCAG 1140

GCAAGTGGAG GCAACATGGG ATCCATAGAA GAACTGAGAG GTGCGATTTA TTTGGCAGAA 1200

GAAGCCTGTC CTGGGATCTC GGACACCATG GTGTCTCAGC TTGTACAGAG GCTACAGAGA 1260

TATTCACTGA GTGGTGGAGG ACCTTCATCC CACTGA 1296

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkhpniv  59

         ++ le+igkG++g+v+++ +++t+++vaik+i+le+  +++e++q+ei+vl+++++p+++

Q: 24    FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAeDEIEDIQQEITVLSQCDSPYVT  83

         7889*******************************99899********************

S: 60    eylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119

         +y++s+lk+++lw++meyl gGs+ dl++      l+E+qia+ilre+lk+L+ylHs+k+

Q: 84    KYYGSYLKDTKLWIIMEYLGGGSALDLLE---PGALDETQIATILREILKGLDYLHSEKK  140

         *****************************...****************************

S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYde  179

         iHrdika+n+Ll+e+geVkL+dfgva ql++t+ kr+t+vgtp+wmAPEvi+  ++ Yd+

Q: 141   IHRDIKAANVLLSEQGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK--QSAYDS  198

         ****************************************************..9*****

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclq  239

         kaDiwslGItaiela+gepP+++l+p+k+l++i+kn+pp+l+ +  +sk +kefve+cl+

Q: 199   KADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLEGN--YSKPLKEFVEACLN  256

         *****************************************776..**************

S: 240   knpekRpsasellkhkFl  257

         k+p++Rp+a+ellkhkF+

Q: 257   KEPSFRPTAKELLKHKFI  274

         *****************7

Domain Sequence
(FASTA)

FTKLEKIGKG SFGEVFKGID NRTQKVVAIK IIDLEEAEDE IEDIQQEITV LSQCDSPYVT 60

KYYGSYLKDT KLWIIMEYLG GGSALDLLEP GALDETQIAT ILREILKGLD YLHSEKKIHR 120

DIKAANVLLS EQGEVKLADF GVAGQLTDTQ IKRNTFVGTP FWMAPEVIKQ SAYDSKADIW 180

SLGITAIELA KGEPPHSELH PMKVLFLIPK NNPPTLEGNY SKPLKEFVEA CLNKEPSFRP 240

TAKELLKHKF I 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006917	; P:induction of apoptosis
GO:0008631	; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0030336	; P:negative regulation of cell migration
GO:0046777	; P:protein autophosphorylation
GO:0048679	; P:regulation of axon regeneration

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013