EKS-MOD-00383
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00383
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl543.21.1E-163530795266
StatusUnreviewed
Ensembl ProteinENSMODP00000031323
UniProt AccessionF6VDX1;
Protein Name
Protein Synonyms/Alias
Gene NameAXL
Gene Synonyms/Alias AXL;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000008491ENSMODP00000031323ENSMODT00000032894
OrganismMonodelphis domestica
Functional Description
Protein Length886
Protein Sequence
(FASTA)
MPGSTRMGRA GLAWCLALWC WGSWAREGVW DPFVTGPGNV TGARGRGAVL RCEVRVAGEA 60
PEVSWLRDGQ VLELADSTQT QVPLGEDGQD DWKVVSQLRI SALQLSDAGR YQCSVAVEGE 120
TFLSPPAYVG LEGLPYFLEE PGDMTVPADT PFNLTCQAQG PPDPVNLLWL QDGAPLASHN 180
PTKGLLHLPG LNKTSSFSCE AHNAKGVTTS RTAMVTVLPQ RPQHLQPVSS SPTTLEVAWT 240
PGASGIYPIT NCALQAVLSD DGVGPGPGAM EPPEEPLAFQ IAVPPHSLHL ENLQPHSAYH 300
IRVACASSQG PSSWTHWVLV ETPEGVPMGP PENVSAIRNG SQALVRWQPP RAPLQGTLQG 360
YKLAYREEDA PEVLVDAGLR REVTLELRGE GVLPNLTLRV AAYTTAGDGP WSVPVQLEPW 420
RPGDGQPIHQ HVKDPPAPAF SWPWWYVLLG AVTAAACVLL LALFLFHRRK KETRYGEVFQ 480
PTVERGELVV RYRVRKSYSR RTTEATLNSL GISEELKEKL RDVMVDRHKV ALGKTLGEGE 540
FGSVMEGQLN QDDSILKVAV KTMKIAICTR SEMEDFLSEA VCMKEFDHPN VMRLIGVCLQ 600
GSECEGFPSP VVILPFMKHG DLHSFLLYSR LGDQPMFLPT QTLVKFMADI ASGMDYLSTK 660
RFIHRDLAAR NCMLNENMSV CVADFGLSKK IYNGDYYRQG RIAKMPVKWI AIESLADRVY 720
TSKSDVWSFG VTMWEIATRG QTPYPGVENS EIYDYLRQGH RLKQPLDCLD GLYELMSRCW 780
SLSPRDRPTF AELREELEMT LKGLPPTQDP EEILYVNMDG EPAGAAGGTP QASPLPVPKA 840
SCNCSCITSA DVHPAGRYVL CPSTAPGPPM PTTRRPPAPP GQEEGA 886
Nucleotide Sequence
(FASTA)
ATGCCTGGGT CCACCAGGAT GGGCAGAGCG GGGCTGGCGT GGTGCCTGGC CCTCTGGTGC 60
TGGGGAAGTT GGGCCCGGGA AGGCGTTTGG GACCCATTTG TGACCGGACC TGGGAATGTG 120
ACAGGGGCCA GGGGCCGAGG GGCTGTCCTT CGCTGTGAGG TGCGAGTGGC CGGGGAGGCC 180
CCAGAGGTGA GCTGGCTCCG AGATGGGCAG GTGCTAGAAC TGGCCGACAG CACCCAGACC 240
CAAGTGCCCC TGGGGGAAGA CGGCCAAGAT GACTGGAAGG TGGTCAGTCA GCTCAGGATC 300
TCAGCCCTGC AGCTCTCAGA TGCTGGGAGA TATCAGTGCT CTGTGGCTGT GGAGGGAGAG 360
ACTTTCCTCT CACCACCAGC CTACGTTGGT CTGGAAGGAC TCCCCTATTT CCTGGAGGAG 420
CCGGGAGATA TGACTGTGCC TGCTGACACC CCATTCAACC TCACCTGCCA AGCTCAGGGG 480
CCCCCTGATC CTGTAAATCT GCTCTGGCTT CAGGATGGTG CCCCCCTGGC CTCACACAAT 540
CCCACAAAGG GCTTGCTCCA CCTGCCAGGC CTGAATAAGA CGTCATCCTT CTCCTGTGAG 600
GCCCATAATG CCAAAGGGGT CACCACTTCC CGGACGGCCA TGGTTACAGT GCTTCCACAA 660
CGTCCCCAGC ACCTCCAGCC CGTTTCCAGC AGTCCCACCA CGCTTGAAGT AGCCTGGACA 720
CCAGGGGCCA GTGGGATTTA CCCCATCACC AATTGTGCCC TGCAGGCTGT GCTATCAGAT 780
GATGGGGTTG GGCCTGGACC TGGAGCCATG GAACCCCCGG AGGAGCCACT GGCATTTCAA 840
ATAGCTGTAC CACCCCACAG CCTGCACCTG GAGAACCTGC AGCCTCACAG TGCCTACCAT 900
ATACGTGTGG CCTGTGCCAG TTCCCAGGGC CCCTCATCCT GGACACACTG GGTGTTGGTG 960
GAGACACCGG AGGGAGTACC AATGGGACCC CCAGAGAATG TGAGTGCCAT CCGAAATGGC 1020
AGCCAAGCTC TGGTGCGCTG GCAGCCACCT CGAGCTCCAT TGCAGGGGAC GCTGCAAGGG 1080
TACAAGCTGG CATACCGGGA AGAGGATGCG CCTGAGGTGC TGGTAGACGC AGGGCTGAGA 1140
CGGGAAGTGA CTCTGGAGCT TCGTGGGGAG GGGGTGTTAC CCAACCTAAC CCTGCGGGTG 1200
GCAGCCTACA CCACTGCCGG TGATGGGCCC TGGAGCGTGC CTGTGCAGCT GGAGCCCTGG 1260
AGACCAGGAG ATGGGCAGCC AATACACCAG CATGTGAAGG ACCCCCCCGC CCCTGCCTTC 1320
TCCTGGCCCT GGTGGTACGT GCTCCTCGGG GCCGTCACGG CTGCCGCCTG TGTGCTCCTC 1380
CTCGCCCTCT TCCTCTTCCA CCGGAGAAAG AAGGAGACCC GTTACGGGGA AGTGTTCCAG 1440
CCCACCGTGG AGCGCGGAGA GCTCGTGGTT CGGTACCGGG TCCGGAAGTC CTACAGCCGC 1500
CGCACTACTG AAGCTACTCT GAACAGCCTG GGCATCAGTG AAGAGCTGAA GGAGAAACTC 1560
AGAGACGTGA TGGTAGACCG GCACAAGGTG GCACTGGGAA AGACCCTGGG AGAAGGAGAA 1620
TTTGGTTCTG TTATGGAAGG GCAGCTGAAC CAGGATGACT CCATCCTCAA AGTGGCTGTG 1680
AAAACCATGA AGATTGCCAT CTGTACGCGG TCAGAGATGG AGGACTTCCT GAGTGAGGCG 1740
GTCTGTATGA AGGAGTTTGA CCATCCCAAT GTCATGAGGC TCATTGGGGT TTGCCTCCAG 1800
GGCTCGGAGT GCGAGGGATT CCCTTCGCCC GTGGTCATTT TGCCCTTCAT GAAACATGGA 1860
GACCTGCACA GTTTCCTGCT CTATTCACGA CTCGGGGACC AGCCCATGTT CCTACCTACT 1920
CAAACGCTGG TGAAGTTCAT GGCCGACATC GCCAGTGGGA TGGACTACCT GAGCACCAAG 1980
AGGTTTATTC ACAGAGACTT GGCTGCCCGG AACTGCATGC TAAATGAGAA CATGTCCGTG 2040
TGCGTGGCCG ACTTTGGCCT CTCCAAGAAG ATCTACAACG GGGATTATTA CCGCCAGGGC 2100
CGTATTGCTA AGATGCCAGT CAAATGGATC GCCATTGAGA GCCTGGCTGA CCGTGTCTAC 2160
ACCAGCAAAA GTGATGTGTG GTCCTTTGGG GTAACCATGT GGGAGATCGC AACTCGAGGC 2220
CAGACACCTT ACCCAGGGGT AGAGAACAGC GAGATCTACG ACTACCTGAG GCAAGGCCAT 2280
CGCCTCAAGC AGCCACTAGA CTGTCTGGAT GGACTGTATG AGCTGATGTC CCGTTGCTGG 2340
TCCCTGAGCC CCAGAGACCG GCCAACCTTC GCAGAACTTC GAGAAGAGCT GGAGATGACA 2400
CTGAAGGGCC TTCCCCCCAC CCAGGACCCT GAAGAGATCC TCTATGTCAA CATGGATGGG 2460
GAACCTGCTG GGGCAGCTGG TGGTACGCCC CAAGCCAGCC CCCTGCCAGT CCCAAAGGCC 2520
TCCTGCAACT GCAGCTGCAT CACCTCTGCC GATGTCCACC CAGCCGGACG ATATGTCCTC 2580
TGCCCCTCCA CAGCCCCCGG GCCCCCAATG CCCACAACCA GGAGGCCACC TGCCCCTCCT 2640
GGCCAGGAGG AGGGGGCCTA G 2661
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lgk+lgegefgsvmegql+q+d silkvavkt+k++i++rse+e+flsea+cmkefdh
Q: 530   VALGKTLGEGEFGSVMEGQLNQDD-SILKVAVKTMKIAICTRSEMEDFLSEAVCMKEFDH  588
         68**********************.***********************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnv+rl+gv+l++se + +p pvvilpfmk+gdlh+fllysrlg++p++lp+qtlvkfm+
Q: 589   PNVMRLIGVCLQGSECEGFPSPVVILPFMKHGDLHSFLLYSRLGDQPMFLPTQTLVKFMA  648
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         diasgm+yls+++fihrdlaarncml+e+m+vcvadfglskkiy+gdyyrqgriak+pvk
Q: 649   DIASGMDYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK  708
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvw+fgvtmweiatrgqtpy+gven+eiydyl+qg+rlkqp dc
Q: 709   WIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGHRLKQPLDC  768
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlre  267
         ld+ly+lm+rcw++ p+drp+f++lre
Q: 769   LDGLYELMSRCWSLSPRDRPTFAELRE  795
         *************************96
Domain Sequence
(FASTA)
VALGKTLGEG EFGSVMEGQL NQDDSILKVA VKTMKIAICT RSEMEDFLSE AVCMKEFDHP 60
NVMRLIGVCL QGSECEGFPS PVVILPFMKH GDLHSFLLYS RLGDQPMFLP TQTLVKFMAD 120
IASGMDYLST KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG HRLKQPLDCL 240
DGLYELMSRC WSLSPRDRPT FAELRE 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00371
EKS-ANC-00385
EKS-BOT-00398
EKS-CAJ-00402
EKS-CAP-00425
EKS-CII-00235
EKS-EQC-00386
EKS-GAA-00486
EKS-GOG-00386
EKS-HOS-00402
EKS-ICT-00374
EKS-LAC-00413
EKS-LOA-00405
EKS-MAM-00398
EKS-MUM-00431
EKS-MUP-00391
EKS-MYL-00394
EKS-ORN-00509
EKS-ORC-00373
EKS-ORL-00466
EKS-OTG-00401
EKS-PAT-00376
EKS-POA-00389
EKS-RAN-00410
EKS-SAH-00366
EKS-TAR-00500
EKS-TEN-00498
EKS-XET-00509
EKS-XIM-00501
Gene Ontology
GO:0009986; C:cell surface
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0001786; F:phosphatidylserine binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0001974; P:blood vessel remodeling
GO:0048469; P:cell maturation
GO:0031668; P:cellular response to extracellular stimulus
GO:0035457; P:cellular response to interferon-alpha
GO:0071222; P:cellular response to lipopolysaccharide
GO:0097028; P:dendritic cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0034101; P:erythrocyte homeostasis
GO:0021885; P:forebrain cell migration
GO:0006954; P:inflammatory response
GO:0001779; P:natural killer cell differentiation
GO:2000669; P:negative regulation of dendritic cell apoptotic process
GO:0032689; P:negative regulation of interferon-gamma production
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0001764; P:neuron migration
GO:0042698; P:ovulation cycle
GO:0030168; P:platelet activation
GO:0001961; P:positive regulation of cytokine-mediated signaling pathway
GO:0032825; P:positive regulation of natural killer cell differentiation
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013