EKS-MOD-00106
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00106
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec466.81.6E-140378628251
StatusUnreviewed
Ensembl ProteinENSMODP00000010566
UniProt AccessionF7FTR6;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000008495ENSMODP00000010566ENSMODT00000010772
OrganismMonodelphis domestica
Functional Description
Protein Length635
Protein Sequence
(FASTA)
MNNCILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKANLAY FEDRQGKKRI LKGSIELSRI 60
KCVEIVKSDI SIPCHYKYPF QVCVAFTNSV ASLPLQVVHD NYLLYVFAPD RESRQRWVLA 120
LKEETKNNNS LVPKYHPNFW IDGRWRCCAQ TEKLASGCAE YDPTKNASKK PLPPTPEDNR 180
RSLREPEEIL VIALYDYNTN DPQELTLQSN EEYYLLNSSE IHWWRVQDKN GHEGYVPSSY 240
LVEKSPNNLE TYEWYNKSIS RDKAEKLLLD EGKEGAFMVR DSRTPGTYTL SVFTKAIVSE 300
NNPCIKHYHI KETNDHPKRY YVAEKFVFDS IPNLIKYHQH NGGGLVTRLR YPVCSWRKKA 360
PITAGLRYGK WVIKPSELTF VQEIGSGQFG LVHLGYWLGK NKVAIKTIQE GAMSEEDFIE 420
EAEVMMKLSH PKLVQLYGVC LEQAPICLVF EFMEHGCLSD YLRNQRGLFS ADTLLGMCQD 480
VCEGMAYLEE ACVIHRDLAA RNCLVGENQV IKVSDFGMTR FVLDDQYTSS TGTKFPVKWA 540
SPEVFSFSRY SSKSDVWSFG VLMWEVFSEG KIPYENSSNT KVVEDISTGY RLYKPRLSSP 600
IIYQVMNDCW KEKPEDRPSF SSLLCQLAEI AESAL 635
Nucleotide Sequence
(FASTA)
ATGAATAACT GTATCCTGCT GGAAGAACAA CTGATCAAAA AATCCCAACA AAAGAGAAGG 60
ACTTCTCCTT CTAACTTCAA AGTGCGCTTC TTTGTTTTAA CCAAAGCCAA CTTAGCATAT 120
TTTGAAGACC GACAAGGGAA GAAACGAATT TTGAAGGGTT CTATTGAACT TTCCAGAATC 180
AAATGTGTGG AGATTGTGAA GAGTGATATC AGCATCCCTT GCCACTATAA ATATCCCTTC 240
CAAGTTTGTG TTGCATTTAC TAATTCTGTT GCATCTCTCC CACTGCAGGT GGTGCATGAT 300
AATTATCTCC TATATGTATT CGCTCCAGAT CGAGAAAGCC GACAGAGATG GGTGTTGGCC 360
CTTAAAGAAG AAACCAAAAA TAACAATAGT TTGGTGCCAA AGTACCACCC CAACTTCTGG 420
ATAGATGGGA GGTGGAGATG CTGTGCCCAG ACTGAAAAGC TTGCATCTGG CTGTGCTGAA 480
TACGATCCAA CCAAGAATGC TTCAAAGAAG CCTCTTCCTC CCACTCCCGA AGACAATCGG 540
AGGTCATTGA GAGAGCCTGA AGAAATCCTA GTCATTGCCC TATATGACTA CAACACAAAT 600
GATCCCCAGG AGCTCACTCT GCAAAGCAAT GAAGAATATT ACTTGCTCAA CAGTTCAGAG 660
ATCCATTGGT GGAGAGTCCA AGACAAGAAT GGGCACGAAG GATATGTTCC AAGCAGTTAC 720
CTGGTAGAGA AATCACCAAA TAACCTGGAA ACATATGAGT GGTACAACAA GAGCATCAGT 780
CGTGACAAAG CCGAAAAGCT CCTTTTAGAT GAGGGCAAAG AAGGAGCCTT CATGGTGAGG 840
GACTCCAGGA CACCAGGAAC ATACACTCTT TCTGTTTTCA CCAAGGCCAT CGTAAGTGAG 900
AACAATCCAT GTATCAAGCA TTATCACATC AAAGAGACCA ATGACCATCC CAAACGATAC 960
TATGTGGCTG AAAAATTTGT GTTTGATTCC ATCCCCAACC TGATTAAATA TCACCAACAC 1020
AATGGAGGAG GTCTTGTTAC ACGTTTACGA TACCCTGTTT GTTCCTGGAG AAAAAAGGCC 1080
CCCATCACAG CTGGATTGAG ATACGGCAAA TGGGTAATCA AACCCTCAGA ACTCACTTTT 1140
GTGCAGGAGA TTGGCAGTGG GCAGTTTGGC CTGGTGCATC TTGGCTACTG GCTGGGAAAG 1200
AACAAGGTTG CCATCAAGAC CATTCAGGAA GGGGCCATGT CAGAAGAGGA TTTCATAGAG 1260
GAGGCTGAAG TCATGATGAA ACTCTCTCAC CCTAAACTGG TTCAGCTCTA TGGGGTCTGT 1320
TTGGAGCAGG CTCCTATCTG CTTGGTGTTT GAGTTCATGG AACATGGCTG TCTATCTGAT 1380
TACCTCCGGA ACCAACGAGG TCTCTTTTCT GCTGACACTC TCCTGGGCAT GTGCCAGGAT 1440
GTGTGTGAGG GAATGGCTTA CTTGGAAGAG GCTTGTGTCA TTCACAGAGA CCTGGCCGCA 1500
CGGAACTGTT TGGTGGGAGA AAACCAAGTT ATCAAAGTGT CAGACTTTGG CATGACAAGG 1560
TTTGTTCTTG ATGACCAGTA TACAAGCTCT ACTGGCACCA AGTTCCCTGT GAAGTGGGCT 1620
TCCCCAGAGG TTTTCTCTTT CAGTCGCTAT AGTAGCAAAT CTGACGTGTG GTCATTTGGA 1680
GTTCTAATGT GGGAAGTCTT CAGTGAGGGC AAAATCCCTT ATGAAAACAG TAGCAACACC 1740
AAAGTGGTGG AGGATATCAG CACTGGATAC CGGCTGTATA AACCTAGGCT GTCCTCCCCT 1800
ATCATCTACC AGGTCATGAA TGATTGCTGG AAAGAGAAAC CAGAAGACAG ACCATCTTTC 1860
TCCAGCCTGC TGTGTCAGCT GGCTGAAATC GCTGAATCTG CACTTTAA 1908
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w +k +vaik+i+egamseedfieea+vmmklshpklvqly
Q: 378   LTFVQEIGSGQFGLVHLGYWLGKNKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  437
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++ +++++ll mc+dvcegm+yle++++ihrd
Q: 438   GVCLEQAPICLVFEFMEHGCLSDYLRNQRGLFSADTLLGMCQDVCEGMAYLEEACVIHRD  497
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 498   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  557
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye+ sn++vve++s+g+rly+p+l+s  +y+vm+ cwkekpe+r
Q: 558   SFGVLMWEVFSEGKIPYENSSNTKVVEDISTGYRLYKPRLSSPIIYQVMNDCWKEKPEDR  617
         ************************************************************
S: 241   ptfkellsale  251
         p+f++ll +l+
Q: 618   PSFSSLLCQLA  628
         *******9986
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LGKNKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60
GVCLEQAPIC LVFEFMEHGC LSDYLRNQRG LFSADTLLGM CQDVCEGMAY LEEACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGKIPYENS SNTKVVEDIS TGYRLYKPRL SSPIIYQVMN DCWKEKPEDR 240
PSFSSLLCQL A 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543; F:phospholipid binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0035556; P:intracellular signal transduction
GO:0001865; P:NK T cell differentiation
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013