EKS-MOD-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	557.8	3.5E-168	499	775	277

Status

Unreviewed

Ensembl Protein

ENSMODP00000010602

UniProt Accession

F7DHF8;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000008525	ENSMODP00000010602	ENSMODT00000010809

Organism

Monodelphis domestica

Functional Description

Protein Length

839

Protein Sequence
(FASTA)

MGLMSTWNYG KGPGIGTVKM VSWGRFMCLV LVTMATFSLA RPSFNLVEET TLEPEEPPTK 60

YQISQPDVYA VLPGEPLELR CSLKDAIMIS WTKDGVQLGP NNRTVLFGEY LQIKGAIPRD 120

SGLYACTAAR TVDSETLYFM VNVTDAIASG DDEDDNEGSE DFVSDNNNMR APYWTHTEKM 180

EKRLHAVPAA NTVKFRCPAG GNPIPSMRWL KNGKEFKQEH RIGGYKVRNQ HWSLIMESVV 240

PSDKGNYTCI VENEYGSINH TYHLDVVERS PHRPILQAGL PANASTVVGG DVEFVCKVYS 300

DAQPHIQWIK HVERNGSKYG PDGLPYLKVL KAAGVNTTDK EIEVLYIRNV TFEDAGEYTC 360

LAGNSIGISF HSAWLTVLPA PVREKEFPAS PEYLEIAIYC IGVFLIACMV VTVILCRMKT 420

TTKKPDFSSQ PAVHKLTKRI PLRRQVTVSA DSSSSMNSNT PLVRITTRLS STADAPMLAG 480

VSEYELPEDP KWEFPRDKLT LGKPLGEGCF GQVVMAEAVG IDKDKPKEAV TVAVKMLKDD 540

ATEKDLSDLV SEMEMMKMIG KHKNIINLLG ACTQDGPLYV IVEYASKGNL REYLRARRPP 600

GMEYSFDINR VPEEQMTFKD LVSCTYQLAR GMEYLASQKC IHRDLAARNV LVTENNVMKI 660

ADFGLARDIN NIDYYKKTTN GRLPVKWMAP EALFDRVYTH QSDVWSFGVL MWEIFTLGGS 720

PYPGIPVEEL FKLLKEGHRM DKPANCTNEL YMMMRDCWHA VPSQRPTFKQ LVEDLDRILT 780

LTTNEEYLDL SGPLEQYSPS YPDTRSSCSS GDDSVFSPDP MPYEPCLPKY QHINGTVKT 839

Nucleotide Sequence
(FASTA)

ATGGGATTAA TGTCCACATG GAACTATGGA AAAGGACCCG GGATTGGCAC AGTGAAGATG 60

GTCAGCTGGG GTCGATTCAT GTGCCTGGTT TTAGTCACCA TGGCAACATT TTCCCTGGCC 120

AGACCATCAT TCAATTTAGT TGAAGAAACC ACCTTAGAAC CTGAAGAGCC ACCAACCAAA 180

TACCAAATCT CTCAGCCAGA TGTATATGCT GTCCTGCCAG GAGAGCCCCT TGAATTGCGC 240

TGCTCGTTGA AAGATGCCAT CATGATCAGT TGGACTAAGG ATGGGGTACA ATTGGGGCCC 300

AACAATAGGA CAGTTCTTTT TGGGGAATAC TTGCAGATTA AAGGCGCCAT TCCTAGAGAT 360

TCCGGCCTCT ATGCTTGCAC TGCTGCTAGG ACTGTAGACA GTGAAACCTT GTACTTCATG 420

GTCAATGTTA CAGATGCAAT TGCCTCAGGA GATGATGAAG ATGACAATGA AGGTTCTGAG 480

GATTTTGTCA GTGATAACAA TAACATGAGA GCACCATATT GGACCCATAC AGAGAAGATG 540

GAAAAGAGGT TACATGCTGT CCCAGCAGCT AACACAGTGA AATTTCGATG TCCTGCTGGG 600

GGAAATCCTA TACCAAGTAT GAGATGGTTA AAGAATGGGA AAGAATTCAA GCAAGAGCAT 660

CGTATTGGTG GATACAAGGT ACGAAATCAG CACTGGAGTC TTATCATGGA GAGTGTGGTT 720

CCATCTGACA AAGGAAATTA TACATGTATA GTTGAAAATG AATATGGATC CATCAACCAC 780

ACATACCATC TTGATGTTGT TGAACGATCT CCCCACCGGC CCATCCTTCA AGCGGGACTA 840

CCAGCAAATG CTTCTACAGT GGTTGGGGGT GATGTGGAGT TTGTCTGCAA AGTCTACAGT 900

GATGCTCAGC CCCATATCCA ATGGATCAAA CATGTAGAAA GGAATGGCAG TAAATATGGG 960

CCAGATGGAT TACCATACCT TAAGGTTCTA AAGGCCGCCG GTGTTAACAC CACGGACAAA 1020

GAGATTGAGG TTCTCTATAT TCGGAATGTA ACTTTTGAGG ATGCTGGGGA GTATACGTGC 1080

TTGGCGGGTA ATTCTATTGG GATATCCTTT CACTCTGCAT GGTTGACAGT TCTGCCAGCA 1140

CCTGTAAGAG AAAAGGAATT TCCAGCTTCC CCAGAGTACC TGGAGATAGC CATTTACTGC 1200

ATAGGGGTCT TCTTAATTGC CTGTATGGTG GTGACAGTTA TACTGTGTCG AATGAAGACA 1260

ACCACCAAGA AGCCGGACTT CAGTAGCCAA CCAGCTGTGC ACAAGCTGAC CAAGCGCATC 1320

CCCTTGAGGA GACAGGTAAC AGTGTCTGCT GATTCCAGCT CCTCCATGAA CTCCAATACA 1380

CCATTGGTGA GAATAACAAC CCGACTGTCC TCAACGGCTG ATGCCCCAAT GTTGGCAGGG 1440

GTCTCTGAGT ACGAATTGCC TGAGGACCCA AAATGGGAGT TTCCAAGAGA CAAGCTGACG 1500

CTGGGCAAAC CCCTTGGGGA AGGTTGCTTT GGGCAAGTTG TAATGGCAGA AGCGGTGGGA 1560

ATTGACAAAG ACAAGCCTAA AGAAGCTGTT ACCGTGGCAG TGAAGATGTT GAAAGATGAT 1620

GCTACAGAGA AAGATCTTTC TGACCTAGTA TCAGAGATGG AGATGATGAA AATGATTGGA 1680

AAACACAAAA ATATCATAAA TCTTCTTGGA GCCTGTACCC AGGATGGTCC ACTGTATGTG 1740

ATAGTTGAGT ATGCTTCTAA AGGAAACCTA AGAGAATATC TCCGAGCCAG GAGACCCCCT 1800

GGGATGGAAT ATTCATTTGA CATAAACAGG GTACCAGAAG AACAGATGAC TTTCAAAGAC 1860

TTGGTATCCT GCACATACCA ACTAGCAAGA GGAATGGAAT ATTTAGCATC ACAAAAATGC 1920

ATTCACCGAG ACTTAGCGGC CAGAAATGTT TTGGTGACAG AAAACAATGT GATGAAAATA 1980

GCAGATTTTG GTTTGGCCAG AGATATCAAC AACATAGATT ACTACAAAAA GACCACAAAT 2040

GGACGACTCC CTGTCAAATG GATGGCTCCT GAGGCTCTTT TTGATAGAGT GTACACACAT 2100

CAAAGTGACG TCTGGTCATT TGGAGTGTTA ATGTGGGAGA TCTTCACTTT AGGGGGATCC 2160

CCCTATCCAG GAATCCCAGT GGAGGAACTC TTTAAGCTGC TTAAGGAAGG CCACAGGATG 2220

GATAAACCAG CTAACTGCAC CAATGAGCTG TACATGATGA TGCGGGATTG TTGGCATGCT 2280

GTTCCTTCTC AAAGACCAAC ATTCAAGCAG TTGGTAGAAG ATTTGGACCG AATTCTCACT 2340

CTCACAACTA ATGAGGAATA CTTGGACCTG AGTGGACCTC TGGAACAGTA TTCACCTAGT 2400

TATCCTGACA CTAGAAGCTC ATGTTCTTCA GGAGATGACT CTGTATTTTC TCCAGATCCA 2460

ATGCCTTATG AACCATGCCT TCCCAAGTAT CAACACATAA ATGGCACTGT TAAAACATGA 2520

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 499   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  558

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s d ++++eeq+t+

Q: 559   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTF  618

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 619   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  678

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 679   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  738

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 739   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  775

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSFDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0009986	; C:cell surface
GO:0031012	; C:extracellular matrix
GO:0005887	; C:integral to plasma membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0001525	; P:angiogenesis
GO:0007409	; P:axonogenesis
GO:0030282	; P:bone mineralization
GO:0060349	; P:bone morphogenesis
GO:0060667	; P:branch elongation involved in salivary gland morphogenesis
GO:0060670	; P:branching involved in labyrinthine layer morphogenesis
GO:0048755	; P:branching morphogenesis of a nerve
GO:0060449	; P:bud elongation involved in lung branching
GO:0045165	; P:cell fate commitment
GO:0048557	; P:embryonic digestive tract morphogenesis
GO:0009880	; P:embryonic pattern specification
GO:0061031	; P:endodermal digestive tract morphogenesis
GO:0060664	; P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060595	; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069	; P:hair follicle morphogenesis
GO:0032808	; P:lacrimal gland development
GO:0060601	; P:lateral sprouting from an epithelium
GO:0070307	; P:lens fiber cell development
GO:0060174	; P:limb bud formation
GO:0048286	; P:lung alveolus development
GO:0060463	; P:lung lobe morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0060615	; P:mammary gland bud formation
GO:0003149	; P:membranous septum morphogenesis
GO:0060915	; P:mesenchymal cell differentiation involved in lung development
GO:0060916	; P:mesenchymal cell proliferation involved in lung development
GO:0030901	; P:midbrain development
GO:0035264	; P:multicellular organism growth
GO:0008285	; P:negative regulation of cell proliferation
GO:0045839	; P:negative regulation of mitosis
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528	; P:neuromuscular junction development
GO:0042476	; P:odontogenesis
GO:0035265	; P:organ growth
GO:0030916	; P:otic vesicle formation
GO:0003148	; P:outflow tract septum morphogenesis
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0051781	; P:positive regulation of cell division
GO:0060501	; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0010518	; P:positive regulation of phospholipase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009791	; P:post-embryonic development
GO:0060527	; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523	; P:prostate epithelial cord elongation
GO:0046777	; P:protein autophosphorylation
GO:0060687	; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453	; P:regulation of cell fate commitment
GO:0040036	; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014	; P:regulation of multicellular organism growth
GO:0051150	; P:regulation of smooth muscle cell differentiation
GO:0008589	; P:regulation of smoothened signaling pathway
GO:0060529	; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489	; P:synaptic vesicle transport
GO:0001657	; P:ureteric bud development
GO:0055010	; P:ventricular cardiac muscle tissue morphogenesis

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013