EKS-MOD-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	342.1	2.2E-102	120	393	274

Status

Unreviewed

Ensembl Protein

ENSMODP00000010636

UniProt Accession

F7DGL7;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000008553	ENSMODP00000010636	ENSMODT00000010843

Organism

Monodelphis domestica

Functional Description

Protein Length

816

Protein Sequence
(FASTA)

AGPAREAPAA GAGCSSSSSS ASSCCSSSSL IAGGSRLWAA LYDYEASGED ELSLRRGQLV 60

EVLSQDAAVS GDEGWWTGQV QRRLGIFPAN YVAPCYPPRP PEPARQRPGS PMQIEFEWLE 120

LKELIGAGGF GQVYRATWAG QEVAVKAARR DPEQDPAAAA DSVLREAKLF SMLRHPNIIQ 180

LRGVCLQQPN LCLVLEFARG GALNRALAAG TPEPSGAAPS PRPARRIPPH ILVNWAVQIA 240

RGMLYLHEEA VVPILHRDLK SSNILLLEKI EHDDICNKTL KITDFGLARE WHRTTKMSAA 300

GTYAWMAPEV IKSSLFSKGS DIWSYGVLLW ELLTGEVPYR GIDGLAVAYG VAVNKLTLPI 360

PSTCPEPFAK LMKECWEQDP HIRPSFALIL EQLTAIEGAV MTEMPQESFH SMQDDWKLEI 420

QQMFDELRTK EKELRSREEE LTRAALQQKS QEELLKRREQ QLAEREIDVL ERELNILIFQ 480

LNQEKPNVKK RKGKFKRSRL KLKDGHRISL PSDFQHKITV QASPNLDKRR SLNSNSSSPP 540

SSPTIIPRLR AIQLTSEESN RTWGKSTAYR QEEFEDVKRN FKKKGCTWGP SSVQTKDRTD 600

CKERVRPLSD GSNPWSTILM KNQKTVPLAS LFVDQQGKCA LKLFPDGLDN KRPKQIKLPN 660

QAYVDLPLWK DDQGDNTIEP ESFEEGTSAS SAASTPQMTP TNSLSRTPPK KKTESALYGC 720

AALLASVALG LDIRELNKVQ SPDELLPKED KKKREGIFHR ASKLRRSSSP PTRLQSKRED 780

VNIPSISPSS NTVNLLSMPS ISTKCLLHSD NEDTFV 816

Nucleotide Sequence
(FASTA)

GCCGGCCCAG CCCGGGAAGC GCCTGCGGCG GGCGCGGGCT GCTCGTCCTC GTCTTCCTCC 60

GCCTCCTCCT GCTGCTCATC CTCGTCTTTG ATAGCAGGGG GCAGCCGACT CTGGGCCGCC 120

CTCTACGACT ATGAGGCGAG CGGCGAGGAT GAGCTGAGCT TGCGGCGGGG CCAGTTGGTA 180

GAGGTGCTGT CGCAGGACGC CGCCGTGTCG GGCGATGAGG GCTGGTGGAC TGGCCAGGTG 240

CAGCGGCGCC TCGGCATCTT CCCCGCCAAC TACGTGGCCC CTTGCTACCC GCCGCGGCCG 300

CCCGAACCCG CCCGCCAGCG GCCCGGCTCC CCTATGCAGA TCGAGTTCGA GTGGCTGGAG 360

CTCAAAGAGC TGATCGGCGC TGGCGGCTTC GGGCAGGTGT ACCGGGCCAC CTGGGCGGGC 420

CAAGAAGTGG CCGTGAAGGC GGCGCGGCGG GATCCTGAGC AGGACCCTGC GGCGGCGGCC 480

GACAGCGTGT TGAGGGAGGC GAAGCTCTTC TCCATGCTGC GGCACCCCAA CATCATCCAG 540

CTGCGCGGCG TCTGCCTGCA GCAGCCCAAC CTCTGCCTCG TCCTGGAGTT CGCCCGTGGA 600

GGCGCTCTCA ACCGGGCCCT GGCAGCAGGG ACCCCAGAGC CATCGGGCGC TGCGCCCAGT 660

CCGCGCCCAG CCCGCCGCAT CCCTCCCCAC ATCCTGGTCA ATTGGGCGGT GCAGATCGCT 720

CGAGGAATGC TCTACCTGCA CGAGGAGGCC GTAGTGCCCA TCCTACATCG GGACCTCAAA 780

TCTAGCAACA TTTTACTACT TGAGAAGATA GAGCATGATG ACATCTGCAA TAAAACACTG 840

AAGATTACAG ATTTTGGTCT GGCTAGAGAA TGGCATAGAA CAACCAAAAT GAGTGCAGCT 900

GGTACATATG CATGGATGGC ACCTGAAGTT ATCAAGTCTT CTTTGTTTTC TAAAGGGAGT 960

GATATCTGGA GTTATGGAGT GTTGCTGTGG GAACTACTTA CAGGAGAAGT TCCCTATCGC 1020

GGCATTGATG GCCTTGCAGT GGCTTATGGA GTAGCTGTCA ATAAGCTCAC TTTACCCATT 1080

CCATCTACCT GTCCTGAGCC TTTTGCTAAG CTAATGAAAG AATGCTGGGA ACAAGATCCT 1140

CACATTCGGC CATCATTTGC TTTAATACTT GAACAGCTAA CTGCCATTGA AGGAGCAGTT 1200

ATGACTGAAA TGCCTCAAGA ATCCTTCCAT TCTATGCAAG ATGACTGGAA ACTAGAAATT 1260

CAGCAAATGT TTGATGAGTT GAGAACTAAA GAAAAGGAAC TTCGATCCCG TGAGGAGGAG 1320

TTAACTAGAG CGGCTCTTCA GCAAAAGTCT CAGGAAGAAT TGTTGAAGAG GCGTGAGCAA 1380

CAACTAGCAG AACGAGAGAT TGATGTTTTG GAGCGAGAAC TTAATATTTT GATTTTCCAA 1440

TTAAATCAAG AGAAGCCTAA TGTTAAAAAG AGGAAAGGAA AATTTAAGAG AAGCCGTTTA 1500

AAACTGAAAG ATGGGCATCG GATTAGTTTA CCCTCAGATT TCCAGCACAA AATAACAGTG 1560

CAAGCTTCTC CAAATTTGGA TAAACGAAGA AGTTTAAACA GTAACAGTTC TAGCCCTCCA 1620

AGTAGCCCAA CAATAATTCC TCGGCTCCGA GCTATACAAC TCACCTCAGA AGAAAGCAAT 1680

AGAACCTGGG GCAAAAGCAC AGCCTATCGC CAAGAAGAAT TTGAGGATGT GAAGAGAAAC 1740

TTCAAAAAGA AAGGTTGTAC CTGGGGACCA AGTTCGGTTC AAACAAAAGA TCGTACTGAC 1800

TGCAAAGAAA GAGTAAGACC CCTTTCAGAT GGTAGTAATC CTTGGTCAAC TATCTTAATG 1860

AAAAACCAGA AAACTGTGCC ATTAGCTTCT TTATTTGTAG ACCAACAAGG TAAGTGTGCT 1920

CTGAAACTTT TCCCTGATGG ACTGGACAAC AAAAGACCAA AGCAAATAAA ATTGCCGAAT 1980

CAGGCCTATG TTGATCTACC TCTTTGGAAA GATGATCAGG GAGATAATAC TATAGAACCT 2040

GAAAGCTTTG AAGAGGGAAC TTCTGCTAGT TCTGCTGCTA GCACTCCCCA AATGACTCCC 2100

ACAAATAGTC TTAGTAGAAC ACCCCCCAAA AAGAAAACGG AATCTGCATT ATATGGGTGT 2160

GCTGCATTAT TGGCTTCTGT GGCTTTGGGA TTGGATATTA GAGAACTAAA TAAGGTACAG 2220

TCTCCTGACG AATTGTTGCC CAAAGAGGAT AAGAAGAAAC GTGAGGGGAT ATTTCATCGT 2280

GCTTCTAAAT TACGAAGAAG TTCCAGTCCT CCAACCAGAT TACAGTCTAA AAGAGAAGAT 2340

GTTAACATTC CATCAATAAG TCCATCATCA AACACTGTGA ACCTACTGTC CATGCCTTCC 2400

ATCTCCACAA AATGTTTGCT ACACTCAGAC AATGAAGACA CATTTGTG 2448

Domain Profile

S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59

         el+elig+g fg+vy+a+w ++evavK++r++ e+  +++++++ reakl+s+l+hpnii

Q: 120   ELKELIGAGGFGQVYRATWAGQEVAVKAARRDPEQdpAAAADSVLREAKLFSMLRHPNII  179

         689********************************988999*******************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhe............kskreidlevlvswalqi  107

         +l+Gvcl++pnl+lv+e+++gg+L+++l++            +  r+i+++ lv+wa+qi

Q: 180   QLRGVCLQQPNLCLVLEFARGGALNRALAAgtpepsgaapspRPARRIPPHILVNWAVQI  239

         *****************************99*********9999****************

S: 108   ArGmaYLhseapkkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsa  160

         ArGm YLh+ea+++i+hrdLks+n+Ll       +  +ktlki+dFG are++++tkmsa

Q: 240   ARGMLYLHEEAVVPILHRDLKSSNILLlekiehdDICNKTLKITDFGLAREWHRTTKMSA  299

         *******************************999999***********************

S: 161   agtlawmaPEvlkeekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlp  220

         agt+awmaPEv+k++ +s+ sD+wSygv+LWellt+evPy++++ la+ay+va+++l+lp

Q: 300   AGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP  359

         ************************************************************

S: 221   ipsscpeklkkLmkecwnedpekRpsfseivksl  254

         ips+cpe+++kLmkecw++dp+ Rpsf+ i+++l

Q: 360   IPSTCPEPFAKLMKECWEQDPHIRPSFALILEQL  393

         ******************************9986

Domain Sequence
(FASTA)

ELKELIGAGG FGQVYRATWA GQEVAVKAAR RDPEQDPAAA ADSVLREAKL FSMLRHPNII 60

QLRGVCLQQP NLCLVLEFAR GGALNRALAA GTPEPSGAAP SPRPARRIPP HILVNWAVQI 120

ARGMLYLHEE AVVPILHRDL KSSNILLLEK IEHDDICNKT LKITDFGLAR EWHRTTKMSA 180

AGTYAWMAPE VIKSSLFSKG SDIWSYGVLL WELLTGEVPY RGIDGLAVAY GVAVNKLTLP 240

IPSTCPEPFA KLMKECWEQD PHIRPSFALI LEQL 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013