EPS-MOD-00020

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00020

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	288.1	8.2E-86	23	289	267

Status

Unreviewed

Ensembl Protein

ENSMODP00000010718

UniProt Accession

F6PH78;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000008615	ENSMODP00000010718	ENSMODT00000010930

Organism

Monodelphis domestica

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL DGWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT NNQDFKSSEG PPSVENVKNG IRTGFLQIDE HMRIISEKKH 120

GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPNNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VYEIERSEKD DQFIILACDG 240

IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPRVSPE 300

AVKKETELDK YLESRVEEII KKQGEGVPDL VHVMRTLATE TIPNLPPGGD LASKRSIIEA 360

VYNRLNPFRN DDTDSTSADD MW 382

Nucleotide Sequence
(FASTA)

ATGGGGGCAT TTTTAGATAA GCCAAAGATG GAAAAGCATA ATGCCCAGGG GCAAGGTAAT 60

GGACTACGCT ATGGGCTAAG CAGTATGCAA GGTTGGCGAG TTGAAATGGA AGATGCGCAT 120

ACAGCTGTGA TTGGTTTGCC AAGTGGACTT GATGGATGGT CATTTTTTGC CGTGTATGAT 180

GGGCATGCTG GTTCCCAGGT TGCCAAATAC TGCTGTGAGC ATTTGTTAGA TCACATCACA 240

AATAACCAGG ATTTTAAAAG TTCTGAAGGA CCACCTTCAG TGGAAAATGT CAAGAATGGA 300

ATAAGAACAG GTTTTCTGCA GATTGATGAA CATATGAGAA TAATATCAGA GAAGAAACAT 360

GGTGCAGACC GAAGTGGGTC AACAGCAGTG GGTGTCCTGA TTTCTCCCCA ACATACATAC 420

TTCATCAACT GTGGCGACTC AAGAGGTTTA CTTTGTAGGA ACAGAAAAGT TCATTTCTTC 480

ACACAAGATC ACAAACCAAA TAATCCTTTG GAAAAAGAAC GTATTCAGAA TGCAGGTGGT 540

TCTGTAATGA TTCAGCGTGT GAATGGCTCC CTTGCTGTAT CTAGGGCACT TGGAGACTTT 600

GATTATAAAT GTGTCCATGG TAAAGGTCCT ACAGAGCAAC TTGTCTCACC AGAGCCAGAA 660

GTCTATGAAA TTGAAAGATC CGAAAAAGAT GATCAATTCA TCATCCTTGC GTGTGATGGT 720

ATCTGGGATG TTATGGGAAA TGAAGAGCTT TGTGATTTTG TAAGATCCAG ACTTGAAGTC 780

ACTGATGACC TTGAGAAAGT ATGCAATGAA GTAGTGGACA CCTGCTTATA TAAGGGAAGT 840

CGAGACAACA TGAGTGTGAT ATTGATCTGT TTTCCAAATG CACCAAGAGT ATCACCAGAG 900

GCAGTGAAGA AAGAGACAGA GTTGGACAAG TACCTGGAAA GCAGAGTAGA AGAAATCATA 960

AAGAAGCAGG GGGAAGGCGT ACCAGACTTA GTCCATGTGA TGCGCACATT AGCAACTGAG 1020

ACCATCCCAA ACCTCCCTCC AGGGGGTGAC TTGGCAAGCA AGCGGAGTAT AATTGAAGCC 1080

GTTTACAATA GACTGAATCC TTTCAGAAAT GATGACACTG ATTCAACATC AGCTGATGAT 1140

ATGTGGTAA 1149

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t+   ++  p+  d ++ff+vyDGh+gs+vak+c e+l +++

Q: 23    RYGLSSMQGWRVEMEDAHTA---VIGLPSGLDGWSFFAVYDGHAGSQVAKYCCEHLLDHI  79

         69****************97...4555555566***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         +++ +    ++ ++ ++vk+ ++++Fl++de++++++ek++  d+sGstav +li++++

Q: 80    TNNQDfkssEGPPSVENVKNGIRTGFLQIDEHMRIISEKKHGADRSGSTAVGVLISPQHT  139

         ***998887777889*********************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcrn+k++  ++dHkp+++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 140   YFINCGDSRGLLCRNRKVHFFTQDHKPNNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  196

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev++++++++d+ f+iLa+DG+wdv+ nee++++vr+

Q: 197   LGDFDYKcvhgkgpteQLVSPEPEVYEIERSEKDDqFIILACDGIWDVMGNEELCDFVRS  256

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +le +++++++++++v+++l +gs+dn+s+i++

Q: 257   RLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILI  289

         ****************************99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPSGLDG WSFFAVYDGH AGSQVAKYCC EHLLDHITNN 60

QDFKSSEGPP SVENVKNGIR TGFLQIDEHM RIISEKKHGA DRSGSTAVGV LISPQHTYFI 120

NCGDSRGLLC RNRKVHFFTQ DHKPNNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVY EIERSEKDDQ FIILACDGIW DVMGNEELCD FVRSRLEVTD 240

DLEKVCNEVV DTCLYKGSRD NMSVILI 267

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004871	; F:signal transducer activity
GO:0010991	; P:negative regulation of SMAD protein complex assembly
GO:0030512	; P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0030177	; P:positive regulation of Wnt receptor signaling pathway
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013