EKS-MOD-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.3	1.3E-185	460	738	279

Status

Unreviewed

Ensembl Protein

ENSMODP00000010766

UniProt Accession

F6PGA8;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000008652	ENSMODP00000010766	ENSMODT00000010979

Organism

Monodelphis domestica

Functional Description

Protein Length

769

Protein Sequence
(FASTA)

MSVQSSSGSL EGPPSWSQLS TSPTPGSAAA AAAAARSLLN HTPPSGRPKE GAMDELHSLD 60

PRRQELLEAR FTGVVSGSTG STGSCSVGAK ASTNNESSNH SFGSLGSLSD KESETPEKKQ 120

SEPSRGRKRK AENQSESSQG KSIGGRGHKI SDYFEYQGGN GSSPVRGIPP AIRSPQNSHS 180

HSTPSSCVRP NSPSPTALAF GDHPITQPKQ LSFKIIQTDL TMLKLAALES NKNQDLEKKE 240

GRIDDLLRAN CDLRRQIDEQ QKLLEKYKER LNKCISMSKK LLIEKSTQEK LASREKSMQD 300

RLRLGHFTTV RHGASFTEQW TDGFAFQNLV KQQEWVNQQR EDIERQRKLL AKRKPPTTNN 360

SQAPSTNSEP KQRKNKAVNG AENDPFVRPN LPQLLTLAEY HEQEEIFKLR LGHLKKEEAE 420

IQAELERLER VRNLHIRELK RINNEDNSQF KDHPTLNERY LLLHLLGRGG FSEVYKAFDL 480

YEQRYAAVKI HQLNKSWRDE KKENYHKHAC REYRIHKELD HPRIVKLYDY FSLDTDTFCT 540

VLEYCEGNDL DFYLKQHKLM SEKEARSIVM QIVNALRYLN EIKPPIIHYD LKPGNILLVD 600

GTACGEIKIT DFGLSKIMDD DSYGVDGMDL TSQGAGTYWY LPPECFVVGK EPPKISNKVD 660

VWSVGVIFFQ CLYGRKPFGH NQSQQDILQE NTILKATEVQ FPVKPVVSNE AKAFIRRCLA 720

YRKEDRFDVH QLANDPYLLP HMRRSNSSGN LHMAGLTAPT PPSSSIISY 769

Nucleotide Sequence
(FASTA)

ATGAGTGTCC AAAGTAGCAG TGGAAGTTTG GAGGGGCCGC CATCTTGGTC CCAGCTCTCC 60

ACGTCTCCAA CCCCAGGCTC GGCGGCGGCA GCGGCAGCGG CAGCCAGGTC CCTGCTGAAT 120

CACACGCCGC CATCCGGGAG GCCCAAGGAA GGTGCAATGG ATGAGCTTCA CAGTTTAGAT 180

CCAAGAAGGC AAGAATTATT GGAAGCTCGA TTTACAGGAG TTGTAAGTGG AAGCACTGGG 240

AGCACTGGAA GTTGCAGTGT TGGAGCTAAA GCCTCAACAA ACAATGAAAG TTCTAATCAT 300

AGTTTTGGAA GCTTGGGATC TCTAAGTGAT AAAGAATCAG AGACTCCAGA GAAGAAACAG 360

TCAGAGCCAT CCAGAGGAAG AAAAAGAAAA GCAGAAAACC AAAGTGAAAG CAGTCAGGGA 420

AAAAGTATTG GGGGACGTGG CCACAAAATT AGTGACTATT TTGAATATCA AGGGGGGAAT 480

GGCTCCAGTC CAGTAAGAGG AATACCTCCT GCCATCAGAT CACCTCAGAA TTCACATTCA 540

CATTCCACTC CTTCCTCTTG TGTTCGGCCG AATAGCCCTT CTCCTACTGC ATTAGCTTTT 600

GGGGACCACC CTATTACACA ACCAAAGCAG TTATCTTTTA AAATTATTCA GACTGATCTC 660

ACAATGCTGA AATTAGCTGC ACTAGAAAGT AATAAAAATC AGGACCTGGA AAAGAAAGAA 720

GGTCGAATAG ATGATTTGCT CAGGGCTAAC TGTGATCTTA GACGTCAAAT AGACGAACAG 780

CAGAAATTAC TTGAAAAATA CAAAGAAAGA TTAAATAAAT GCATTTCAAT GAGTAAGAAA 840

CTTTTAATAG AAAAAAGCAC ACAAGAAAAA CTGGCAAGCA GGGAGAAGAG TATGCAAGAC 900

AGACTACGCC TTGGGCATTT TACAACAGTT AGACATGGTG CTTCATTTAC TGAACAATGG 960

ACAGATGGTT TTGCCTTTCA GAATCTTGTG AAACAACAAG AATGGGTAAA TCAACAAAGG 1020

GAGGATATTG AAAGGCAAAG AAAGCTCCTG GCAAAGAGAA AACCACCGAC TACTAATAAT 1080

TCTCAGGCAC CCTCTACCAA TTCTGAACCA AAACAAAGGA AAAACAAAGC TGTCAATGGA 1140

GCAGAAAATG ATCCTTTTGT TAGACCTAAT TTACCACAAT TGCTCACTTT AGCAGAATAC 1200

CATGAACAAG AAGAGATTTT CAAACTTAGA CTAGGACATC TCAAAAAGGA AGAAGCAGAA 1260

ATCCAGGCAG AACTTGAACG TTTGGAAAGA GTCCGGAATC TTCATATACG GGAACTCAAA 1320

AGGATAAACA ATGAAGATAA TTCACAGTTT AAAGATCATC CCACGTTAAA TGAACGATAC 1380

TTGTTACTTC ATCTGCTTGG TAGAGGTGGC TTTAGTGAAG TATATAAGGC TTTTGACCTT 1440

TATGAACAAA GATATGCTGC TGTGAAGATC CACCAGCTTA ATAAAAGCTG GAGAGATGAG 1500

AAGAAGGAAA ACTACCACAA ACATGCCTGC AGAGAGTATA GAATACACAA AGAACTGGAC 1560

CACCCCAGGA TAGTTAAACT ATATGATTAT TTCTCCTTGG ATACAGACAC GTTTTGTACA 1620

GTGTTAGAAT ACTGTGAAGG CAATGACTTG GATTTCTATC TCAAGCAACA TAAATTAATG 1680

TCAGAGAAAG AAGCTAGGTC CATTGTAATG CAAATTGTAA ATGCACTAAG ATATCTCAAC 1740

GAGATCAAAC CCCCTATTAT CCATTATGAT CTTAAACCAG GAAATATCCT TTTAGTAGAT 1800

GGAACAGCAT GCGGAGAAAT CAAAATTACT GATTTTGGCC TGTCCAAAAT TATGGATGAT 1860

GATAGTTATG GCGTGGATGG AATGGATCTA ACCTCTCAAG GGGCAGGGAC TTATTGGTAT 1920

TTACCTCCAG AATGTTTTGT AGTTGGCAAA GAGCCTCCAA AGATTTCCAA CAAGGTTGAT 1980

GTATGGTCTG TTGGAGTCAT CTTTTTTCAG TGTCTTTATG GTAGAAAGCC ATTTGGTCAC 2040

AATCAGTCTC AACAAGACAT CCTTCAAGAA AACACAATAT TAAAAGCCAC AGAAGTCCAG 2100

TTCCCAGTGA AACCTGTTGT AAGCAATGAA GCCAAGGCTT TCATAAGACG TTGTTTAGCA 2160

TACCGTAAAG AGGATCGATT TGATGTCCAT CAGCTGGCCA ATGATCCTTA CCTTCTCCCC 2220

CACATGAGAA GATCAAATTC TTCAGGAAAT TTGCATATGG CTGGACTGAC AGCCCCTACA 2280

CCCCCTTCTT CAAGTATAAT TTCTTATTGA 2310

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 460   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  519

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 520   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  579

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 580   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  638

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 639   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  698

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvs+eakafirrclayrkedr+dv+qla+d+yl

Q: 699   VQFPVKPVVSNEAKAFIRRCLAYRKEDRFDVHQLANDPYL  738

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSN EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

mdo:100024843

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013