EKS-MOD-00204

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00204

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	517.7	6.5E-156	4	286	283

Status

Unreviewed

Ensembl Protein

ENSMODP00000010962

UniProt Accession

F6QB22;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL4

Gene Synonyms/Alias

CDKL4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000008806	ENSMODP00000010962	ENSMODT00000011178

Organism

Monodelphis domestica

Functional Description

Protein Length

342

Protein Sequence
(FASTA)

MEKYEKLGKI GEGSYGVVFK CRNKNSGQVV AIKKFVESED DPIVKKIALR EIRLLKQLKH 60

ANLVNLIEVF RRKRKMHLVF EYCDHTLLNE LERNPNGVAD RMLKSVLWQT LQALSFCHKH 120

NCIHRDVKPE NILITKQGMI KICDFGFARL LSPGDAYTDY VATRWYRAPE LLVGDTKYGP 180

TVDVWAVGCV FAELLTGQPL WPGKSDVDQL YLIIRTLGKL IPRHQSIFKS NQFFRGINIP 240

EPKDMETLEE KFPGTSLVAM NFMKNCLKMN PDDRLTCAQL LESPYFESFR ENQVKRKSRN 300

EGKPKKRSQS QLLPLIPGSH NTPTPDGRRP VLQLKFEHLP NI 342

Nucleotide Sequence
(FASTA)

ATGGAAAAGT ATGAAAAACT TGGTAAAATT GGAGAAGGAT CTTATGGTGT CGTGTTCAAG 60

TGCAGAAATA AAAACTCTGG ACAAGTCGTG GCCATTAAAA AATTTGTGGA ATCTGAGGAT 120

GATCCCATTG TTAAGAAGAT AGCATTAAGA GAAATACGCT TATTGAAGCA ACTAAAGCAT 180

GCAAATCTTG TGAACCTCAT TGAAGTGTTC CGAAGGAAGC GGAAAATGCA CTTGGTTTTT 240

GAATACTGTG ATCATACGCT TTTGAACGAG CTGGAGAGAA ATCCAAATGG AGTTGCTGAC 300

CGTATGCTCA AGAGTGTTTT GTGGCAAACA CTTCAGGCTC TCAGTTTCTG CCACAAACAT 360

AACTGTATTC ACAGGGATGT TAAACCTGAA AACATTCTGA TAACAAAGCA AGGAATGATC 420

AAGATCTGCG ATTTTGGATT CGCTCGGCTT CTGAGTCCAG GAGATGCCTA TACTGATTAT 480

GTTGCTACAA GATGGTACCG AGCACCTGAG CTTCTGGTAG GAGATACTAA GTATGGCCCT 540

ACAGTAGATG TGTGGGCAGT TGGATGTGTT TTTGCTGAAT TGCTGACTGG ACAACCCCTT 600

TGGCCTGGAA AATCAGATGT GGATCAACTC TATCTGATCA TAAGAACTCT AGGAAAACTA 660

ATTCCGAGGC ATCAGTCCAT CTTTAAAAGT AACCAGTTTT TCCGTGGCAT AAATATTCCT 720

GAACCAAAAG ACATGGAGAC ACTTGAGGAA AAGTTTCCTG GTACTTCCCT AGTGGCTATG 780

AACTTCATGA AGAATTGCTT GAAGATGAAT CCAGATGATA GATTAACTTG TGCACAGCTC 840

TTAGAAAGTC CTTACTTTGA ATCATTTCGA GAGAATCAAG TTAAAAGAAA ATCACGGAAT 900

GAAGGAAAAC CCAAAAAACG TTCACAGAGT CAGCTGTTGC CACTCATACC GGGAAGCCAC 960

AACACCCCCA CACCTGATGG AAGAAGACCG GTCCTCCAAT TAAAATTTGA ACATCTTCCA 1020

AATATTTAG 1029

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yeklgk+GeGsyGvv+kcrnk++gq+vaikkf+esedd+ vkkialrei+llkqlkh nl

Q: 4     YEKLGKIGEGSYGVVFKCRNKNSGQVVAIKKFVESEDDPIVKKIALREIRLLKQLKHANL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl+evfrrk+k++lvfey+d+t+l+eler+pnGv ++++k++l+q+l+a++fchk+n+i

Q: 64    VNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADRMLKSVLWQTLQALSFCHKHNCI  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrd+kpenili+k+g++k+cdfGfarll+ pgd+ytdyvatrwyrapellvgdtkyG++v

Q: 124   HRDVKPENILITKQGMIKICDFGFARLLS-PGDAYTDYVATRWYRAPELLVGDTKYGPTV  182

         ****************************9.******************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwa+Gc++aelltG+pl+pgksdvdqly+i++tlG+liprhq+if++n++f+G+++pe+

Q: 183   DVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNQFFRGINIPEP  242

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +d+e+le+k+p  + v+++++k+clk++p++rl+c++ll+++yf

Q: 243   KDMETLEEKFPGTSLVAMNFMKNCLKMNPDDRLTCAQLLESPYF  286

         ******************************************98

Domain Sequence
(FASTA)

YEKLGKIGEG SYGVVFKCRN KNSGQVVAIK KFVESEDDPI VKKIALREIR LLKQLKHANL 60

VNLIEVFRRK RKMHLVFEYC DHTLLNELER NPNGVADRML KSVLWQTLQA LSFCHKHNCI 120

HRDVKPENIL ITKQGMIKIC DFGFARLLSP GDAYTDYVAT RWYRAPELLV GDTKYGPTVD 180

VWAVGCVFAE LLTGQPLWPG KSDVDQLYLI IRTLGKLIPR HQSIFKSNQF FRGINIPEPK 240

DMETLEEKFP GTSLVAMNFM KNCLKMNPDD RLTCAQLLES PYF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mdo:100010399

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013