EKS-MOD-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.6	1.5E-122	189	476	288

Status

Unreviewed

Ensembl Protein

ENSMODP00000011076

UniProt Accession

F7BRY9;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000008889	ENSMODP00000011076	ENSMODT00000011293

Organism

Monodelphis domestica

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

MTAPWVTFAL LWGSLCAGEW RGEVETRECI YYNANWELEK TNQSGLERCE GEKDKRLHCY 60

ASWRNSSGSI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN EKFTHLPEVT 120

GPEVTYEPPS TVPLLTVLAY ALLPIGGLSL AIVIAFWMYR HRKPPYGHVD VNEDPGPPPP 180

SPLVGLKPLQ LLEIKARGRF GCVWKAQLMN DYVAVKIFPL QDKQSWQSER DIFSTPGMKH 240

ENLLQFIAAE KRGSNLEVEL WLITAFHDKG SLTDYLKGNI VTWNELCHVA ETMSRGLSYL 300

HEDVPWCRGE GHKPAIAHRD FKSKNVLLKS DLTAVLADFG LAVRFEPGKP PGDTHGQVGT 360

RRYMAPEVLE GAINFQRDAF LRIDMYAMGL VLWELVSRCT AVDGPVDEYM LPFEEEIGQH 420

PSLEDLQEVV VHKKMRPAFK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERVSLI 480

RKSVNGTTSD CLVSLVTSVT NVDLPPKESS I 511

Nucleotide Sequence
(FASTA)

ATGACGGCGC CTTGGGTCAC TTTCGCCCTG CTCTGGGGAT CGCTCTGCGC AGGTGAGTGG 60

CGTGGGGAAG TTGAGACACG GGAATGCATC TACTACAATG CCAACTGGGA ACTGGAAAAG 120

ACAAACCAGA GTGGTCTGGA ACGTTGTGAG GGAGAGAAGG ACAAGCGCCT TCATTGCTAT 180

GCTTCATGGA GGAATAGCTC TGGTTCCATT GAACTTGTGA AGAAGGGCTG CTGGCTGGAT 240

GACTTCAATT GCTATGATAG GCAGGAATGC GTAGCCACTG AAGAAAACCC CCAGGTCTAC 300

TTCTGTTGCT GTGAAGGAAA CTTCTGCAAT GAAAAGTTCA CGCATTTACC TGAGGTCACT 360

GGCCCTGAAG TTACCTATGA GCCACCTTCG ACTGTCCCTC TGCTCACAGT GCTTGCATAT 420

GCCTTGCTGC CTATCGGGGG CCTCTCTCTG GCTATCGTCA TTGCATTCTG GATGTACAGG 480

CACCGAAAGC CTCCCTACGG TCATGTGGAT GTCAATGAGG ACCCGGGTCC TCCACCCCCT 540

TCTCCACTTG TTGGCCTGAA GCCATTGCAA CTGCTGGAGA TCAAGGCCCG GGGACGTTTT 600

GGCTGTGTCT GGAAGGCTCA GCTTATGAAT GACTATGTAG CAGTGAAGAT TTTCCCATTA 660

CAGGACAAAC AGTCCTGGCA GAGTGAACGA GACATCTTCA GCACACCAGG CATGAAGCAT 720

GAAAATCTGC TCCAGTTCAT CGCAGCTGAA AAAAGAGGTT CCAACCTGGA GGTGGAGCTG 780

TGGCTCATTA CAGCCTTCCA TGACAAGGGT TCTCTCACAG ATTACTTAAA AGGGAATATT 840

GTTACTTGGA ACGAGCTGTG TCACGTAGCA GAGACCATGT CCCGAGGTCT GTCCTATCTG 900

CATGAGGATG TGCCCTGGTG CCGGGGAGAG GGGCACAAGC CAGCCATTGC CCACAGGGAC 960

TTCAAGAGCA AGAATGTCTT ACTGAAGAGT GACCTCACAG CTGTCCTGGC TGACTTTGGA 1020

CTGGCTGTGC GGTTTGAACC AGGAAAGCCA CCAGGGGACA CACATGGGCA GGTTGGAACG 1080

AGGCGGTACA TGGCCCCTGA GGTGCTGGAG GGAGCAATCA ACTTCCAGAG AGATGCTTTC 1140

CTGAGAATTG ATATGTATGC CATGGGGCTG GTTCTGTGGG AGCTGGTGTC TAGATGCACA 1200

GCTGTGGATG GGCCAGTGGA TGAGTACATG TTACCCTTTG AGGAGGAGAT TGGTCAACAT 1260

CCATCGCTGG AAGACCTGCA GGAGGTGGTG GTGCATAAAA AGATGCGCCC TGCCTTCAAG 1320

GATCACTGGT TGAAGCATCC TGGATTGGCA CAGCTTTGTG TGACCATCGA AGAGTGCTGG 1380

GACCATGATG CCGAGGCCAG GCTCTCTGCA GGCTGCGTGG AGGAACGCGT GTCCTTGATT 1440

CGCAAATCTG TCAATGGCAC TACCTCGGAC TGCCTCGTCT CCCTTGTGAC ATCTGTCACC 1500

AATGTGGACT TGCCCCCCAA AGAGTCGAGT ATCTAA 1536

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l++++vAvKif+ +d++sw++E++i++t+ ++hen+lqfia

Q: 189   LQLLEIKARGRFGCVWKAQLMNDYVAVKIFPLQDKQSWQSERDIFSTPGMKHENLLQFIA  248

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 249   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIVTWNELCHVAETMSRGLSYLHEDVPWCR  308

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +KpaiaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 309   GeGHKPAIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  366

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc++vd+ v+ey+lpfee++g++Psle+

Q: 367   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCTAVDGPVDEYMLPFEEEIGQHPSLED  425

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP ++++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 426   LQEVVVHKKMRPAFKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  476

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDYVAVKIF PLQDKQSWQS ERDIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIVTWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPAIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CTAVDGPVDE YMLPFEEEIG QHPSLEDLQE 240

VVVHKKMRPA FKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0032147	; P:activation of protein kinase activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048617	; P:embryonic foregut morphogenesis
GO:0001702	; P:gastrulation with mouth forming second
GO:0007507	; P:heart development
GO:0030073	; P:insulin secretion
GO:0001822	; P:kidney development
GO:0030324	; P:lung development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0007498	; P:mesoderm development
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0035265	; P:organ growth
GO:0060021	; P:palate development
GO:0031016	; P:pancreas development
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0009791	; P:post-embryonic development
GO:0009749	; P:response to glucose stimulus
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0023014	; P:signal transduction by phosphorylation
GO:0048705	; P:skeletal system morphogenesis
GO:0060841	; P:venous blood vessel development

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013