EKS-MOD-00292

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00292

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	497.2	9.8E-150	712	969	258

Status

Unreviewed

Ensembl Protein

ENSMODP00000011264

UniProt Accession

F7B2I8;

Protein Name

Protein Synonyms/Alias

Gene Name

EGFR

Gene Synonyms/Alias

EGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000009033	ENSMODP00000011264	ENSMODT00000011482

Organism

Monodelphis domestica

Functional Description

Protein Length

1212

Protein Sequence
(FASTA)

MGLYGAAGAA VLVLLVGHFS QGLALEEKKV CQGTSNKLTQ LGTFEDHFVS LQRMFNNCEV 60

VLGNLEITYV QKNYDLSFLK TIQEVAGYVL IALNAVEKIP LENLQVIRGN VLYENFYALS 120

VLSNYDVNKT GVKELPMRNL LEILIGGVRF NNNPSLCNVE TIQWKDIVNP IYINNITIDN 180

NSHPKSCEKC DSSCPNGSCW GPGPQYCQTL TKTICAQQCS GRCRGSSPSD CCHNQCAAGC 240

TGPRESDCLV CRKFRDEATC KDNCPSLLQY NPTTYQMDVN PDGKYSFGAT CVRKCPHNYV 300

VTDHGSCVRS CNADTYEVEE DGVRKCKKCE GPCSKVCNGI GIGEFKDVLS INATNIKQFQ 360

NCTIISGDLH ILPVAFKGDS FTNTPPLDPR ELNILRTVKE ISGFLLIQSW PENMTDLHAF 420

EHLEIIRGRT KQHGQFSLAV VDVNISSLGL RSLKEISDGD VIISKNRRLC YANTINWTKL 480

FGTKSQKAKI TNNKDERECR ALGHVCHELC SSDGCWGPKP SHCLSCRHVS RHKKCVEKCN 540

ILEGEPREYM ENLKCMQCHS ECLPQVMNLT CTGPGPDKCI QCAHYIDGPH CVKTCPAGIM 600

GENDTLVWKY ADADKVCQRC HPNCTYGCEG PGLEGCPTPG PKIPSIATGI IGGLLLLVVL 660

GLGIGLFFRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS 720

GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 780

CLTSTVQLIT QLMPFGCLLD YIREHKDNIG SQYLLNWCVQ IAKGMSYLEE RRLVHRDLAA 840

RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY 900

GVTVWELMTF GSKPYDGIPA SDISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 960

FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSKFYRT LMEEEDMEDI VDADEYLIPQ 1020

QGFFNSPSTS RTPLLSSLSA TSNNSATVCI DRNGTCPGKE ENFIQRYSSD PTTVLTEDNV 1080

DDSFQPVPEY INQSAPKNPT GSAIQNPVYH NQPLNPDASK DSLYQNSHNN SAVDNPEYLN 1140

TTQPNLAKKA FDSNSCWNPT AKHPINLDNP DYQQDFFPQE AKPNGVFKVP AAENPEYLRV 1200

AAQQSEFIQA SA 1212

Nucleotide Sequence
(FASTA)

ATGGGGCTCT ACGGGGCTGC AGGAGCCGCT GTCCTGGTGC TGCTTGTCGG ACACTTCTCC 60

CAGGGCTTGG CGCTGGAGGA AAAAAAAGTT TGCCAAGGAA CAAGTAACAA ACTGACGCAG 120

TTGGGTACTT TTGAGGACCA CTTCGTGAGT CTCCAGAGGA TGTTCAATAA CTGTGAGGTG 180

GTGCTTGGAA ATTTAGAAAT TACCTACGTC CAAAAAAATT ATGACCTGTC CTTCCTCAAG 240

ACCATCCAGG AGGTTGCTGG CTACGTGCTT ATTGCACTCA ATGCAGTAGA GAAAATCCCT 300

TTGGAAAATC TGCAAGTCAT CAGAGGAAAT GTGTTGTATG AAAACTTTTA TGCTCTTTCT 360

GTGCTATCCA ACTATGATGT GAATAAAACC GGAGTGAAGG AACTGCCCAT GAGGAATCTA 420

CTAGAAATCC TTATTGGTGG TGTTCGATTC AACAATAACC CATCTTTGTG TAATGTGGAG 480

ACGATCCAGT GGAAGGATAT TGTGAACCCT ATCTACATCA ACAACATCAC CATAGACAAT 540

AACAGCCATC CAAAGAGTTG TGAAAAGTGT GATTCTAGTT GTCCCAATGG GAGCTGTTGG 600

GGTCCTGGGC CACAATATTG CCAGACTTTG ACAAAAACCA TCTGTGCCCA GCAGTGCTCA 660

GGACGGTGTC GTGGTAGTTC CCCCAGCGAC TGTTGCCACA ACCAGTGTGC AGCGGGTTGT 720

ACTGGACCCC GAGAGAGTGA CTGCTTGGTC TGCCGAAAGT TTCGAGATGA AGCCACGTGC 780

AAAGACAATT GCCCCTCTCT GCTGCAATAC AACCCAACCA CATACCAGAT GGACGTCAAC 840

CCAGATGGCA AATACAGCTT TGGGGCCACC TGTGTTCGCA AATGCCCACA TAACTATGTG 900

GTGACAGACC ATGGTTCCTG TGTTCGTTCC TGTAATGCTG ACACCTATGA AGTGGAAGAA 960

GATGGTGTCC GAAAATGTAA AAAGTGTGAA GGTCCATGTA GTAAAGTTTG CAATGGAATA 1020

GGAATCGGTG AATTTAAAGA TGTTCTCTCC ATCAATGCAA CAAACATCAA ACAATTCCAG 1080

AACTGTACCA TAATCAGCGG TGATCTGCAT ATCTTGCCCG TTGCATTTAA AGGGGATTCC 1140

TTCACCAATA CTCCACCTCT GGATCCCAGA GAACTGAATA TTCTCAGAAC TGTAAAAGAA 1200

ATATCAGGAT TTTTGCTGAT TCAGTCTTGG CCTGAAAACA TGACTGACCT CCATGCTTTT 1260

GAACATCTGG AAATTATACG AGGCAGAACA AAGCAGCATG GCCAGTTTTC TCTTGCTGTT 1320

GTTGATGTGA ACATAAGTTC CTTGGGCTTA CGCTCCCTTA AGGAAATCAG TGATGGGGAT 1380

GTCATCATTT CCAAGAACAG AAGACTCTGC TATGCAAACA CAATAAACTG GACGAAATTG 1440

TTTGGAACAA AAAGTCAGAA AGCCAAAATC ACCAACAACA AAGATGAAAG AGAGTGCCGT 1500

GCTCTGGGTC ATGTTTGTCA TGAGTTATGC TCATCTGATG GTTGCTGGGG TCCAAAGCCA 1560

AGCCACTGCT TGTCCTGTCG CCATGTGAGT CGTCACAAGA AATGTGTTGA GAAATGCAAC 1620

ATTCTGGAAG GAGAGCCAAG GGAATATATG GAGAATCTGA AATGTATGCA GTGCCACTCT 1680

GAGTGTCTGC CTCAAGTGAT GAATCTAACC TGCACTGGAC CGGGTCCTGA CAAATGTATC 1740

CAGTGTGCTC ATTATATAGA TGGTCCACAC TGTGTGAAAA CTTGTCCAGC TGGAATCATG 1800

GGAGAAAATG ATACCTTGGT CTGGAAATAT GCTGATGCAG ATAAGGTTTG CCAACGATGC 1860

CATCCAAATT GTACCTATGG GTGTGAAGGA CCAGGTCTTG AAGGTTGTCC CACACCTGGC 1920

CCCAAGATTC CTTCCATTGC CACTGGAATT ATAGGTGGCC TTCTCTTACT AGTGGTGTTG 1980

GGCCTTGGCA TTGGTCTCTT CTTTCGAAGG CGCCATATTG TTCGTAAACG CACACTGCGC 2040

AGGCTGCTAC AGGAAAGGGA GCTTGTTGAG CCTCTTACCC CCAGTGGAGA AGCTCCGAAC 2100

CAAGCTCTTT TGAGGATCCT AAAGGAGACA GAATTTAAAA AGATCAAAGT TCTTGGCTCT 2160

GGAGCTTTTG GCACAGTGTA TAAGGGACTG TGGATTCCAG AAGGAGAGAA GGTGAAAATT 2220

CCTGTTGCCA TTAAAGAATT AAGAGAGGCC ACTTCTCCGA AAGCCAATAA GGAAATTCTT 2280

GATGAAGCCT ATGTGATGGC CAGTGTAGAC AATCCCCATG TATGTCGTCT CCTGGGAATC 2340

TGTCTGACTT CCACAGTCCA ACTCATAACA CAGCTCATGC CATTCGGCTG CCTCCTGGAC 2400

TACATACGAG AACACAAGGA CAATATTGGC TCCCAGTACC TTCTCAACTG GTGTGTGCAG 2460

ATTGCCAAGG GGATGAGTTA CCTAGAAGAG CGCCGCTTGG TACACCGTGA CTTAGCAGCC 2520

AGAAATGTCC TTGTAAAGAC ACCTCAACAT GTCAAGATCA CAGATTTTGG GCTGGCAAAA 2580

TTACTTGGTG CTGAGGAGAA AGAATACCAT GCAGAAGGAG GCAAGGTGCC TATTAAATGG 2640

ATGGCTCTGG AATCGATTTT ACACCGTATT TATACCCACC AAAGTGATGT CTGGAGCTAT 2700

GGTGTCACCG TGTGGGAGCT GATGACGTTT GGGTCCAAGC CTTACGATGG GATCCCTGCA 2760

AGTGACATTT CATCGATATT AGAGAAAGGG GAGCGCCTTC CTCAGCCACC CATCTGCACC 2820

ATTGATGTCT ACATGATCAT GGTCAAATGC TGGATGATAG ATGCTGATAG TCGCCCCAAG 2880

TTTCGTGAGT TAATCATAGA ATTCTCTAAA ATGGCCCGTG ATCCCCAACG CTACCTTGTT 2940

ATACAGGGAG ATGAAAGAAT GCACTTACCA AGCCCCACAG ACTCCAAATT TTATCGCACC 3000

CTAATGGAAG AGGAGGACAT GGAAGATATC GTCGATGCGG ATGAGTACCT TATCCCACAG 3060

CAAGGGTTCT TCAATAGCCC TTCCACATCT CGGACTCCTC TCCTAAGCTC TCTGAGTGCT 3120

ACCAGCAATA ATTCTGCCAC AGTGTGCATT GACAGAAACG GGACTTGTCC TGGAAAGGAA 3180

GAAAACTTCA TCCAGAGATA CAGTTCTGAT CCTACTACTG TCTTAACTGA AGACAATGTG 3240

GATGACAGCT TCCAGCCCGT ACCGGAATAT ATAAACCAGT CGGCTCCAAA AAACCCCACA 3300

GGCTCTGCCA TCCAGAACCC TGTTTATCAC AATCAGCCTT TAAATCCAGA TGCCTCTAAA 3360

GACTCTCTGT ACCAAAATTC ACACAACAAC AGTGCAGTGG ACAACCCTGA GTATCTCAAC 3420

ACAACCCAGC CCAACTTGGC CAAAAAGGCA TTCGACAGCA ATTCCTGCTG GAACCCAACA 3480

GCCAAGCACC CGATCAATCT GGACAACCCC GACTACCAAC AGGACTTCTT CCCCCAGGAA 3540

GCCAAGCCAA ATGGGGTTTT TAAAGTCCCT GCTGCGGAAA ATCCTGAGTA CCTCAGGGTA 3600

GCAGCCCAAC AAAGCGAATT CATTCAAGCT TCAGCATGA 3639

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 712   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  771

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldy+rehkd++Gsq+llnwcvqiakGmsylee+

Q: 772   PHVCRLLGICLTSTVQLITQLMPFGCLLDYIREHKDNIGSQYLLNWCVQIAKGMSYLEER  831

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y

Q: 832   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  891

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa++i+++lekGerl+qppictidvym++vkcw

Q: 892   THQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCW  951

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el+ efs

Q: 952   MIDADSRPKFRELIIEFS  969

         ****************96

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY IREHKDNIGS QYLLNWCVQI AKGMSYLEER 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS DISSILEKGE RLPQPPICTI DVYMIMVKCW 240

MIDADSRPKF RELIIEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013