EKS-MOD-00392
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00392
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR557.11.9E-167609940332
StatusUnreviewed
Ensembl ProteinENSMODP00000011284
UniProt AccessionF6TMY2;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000009045ENSMODP00000033356ENSMODT00000034934
ENSMODG00000009045ENSMODP00000011284ENSMODT00000011503
OrganismMonodelphis domestica
Functional Description
Protein Length990
Protein Sequence
(FASTA)
MLVFWLQGGR GQLRLLVVIS AMAFGFIESQ EPPLIKCMLI DNKISDSSIR TSSISMASDL 60
MKDLGCSLRP ESTGVVYEAA ETVEVDIFAA ITLQVMLSIP GNISCTWFFK NNSTVCHPDF 120
DVQNRGIVSI VILKMTEIQA GEYLLSIQSE AMNYTVMFTV SVRSKLGKLG KPYFRKMENQ 180
NAVVCISESF PDPVIEWSFC SSQSKSCQRE SQVVIRRKER VLDDLFGTDI WCCARNDLGE 240
KCTKLYTLDL NQNPGSTLPQ LFIKEGEPLL IRCKAIYENY EFRLAWKLEN RTLKEENLFK 300
MSTYSTNRTM IRILFAFVAS VGRSDTGCYT CASSKHPNQS ALVTVLEKGF INASNLSKDY 360
EIDEHEEFCF SVQFKAYPQV VCTWTFSQKS VPCKQSLKNG FSVSEFCDHK NQPGEYTFHA 420
ENGDAQFTKT FTLYVKRKPQ VKMDTSANQA SCYSDGYLPQ SWTWKKCTDK SPNCTEITEG 480
IWNKRANREV FGQWTSSSTL NLSEQYQGLL VECCANNSLG SSCDSKLLSI PGFYYIIQDK 540
VSFYTTIGFC LLFIAVLLIL ISHKYRKQYR YESQLQMVQV TGSSDNEYFY VNFREFEYDL 600
KWEFPRENLE FGQVLGSGAF GKVMNATAYG ISETGVSIQV AVKMLKEKSD SSEKDALMSE 660
LKMMTHIGSH ENIVNLLGAC TLSGPIYLIF EYCCYGDLLN YLRSKREKFH RTWTEVFKQH 720
NFSFYPTFHS SSRMPGLGGL HISQDIDLTS GFNGNSFYSE EEIEYENQKR LVEEEDFNVL 780
TFEDLLCFSY QVAKGMEFLE LKSCVHRDLA ARNVLVTHGK VVKICDFGLA RDIMNDSNYV 840
VRGNARLPVK WMAPESLFEG IYTIKSDVWS FGILLWEIFS LGVNPYPGIP VDNNFYKLIQ 900
SGFKMDQPFY ATEEIYFIMQ SCWSFDSKKR PSFPHLTSFL GCQLANAEVA MYQNIGDGIS 960
KPLSSYQNRS SCSSHVSPGQ PPPQAQDKDS 990
Nucleotide Sequence
(FASTA)
ATGCTGGTGT TCTGGCTCCA AGGCGGCCGC GGCCAGCTCC GGCTGCTCGT TGTTATTTCA 60
GCAATGGCAT TTGGATTTAT TGAAAGCCAA GAACCACCTC TAATAAAGTG TATGTTAATT 120
GATAACAAGA TCAGCGATTC ATCAATAAGG ACATCATCAA TATCTATGGC ATCAGATCTA 180
ATGAAAGACC TTGGATGTTC CTTGAGACCT GAAAGCACAG GAGTTGTATA TGAAGCAGCT 240
GAGACAGTTG AAGTAGACAT TTTTGCAGCC ATTACATTGC AAGTGATGTT GAGCATCCCA 300
GGGAACATTT CATGTACTTG GTTCTTTAAG AATAACTCAA CTGTCTGCCA TCCTGATTTT 360
GATGTACAAA ACAGAGGAAT TGTTTCCATA GTCATTTTGA AAATGACAGA AATTCAAGCT 420
GGAGAATATC TACTCTCAAT TCAAAGTGAA GCTATGAATT ACACTGTGAT GTTTACAGTG 480
AGTGTAAGAA GTAAGTTGGG AAAACTTGGA AAGCCATACT TTAGAAAAAT GGAAAACCAG 540
AATGCAGTAG TCTGCATATC AGAAAGCTTT CCAGATCCAG TCATAGAGTG GTCTTTTTGC 600
AGCTCACAGA GTAAAAGCTG CCAAAGAGAA AGTCAAGTGG TCATTAGAAG GAAGGAAAGA 660
GTACTTGATG ATTTATTTGG AACAGACATA TGGTGTTGTG CAAGAAATGA CTTGGGCGAG 720
AAATGCACAA AGCTATATAC ACTAGATCTA AATCAAAACC CTGGATCAAC TTTACCACAA 780
TTATTCATTA AGGAAGGGGA ACCTTTGTTG ATAAGATGCA AAGCTATTTA TGAAAACTAT 840
GAATTCAGGC TTGCCTGGAA ATTAGAAAAC AGGACATTAA AAGAGGAAAA CCTTTTTAAG 900
ATGAGCACCT ATTCAACTAA CAGGACTATG ATTCGGATTC TGTTTGCTTT TGTGGCATCA 960
GTAGGAAGAA GTGATACTGG GTGTTATACT TGTGCCTCAT CAAAGCATCC CAATCAATCA 1020
GCTTTGGTTA CTGTTTTAGA AAAAGGATTT ATAAATGCTT CCAACTTAAG TAAAGATTAT 1080
GAAATTGATG AACATGAAGA ATTTTGCTTC TCAGTACAGT TTAAAGCATA TCCACAAGTT 1140
GTTTGCACAT GGACCTTTTC TCAAAAGTCA GTTCCTTGTA AACAAAGTCT CAAGAATGGA 1200
TTCAGCGTAT CTGAGTTCTG TGACCATAAG AACCAGCCAG GAGAATATAC CTTCCATGCA 1260
GAAAATGGTG ATGCTCAGTT TACGAAAACA TTTACACTCT ATGTAAAAAG GAAACCTCAA 1320
GTAAAAATGG ACACATCAGC AAATCAGGCT TCTTGTTACT CTGATGGTTA CCTTCCACAA 1380
TCTTGGACCT GGAAGAAGTG TACAGACAAG TCTCCCAACT GCACAGAAAT CACAGAAGGG 1440
ATTTGGAATA AGAGAGCTAA CAGAGAAGTG TTTGGACAGT GGACATCAAG CAGCACCCTA 1500
AATCTGAGTG AGCAGTACCA AGGACTCCTA GTTGAGTGCT GTGCCAATAA TTCACTGGGC 1560
TCCTCCTGTG ACTCAAAACT TCTCAGTATC CCAGGATTTT ATTATATCAT CCAGGACAAG 1620
GTTTCTTTCT ATACCACCAT TGGATTTTGT CTTCTCTTCA TTGCTGTCTT ACTCATACTC 1680
ATTTCTCACA AGTACAGAAA GCAATATAGG TATGAAAGTC AACTGCAAAT GGTACAAGTG 1740
ACGGGCTCTT CGGATAATGA ATACTTCTAT GTAAATTTCA GAGAATTTGA ATATGACCTC 1800
AAGTGGGAGT TTCCAAGAGA AAACTTAGAA TTTGGACAGG TCCTAGGCTC TGGTGCCTTT 1860
GGAAAAGTGA TGAATGCTAC AGCTTATGGA ATCAGTGAGA CTGGAGTCTC AATCCAAGTG 1920
GCTGTCAAAA TGCTGAAAGA AAAGTCTGAC AGCTCAGAAA AAGATGCTCT CATGTCAGAG 1980
CTCAAGATGA TGACTCACAT TGGAAGCCAC GAGAATATTG TGAACCTATT AGGAGCCTGC 2040
ACACTATCAG GACCGATTTA TTTGATATTT GAATACTGTT GCTATGGAGA TCTTCTAAAT 2100
TACTTAAGAA GTAAAAGAGA AAAATTTCAT AGGACATGGA CTGAAGTCTT CAAACAGCAC 2160
AATTTCAGCT TTTATCCCAC TTTCCATTCA AGTTCCAGAA TGCCTGGTTT AGGAGGTCTT 2220
CACATAAGCC AAGATATAGA TCTGACCTCT GGATTCAACG GGAATTCATT TTATTCTGAA 2280
GAAGAAATTG AATATGAAAA CCAAAAAAGA CTGGTTGAAG AAGAGGACTT CAATGTGCTT 2340
ACATTTGAGG ATCTTCTCTG CTTCTCTTAT CAAGTTGCCA AAGGAATGGA ATTTCTTGAA 2400
TTAAAGTCGT GTGTTCACAG AGACCTTGCA GCCAGGAATG TCCTTGTGAC TCATGGGAAA 2460
GTGGTGAAGA TATGTGACTT TGGATTGGCC AGAGACATAA TGAATGACTC CAACTACGTT 2520
GTCAGGGGCA ATGCTCGGTT ACCTGTGAAG TGGATGGCTC CTGAAAGCCT ATTTGAAGGC 2580
ATATATACAA TTAAGAGTGA TGTCTGGTCC TTTGGAATAT TGCTCTGGGA AATATTTTCT 2640
CTTGGTGTTA ATCCTTACCC TGGCATTCCA GTAGACAACA ATTTCTACAA ACTCATTCAA 2700
AGTGGTTTTA AAATGGATCA GCCATTTTAT GCTACAGAAG AAATCTACTT TATAATGCAG 2760
TCCTGCTGGT CTTTTGACTC CAAGAAAAGG CCATCCTTCC CACATCTGAC TTCTTTTCTG 2820
GGATGTCAAC TAGCAAATGC AGAAGTTGCG ATGTATCAAA ATATTGGAGA TGGAATTTCT 2880
AAACCTTTGT CCAGTTACCA AAACAGGTCA TCTTGCAGCA GTCACGTCAG TCCAGGCCAA 2940
CCTCCTCCTC AGGCTCAGGA TAAAGATTCC TAG 2973
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+G+vlGsGafGkv++atayG+s+++++++vavkmlk++++ssek+almselk+++h+G
Q: 609   LEFGQVLGSGAFGKVMNATAYGISETGVSIQVAVKMLKEKSDSSEKDALMSELKMMTHIG  668
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e +k+++++++ + 
Q: 669   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEVFKQHNFSFYPT-  727
         ********************************************************999.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               +  +ss+ +++ +  +++++d++  s ++ ++++se++ +++++++   +eeed
Q: 728   ------F--HSSSRMPGLGG-LHISQDIDLTSGFNGNSFYSEEEIEYENQKRL--VEEED  776
         ......4..55666778888.99************************999876..89999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+fsyqvakGmefl+ k+cvhrdlaarnvl+t+GkvvkicdfGlardim+d
Q: 777   FNVLTFEDLLCFSYQVAKGMEFLELKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMND  836
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlpvkwmapes+f+++yt+ksdvws+GillweifslG++pypg++vd++fy
Q: 837   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSFGILLWEIFSLGVNPYPGIPVDNNFY  896
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw ++++krpsf +l+++l
Q: 897   KLIQSGFKMDQPFYATEEIYFIMQSCWSFDSKKRPSFPHLTSFL  940
         ****************************************9986
Domain Sequence
(FASTA)
LEFGQVLGSG AFGKVMNATA YGISETGVSI QVAVKMLKEK SDSSEKDALM SELKMMTHIG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEVFK QHNFSFYPTF 120
HSSSRMPGLG GLHISQDIDL TSGFNGNSFY SEEEIEYENQ KRLVEEEDFN VLTFEDLLCF 180
SYQVAKGMEF LELKSCVHRD LAARNVLVTH GKVVKICDFG LARDIMNDSN YVVRGNARLP 240
VKWMAPESLF EGIYTIKSDV WSFGILLWEI FSLGVNPYPG IPVDNNFYKL IQSGFKMDQP 300
FYATEEIYFI MQSCWSFDSK KRPSFPHLTS FL 332
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0002318; P:myeloid progenitor cell differentiation
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0002328; P:pro-B cell differentiation
GO:0002572; P:pro-T cell differentiation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013