EKS-MOD-00462

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00462

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	367.4	4.9E-110	15	305	291

Status

Unreviewed

Ensembl Protein

ENSMODP00000033244

UniProt Accession

F6XZK6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK15

Gene Synonyms/Alias

MAPK15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000009057	ENSMODP00000033244	ENSMODT00000034821

Organism

Monodelphis domestica

Functional Description

Protein Length

572

Protein Sequence
(FASTA)

MSATEVDEHV SQLYLIKRRL GKGAYGIVWK AVDRRTGEIV AIKKIFDAFR NKTDAQRTFR 60

EIMFLQEFDN HPNIIRLLNV IRAENDRDIY LVFESMDTDL HSVIRKGNLL KDIHKCYILY 120

QLLRATKFIH SGNVIHRDQK PSNVLLDADC CVKLCDFGLA RSLSQLHEEP GNPALTEYVA 180

TRWYRAPEIL LSSHRYTQGV DMWSLGCILG EMLLGRPLFP GTSTLNQLEL ILAAIPAPNK 240

EDFLTFGSDY SASVLHRMGP RQLLTLGSRL PPSTPPEALD LLERLLVFDP EKRLTADEAL 300

RHPYVKRFHC PAKEPALDYE VTLPVDDGVQ LSVMEYRNRL YRMILERKSN NRHQRLEIQK 360

EGLGDLPRAS SLPLPSQKDP YLQNSASDPT QAPGELRPPG LRELRSKISG SRPQSEPSPF 420

HDTLGPRQGS APSIRPQHRG FTGKRGQSFW GDARSLTGTP GERPGLRWAP STPSLTAQAA 480

AAVTNQALTR KDSPLAGVMT TTSTRLVPRL PPGQAQDIRT PLRPTKRMFQ SFGSQGTLGG 540

ARASLGGYSQ AYGTIWRYSQ PALSHGFPSL DL 572

Nucleotide Sequence
(FASTA)

ATGAGCGCGA CTGAGGTGGA CGAACACGTG TCCCAGCTCT ACCTTATCAA GCGGCGCCTC 60

GGGAAGGGGG CCTATGGCAT CGTTTGGAAA GCTGTGGATC GGAGGACAGG AGAAATTGTG 120

GCCATTAAGA AGATCTTTGA TGCCTTCAGG AATAAGACAG ATGCACAGAG AACGTTCCGA 180

GAAATCATGT TTCTTCAGGA GTTTGATAAT CATCCCAACA TCATCCGTCT TTTGAATGTC 240

ATCAGAGCAG AAAATGACAG GGACATTTAC CTAGTATTTG AATCCATGGA CACAGACCTG 300

CATTCTGTCA TCCGGAAAGG GAACCTGCTG AAGGATATTC ACAAGTGTTA CATCCTTTAC 360

CAACTTCTAC GTGCGACCAA GTTCATTCAC TCGGGGAATG TCATCCACAG AGACCAAAAG 420

CCCTCCAATG TTCTTCTGGA TGCTGACTGT TGTGTGAAAC TCTGTGACTT TGGCCTTGCA 480

CGTTCCCTGA GTCAACTTCA TGAGGAACCA GGGAACCCAG CCCTGACAGA ATATGTGGCC 540

ACACGCTGGT ACCGAGCCCC AGAAATCCTC TTATCTTCAC ACCGGTACAC ACAGGGTGTG 600

GACATGTGGA GCTTGGGCTG TATCCTAGGG GAGATGCTGC TTGGGAGACC TTTGTTCCCA 660

GGAACTTCTA CCCTTAACCA GCTTGAGCTG ATCCTTGCAG CCATCCCAGC CCCAAACAAA 720

GAAGACTTCC TGACCTTTGG TTCAGACTAC AGTGCCTCTG TTCTCCACCG AATGGGGCCC 780

AGGCAGCTAC TGACCCTGGG CTCCCGCCTG CCACCATCTA CCCCTCCTGA GGCCCTGGAT 840

CTGTTAGAAA GACTCCTGGT GTTTGACCCT GAGAAGCGAC TGACTGCAGA TGAGGCTCTA 900

AGGCACCCTT ATGTGAAAAG GTTCCATTGT CCAGCCAAGG AACCAGCCCT GGACTATGAA 960

GTGACCCTGC CTGTGGATGA CGGTGTGCAG CTCTCTGTGA TGGAGTATCG TAACCGGCTC 1020

TACAGGATGA TCCTGGAGCG AAAATCAAAC AATCGGCATC AAAGGTTGGA AATTCAGAAA 1080

GAAGGCCTGG GGGACCTCCC CAGGGCAAGC TCTTTGCCCC TACCCTCCCA GAAGGATCCC 1140

TATCTGCAGA ATTCTGCCTC TGATCCAACC CAGGCCCCAG GGGAACTGCG ACCCCCTGGC 1200

CTGAGAGAAC TTCGTTCAAA AATTTCTGGA TCCAGACCAC AAAGTGAACC CTCTCCCTTC 1260

CATGACACCC TTGGTCCCCG GCAGGGGTCA GCACCCTCTA TCCGGCCACA ACATCGAGGT 1320

TTCACAGGGA AGAGGGGACA ATCATTTTGG GGTGATGCTC GCAGTCTCAC TGGCACCCCT 1380

GGGGAGAGGC CAGGCCTCAG ATGGGCCCCC TCTACCCCCT CTCTCACTGC CCAAGCAGCA 1440

GCTGCAGTGA CCAACCAGGC CCTGACACGA AAGGACAGTC CCCTGGCAGG TGTGATGACT 1500

ACCACAAGCA CCAGGCTGGT CCCTCGTCTG CCCCCTGGCC AAGCTCAGGA TATTCGAACT 1560

CCCCTGCGGC CCACAAAAAG GATGTTCCAG TCCTTTGGCT CCCAGGGGAC GTTAGGGGGA 1620

GCTAGGGCCT CCCTAGGAGG CTATTCTCAA GCCTATGGAA CCATCTGGAG ATATTCCCAG 1680

CCTGCCTTAT CCCATGGATT TCCCTCACTT GATCTCTGA 1719

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheNi  60

           +++lg+Gayg+v++avd+rt+e vaikk++++f+++t+a+rt+RE+++l+e+ +h+Ni

Q: 15    LIKRRLGKGAYGIVWKAVDRRTGEIVAIKKIFDAFRNKTDAQRTFREIMFLQEFdNHPNI  74

         56789*************************************************99****

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i+ll+v+++e+     +d+Ylv+e m+tdL++vi++   l+d h  ++lyq+lr++k++H

Q: 75    IRLLNVIRAEN----DRDIYLVFESMDTDLHSVIRKGnLLKDIHKCYILYQLLRATKFIH  130

         ********999....9********************98899*******************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPeil  175

         s nviHrD+KPsN+l+++dc +k++dFGlars ++ +e+     lteyvatrwYraPeil

Q: 131   SGNVIHRDQKPSNVLLDADCCVKLCDFGLARSLSQLHEEPgnpaLTEYVATRWYRAPEIL  190

         ********************************998877778899****************

S: 176   lslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiesee  235

         ls+++yt+ vD+Ws+GCIl+E+l g+plfpg+++++qle+il  ++ p++e++ ++ s+

Q: 191   LSSHRYTQGVDMWSLGCILGEMLLGRPLFPGTSTLNQLELILAAIPAPNKEDFLTFGSDY  250

         ************************************************************

S: 236   arnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289

          +++++++ +++  ++ + +p  + +ealdLle+lLv+dp+kR++++eaL+hpY+

Q: 251   SASVLHRMGPRQLLTLGSRLPPsTPPEALDLLERLLVFDPEKRLTADEALRHPYV  305

         ***************98888764889****************************7

Domain Sequence
(FASTA)

LIKRRLGKGA YGIVWKAVDR RTGEIVAIKK IFDAFRNKTD AQRTFREIMF LQEFDNHPNI 60

IRLLNVIRAE NDRDIYLVFE SMDTDLHSVI RKGNLLKDIH KCYILYQLLR ATKFIHSGNV 120

IHRDQKPSNV LLDADCCVKL CDFGLARSLS QLHEEPGNPA LTEYVATRWY RAPEILLSSH 180

RYTQGVDMWS LGCILGEMLL GRPLFPGTST LNQLELILAA IPAPNKEDFL TFGSDYSASV 240

LHRMGPRQLL TLGSRLPPST PPEALDLLER LLVFDPEKRL TADEALRHPY V 291

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013