EKS-MOD-00398
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00398
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK286.62.3E-85173453281
StatusUnreviewed
Ensembl ProteinENSMODP00000011339
UniProt AccessionF7FQL3;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK3
Gene Synonyms/Alias IRAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000009096ENSMODP00000011339ENSMODT00000011559
OrganismMonodelphis domestica
Functional Description
Protein Length616
Protein Sequence
(FASTA)
MAWAPVDGRS SPWEPAAFPA SLPLFDLPPS LLGAFCSILD SCDGVLGWRG LAERISSSWL 60
EVRHIEKYME QGKSGTRELL WSWAQKNKTI GDLLQILQEM GHERAINLIV NHGRTISAST 120
KQSQQSAGFP NIPSQVPTDS TIDKQGEMPE YRKEIRLKPS FNFKSIIEGT KNFHKDLLIG 180
EGEFFKVFRV ELQNGTYAVK LFKQETTIQN KKNWKMFFSE LEVLNLKSTH HPLYRETSYY 240
HISVPSFCSL FQLPPQISLY KKLENVGDDN TFPLSWQLRL SILIGAAKAI QYLHHVEPCS 300
VICGNITSSN ILLDSQFQPK LTNFVTAHLR PHLEKQSSTI NMESSRNKYL LYMPEEYIRQ 360
RRLSIKTDVY SFGIVIMEVL TGYQVVLEGP KYVRLRDLLV ELMEKRGLES CLSLLDKKIS 420
PCPQNFSWKL FTLANQCASS RAKLRPTMDE VLVALESSCP NLHFTEDPPK SLKSFRSPSP 480
LFLNHLPSVP MENDENQDFC SLPNENLDKD GFAQKTPLEC SQSEVTFLGL DRKALGKGKT 540
PVSEVPVSSW EDNFSSNHLH PSQDSSVCVM NMYLSSESGN PVLSKLVEPS SSSESYRNKN 600
EEMEKMTSEN ILQSDF 616
Nucleotide Sequence
(FASTA)
ATGGCTTGGG CGCCGGTGGA CGGCAGGAGC AGCCCCTGGG AGCCCGCAGC CTTCCCCGCG 60
AGTCTGCCTC TGTTTGACCT GCCCCCTTCC CTTCTGGGAG CCTTCTGTTC TATTCTGGAC 120
AGCTGCGACG GAGTGCTGGG CTGGCGCGGA CTAGCTGAAC GCATTTCCAG TAGTTGGCTA 180
GAAGTTCGAC ACATTGAAAA ATACATGGAG CAAGGTAAAA GTGGAACCAG GGAATTACTG 240
TGGTCTTGGG CGCAGAAAAA CAAGACTATC GGTGACCTTT TGCAGATTCT ACAGGAAATG 300
GGCCATGAGC GAGCAATTAA TTTAATTGTG AATCATGGAA GGACCATAAG TGCCTCAACT 360
AAGCAGAGTC AGCAGTCAGC TGGATTTCCA AATATCCCTT CTCAGGTACC AACTGACAGT 420
ACTATTGATA AACAAGGAGA GATGCCTGAA TATCGGAAAG AAATAAGGCT GAAACCTTCC 480
TTCAACTTTA AAAGCATCAT AGAAGGAACC AAAAACTTCC ATAAAGACTT GCTAATTGGA 540
GAAGGGGAAT TCTTCAAAGT ATTCAGAGTG GAACTTCAAA ATGGAACATA TGCTGTTAAG 600
TTATTTAAAC AGGAGACAAC TATACAGAAT AAGAAAAATT GGAAGATGTT TTTCTCAGAA 660
CTTGAAGTCT TGAATTTAAA GTCCACTCAT CACCCTTTAT ATAGAGAGAC TTCGTATTAT 720
CATATTTCAG TTCCTTCTTT CTGCTCTCTT TTCCAATTGC CTCCACAAAT CTCACTCTAT 780
AAGAAATTAG AAAATGTAGG TGATGATAAT ACTTTTCCAC TTTCTTGGCA ACTTCGACTC 840
AGTATATTGA TCGGGGCAGC CAAAGCCATT CAATATTTGC ACCATGTGGA ACCATGCTCT 900
GTCATCTGTG GCAACATAAC AAGTTCAAAC ATACTTTTGG ACAGTCAGTT TCAACCCAAA 960
CTAACAAATT TTGTCACGGC CCACCTCCGA CCTCATCTGG AAAAACAGAG TTCCACGATA 1020
AATATGGAAA GCAGTAGGAA TAAGTACCTG TTGTACATGC CAGAAGAGTA TATCAGGCAG 1080
AGGAGACTAT CCATTAAAAC TGATGTCTAC AGCTTTGGAA TTGTGATAAT GGAAGTTCTG 1140
ACAGGTTATC AAGTGGTTCT AGAAGGTCCA AAATATGTTC GACTGAGGGA CCTCCTTGTG 1200
GAACTGATGG AGAAGAGAGG TCTTGAGTCA TGTCTCTCCT TATTAGATAA AAAAATAAGT 1260
CCGTGTCCTC AGAATTTCTC CTGGAAATTA TTTACTTTAG CAAACCAATG TGCATCATCC 1320
CGGGCAAAGT TGAGGCCAAC AATGGATGAA GTCCTGGTTG CTCTTGAAAG TTCTTGCCCT 1380
AACTTACATT TTACAGAAGA CCCTCCCAAA TCACTGAAGT CCTTCAGGTC TCCTTCTCCC 1440
CTTTTCCTCA ATCATTTACC CAGTGTTCCC ATGGAAAATG ATGAAAATCA GGATTTTTGC 1500
TCACTTCCTA ATGAAAACTT GGACAAAGAT GGATTTGCCC AGAAAACTCC ATTAGAGTGT 1560
AGCCAGTCTG AAGTCACCTT TCTGGGCTTG GACAGAAAGG CTCTGGGTAA AGGAAAGACC 1620
CCTGTTTCGG AAGTGCCTGT GTCTTCCTGG GAAGACAACT TCTCATCGAA CCATCTACAT 1680
CCATCGCAGG ACTCAAGTGT TTGTGTTATG AATATGTACC TTTCCTCAGA GTCTGGAAAT 1740
CCTGTTCTGA GCAAGCTGGT GGAACCTAGC TCTTCCTCAG AATCATATAG GAATAAAAAT 1800
GAAGAGATGG AAAAGATGAC TTCTGAAAAT ATTTTACAAT CAGATTTTTA A 1851
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvla..rfrHd  58
         f++d  igeG+f++v+r+el+n ++avk +k+e+ ++ k+ ++ f +El+vl+  + +H+
Q: 173   FHKDLLIGEGEFFKVFRVELQNGTYAVKLFKQETTIQNKKNWKMFFSELEVLNlkSTHHP  232
         899***********************************************9863267888
S: 59    nilellgysaeseklcLvYqymknGsLedrLqcq..kgsepLsWpqRlsillGtaraief  116
            e   y +   ++c ++q+ +  sL  +L+    +++ pLsW+ Rlsil+G+a+ai++
Q: 233   LYRETSYYHISVPSFCSLFQLPPQISLYKKLENVgdDNTFPLSWQLRLSILIGAAKAIQY  292
         888999999**********************987658899********************
S: 117   LHeasp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaY  175
         LH+++p s+i+g+i s+NiLLD +++pKl++f  a+++p+ ekqsst+++ s+ ++ l Y
Q: 293   LHHVEPcSVICGNITSSNILLDSQFQPKLTNFVTAHLRPHLEKQSSTINMESSRNKYLLY  352
         ************************************************************
S: 176   lpeefirvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveile  235
         +pee+ir+++l++k+DvySfGiV++EvltG ++v e++k + L+dll e +e++++e++ 
Q: 353   MPEEYIRQRRLSIKTDVYSFGIVIMEVLTGYQVVLEGPKYVRLRDLLVELMEKRGLESCL  412
         ************************************************************
S: 236   kfldkkagkleeellealielalaclaekakkrPtmsqvle  276
         + ldkk+++++++++ +l++la +c+ ++ak rPtm++vl 
Q: 413   SLLDKKISPCPQNFSWKLFTLANQCASSRAKLRPTMDEVLV  453
         **************************************986
Domain Sequence
(FASTA)
FHKDLLIGEG EFFKVFRVEL QNGTYAVKLF KQETTIQNKK NWKMFFSELE VLNLKSTHHP 60
LYRETSYYHI SVPSFCSLFQ LPPQISLYKK LENVGDDNTF PLSWQLRLSI LIGAAKAIQY 120
LHHVEPCSVI CGNITSSNIL LDSQFQPKLT NFVTAHLRPH LEKQSSTINM ESSRNKYLLY 180
MPEEYIRQRR LSIKTDVYSF GIVIMEVLTG YQVVLEGPKY VRLRDLLVEL MEKRGLESCL 240
SLLDKKISPC PQNFSWKLFT LANQCASSRA KLRPTMDEVL V 281
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00378
EKS-BOT-00407
EKS-CAJ-00410
EKS-CAF-00407
EKS-CAP-00435
EKS-DAR-00794
EKS-ECT-00006
EKS-EQC-00399
EKS-FEC-00390
EKS-GAA-00494
EKS-HOS-00413
EKS-ICT-00386
EKS-LAC-00422
EKS-LOA-00416
EKS-MAM-00405
EKS-MUM-00439
EKS-MUP-00401
EKS-MYL-00402
EKS-NOL-00370
EKS-OCP-00086
EKS-ORA-00355
EKS-ORC-00382
EKS-OTG-00409
EKS-PAT-00385
EKS-POA-00397
EKS-RAN-00421
EKS-SAH-00378
EKS-SUS-00359
EKS-TUT-00121
EKS-VIP-00063
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0045824; P:negative regulation of innate immune response
GO:0010936; P:negative regulation of macrophage cytokine production
GO:0043407; P:negative regulation of MAP kinase activity
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0042177; P:negative regulation of protein catabolic process
GO:0043242; P:negative regulation of protein complex disassembly
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0010933; P:positive regulation of macrophage tolerance induction
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0043330; P:response to exogenous dsRNA
GO:0032496; P:response to lipopolysaccharide
GO:0032494; P:response to peptidoglycan
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00531; Death; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013