EKS-MOD-00366
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00366
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK343.96.0E-103107364258
StatusUnreviewed
Ensembl ProteinENSMODP00000012058
UniProt AccessionF6QT87;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K11
Gene Synonyms/Alias MAP3K11;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000009647ENSMODP00000012058ENSMODT00000012282
OrganismMonodelphis domestica
Functional Description
Protein Length832
Protein Sequence
(FASTA)
MEPLKNLLLK SPLGPWGGGG RTDGPPKAGY PGPVWTALFD YEASGRDELT LRKGDRVEVL 60
SRDAAISGDE GWWAGKVGDQ VGIFPSNYVS RGGAPQPEVA RFQELRLEEV IGVGGFGKVY 120
RGSWRGELVA VKAARQDPDE DISVTAESVR QEARLFAMLA HPNIIALKAV CLEEPNLCLV 180
MEYAAGGPLS RALAGRRVPP HVLVNWGVQI ARGMHYLHCE ALVPVIHRDL KSNNILLLQP 240
VEGDNVEQKT LKITDFGLAR EWHKTTQMSA AGTYAWMAPE VIKASTFSKG SDVWSFGVLL 300
WELLTGEVPY RGIDGLAVAY GVAVNKLTLP IPSTCPEPFA QLMAECWAQD PHRRPDFSAI 360
LQQLSALEAQ VLREMPRDSF HSMQDGWKRE IQGLFDEIRA KEKELLSREE ELTRAAREQR 420
SQAEQLRRRE HLLAQWELEV FERELTLLLQ QVDRERPHVR RRRGTFKRSK LRARDGGERI 480
SMPLDFKHRI TVQASPGLDR RKNVFEVGAG DSPTFPRFRA IQLEAPDTGQ VWGRQSPRRL 540
EDPGNGERRP CWAWGPGSPK PGEAQNGRRR SRMEETTWYL DSNDPSPLGS PSTPPTLNGD 600
VRPPEPEEPR RPGPSDRSGT PKIIQRALLR GTALLASLGL GRDLQQAGSG ARDKGDATPE 660
EALSSPPSPL IRFSPKTPDA PTSPLNLDTE TPPSPPLLDL GTPGGQPSAK SPRREEETRG 720
GAVSPPPGAF RSPPGTPRSP TLGLIGRPRP SPLRSRIDPW SFVSTGPRPS PLPSPQPAPR 780
RAPWTLFPDS DPFRDPPPFN PFSPGSPQNS RAQTKDMGGQ APWGATGPEG SP 832
Nucleotide Sequence
(FASTA)
ATGGAGCCCC TCAAGAACCT GCTCCTCAAG AGCCCGCTGG GGCCCTGGGG CGGAGGGGGT 60
CGGACTGACG GGCCCCCCAA GGCCGGTTAC CCCGGCCCCG TGTGGACGGC GCTCTTCGAC 120
TATGAGGCCA GCGGGCGCGA TGAGCTGACC CTGCGCAAGG GCGACCGCGT GGAGGTGCTG 180
TCCAGGGATG CGGCCATCTC AGGAGACGAA GGCTGGTGGG CGGGCAAGGT GGGCGACCAG 240
GTTGGCATCT TCCCCTCCAA CTACGTGTCC CGGGGTGGTG CCCCGCAGCC GGAGGTGGCC 300
CGCTTCCAGG AGCTGCGCTT GGAGGAGGTG ATTGGCGTGG GGGGCTTCGG CAAGGTCTAC 360
CGAGGTAGCT GGAGGGGCGA GCTTGTGGCT GTCAAGGCTG CCCGCCAGGA CCCAGACGAG 420
GACATCAGCG TGACGGCTGA GAGCGTCCGC CAAGAGGCGC GCCTCTTCGC CATGCTGGCG 480
CACCCCAACA TCATTGCACT GAAAGCCGTT TGCCTGGAGG AGCCCAACCT GTGCCTGGTG 540
ATGGAGTATG CGGCTGGTGG GCCCCTCAGC CGGGCTCTGG CAGGCCGGCG GGTCCCCCCT 600
CATGTGCTGG TCAACTGGGG GGTGCAGATA GCCAGGGGGA TGCACTACCT GCACTGTGAG 660
GCCCTTGTGC CTGTCATCCA CCGGGACCTC AAGTCTAACA ACATCCTGCT GCTGCAGCCT 720
GTGGAGGGGG ACAACGTGGA ACAGAAGACC CTGAAGATCA CCGACTTCGG CCTGGCCCGA 780
GAGTGGCACA AGACCACCCA GATGAGCGCG GCGGGCACCT ACGCCTGGAT GGCCCCCGAA 840
GTCATCAAGG CCTCCACGTT CTCCAAGGGC AGCGACGTCT GGAGCTTCGG GGTGCTGCTG 900
TGGGAACTGC TGACCGGAGA GGTGCCCTAC CGGGGCATCG ACGGCCTGGC CGTGGCCTAT 960
GGAGTGGCCG TGAACAAGCT CACCCTGCCC ATCCCCTCCA CCTGCCCCGA GCCCTTTGCA 1020
CAGCTCATGG CCGAGTGCTG GGCCCAGGAC CCCCACCGCC GGCCCGACTT CTCGGCCATC 1080
CTGCAACAGC TGTCGGCCCT GGAGGCCCAG GTGCTGAGGG AGATGCCCCG GGACTCCTTC 1140
CACTCCATGC AGGACGGCTG GAAGCGCGAG ATCCAAGGCC TCTTCGACGA GATCCGAGCC 1200
AAGGAAAAGG AGCTGCTGAG CCGAGAGGAG GAACTGACCC GGGCGGCTCG GGAGCAGCGC 1260
TCCCAGGCCG AGCAGCTGCG CCGCCGCGAG CACCTGCTGG CGCAGTGGGA GCTGGAGGTG 1320
TTTGAGCGCG AGCTGACCCT GCTCCTGCAG CAGGTGGACC GCGAACGGCC GCATGTGCGC 1380
CGCCGCCGAG GCACCTTCAA GCGCAGCAAG CTGCGGGCCC GGGACGGAGG CGAGAGGATC 1440
AGCATGCCTC TGGACTTCAA GCACCGGATC ACCGTGCAGG CCTCTCCTGG CTTAGACCGG 1500
AGGAAAAATG TCTTTGAGGT CGGGGCCGGG GACTCGCCCA CCTTTCCTCG CTTCAGGGCC 1560
ATCCAGTTGG AAGCCCCAGA CACAGGACAG GTTTGGGGTC GCCAGTCCCC TCGGCGATTG 1620
GAAGACCCAG GAAATGGGGA GCGCCGGCCA TGCTGGGCCT GGGGGCCCGG TTCCCCTAAG 1680
CCAGGGGAGG CTCAGAATGG GAGGAGACGG TCCCGAATGG AGGAGACGAC GTGGTACCTG 1740
GACTCCAATG ACCCTTCCCC TCTGGGGTCC CCGTCCACAC CCCCCACACT CAATGGCGAT 1800
GTCCGTCCCC CAGAGCCTGA GGAGCCACGG CGGCCGGGCC CCTCGGACCG GAGCGGGACC 1860
CCCAAGATTA TCCAGCGTGC CTTGCTCCGG GGGACAGCCC TGTTAGCCTC CCTGGGGCTG 1920
GGCCGGGACC TTCAGCAGGC TGGCAGCGGG GCACGTGACA AGGGAGATGC CACCCCCGAA 1980
GAGGCGCTGT CTTCGCCGCC CTCCCCCCTC ATCCGCTTCT CTCCCAAAAC GCCAGATGCC 2040
CCGACCTCGC CCCTGAACCT GGACACGGAG ACGCCTCCCA GCCCCCCACT GCTTGACCTG 2100
GGCACCCCTG GGGGGCAGCC CTCTGCCAAA AGCCCCCGCC GAGAGGAGGA GACGCGGGGG 2160
GGAGCCGTCT CCCCGCCTCC TGGGGCCTTC CGTTCTCCGC CCGGCACCCC CCGATCCCCG 2220
ACGCTGGGCC TCATCGGCAG GCCTCGGCCT TCGCCCCTCC GGAGCCGCAT CGACCCGTGG 2280
AGTTTTGTGT CCACTGGACC CCGCCCGTCC CCCCTTCCAT CTCCACAGCC TGCCCCACGT 2340
CGGGCCCCCT GGACCCTGTT CCCAGACTCA GACCCCTTCC GAGACCCCCC GCCTTTCAAC 2400
CCTTTCAGCC CAGGGTCCCC ACAGAACAGC AGAGCCCAGA CCAAAGACAT GGGGGGCCAG 2460
GCTCCTTGGG GAGCCACAGG ACCAGAGGGG AGCCCCTGA 2499
Domain Profile
S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60
         lee+ig g fgkvy+++wr++ vavK++r++  e  + ++e++++ea+l+++l+hpnii+
Q: 107   LEEVIGVGGFGKVYRGSWRGELVAVKAARQDPDEdiSVTAESVRQEARLFAMLAHPNIIA  166
         789****************************99988999*********************
S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120
         l++vcleepnl+lvmey++gg Ls++l++   r+++++vlv+w +qiArGm+YLh ea +
Q: 167   LKAVCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWGVQIARGMHYLHCEALV  223
         *****************************...9***************************
S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173
         ++ihrdLks+n+Ll       + e+ktlki+dFG are++k+t+msaagt+awmaPEv+k
Q: 224   PVIHRDLKSNNILLlqpvegdNVEQKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIK  283
         ********************999*************************************
S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233
         ++++s+ sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++Lm
Q: 284   ASTFSKGSDVWSFGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAQLM  343
         ************************************************************
S: 234   kecwnedpekRpsfseivksl  254
          ecw++dp++Rp+fs i+++l
Q: 344   AECWAQDPHRRPDFSAILQQL  364
         *****************9986
Domain Sequence
(FASTA)
LEEVIGVGGF GKVYRGSWRG ELVAVKAARQ DPDEDISVTA ESVRQEARLF AMLAHPNIIA 60
LKAVCLEEPN LCLVMEYAAG GPLSRALAGR RVPPHVLVNW GVQIARGMHY LHCEALVPVI 120
HRDLKSNNIL LLQPVEGDNV EQKTLKITDF GLAREWHKTT QMSAAGTYAW MAPEVIKAST 180
FSKGSDVWSF GVLLWELLTG EVPYRGIDGL AVAYGVAVNK LTLPIPSTCP EPFAQLMAEC 240
WAQDPHRRPD FSAILQQL 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00376
EKS-CAJ-00383
EKS-CAF-00376
EKS-CAP-00409
EKS-DIO-00059
EKS-EQC-00374
EKS-FEC-00364
EKS-GAA-00460
EKS-GOG-00367
EKS-HOS-00383
EKS-ICT-00356
EKS-LAC-00397
EKS-LOA-00385
EKS-MAM-00375
EKS-MUM-00408
EKS-MUP-00370
EKS-MYL-00374
EKS-NOL-00344
EKS-ORN-00483
EKS-ORC-00352
EKS-ORL-00446
EKS-OTG-00378
EKS-PAT-00356
EKS-PES-00335
EKS-POA-00366
EKS-PTV-00099
EKS-RAN-00391
EKS-SAH-00352
EKS-TAR-00479
EKS-TEN-00477
EKS-XIM-00473
Gene Ontology
GO:0005813; C:centrosome
GO:0005874; C:microtubule
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0007257; P:activation of JUN kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0008283; P:cell proliferation
GO:0000080; P:G1 phase of mitotic cell cycle
GO:0007017; P:microtubule-based process
GO:0046330; P:positive regulation of JNK cascade
KEGG
mdo:100030111;
InterPros
IPR011009; Kinase-like_dom.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00018; SH3_1; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013