EKS-MOD-00394
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00394
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR278.41.1E-82588808221
StatusUnreviewed
Ensembl ProteinENSMODP00000012168
UniProt AccessionF6XAD2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000009737ENSMODP00000012168ENSMODT00000012393
OrganismMonodelphis domestica
Functional Description
Protein Length1061
Protein Sequence
(FASTA)
MLSVFSGWLW LLLLLPEAKA LKITPHGSEF ILNLSSTFVL TCTGDAPVAW EKIPQQTPPP 60
VLEAQDGTFS SILTLTNVTG LDTGEYICSY NGSQGLEFGG QKRVYIFVPD PSVGFLPVDP 120
EELFIFFTGD SETTIPCRVT DPKLVVTLHE KKVDVSLPVP YDHQRGFTGP FEDKTYICKT 180
IIDEKEVDSE AYYVYRIQVS SINVSVNAVQ SVVRKGENIT VLCIVKGNEV VNFDWTYPRM 240
ESKRLVEPVT DFLSGLEYDI RSILHIPSAE LGDSGTYVCN VSESYNGHRD MKGVNITVID 300
KGFVRFLGEL DDLEFAELHK SRTLQMFIEA YPAPTIVWLK DNQTLGSGTA SEISISTRNL 360
SETRYVSELT LVRVKVNEGG YYTLRAFHDD AADSFSFQLQ INVPAKVIDL SESHPSSGEQ 420
LLTCRSQGMP QPVLNWFSCN DFKRCPRDVL PTFLGNSSSE EAQLETNVTY WEQEKLFEVV 480
SILSFQRVDQ PLSVICEVHN LLGRDSKEVT IVPHSLPFKV VVISAILALV VLTIISMVIL 540
IILWQKKPRY EIRWKVIESV SSDGHEYIYV DPMQLPYDSS WELPRERLVL GRTLGSGAFG 600
QVVEATAHGL SHSQATMKVA VKMLKSTARS SEKQALMSEL KIMSHLGPHL NIVNLLGACT 660
KGGPIYIITE YCRYGDLVDY LHRTKHTFLQ HCPEKGGPYQ SSEVLDHPEH QLHRQTSLSG 720
ESDGGYMDMR KDDCVDYVPM LGMKGEIMYV DIESSNYSSP YDSYAPSVPE RSYRTTLINE 780
SPILSYMDLV GFSYQVANGM EFLASKNTFL PLKWMAPESI FNSLYTTLSD VWSFGILLWE 840
IFTLGGTPYP ELPMNEQFYN AIKRGYRMAK PTHASEEIYE IMQKCWEEKF EIRPSFSQLV 900
ILMEGLLGEG YKKKYQQVDE EFLRSDHPAI LRTRAQLPVF SGPRGPLDTS SVLYTAVQQN 960
EGDNDYIIPL PDPKPEGPDA APLESSHSLA SSTLNEANTS STISCDSPLE LQEELDPESE 1020
EPETEPKPEP KSEPEPEPEP EPRPILDHQD QGQPEMEDSF L 1061
Nucleotide Sequence
(FASTA)
ATGCTTTCTG TCTTCTCAGG TTGGCTGTGG CTGTTGCTAT TATTGCCTGA GGCTAAGGCA 60
CTGAAGATAA CACCCCATGG CTCAGAGTTC ATCCTCAACC TCTCCAGCAC CTTCGTCCTG 120
ACTTGCACAG GGGATGCCCC AGTGGCTTGG GAAAAGATTC CTCAGCAGAC TCCACCACCT 180
GTTCTTGAGG CCCAGGATGG CACCTTCTCC AGCATCTTGA CCCTCACTAA TGTCACTGGC 240
CTTGACACAG GAGAGTACAT CTGTTCCTAC AATGGCTCCC AAGGGCTGGA GTTTGGTGGG 300
CAGAAGCGGG TCTACATCTT TGTGCCAGAT CCCTCTGTGG GCTTTCTCCC AGTGGATCCT 360
GAGGAGTTGT TCATCTTCTT CACGGGAGAC AGTGAGACAA CAATCCCATG CCGAGTGACT 420
GACCCAAAGT TAGTGGTGAC ACTGCATGAG AAAAAGGTGG ATGTGTCATT GCCTGTTCCC 480
TATGACCACC AGCGTGGCTT CACTGGCCCC TTTGAAGACA AGACCTATAT CTGCAAAACC 540
ATCATTGATG AGAAAGAGGT CGACTCTGAA GCCTATTATG TCTACCGTAT CCAAGTCTCA 600
TCCATTAATG TCTCTGTAAA TGCAGTTCAG AGTGTGGTGA GGAAGGGTGA GAACATCACT 660
GTGCTCTGCA TCGTGAAGGG TAATGAGGTG GTGAACTTTG ACTGGACCTA CCCTCGAATG 720
GAGAGCAAGA GACTGGTGGA ACCAGTGACA GACTTCCTGT CAGGGTTAGA GTATGACATC 780
CGCTCCATCC TGCATATTCC CAGTGCTGAG CTAGGAGATT CTGGTACCTA TGTCTGCAAT 840
GTCTCAGAGA GCTACAATGG TCACAGGGAT ATGAAAGGAG TCAATATCAC TGTAATTGAC 900
AAAGGGTTTG TGAGGTTTTT GGGGGAGCTG GATGACCTGG AGTTTGCTGA GCTGCACAAG 960
AGTCGGACAT TACAGATGTT CATCGAAGCA TACCCTGCAC CCACCATTGT ATGGCTCAAG 1020
GACAACCAAA CACTGGGCTC TGGTACTGCC AGTGAGATCT CCATCTCCAC CAGGAATCTG 1080
TCTGAGACAA GGTACGTGTC AGAGCTGACT CTAGTAAGGG TGAAGGTGAA TGAAGGAGGT 1140
TATTATACCC TTAGAGCCTT CCATGACGAT GCTGCTGATT CATTCTCATT CCAGTTGCAA 1200
ATCAATGTTC CTGCTAAGGT GATAGATCTG AGTGAGAGCC ACCCCAGCAG TGGGGAGCAA 1260
CTCCTCACCT GTCGCAGCCA GGGAATGCCA CAGCCTGTCC TTAACTGGTT CAGTTGCAAT 1320
GATTTTAAGA GGTGTCCCCG TGATGTTCTG CCTACCTTCC TGGGGAACAG TTCCAGTGAG 1380
GAAGCCCAGC TGGAAACCAA TGTGACGTAC TGGGAGCAGG AGAAATTGTT TGAGGTAGTC 1440
AGCATCCTGA GTTTTCAACG TGTGGACCAG CCCCTCTCCG TCATCTGTGA AGTACACAAC 1500
CTCCTGGGGA GAGACAGCAA GGAAGTCACC ATTGTTCCAC ACTCCCTGCC CTTCAAGGTG 1560
GTTGTCATCT CAGCCATCCT GGCATTAGTG GTCCTCACAA TCATTTCCAT GGTCATCCTT 1620
ATCATTCTGT GGCAGAAGAA ACCCCGCTAT GAGATCCGGT GGAAGGTGAT TGAATCTGTG 1680
AGCTCTGATG GGCATGAGTA CATCTATGTG GATCCCATGC AGCTGCCCTA TGACTCCAGC 1740
TGGGAACTGC CCCGAGAGCG ACTTGTGCTC GGCCGAACAC TTGGCTCTGG GGCCTTTGGG 1800
CAAGTAGTAG AGGCCACAGC GCATGGACTG AGTCACTCCC AGGCCACAAT GAAGGTTGCT 1860
GTCAAGATGT TGAAATCCAC TGCCCGTAGT AGTGAGAAGC AGGCCCTTAT GTCTGAATTG 1920
AAGATCATGA GCCATCTTGG ACCCCACCTG AATATTGTCA ACCTGCTGGG GGCATGTACC 1980
AAAGGAGGTC CCATCTACAT CATCACAGAA TATTGTCGTT ATGGAGACCT CGTGGACTAC 2040
CTACATCGAA CCAAACACAC ATTTCTGCAG CATTGCCCTG AGAAAGGAGG GCCTTACCAA 2100
TCCTCAGAGG TCCTGGACCA TCCTGAACAT CAATTGCACA GACAAACATC ACTATCAGGG 2160
GAGAGTGATG GAGGCTACAT GGACATGAGG AAGGATGACT GTGTGGACTA TGTACCAATG 2220
CTGGGCATGA AGGGAGAGAT CATGTATGTG GATATTGAAT CTTCCAACTA TAGCTCGCCC 2280
TATGATAGCT ACGCACCCTC AGTTCCTGAG AGATCCTACA GGACAACCCT GATCAATGAG 2340
TCCCCTATCC TCAGCTACAT GGACCTTGTG GGCTTCAGTT ACCAGGTGGC CAATGGCATG 2400
GAATTCCTGG CTTCCAAGAA CACTTTCCTG CCCCTGAAAT GGATGGCTCC AGAGAGCATC 2460
TTCAACAGCC TGTATACCAC CTTGAGTGAT GTGTGGTCCT TTGGTATCCT TCTCTGGGAG 2520
ATCTTCACCC TAGGTGGCAC CCCTTACCCA GAATTACCCA TGAATGAGCA GTTCTATAAT 2580
GCCATCAAGA GAGGTTACCG TATGGCCAAG CCCACCCATG CCTCAGAAGA AATCTATGAA 2640
ATCATGCAGA AGTGCTGGGA GGAGAAATTT GAGATTCGAC CTTCCTTCTC TCAGCTGGTC 2700
ATTCTGATGG AGGGCCTTCT GGGGGAGGGC TACAAGAAGA AGTACCAGCA GGTAGATGAA 2760
GAATTTCTGA GGAGCGATCA CCCAGCCATT CTTCGTACCC GAGCCCAGCT CCCTGTATTT 2820
AGTGGCCCAA GGGGTCCCCT CGACACCAGC TCTGTCCTCT ACACAGCTGT GCAGCAGAAT 2880
GAGGGGGACA ATGATTACAT CATCCCCCTG CCTGACCCTA AGCCTGAAGG ACCTGATGCA 2940
GCCCCACTGG AGAGTTCCCA CAGCCTTGCC AGCTCTACCC TTAATGAGGC CAACACATCA 3000
TCCACCATCT CCTGTGATAG CCCCCTGGAG CTGCAGGAGG AATTAGACCC AGAATCAGAG 3060
GAGCCGGAAA CAGAGCCAAA GCCAGAACCA AAGTCAGAGC CAGAGCCGGA GCCAGAACCT 3120
GAACCCAGGC CAATCTTGGA TCACCAGGAT CAGGGGCAGC CAGAGATGGA GGATAGTTTT 3180
CTGTAG 3186
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 588   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  647
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactkgGpiy+iteyc+yGdl++yl+r +++fl++  ek  + +++     
Q: 648   PHLNIVNLLGACTKGGPIYIITEYCRYGDLVDYLHRTKHTFLQHCPEKGGPYQSSEVLD-  706
         ******************************************99999977666554444.
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
            +++l++++sls es++ y+d++kd                + d++ss+++++++++ 
Q: 707   -HPEHQLHRQTSLSGESDGGYMDMRKDdcvdyvpmlgmkgeimYVDIESSNYSSPYDSYA  765
         .457899*****************************************************
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflasknc  208
          s+ er+++++l++e s  l+++dl+ fsyqva+Gmeflaskn 
Q: 766   PSVPERSYRTTLINE-SPILSYMDLVGFSYQVANGMEFLASKNT  808
         *************99.9*************************95
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNIVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRTKHT FLQHCPEKGG PYQSSEVLDH 120
PEHQLHRQTS LSGESDGGYM DMRKDDCVDY VPMLGMKGEI MYVDIESSNY SSPYDSYAPS 180
VPERSYRTTL INESPILSYM DLVGFSYQVA NGMEFLASKN T 221
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORA-00353
EKS-ORC-00377
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-XET-00513
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013