EKS-MOD-00393
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00393
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR528.78.3E-159586906321
StatusUnreviewed
Ensembl ProteinENSMODP00000012194
UniProt AccessionF6WT52;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000009759ENSMODP00000012194ENSMODT00000012419
OrganismMonodelphis domestica
Functional Description
Protein Length959
Protein Sequence
(FASTA)
MAPGILIPLM AVVVWHSQAT PMIEPSGPNL VVERGSTITL RCEGNANVDW VSDVNLHTNG 60
WIQDTMGNLS TLSIINSTIS HTGTYQCLEK GEENSNGDNS TASLHLYVKD PENLWSVPHS 120
EVTAEEDSDV LLPCRITDPT AEPWVSLEHS YGKPFRSHYT FDSRKGITIQ KVQFIHRGDY 180
RCKTVVGGKS KYSSKISLIV DKVLLGPPKL WLEPSELVQI QGEPVQIICR ATNPDVHFDL 240
VFKHQQKETS YLNKYDYNSN DDVYQNTINF TIPAVGPEDG GTYFCNASNP KGYNISFTVL 300
KVVEHGYVNL SSEQSLRLEM DVGKDLVLMV SVETYPTMLH WNWTYDGPFL NSQRSLPNSI 360
SETTYRFNTT LPLSRLKESE AGYYTFHAEN SDAKASLSFE VILNYPPEVQ VQQAEFNISN 420
VLRCIAFGYP APEIMWYRCS GKEERCNQDR VLLWRDINAS VVSQEPFHKV KVESMLHIQT 480
LMENTTYMCM ASNKVGNNSH SFWPILTKPS FQPERDSLFT PILMVCISIM VVLSLLLLLL 540
LYKYKQKPKY QVRWKIIEAC EGNNYIFIDP TQLPYNEKWE FPRNNLQFGK TLGAGAFGKV 600
VEATAFGLGK EDAVLKVAVK MLKSTAHADE KEALMSELKI MSHLGQHENI VNLLGACTHG 660
GPVLVITEYC HYGDLLNFLR RKAEDMLVPT LSAEPDGGPG YRNVHLEKKY MHGQGLDTYV 720
EMRPVSSSSS GSFSEQELDQ EDGRPLELCD LLRFSSQVAQ GMAFLASKNC IHRDVAARNV 780
LVTSRRVAKI GDFGLARDIM NDTNYVVKGN ARLPVKWMAP ESIFDCVYTV QSDVWSYGIL 840
LWEIFSLGLS PYPGILVNSK FYKLVKEGYQ MAQPNFSPPN IYSIMQACWD LEPTRRPTFQ 900
QICSFLQEEM DATSKKQDYA NLPSSGSSEE EDSVSEPLDC CDQVDSSQPL LQANNYQFC 959
Nucleotide Sequence
(FASTA)
ATGGCTCCTG GGATCCTGAT ACCACTGATG GCAGTGGTCG TCTGGCACAG TCAGGCAACT 60
CCCATGATTG AGCCCAGTGG TCCAAATCTG GTGGTGGAAC GTGGATCAAC TATAACTCTT 120
CGCTGTGAGG GCAATGCCAA TGTGGACTGG GTCAGTGATG TGAACTTGCA CACCAATGGC 180
TGGATTCAGG ACACCATGGG CAACCTCAGC ACCCTTAGTA TCATCAATTC TACAATTAGT 240
CATACAGGCA CCTACCAATG TTTGGAAAAG GGGGAAGAAA ACTCAAACGG GGACAACTCT 300
ACCGCCTCCC TGCATCTCTA TGTGAAAGAT CCAGAAAATC TTTGGAGCGT CCCTCACAGT 360
GAGGTCACTG CTGAGGAGGA CAGTGATGTG CTGCTGCCAT GTCGGATAAC AGATCCCACA 420
GCAGAGCCTT GGGTATCTCT GGAACACAGC TATGGAAAAC CTTTCCGGAG CCACTACACC 480
TTTGACTCTC GGAAGGGCAT CACTATCCAA AAGGTCCAGT TCATCCACAG AGGGGATTAC 540
CGCTGTAAGA CTGTGGTTGG AGGAAAGAGC AAATACTCCT CAAAGATCTC TCTGATTGTG 600
GATAAAGTCC TCTTAGGGCC TCCAAAGCTG TGGCTAGAAC CTTCTGAGCT GGTGCAGATT 660
CAAGGGGAAC CTGTCCAGAT TATCTGCAGA GCAACCAATC CAGATGTACA TTTTGATCTT 720
GTCTTCAAAC ATCAACAGAA GGAGACCTCT TATCTGAACA AATATGACTA TAATTCTAAT 780
GATGACGTCT ATCAAAATAC CATCAACTTC ACCATACCAG CTGTGGGCCC AGAGGATGGG 840
GGCACTTATT TCTGTAATGC TTCCAACCCT AAGGGCTACA ACATTTCTTT CACTGTTCTA 900
AAGGTGGTGG AGCATGGATA TGTGAACCTA TCTTCTGAGC AAAGCCTGCG CCTAGAGATG 960
GATGTTGGGA AGGACTTGGT CTTGATGGTC AGTGTTGAGA CTTATCCTAC AATGCTTCAT 1020
TGGAACTGGA CTTATGATGG CCCCTTTCTC AACTCCCAGC GCAGTCTTCC CAACTCCATT 1080
TCAGAGACAA CCTACAGGTT CAACACAACC CTCCCTCTAT CTCGCCTGAA AGAGTCAGAA 1140
GCTGGGTACT ACACTTTCCA TGCTGAAAAC TCGGATGCTA AGGCTTCTCT CAGCTTTGAG 1200
GTCATCCTAA ACTACCCTCC AGAGGTACAA GTCCAGCAGG CAGAATTCAA CATCTCTAAT 1260
GTCCTTCGCT GCATCGCTTT TGGGTATCCA GCCCCTGAGA TTATGTGGTA CCGCTGTTCT 1320
GGCAAGGAAG AAAGGTGCAA CCAGGACAGA GTACTGCTGT GGCGTGATAT CAATGCCTCA 1380
GTCGTGAGCC AGGAGCCCTT TCACAAAGTG AAGGTTGAGA GTATGCTTCA TATCCAAACC 1440
CTGATGGAAA ACACTACCTA CATGTGCATG GCTAGCAACA AGGTCGGGAA CAACTCACAC 1500
AGCTTCTGGC CCATCCTAAC AAAACCATCC TTCCAGCCTG AAAGAGACAG TCTTTTTACC 1560
CCTATCCTCA TGGTCTGCAT TTCCATTATG GTCGTACTTT CTCTTCTGCT CCTCCTACTC 1620
CTGTACAAAT ACAAACAGAA ACCCAAGTAC CAAGTACGCT GGAAGATCAT TGAGGCCTGT 1680
GAAGGGAATA ACTACATCTT CATTGATCCT ACACAACTGC CCTATAATGA GAAATGGGAA 1740
TTCCCCCGAA ATAACCTGCA GTTTGGTAAG ACCCTGGGAG CTGGAGCTTT TGGGAAAGTA 1800
GTGGAAGCCA CAGCCTTTGG TCTGGGGAAG GAAGATGCTG TCCTCAAAGT GGCTGTGAAG 1860
ATGCTGAAGT CCACTGCTCA TGCAGATGAG AAGGAGGCCC TCATGTCTGA ACTGAAGATC 1920
ATGAGCCACC TGGGGCAGCA TGAGAACATC GTCAATCTGT TGGGAGCATG TACCCATGGA 1980
GGCCCAGTCC TGGTCATCAC AGAGTATTGT CACTATGGTG ACCTGCTCAA CTTTCTACGC 2040
CGTAAGGCAG AGGACATGCT GGTGCCAACC CTAAGTGCTG AGCCTGATGG AGGCCCCGGG 2100
TACCGGAACG TCCATCTGGA GAAGAAATAT ATGCATGGCC AGGGCCTGGA CACCTACGTG 2160
GAGATGAGAC CCGTCTCCTC CTCCTCTTCT GGCTCCTTCT CTGAGCAGGA GCTGGATCAG 2220
GAGGATGGAC GGCCCCTAGA ACTCTGTGAC CTGCTCCGTT TCTCCAGTCA AGTGGCCCAG 2280
GGCATGGCGT TCCTCGCCTC CAAGAACTGC ATTCACCGGG ATGTAGCTGC CAGAAACGTG 2340
CTGGTGACCA GCAGGCGAGT AGCCAAGATT GGGGACTTTG GGCTGGCGAG GGACATCATG 2400
AATGACACTA ACTACGTGGT CAAAGGCAAT GCTCGCCTGC CTGTGAAGTG GATGGCTCCA 2460
GAAAGCATCT TTGATTGTGT CTACACCGTG CAGAGTGACG TCTGGTCCTA TGGCATTTTG 2520
CTCTGGGAAA TCTTCTCCCT GGGTTTGAGC CCTTACCCTG GCATCCTGGT GAACAGTAAG 2580
TTCTACAAGT TGGTGAAGGA GGGATATCAG ATGGCTCAGC CCAACTTCTC TCCCCCAAAC 2640
ATATACAGCA TTATGCAGGC ATGCTGGGAC CTGGAGCCCA CTCGAAGACC CACCTTCCAG 2700
CAGATCTGTT CCTTTCTTCA AGAGGAGATG GATGCTACTA GTAAAAAGCA GGACTATGCC 2760
AACCTACCCA GTAGTGGCAG CAGTGAGGAA GAAGACAGCG TCAGTGAGCC GCTGGACTGT 2820
TGTGACCAAG TAGACAGCAG CCAGCCCCTA TTGCAGGCCA ACAACTACCA GTTCTGTTAA 2880
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 586   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  645
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyc yGdlln+lrrk+e +l   l+   e++    +++
Q: 646   QHENIVNLLGACTHGGPVLVITEYCHYGDLLNFLRRKAEDMLVPTLSA--EPDGGPGYRN  703
         ******************************************888877..7777777777
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l+      k+ +  ++ ++yv++++    vsss++ ++++++            l++e
Q: 704   VhLE------KKYMHGQGLDTYVEMRP----VSSSSSGSFSEQE------------LDQE  741
         7223......3345568999*******....8888888877766............7899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++lel dll fs+qva+Gm+flasknc+hrd+aarnvl+t+ +v+ki+dfGlardim+
Q: 742   DGRPLELCDLLRFSSQVAQGMAFLASKNCIHRDVAARNVLVTSRRVAKIGDFGLARDIMN  801
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         d+nyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 802   DTNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLSPYPGILVNSKF  861
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+keGy+maqp++++ +iy+imq+cw+ ep++rp+f+q++++l
Q: 862   YKLVKEGYQMAQPNFSPPNIYSIMQACWDLEPTRRPTFQQICSFL  906
         ******************************************986
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCHYGDL LNFLRRKAED MLVPTLSAEP DGGPGYRNVH 120
LEKKYMHGQG LDTYVEMRPV SSSSSGSFSE QELDQEDGRP LELCDLLRFS SQVAQGMAFL 180
ASKNCIHRDV AARNVLVTSR RVAKIGDFGL ARDIMNDTNY VVKGNARLPV KWMAPESIFD 240
CVYTVQSDVW SYGILLWEIF SLGLSPYPGI LVNSKFYKLV KEGYQMAQPN FSPPNIYSIM 300
QACWDLEPTR RPTFQQICSF L 321
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 4.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013