EKS-MOD-00064

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00064

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	365.5	1.9E-109	135	419	285

Status

Unreviewed

Ensembl Protein

ENSMODP00000013151

UniProt Accession

F7EAF5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK14

Gene Synonyms/Alias

CDK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000010497	ENSMODP00000013151	ENSMODT00000013393

Organism

Monodelphis domestica

Functional Description

Protein Length

469

Protein Sequence
(FASTA)

MCDLIESQPA EKMSKMKKLR RTLSESFSRI ALKKEDSSFD EICVTKMSTR NCPGMDSVIK 60

PLDTIPEDKK VRVQRTQSTF DPFEKPATQV KRVHSENNAC INFKSSSSGK ESPKARRHSS 120

PSSPTSPKFG KADSYEKLEK LGEGSYATVY KGKSKVNGKL VALKVIRLQE EEGTPFTAIR 180

EASLLKGLKH ANIVLLHDII HTKETLTLVF EYVHTDLCQY MDKHPGGLHP DNVKLFLFQL 240

LRGLSYIHQR YILHRDLKPQ NLLISDTGEL KLADFGLARA KSVPSHTYSN EVVTLWYRPP 300

DVLLGSTEYS TCLDMWGVGC IFVEMIQGVA AFPGMKDIQD QLERIFLVLG TPNEDTWPGV 360

YSLPHFKPER FTLYSSKNLR QAWNKLSYVN HAEDLASKLL QCFPKNRLSA PAALNHEYFS 420

DLPPRLWELT DMSSVFTVPN VRLQPEAGES MRAFGKNNSY GKSLSNSKH 469

Nucleotide Sequence
(FASTA)

ATGTGTGACC TGATTGAGTC CCAGCCGGCG GAGAAGATGA GCAAGATGAA GAAGTTGCGC 60

CGAACTTTGT CAGAGAGTTT CAGTCGCATA GCTTTGAAGA AAGAGGACAG CAGCTTTGAT 120

GAGATATGTG TCACAAAGAT GTCTACACGG AACTGCCCGG GAATGGACTC AGTGATCAAA 180

CCCCTGGACA CAATTCCTGA GGACAAGAAA GTCCGAGTTC AGAGGACACA AAGCACTTTC 240

GACCCATTCG AGAAGCCTGC CACCCAAGTA AAGAGGGTGC ATTCTGAGAA CAATGCTTGC 300

ATTAATTTCA AGTCTTCTTC CAGTGGGAAG GAATCTCCCA AAGCTCGCCG GCATTCTAGC 360

CCCAGCTCGC CCACAAGTCC CAAATTTGGA AAAGCCGACT CTTATGAAAA ATTGGAGAAG 420

TTGGGAGAAG GGTCTTATGC CACTGTGTAC AAAGGAAAAA GCAAGGTAAA TGGGAAACTA 480

GTGGCTCTGA AGGTGATTCG GCTCCAGGAG GAAGAAGGTA CTCCCTTCAC AGCAATCCGG 540

GAAGCCTCTC TGTTAAAAGG ACTAAAGCAT GCTAATATTG TATTACTTCA TGACATCATC 600

CATACCAAGG AGACATTGAC ACTTGTGTTT GAATATGTGC ACACTGATTT ATGTCAGTAC 660

ATGGACAAAC ACCCTGGAGG GCTTCATCCA GACAATGTGA AGTTGTTTTT ATTTCAGTTG 720

CTGCGAGGAC TGTCTTACAT CCACCAGCGT TATATTTTGC ACAGAGACCT GAAGCCACAG 780

AATCTTCTCA TCAGTGACAC GGGGGAGTTA AAGCTGGCAG ATTTCGGTCT TGCAAGAGCA 840

AAATCGGTCC CTAGCCACAC CTACTCCAAT GAAGTGGTTA CTCTGTGGTA CAGGCCTCCA 900

GATGTCCTCT TGGGCTCAAC AGAATACTCC ACCTGCCTTG ATATGTGGGG AGTTGGCTGT 960

ATCTTTGTTG AAATGATCCA AGGGGTTGCT GCTTTTCCAG GAATGAAAGA TATTCAAGAC 1020

CAACTTGAAC GAATATTTCT GGTTCTTGGA ACGCCAAATG AGGATACGTG GCCTGGAGTC 1080

TATTCCCTGC CACATTTTAA GCCGGAACGC TTTACCCTGT ACAGCTCTAA AAACCTTAGA 1140

CAAGCATGGA ATAAGCTCAG CTATGTGAAC CATGCAGAGG ATCTGGCCTC CAAACTACTC 1200

CAGTGTTTCC CAAAGAACAG ATTGTCTGCC CCAGCAGCCC TCAACCATGA GTATTTCAGT 1260

GATCTGCCCC CCCGGCTATG GGAGCTAACT GATATGTCTT CTGTTTTTAC TGTCCCAAAT 1320

GTAAGATTAC AACCAGAAGC TGGAGAAAGT ATGCGGGCCT TTGGAAAAAA CAATAGTTAT 1380

GGCAAAAGTC TATCAAATAG CAAGCACTGA 1410

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklek+geG+y++vyk+k+k +g++vAlK irl++e eg p+ta+rE sllk lkh+ni

Q: 135   YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI  193

         99********************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ +k++l+Lvfe++++dL ++++k++  +l++++vk +l+qll+gl+y+H++

Q: 194   VLLHDIIH-TKETLTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRGLSYIHQRY  251

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s+p++ty++evvTlwYr+P++Llg++eYst

Q: 252   ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST  311

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

          +D+W+vgci++e+++  + f+g ++ +dqlerif +lgtp+e++wp+v +lp++k ++f

Q: 312   CLDMWGVGCIFVEMIQGVAAFPGMKDiQDQLERIFLVLGTPNEDTWPGVYSLPHFKpERF  371

         ************************99679***************************9999

S: 239   pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

         + +++k+l++ ++kl+  ++a dl +kll++ pk+R+sa +al+h+yf

Q: 372   TLYSSKNLRQAWNKLSyvNHAEDLASKLLQCFPKNRLSAPAALNHEYF  419

         99**********99997678***************************9

Domain Sequence
(FASTA)

YEKLEKLGEG SYATVYKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV 60

LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLHPDNVK LFLFQLLRGL SYIHQRYILH 120

RDLKPQNLLI SDTGELKLAD FGLARAKSVP SHTYSNEVVT LWYRPPDVLL GSTEYSTCLD 180

MWGVGCIFVE MIQGVAAFPG MKDIQDQLER IFLVLGTPNE DTWPGVYSLP HFKPERFTLY 240

SSKNLRQAWN KLSYVNHAED LASKLLQCFP KNRLSAPAAL NHEYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000308	; C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0060828	; P:regulation of canonical Wnt receptor signaling pathway

KEGG

mdo:100021354

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013