EKS-MOD-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	554.5	3.5E-167	349	625	277

Status

Unreviewed

Ensembl Protein

ENSMODP00000005258

UniProt Accession

F6TVE0;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000010647	ENSMODP00000013335	ENSMODT00000013580
ENSMODG00000010647	ENSMODP00000005258	ENSMODT00000005371

Organism

Monodelphis domestica

Functional Description

Protein Length

693

Protein Sequence
(FASTA)

DSSSEEKESD NTKPNPVAPY WTSPEKMENK LHAVPAAKTV KFKCPSNGTP NPSLRCLKNG 60

KEFKPDHRIG GYKVRYATWS IIMDSVVPSD KGNYTCIVEI TFSCFSFPFF SVERSPHRPI 120

LQAGLPANKT VALGSNVEFM CKVYSDPQPH IQWLKHIEVN GSKIGPDNLP YVQILKHSGI 180

NSSDAEVLTL FNVTEAHSGE YVCKVSNYIG EARQSAWLTV TRPVAKALEE RPAVMTSPVY 240

LEIIIYCTGA FLISCMVGSV IIYKMKSGTK KSDFHSQMAV HKLAKSIPLR RQVTESRWGV 300

SADSSASMNS GVLLVRPSRL SSSGTPMLAG VSEYELPEDP RWELPRDRLV LGKPLGEGCF 360

GQVVLAEAIG LDKDKPNRVT KVAVKMLKSD ATEKDLSDLI SEMEMMKMIG KHKNIINLLG 420

ACTQDGPLYV IVEYASKGNL REYLQARRPP GLEYCYNPSH APEEQLSSKD LVSCAYQVAR 480

GMEYLASKKC IHRDLAARNV LVTEDNVMKI ADFGLARDIH HIDYYKKTTN GRLPVKWMAP 540

EALFDRIYTH QSDVWSFGVL LWEIFTLGGS PYPGVPVEEL FKLLKEGHRM DKPSNCTNEL 600

YMMMRDCWHA IPSQRPTFKQ LVEDLDRIVA LTSNQEYLDL SVPLDQYSPS FPDTRSSTCS 660

SGEDSVFSHD PLPEEPCLPR HPTQLANGGL KRR 693

Nucleotide Sequence
(FASTA)

GACTCCTCAT CAGAGGAGAA AGAGTCAGAT AACACTAAGC CAAACCCCGT GGCTCCATAC 60

TGGACATCAC CAGAAAAGAT GGAAAATAAA TTGCACGCTG TACCAGCAGC TAAAACAGTG 120

AAGTTCAAAT GTCCTTCAAA TGGCACTCCT AACCCCAGTC TGCGTTGCTT GAAGAATGGC 180

AAAGAATTCA AACCTGACCA CCGAATTGGG GGCTACAAGG TCCGCTATGC CACCTGGAGC 240

ATCATAATGG ATTCGGTGGT GCCATCTGAT AAAGGCAACT ACACTTGCAT TGTGGAGATC 300

ACATTTTCCT GTTTCTCCTT CCCTTTCTTC TCTGTAGAGA GGTCACCTCA CCGACCCATC 360

CTGCAGGCTG GATTACCTGC CAATAAAACT GTGGCTTTAG GCAGCAATGT GGAGTTTATG 420

TGCAAGGTGT ACAGTGACCC ACAGCCTCAC ATCCAGTGGC TAAAGCACAT CGAGGTGAAT 480

GGAAGTAAGA TTGGCCCGGA CAACCTGCCA TATGTGCAAA TTCTTAAGCA TTCGGGGATT 540

AATAGCTCAG ATGCGGAAGT GCTGACCCTG TTCAATGTGA CAGAGGCCCA CAGCGGGGAG 600

TATGTGTGTA AGGTTTCCAA TTATATTGGT GAAGCTCGCC AGTCTGCGTG GCTCACTGTC 660

ACCAGACCTG TGGCAAAAGC CCTGGAGGAG AGACCAGCAG TGATGACCTC GCCTGTCTAT 720

CTGGAGATCA TCATCTATTG CACGGGGGCT TTCCTTATCT CCTGTATGGT GGGATCTGTC 780

ATCATCTACA AGATGAAGAG TGGTACCAAA AAGAGCGACT TCCACAGCCA AATGGCTGTG 840

CACAAGCTGG CCAAGAGCAT CCCCCTGCGC AGACAGGTAA CAGAAAGTAG ATGGGGGGTG 900

TCTGCTGATT CCAGTGCCTC TATGAACTCA GGGGTCCTAC TGGTTCGGCC ATCAAGGCTT 960

TCTTCCAGTG GGACCCCTAT GCTGGCAGGT GTCTCTGAGT ATGAACTTCC TGAGGATCCC 1020

CGTTGGGAAC TGCCCCGAGA CAGGTTGGTT TTAGGCAAAC CACTGGGTGA GGGCTGCTTC 1080

GGACAAGTAG TGTTGGCAGA GGCCATTGGG TTGGATAAAG ACAAACCCAA CCGGGTGACC 1140

AAGGTGGCAG TGAAGATGCT GAAATCGGAT GCAACAGAGA AGGACCTGTC AGATCTGATC 1200

TCAGAAATGG AGATGATGAA GATGATTGGG AAACACAAGA ACATTATCAA CTTGTTGGGG 1260

GCCTGCACAC AGGACGGCCC TCTGTATGTC ATTGTGGAAT ACGCCTCCAA GGGCAACCTC 1320

CGAGAGTACC TGCAGGCCAG GCGGCCCCCT GGGCTCGAAT ACTGTTACAA CCCCAGCCAT 1380

GCCCCAGAAG AGCAGCTCTC CTCCAAGGAC CTAGTGTCTT GTGCTTACCA GGTGGCCAGG 1440

GGCATGGAGT ACCTTGCCTC CAAGAAGTGC ATCCACCGGG ATCTGGCAGC CCGAAATGTC 1500

TTGGTGACTG AAGACAATGT GATGAAAATT GCGGACTTTG GTCTTGCTCG GGACATCCAT 1560

CACATTGACT ACTACAAAAA GACAACCAAT GGTCGGCTGC CTGTGAAGTG GATGGCTCCT 1620

GAGGCACTCT TTGACCGGAT CTATACACAC CAGAGTGACG TGTGGTCATT CGGGGTGCTG 1680

CTGTGGGAAA TCTTCACACT GGGAGGCTCC CCTTATCCTG GTGTGCCTGT AGAGGAGCTT 1740

TTCAAGTTGC TGAAGGAGGG TCATCGAATG GACAAACCCA GCAATTGCAC CAATGAACTG 1800

TACATGATGA TGAGGGACTG CTGGCATGCA ATTCCCTCTC AGAGGCCTAC CTTCAAGCAG 1860

CTTGTGGAGG ACCTGGATCG AATTGTGGCC TTGACCTCTA ACCAGGAGTA CTTGGACCTG 1920

TCAGTACCGC TGGACCAGTA TTCACCAAGC TTTCCAGACA CTCGCAGCTC TACTTGCTCC 1980

TCTGGAGAGG ATTCAGTCTT CTCCCATGAC CCATTGCCTG AGGAGCCCTG CCTGCCCCGA 2040

CATCCCACCC AGCTGGCCAA TGGGGGACTT AAACGGCGCT GA 2082

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 349   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  408

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+a+eeql++

Q: 409   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHAPEEQLSS  468

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 469   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  528

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 529   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  588

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha +s+rptfkqlvedl

Q: 589   RMDKPSNCTNELYMMMRDCWHAIPSQRPTFKQLVEDL  625

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHAPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAIPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0002062	; P:chondrocyte differentiation
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0007605	; P:sensory perception of sound
GO:0001657	; P:ureteric bud development
GO:0021847	; P:ventricular zone neuroblast division

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013