EKS-MOD-00172

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00172

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	438.3	1.1E-131	350	604	255

Status

Unreviewed

Ensembl Protein

ENSMODP00000013341

UniProt Accession

F7D467;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCD

Gene Synonyms/Alias

PRKCD;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000010650	ENSMODP00000013341	ENSMODT00000013586

Organism

Monodelphis domestica

Functional Description

Protein Length

677

Protein Sequence
(FASTA)

MAPFLRISFN SYELGSLQTP EDNCQPFCAV KMKESLTTER GKTLVQKKPT MYPEWSSTFD 60

AHIYEGRVIQ IVLMKAAEEP LSEVTVGVSV LAERCKKNSG KAEFWLDLQP QAKVLMSVQY 120

FLEDTDCKQS LRMEDESKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKDFVW 180

GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTMF QKERFNIDMP HRFKVYNYMS 240

PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCQNKVANLC GINQKLLAEA LNQVSQKSSR 300

KSDTGSVENF GIYQGFEKKA GSSGEDTTDN ETYGKIWEGS TPSKFNIDNF TFHKVLGKGS 360

FGKVLLAELK GKAEFFAVKA LKKDVVLIDD DVECTMVEKR VLALAWENPF LTHLYCTFQT 420

KDHLFFVMEF LNGGDLMFHI QDKGRFDLYR ATFYSAEILC GLQFLHSKGI IYRDLKLDNV 480

MLDKEGHIKI ADFGMCKENV VGENRASTFC GTPDYIAPEI LQGLKYTFSV DWWSFGVLLY 540

EMLIGQSPFH GDDEDELFES IRVDTPHYPR WITKESKDIL EKLFERDPTK RLGVTGNIKV 600

HPFFKTINWT LLEKREVEPP FKPKVKSAGD YNNFDREFLS EKARLSFSDK NLIDSMDQTA 660

FAGFSFVNPK FERLLEK 677

Nucleotide Sequence
(FASTA)

ATGGCCCCAT TCCTGCGCAT TTCCTTCAAC TCCTATGAGC TTGGATCTCT GCAGACTCCT 60

GAGGACAACT GTCAACCTTT CTGTGCTGTC AAGATGAAAG AATCACTGAC AACAGAAAGA 120

GGGAAGACCC TGGTCCAGAA GAAGCCCACC ATGTACCCAG AGTGGTCCTC GACGTTTGAT 180

GCCCACATCT ATGAGGGACG AGTCATCCAG ATTGTCCTGA TGAAGGCAGC TGAGGAGCCC 240

CTCTCGGAGG TGACTGTGGG GGTGTCTGTC CTGGCCGAGA GGTGCAAGAA GAACAGTGGC 300

AAAGCAGAAT TCTGGCTGGA CCTACAACCT CAGGCCAAAG TGCTCATGTC TGTCCAGTAT 360

TTCTTGGAAG ATACAGATTG CAAGCAGTCC TTGAGGATGG AGGATGAGAG CAAATTCCCC 420

ACCATGAACC GGCGGGGAGC CATCAAGCAG GCCAAGATCC ATTATATCAA GAACCACGAG 480

TTCATCGCCA CCTTCTTTGG CCAGCCCACC TTCTGCTCAG TCTGCAAGGA CTTTGTCTGG 540

GGCCTTAACA AGCAAGGCTA CAAATGCAGA CAATGTAACG CAGCGATCCA CAAGAAATGC 600

ATCGACAAGA TCATCGGCCG GTGCACGGGC ACAGCGGCCA ATAGCAGAGA TACCATGTTC 660

CAGAAGGAGC GTTTCAACAT AGACATGCCG CATCGCTTCA AGGTGTACAA TTACATGAGC 720

CCCACCTTCT GCGACCACTG TGGGAGCCTG CTCTGGGGAC TAGTGAAGCA GGGTTTAAAG 780

TGTGAAGACT GTGGGATGAA TGTGCATCAT AAGTGTCAGA ATAAAGTGGC CAATTTATGT 840

GGCATCAACC AGAAGCTGTT AGCCGAAGCA TTAAACCAAG TCAGCCAGAA ATCTTCCCGG 900

AAATCAGACA CAGGGTCTGT GGAGAACTTT GGCATCTACC AGGGCTTTGA GAAGAAAGCC 960

GGGTCTTCTG GGGAAGATAC AACAGATAAT GAGACCTATG GCAAGATCTG GGAAGGCAGC 1020

ACACCCTCCA AGTTCAACAT CGACAACTTC ACATTCCACA AAGTCCTGGG CAAAGGCAGC 1080

TTTGGGAAGG TGCTGCTGGC TGAACTGAAG GGCAAGGCTG AGTTCTTTGC AGTAAAGGCA 1140

TTGAAGAAAG ATGTTGTTCT GATAGATGAT GATGTGGAGT GCACCATGGT GGAGAAGCGA 1200

GTGCTGGCAC TTGCCTGGGA GAACCCATTC CTGACTCACC TCTACTGTAC CTTCCAAACC 1260

AAGGATCACC TGTTCTTTGT GATGGAGTTC CTCAATGGAG GGGACCTGAT GTTTCATATC 1320

CAGGATAAGG GACGCTTTGA CCTATATCGA GCCACGTTTT ACAGTGCTGA GATCCTGTGT 1380

GGTTTACAGT TCCTGCACAG CAAAGGCATC ATTTACAGGG ATCTCAAATT GGACAACGTG 1440

ATGCTGGATA AAGAAGGCCA CATCAAGATA GCTGATTTTG GAATGTGCAA GGAGAATGTG 1500

GTTGGAGAGA ACAGGGCCAG CACCTTCTGT GGTACACCAG ACTACATCGC CCCTGAGATC 1560

TTGCAGGGCT TGAAGTATAC ATTCTCAGTG GACTGGTGGT CCTTCGGTGT CCTCCTGTAT 1620

GAGATGCTCA TTGGACAGTC CCCCTTCCAT GGGGATGATG AGGATGAGCT CTTTGAGTCC 1680

ATCCGTGTGG ACACTCCTCA CTACCCCCGG TGGATCACCA AGGAATCAAA AGACATCCTG 1740

GAAAAGCTGT TTGAAAGGGA TCCCACCAAG AGACTGGGGG TGACAGGTAA CATTAAAGTC 1800

CACCCGTTCT TCAAGACCAT CAACTGGACT CTTCTGGAGA AGCGGGAGGT AGAGCCACCA 1860

TTTAAGCCCA AAGTGAAATC AGCTGGTGAC TACAACAATT TTGACCGTGA ATTCCTAAGC 1920

GAGAAGGCCC GCCTGTCCTT CAGTGACAAG AACCTCATCG ATTCCATGGA CCAGACAGCC 1980

TTTGCAGGCT TCTCCTTTGT CAATCCCAAA TTTGAGCGAC TCCTGGAAAA ATGA 2034

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+++kvlGkGsfgkvllaelk++ e++a+k lkkdvvl dddve+t+vekrvlala+++p

Q: 350   FTFHKVLGKGSFGKVLLAELKGKAEFFAVKALKKDVVLIDDDVECTMVEKRVLALAWENP  409

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl++l+++fqt+d+lffv+e++nGGdlmfhiq++++++  ra+fy+aei+++l+flh+kg

Q: 410   FLTHLYCTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFDLYRATFYSAEILCGLQFLHSKG  469

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke+++ ++++stfcGtPdyiaPeil++ +y++s

Q: 470   IIYRDLKLDNVMLDKEGHIKIADFGMCKENVVGENRASTFCGTPDYIAPEILQGLKYTFS  529

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP++++ke+++il++l+++dp+

Q: 530   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERDPT  589

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlGv  +g  +ik h+ff

Q: 590   KRLGV--TG--NIKVHPFF  604

         *****..56..89999998

Domain Sequence
(FASTA)

FTFHKVLGKG SFGKVLLAEL KGKAEFFAVK ALKKDVVLID DDVECTMVEK RVLALAWENP 60

FLTHLYCTFQ TKDHLFFVME FLNGGDLMFH IQDKGRFDLY RATFYSAEIL CGLQFLHSKG 120

IIYRDLKLDN VMLDKEGHIK IADFGMCKEN VVGENRASTF CGTPDYIAPE ILQGLKYTFS 180

VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRVDTPHYP RWITKESKDI LEKLFERDPT 240

KRLGVTGNIK VHPFF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013