EKS-MOD-00053
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00053
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF210.92.9E-62334461128
StatusUnreviewed
Ensembl ProteinENSMODP00000013593
UniProt AccessionF7AR37;
Protein Name
Protein Synonyms/Alias
Gene NameARAF
Gene Synonyms/Alias ARAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000010855ENSMODP00000013593ENSMODT00000013842
OrganismMonodelphis domestica
Functional Description
Protein Length496
Protein Sequence
(FASTA)
MSRGPAATPV EAFSRGLAPP GDPSATPSTS ARVGGTVKVY LPNQQRTVVT ARDGMTVSDS 60
LDKALKVRGL NQDCCAVYRL VQGRKTATAW DAAIAPLHGE ELTVEVRADV PLAAAHNFAR 120
KTFLALTFCD FCRRFLFHGF RCQTCGYKFH QHCSARVPTI CVDMATARQP FYRSIQDLAG 180
GPRAHEVQPD NQALCEPLTP KSPRYTRQTS HGGEAFAFPG PGGPALQRIR STSTPNVHMI 240
STTMPVDSRL IQFSSSGPAG AFLSGFLSVG TGGERIPQSS PGLVSPPGKK SPHPKASAEP 300
TERKAPALAD DKKKVKSLGY RDSGYYWEVA PGEVQLLKRI GTGSFGTVFH GRWHGDVAVK 360
VLKVAQPTAE QAQAFKNEMQ VLRKTRHVNI LLFMGFMTRP DFAIITQWCE GSSLYHHLHV 420
ADTHFDMVQL IDVARQTAQG MDYLHAKNII HRDLKSNSIH LACVCVWGGG GGKVFQCLKG 480
PWKGRQNLSC PRDEGE 496
Nucleotide Sequence
(FASTA)
ATGAGTCGAG GCCCAGCAGC CACCCCAGTG GAAGCCTTCA GCAGGGGTTT AGCCCCACCT 60
GGAGATCCCA GTGCCACCCC TTCTACCAGT GCTCGGGTTG GGGGCACTGT GAAGGTCTAT 120
TTGCCCAACC AACAGCGCAC TGTGGTGACT GCACGGGATG GGATGACTGT CTCCGACTCA 180
TTGGACAAGG CACTGAAGGT TCGGGGGCTG AATCAGGATT GCTGTGCTGT CTATCGCTTG 240
GTACAGGGCC GGAAGACAGC AACAGCCTGG GATGCTGCCA TCGCTCCCTT GCATGGGGAA 300
GAATTGACTG TGGAGGTCCG GGCTGATGTC CCCCTTGCGG CAGCCCACAA CTTCGCCCGG 360
AAGACGTTTC TGGCTCTTAC CTTCTGTGAC TTCTGCCGCC GCTTCCTCTT TCATGGATTC 420
CGCTGCCAGA CATGTGGCTA CAAGTTTCAC CAACACTGCA GTGCCCGAGT CCCCACCATC 480
TGTGTCGACA TGGCTACTGC CCGCCAACCT TTCTACCGCA GTATCCAGGA TTTGGCTGGA 540
GGGCCCCGTG CTCATGAGGT TCAACCAGAC AACCAGGCCC TCTGTGAGCC TCTCACTCCA 600
AAGAGCCCCA GGTATACCAG GCAGACCTCC CATGGGGGGG AAGCCTTTGC TTTCCCTGGG 660
CCTGGAGGCC CAGCCTTACA GAGGATCCGT TCTACATCCA CACCTAATGT GCACATGATC 720
AGCACCACGA TGCCTGTGGA CAGCAGGCTC ATCCAGTTCT CCTCCTCTGG CCCTGCCGGA 780
GCTTTCCTCT CTGGGTTCTT ATCTGTAGGA ACAGGTGGTG AGAGGATCCC TCAAAGCAGT 840
CCTGGCCTTG TTTCCCCTCC TGGAAAGAAA TCCCCACACC CCAAGGCTTC AGCAGAGCCC 900
ACTGAGCGCA AAGCCCCAGC CTTGGCTGAT GACAAGAAGA AAGTGAAGTC CCTGGGCTAC 960
CGAGACTCAG GCTACTATTG GGAGGTGGCA CCAGGGGAGG TACAGCTGCT GAAGAGGATC 1020
GGGACAGGCT CATTTGGGAC CGTGTTCCAT GGGCGCTGGC ACGGGGACGT GGCGGTGAAG 1080
GTGCTAAAGG TGGCGCAGCC CACTGCTGAG CAAGCCCAGG CCTTCAAAAA TGAGATGCAA 1140
GTCCTCAGGA AGACTCGCCA CGTCAACATC CTCTTGTTCA TGGGTTTCAT GACGAGGCCT 1200
GACTTTGCCA TCATCACCCA GTGGTGCGAG GGCTCCAGCC TCTACCACCA CCTCCATGTG 1260
GCTGATACTC ACTTTGACAT GGTGCAGCTG ATTGATGTGG CTCGGCAGAC AGCTCAGGGC 1320
ATGGATTACC TCCACGCCAA GAACATCATT CACCGAGATC TCAAATCCAA CAGTATCCAC 1380
CTAGCCTGTG TGTGTGTGTG GGGGGGGGGG GGGGGGAAGG TTTTTCAATG TCTAAAAGGG 1440
CCCTGGAAAG GGAGGCAAAA TCTTTCTTGC CCAAGGGATG AAGGGGAA 1488
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+l ++iG+G+fGtv++g+whGdvavk+l+v ++++eq++aFk+e+++++ktRh+ni+LF
Q: 334   VQLLKRIGTGSFGTVFHGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLF  393
         67899*******************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mG++++p++ai+t++c+gssLy++lh+++t++d+++lid+arq+aqgmdYLhak+i+h+D
Q: 394   MGFMTRPDFAIITQWCEGSSLYHHLHVADTHFDMVQLIDVARQTAQGMDYLHAKNIIHRD  453
         ************************************************************
S: 121   lksknill  128
         lks+ i l
Q: 454   LKSNSIHL  461
         *****987
Domain Sequence
(FASTA)
VQLLKRIGTG SFGTVFHGRW HGDVAVKVLK VAQPTAEQAQ AFKNEMQVLR KTRHVNILLF 60
MGFMTRPDFA IITQWCEGSS LYHHLHVADT HFDMVQLIDV ARQTAQGMDY LHAKNIIHRD 120
LKSNSIHL 128
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Macropus eugenii"; ?>Sarcophilus harrisii"; ?>
EKS-MAE-00026
EKS-SAH-00049
Gene Ontology
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013