EKS-MOD-00276

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00276

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	446.9	3.1E-134	230	517	288

Status

Unreviewed

Ensembl Protein

ENSMODP00000013961

UniProt Accession

F7AN33;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1A

Gene Synonyms/Alias

BMPR1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000011158	ENSMODP00000013961	ENSMODT00000014216
ENSMODG00000011158	ENSMODP00000037791	ENSMODT00000039396

Organism

Monodelphis domestica

Functional Description

Protein Length

528

Protein Sequence
(FASTA)

MTQPSIYITF LGAYLLIIFY VQGQNPDSRF LHGTEMKSDP NKKKQENGVT LAPEDTLPFL 60

KCHCSGHCPD DAINNTCITN GHCFAIIEED DQGETTLASG CMKYEGSDFQ CKDSPKAQLR 120

RTIECCRTNL CNQYLQPTLP PVVIGRLLNS RRRKSKSFKA YNSLCIIFNL ILLHYCKRIA 180

RSHCYNRDLE QDEAFIPVGE SLKDLIDQSQ SSGSGSGLPL LVQRTIAKQI QMVRQVGKGR 240

YGEVWMGKWR GEKVAVKVFF TTEEASWFRE TEIYQTVLMR HENILGFIAA DIKGTGSWTQ 300

LYLITDYHEN GSLYDFLKCT TLDTRALLKL AYSAACGLCH LHTEIYGTQG KPAIAHRDLK 360

SKNILIKKNG SCCIADLGLA VKFNSDTNEV DVPLNTRVGT KRYMAPEVLD ESLNKNHFQP 420

YIMADIYSFG LIMWEMARRC VTGGMTEEYQ LPYYNMVPHD PSYEDMREVV CVKRLRPIVS 480

NRWNSDECLR AILKLMSECW AHNPASRLTA LRIKKTLAKM VESQDVKI 528

Nucleotide Sequence
(FASTA)

ATGACTCAGC CAAGCATTTA CATCACATTT TTGGGAGCCT ATCTGCTCAT CATTTTTTAT 60

GTACAAGGAC AGAATCCAGA TAGTCGATTT CTTCATGGTA CAGAAATGAA GTCGGACCCA 120

AACAAAAAAA AGCAGGAAAA TGGAGTGACC TTAGCTCCAG AGGATACTTT GCCTTTTTTG 180

AAATGCCACT GTTCAGGACA TTGCCCCGAT GATGCTATTA ATAACACGTG CATAACTAAT 240

GGTCATTGCT TTGCCATCAT AGAAGAAGAT GATCAAGGAG AAACTACATT AGCTTCAGGC 300

TGTATGAAAT ATGAAGGTTC AGACTTTCAG TGCAAGGATT CACCAAAAGC TCAGCTACGA 360

AGGACAATTG AATGTTGCCG AACCAATTTG TGTAACCAGT ATTTGCAGCC TACACTACCC 420

CCTGTTGTTA TAGGTAGGTT ACTTAACTCA AGAAGGAGAA AGAGTAAGTC TTTCAAAGCT 480

TATAATTCAT TGTGTATCAT TTTTAACTTA ATTCTGTTGC ATTACTGCAA AAGAATAGCA 540

AGAAGCCATT GTTATAATCG TGACCTAGAA CAGGATGAAG CTTTTATACC GGTGGGAGAG 600

TCATTGAAAG ACCTTATTGA TCAGTCACAA AGTTCTGGAA GTGGATCTGG ACTTCCTTTG 660

CTGGTTCAAC GAACGATTGC CAAGCAGATT CAGATGGTTC GGCAAGTGGG AAAGGGTCGC 720

TATGGAGAAG TGTGGATGGG GAAATGGAGG GGTGAAAAAG TGGCAGTCAA AGTGTTCTTC 780

ACCACCGAAG AGGCCAGCTG GTTCCGGGAA ACAGAGATCT ACCAAACTGT ATTGATGCGT 840

CATGAGAATA TCCTGGGTTT CATCGCCGCC GACATCAAGG GCACAGGCTC TTGGACGCAG 900

CTCTACTTGA TCACCGACTA CCATGAAAAC GGCTCTCTGT ACGACTTCCT GAAGTGCACC 960

ACTCTGGACA CGAGGGCCCT CCTCAAGTTG GCATATTCAG CTGCCTGTGG TCTGTGCCAT 1020

CTCCACACAG AGATCTATGG GACCCAAGGA AAGCCCGCAA TTGCTCACCG AGACCTGAAG 1080

AGCAAAAATA TCCTGATCAA GAAGAATGGC AGTTGTTGTA TTGCTGACCT GGGGCTCGCC 1140

GTGAAATTTA ACAGTGACAC AAATGAAGTT GATGTCCCTT TGAACACCAG AGTTGGTACA 1200

AAGCGTTACA TGGCTCCAGA AGTGCTCGAT GAAAGCCTAA ATAAAAATCA CTTTCAGCCA 1260

TATATCATGG CTGACATCTA TAGCTTTGGC CTGATCATGT GGGAGATGGC TCGTCGCTGT 1320

GTCACAGGAG GCATGACAGA GGAGTACCAA TTGCCTTATT ACAACATGGT GCCTCATGAT 1380

CCTTCCTATG AAGACATGCG GGAGGTGGTG TGTGTTAAGC GTCTGCGTCC CATCGTGTCG 1440

AACCGATGGA ACAGTGATGA ATGTCTGAGA GCCATCTTGA AGCTAATGTC AGAATGCTGG 1500

GCCCACAACC CTGCTTCAAG ACTCACCGCA TTGAGAATCA AGAAGACGCT GGCCAAGATG 1560

GTCGAATCTC AAGATGTAAA GATTTGA 1587

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 230   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  289

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk +tld++ ll+la+s+a+Gl+hLH+ei gt+

Q: 290   ADIKGTGSWTQLYLITDYHENGSLYDFLKCTTLDTRALLKLAYSAACGLCHLHTEIYGTQ  349

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+kk+++cciaDlGLa+k++++++e+d+  n++vGtkRYmaPE

Q: 350   G--KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPE  407

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+ + +aD+Ys+gL++WE+a+Rc + ++++eey+lp++++v++dPs+e+m

Q: 408   VLDESLNKNHFQPYIMADIYSFGLIMWEMARRCVT-GGMTEEYQLPYYNMVPHDPSYEDM  466

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalr+kk+l

Q: 467   REVVCVKRLRPIVSNRWNSDECLRAILKLMSECWAHNPASRLTALRIKKTL  517

         *************************************************97

Domain Sequence
(FASTA)

IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDFLKC TTLDTRALLK LAYSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKKN GSCCIADLGL AVKFNSDTNE VDVPLNTRVG TKRYMAPEVL 180

DESLNKNHFQ PYIMADIYSF GLIMWEMARR CVTGGMTEEY QLPYYNMVPH DPSYEDMREV 240

VCVKRLRPIV SNRWNSDECL RAILKLMSEC WAHNPASRLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005524	; F:ATP binding
GO:0000981	; F:sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0051216	; P:cartilage development
GO:0048589	; P:developmental growth
GO:0009950	; P:dorsal/ventral axis specification
GO:0007398	; P:ectoderm development
GO:0042733	; P:embryonic digit morphogenesis
GO:0048568	; P:embryonic organ development
GO:0003272	; P:endocardial cushion formation
GO:0060914	; P:heart formation
GO:0035137	; P:hindlimb morphogenesis
GO:0006955	; P:immune response
GO:0001701	; P:in utero embryonic development
GO:0048368	; P:lateral mesoderm development
GO:0030324	; P:lung development
GO:0048382	; P:mesendoderm development
GO:0001707	; P:mesoderm formation
GO:0001880	; P:Mullerian duct regression
GO:0050768	; P:negative regulation of neurogenesis
GO:0014032	; P:neural crest cell development
GO:0021998	; P:neural plate mediolateral regionalization
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0060021	; P:palate development
GO:0048352	; P:paraxial mesoderm structural organization
GO:0021983	; P:pituitary gland development
GO:0030501	; P:positive regulation of bone mineralization
GO:0050679	; P:positive regulation of epithelial cell proliferation
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0001756	; P:somitogenesis
GO:0019827	; P:stem cell maintenance

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013