EKS-MOD-00109
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00109
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec461.85.4E-139402639238
StatusUnreviewed
Ensembl ProteinENSMODP00000014600
UniProt AccessionF6YES1;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000011651ENSMODP00000014600ENSMODT00000014868
OrganismMonodelphis domestica
Functional Description
Protein Length642
Protein Sequence
(FASTA)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVQKLSYY EYDFERGRRG SKKGSVDVEK 60
ITCVETVVPE KNPPPERQIP RKGEEASEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120
RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180
HRKTKKPLPP TPEEDQILNK PLPPEPTGGP NSTTELKRVV ALYDYMPMNA NDLRLQKGEE 240
YFILEESTLP WWKARDKNGQ EGYIPNNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300
EGGFIVRDSS KAGKYTVSVF TKSAGDPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 360
YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPR DLTFLKELGT GQFGVVKYGK 420
WRGQYDVAIK MIREGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480
CLLNYLREMR HRFQTPQLLE MCRDVCEAMD YLESKQFLHR DLAARNCLVN DQGIVKVSDF 540
GLSRYVLDDE YTSSAGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600
FSNSETAEHI AKGLRLYRPQ LASERVYAIM YSCWHEKVDG ID 642
Nucleotide Sequence
(FASTA)
ATGGCTGCTG TAATCCTAGA AAGTATCTTC CTGAAGCGAT CCCAGCAGAA AAAGAAGACC 60
TCCCCTCTGA ACTTCAAGAA ACGACTCTTT CTCTTGACAG TTCAGAAACT CTCATATTAT 120
GAATATGACT TCGAACGTGG GAGACGAGGA AGTAAGAAGG GTTCAGTAGA TGTTGAAAAG 180
ATCACCTGTG TTGAAACAGT AGTTCCTGAA AAAAATCCTC CCCCTGAGCG GCAGATCCCG 240
AGAAAGGGGG AAGAGGCCAG TGAGATGGAA CAGATCTCTA TCATTGAGAG GTTCCCCTAC 300
CCCTTTCAGG TGGTATATGA CGAAGGCCCC CTGTATGTCT TCTCCCCAAC CGAAGAGCTG 360
AGGAAGCGCT GGATTCACCA GCTCAAAAAC GTGATCCGGT ACAACAGTGA CCTGGTGCAG 420
AAATACCATC CTTGCTTCTG GATTGATGGA CAGTATCTGT GCTGCTCTCA GACAGCCAAA 480
AATGCCATGG GCTGTCAAAT CCTGGAGAAT CGGAATGGAA GCTTAAAACC AGGAAGCTCT 540
CACCGGAAGA CCAAAAAGCC TCTTCCTCCC ACCCCCGAGG AAGACCAGAT TCTAAACAAG 600
CCACTACCTC CTGAGCCAAC AGGAGGCCCC AACTCCACAA CGGAGCTCAA GAGAGTTGTT 660
GCCCTTTATG ATTATATGCC AATGAATGCA AATGACCTGC GATTACAGAA GGGTGAAGAG 720
TATTTTATCC TGGAGGAGAG CACTTTGCCT TGGTGGAAAG CTCGAGATAA AAATGGACAG 780
GAAGGTTACA TCCCTAACAA CTATGTCACG GAGGCGGAAG ACTCCATTGA GATGTATGAG 840
TGGTATTCCA AACATATGAC CCGGAGCCAA GCAGAGCAAT TACTAAAGCA GGAGGGTAAA 900
GAAGGTGGTT TCATTGTCAG AGACTCCAGC AAAGCAGGAA AATACACTGT GTCTGTGTTT 960
ACCAAATCAG CTGGGGATCC TCAAGGGGTG ATCCGCCATT ATGTTGTGTG CTCCACCCCT 1020
CAGAGTCAAT ACTATCTAGC TGAGAAGCAT CTCTTCAGCA CCATTCCTGA ACTCATCAAC 1080
TACCACCAGC ACAACTCTGC AGGCCTCATC TCCAGACTCA AGTATCCAGT GTCTCAACAA 1140
AACAAGAACG CTCCCTCCAC GGCAGGGCTG GGCTATGGGT CTTGGGAGAT TGATCCAAGG 1200
GACCTGACAT TCTTGAAGGA ACTGGGGACT GGACAGTTTG GGGTGGTGAA GTATGGGAAA 1260
TGGAGAGGCC AATATGACGT GGCCATCAAG ATGATCAGAG AAGGCTCCAT GTCAGAGGAT 1320
GAGTTCATTG AGGAGGCCAA AGTCATGATG AACCTGTCAC ATGAGAAACT GGTCCAGTTA 1380
TATGGGGTCT GTACCAAGCA GCGTCCTATC TTCATCATCA CTGAGTACAT GGCCAACGGC 1440
TGCCTCCTGA ACTACCTGAG GGAAATGCGG CACCGCTTCC AGACCCCACA GTTGCTGGAG 1500
ATGTGCAGGG ACGTGTGTGA GGCCATGGAC TACCTGGAAT CTAAGCAGTT CCTTCACCGG 1560
GATCTAGCTG CTCGAAATTG TTTGGTCAAT GACCAAGGGA TTGTCAAAGT GTCTGACTTC 1620
GGTCTCTCCA GGTATGTCTT GGATGATGAA TATACCAGCT CAGCAGGTTC CAAATTTCCA 1680
GTTCGGTGGT CTCCACCAGA AGTCCTCATG TACAGCAAGT TCAGTAGCAA ATCTGACATC 1740
TGGGCTTTTG GGGTTTTGAT GTGGGAAATT TACTCTCTGG GGAAGATGCC GTATGAGAGA 1800
TTTAGTAACA GTGAAACAGC AGAACACATT GCCAAAGGCC TCCGTCTATA TCGACCTCAG 1860
CTAGCTTCAG AACGAGTGTA TGCCATCATG TACAGTTGCT GGCATGAGAA AGTAGATGGA 1920
ATAGACTAG 1929
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+i+eg+mse++fieeakvmm+lsh+klvqly
Q: 402   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLY  461
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre+++++++ +llemc+dvce+m+yle+k+f+hrd
Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTPQLLEMCRDVCEAMDYLESKQFLHRD  521
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ +vkvsdfgl+ryvldd+y+ss+g+kfpv+wsppevl+ysk+ssksd+w
Q: 522   LAARNCLVNDQGIVKVSDFGLSRYVLDDEYTSSAGSKFPVRWSPPEVLMYSKFSSKSDIW  581
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpe  238
         afgvlmwe++s+gk+pye++snse++e++++glrlyrp+las++vy +m+scw+ek +
Q: 582   AFGVLMWEIYSLGKMPYERFSNSETAEHIAKGLRLYRPQLASERVYAIMYSCWHEKVD  639
         *******************************************************987
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IREGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTPQLLEM CRDVCEAMDY LESKQFLHRD 120
LAARNCLVND QGIVKVSDFG LSRYVLDDEY TSSAGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKMPYERF SNSETAEHIA KGLRLYRPQL ASERVYAIMY SCWHEKVD 238
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0031410; C:cytoplasmic vesicle
GO:0005829; C:cytosol
GO:0045121; C:membrane raft
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713; F:protein tyrosine kinase activity
GO:0048469; P:cell maturation
GO:0007249; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108; P:peptidyl-tyrosine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013