EKS-MOD-00114

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00114

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	392.8	8.4E-118	46	309	264

Status

Unreviewed

Ensembl Protein

ENSMODP00000014793

UniProt Accession

F7CBB5;

Protein Name

Protein Synonyms/Alias

Gene Name

AAK1

Gene Synonyms/Alias

AAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000011819	ENSMODP00000014793	ENSMODT00000015065

Organism

Monodelphis domestica

Functional Description

Protein Length

957

Protein Sequence
(FASTA)

MKKFFDSRRE QGGSGPGSGS SGGGGSTSGP GSGHIGRVFG IGRHQVTVDE VLAEGGFAIV 60

FLVRTSNGMK CALKRMFVNN EHDLQVCKRE IQIMRDLSGH KNIVGYIDSS INNVSSGDVW 120

EVLILMDFCR GGQVVNLMNQ RLQTGFTENE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 180

NILLHDRGHY VLCDFGSATN RFQNPQAEGV NAVEDEIKKY TTLSYRAPEM VNLYSGKIIT 240

TKADIWALGC LLYKLCYFTL PFGESQVAIC DGNFTIPDNS RYSQDMHCLI RYMLEPDPDK 300

RPDIYQISYF SFKLAKRECP IQNVQNSPIP AKLPEPVKAS EAAAKKTQPK ARLTDPIPTT 360

ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRPTVQPPA QPTDKTAQMK KELEASNRRA 420

DKAEKQNQSL MTRIKQLEES EMIKQQESIK QTQKINELEE NIKYLTEKHL LRKDQSSIKS 480

GPNEQLIPHM TCSPFSKRNK EEKSRISRQR TLEDVLFVKF TNILPLCHPC DQYLKFIINF 540

FHLAKQSAQQ KTSVAAGQSK QQAPSHPQPQ VQLAAAQQPP PAQEPVQKQA PIRQQVKAQT 600

TPPPAIQGQK LGSLTPPSSP KAQRAGHRRI LSDVTHSAVF GVPASQSTQL LQAAAAEASL 660

NKSKSASTTP SGSPRTSQQN VYNPSEGSTW NPFDDDNFSK LTAEELLNKD FAKLGDGKSE 720

KLGGSAESLI PGFQPGPATT QSDAFGSTSF STGTAETTKA VLGLDVSPPL LNVSDPFIPL 780

SAPDAPEKLI EGLKSPSTSL LLPDLLPLAD PFGSTSDAVN GKVDVAVESL IPGLEPPMPQ 840

RLSSQTDSVT SNRTDSLPGE DSLLDSSLLS NPATDLLDEF TPMAISAPTH KEDSNLISGF 900

DDPEGPEKVA EDEFDPIPVL ISKNSQGGHS RNSSGSSESS LPNLARSLLL VDQLIDL 957

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TTTTTGACTC CCGCCGAGAG CAAGGAGGCT CTGGCCCGGG GTCTGGCTCC 60

AGCGGAGGAG GAGGGAGCAC CTCGGGCCCA GGGAGTGGGC ACATTGGCCG CGTCTTTGGC 120

ATTGGGAGAC ATCAGGTCAC TGTGGATGAG GTATTGGCTG AAGGGGGATT TGCCATTGTC 180

TTCCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCCTCA AACGCATGTT TGTCAACAAT 240

GAACATGACC TCCAAGTGTG CAAGAGAGAA ATTCAGATCA TGAGGGACCT GTCGGGACAC 300

AAGAACATTG TTGGATACAT TGATTCTAGT ATCAATAATG TGAGTAGCGG CGATGTGTGG 360

GAAGTTCTAA TACTCATGGA TTTTTGCCGA GGAGGTCAAG TGGTGAACTT GATGAACCAG 420

CGTTTACAGA CAGGCTTCAC AGAGAATGAA GTGCTACAGA TATTCTGTGA CACGTGTGAA 480

GCTGTTGCCC GCTTACATCA GTGCAAAACA CCCATTATCC ACCGGGATCT GAAGGTGGAA 540

AACATCCTGC TGCATGACCG AGGCCATTAT GTCCTGTGTG ACTTTGGGAG TGCCACTAAC 600

AGATTCCAGA ATCCACAAGC CGAGGGCGTC AACGCGGTAG AGGACGAGAT TAAGAAGTAC 660

ACCACGCTTT CCTACCGAGC CCCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACG 720

ACAAAGGCTG ACATTTGGGC CCTCGGTTGT TTGTTATATA AATTATGCTA CTTTACATTA 780

CCATTTGGGG AGAGTCAGGT AGCCATTTGT GATGGAAACT TCACGATTCC TGATAATTCG 840

CGGTATTCCC AAGACATGCA TTGCCTCATA CGGTATATGT TGGAGCCAGA CCCTGACAAG 900

AGGCCAGATA TTTATCAGAT CTCGTACTTC TCATTTAAGC TCGCCAAGAG AGAGTGTCCC 960

ATTCAGAATG TTCAGAACTC TCCCATCCCT GCTAAGCTTC CAGAACCAGT GAAAGCCAGT 1020

GAGGCAGCTG CTAAAAAAAC CCAGCCAAAG GCCAGGCTGA CAGACCCTAT CCCCACCACA 1080

GAGACATCCA TTGCACCCCG CCAGCGGCCG AAAGCTGGAC AGACCCAACC AAACCCAGGA 1140

ATTCTCCCTA TTCAGCCAGC CCTGACACCT CGAAAGAGGC CTACAGTCCA GCCCCCAGCT 1200

CAACCGACAG ATAAGACTGC TCAAATGAAA AAAGAACTTG AAGCATCCAA TAGAAGGGCA 1260

GACAAAGCTG AAAAGCAAAA CCAGTCCCTA ATGACCAGAA TCAAGCAACT CGAAGAAAGC 1320

GAGATGATAA AACAGCAAGA ATCAATAAAG CAAACCCAAA AAATTAATGA ATTAGAAGAA 1380

AACATAAAAT ATCTCACTGA GAAGCATTTG CTAAGAAAAG ACCAGAGCTC TATAAAATCG 1440

GGTCCTAATG AACAATTAAT TCCTCATATG ACTTGCTCTC CCTTCTCTAA GAGGAATAAG 1500

GAAGAGAAGT CAAGAATTAG CAGGCAGCGT ACTCTTGAAG ATGTCCTCTT TGTTAAATTC 1560

ACAAATATCC TGCCTCTCTG CCATCCTTGT GATCAGTACC TAAAGTTCAT TATTAATTTC 1620

TTCCATCTGG CCAAACAGTC TGCTCAGCAG AAGACATCTG TGGCAGCAGG ACAGTCAAAG 1680

CAACAGGCTC CTTCCCATCC CCAGCCACAG GTGCAGCTGG CTGCTGCCCA GCAGCCCCCC 1740

CCTGCCCAGG AGCCTGTGCA GAAACAAGCA CCAATAAGAC AACAAGTAAA AGCTCAGACC 1800

ACCCCACCCC CTGCCATCCA GGGGCAAAAG CTTGGATCTC TCACTCCTCC ATCATCCCCC 1860

AAAGCCCAGC GGGCCGGACA CAGGAGAATC CTCAGTGATG TGACCCATAG CGCTGTCTTT 1920

GGGGTCCCTG CCAGCCAGTC GACTCAGTTG CTCCAGGCGG CTGCAGCTGA AGCAAGCCTC 1980

AATAAGTCCA AGTCTGCATC CACCACTCCA TCAGGTTCTC CCCGGACCTC TCAACAAAAC 2040

GTTTACAACC CTTCTGAAGG CTCTACTTGG AATCCTTTTG ATGATGATAA TTTCTCCAAA 2100

CTCACAGCTG AGGAGCTACT GAACAAGGAC TTTGCAAAAC TTGGTGATGG TAAATCTGAA 2160

AAACTTGGTG GTTCAGCAGA GAGTTTGATC CCAGGCTTTC AACCAGGTCC AGCCACTACT 2220

CAGTCAGATG CTTTTGGCTC CACCTCCTTT TCTACTGGAA CTGCTGAAAC AACGAAAGCT 2280

GTGCTTGGTC TGGATGTGAG TCCTCCTCTT CTGAACGTGT CTGACCCTTT CATCCCTCTC 2340

TCAGCACCTG ATGCGCCAGA AAAGCTTATC GAGGGGCTCA AATCTCCCAG TACTTCACTT 2400

CTCCTTCCTG ACCTCTTGCC TCTGGCAGAT CCCTTTGGCA GCACTTCAGA TGCTGTGAAT 2460

GGAAAAGTTG ATGTTGCTGT TGAAAGTCTC ATACCAGGAT TGGAGCCCCC AATGCCCCAG 2520

CGCCTCTCAT CTCAGACTGA CTCTGTCACA TCCAACCGAA CAGATTCTCT CCCTGGGGAA 2580

GATTCCCTTC TTGACTCCTC TCTGCTTTCT AACCCAGCTA CTGACCTTCT AGATGAGTTC 2640

ACTCCCATGG CAATTTCTGC TCCAACTCAT AAAGAAGATA GTAATCTCAT CTCAGGTTTT 2700

GATGATCCTG AGGGCCCCGA AAAGGTGGCA GAAGATGAGT TTGACCCCAT TCCTGTGTTG 2760

ATATCCAAAA ACTCACAAGG TGGGCACTCT AGAAACAGCA GTGGGAGCTC TGAGTCCAGT 2820

CTTCCCAACC TAGCCAGGTC TTTGCTGCTG GTGGATCAGC TCATAGACCT GTAG 2874

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfa+v+l++ +s+g k+alKr++vn+e+dl+ +krEi+im++lsghkniv

Q: 46    VTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV  104

         6899***************.99**************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 105   GYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA  163

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+ +++++ +++++a+++ei+k+tt

Q: 164   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNRFQNPQ-AEGVNAVEDEIKKYTT  222

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys+++i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 223   LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGNFTIPDNSR  281

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         ys+++++li++mle+dp++Rp+i+q+++

Q: 282   YSQDMHCLIRYMLEPDPDKRPDIYQISY  309

         *************************986

Domain Sequence
(FASTA)

VTVDEVLAEG GFAIVFLVRT SNGMKCALKR MFVNNEHDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINNVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTENEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNRFQNP QAEGVNAVED EIKKYTTLSY 180

RAPEMVNLYS GKIITTKADI WALGCLLYKL CYFTLPFGES QVAICDGNFT IPDNSRYSQD 240

MHCLIRYMLE PDPDKRPDIY QISY 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013