EKS-MOD-00431

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00431

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	460.3	2.1E-138	131	393	263

Status

Unreviewed

Ensembl Protein

ENSMODP00000014966

UniProt Accession

F7DDX8;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK2

Gene Synonyms/Alias

ROCK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000011938	ENSMODP00000014966	ENSMODT00000015241

Organism

Monodelphis domestica

Functional Description

Protein Length

1427

Protein Sequence
(FASTA)

RGGAGRDGEG PGAGGSGSPP APRERGPERD EPGIVSGGSR MSQPRVEKMS GAPETEPWNW 60

AFASRQRQLE AMIRDPRSPI YVESLLDGLN SLVLDLDFPA LRKNKNIDNF LIRYEKIVTK 120

IRCLQMKAED FDVVKVIGRG AFGEVQLVRH KASQNVYAMK LLSKFEMIKR SDSAFFWEER 180

DIMAFANSPW VVQLFCAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA 240

LDAIHSMGLI HRDVKPDNML LDKNGHLKLA DFGTCMKMDE TGMVHCDTAV GTPDYISPEV 300

LKSQGGDGYY GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLNFPEDAEI 360

SKHAKNLICA FLTDREVRLG RNGVEEIKQH SFFKSDQWNW DNIRETAAPV VPELSSDIDS 420

SNFDDIEDDK GDVETFPIPK AFVGNQLPFI GFTYYRENLL LSDSSSSCTE NDSVQSRKNE 480

QSVQIQKKLF LLEEHLNNEI QAKEDLDQKC KLVSTRLEKI TKELEEEVTS RKNVESTLRQ 540

LEREKALLQH KNTEYQRKAE YEADKKRNLE NDVNSLKDQL EDLKKRNQNS QISNEKVNQL 600

QRQLDEANAL LRTESDTAAR LRKNQTESSK QIQQLECNNR ELQDKNCMLE NAKLKLEKDF 660

INLQSALESE RRDKTHGSEI INDLQGRISG LEEDIKNGKI SLTKMELEKR QLQERFTDLE 720

KEKSNMEIDM TYKLKVIQQS LEQEEAEHKT TKARLADKNK IYESIEEAKS EAMKEMEKKL 780

LEERTLKQKV ENLLLEAEKR CSMLDCDLKQ SQQKVNELLK QKDKLNEDVR NLTLKIEQET 840

QKRCLTQNDL KMQTQQVNTL KMSEKQMKQE NNHLMEIKMS LEKQNIELRK ERQDADGQMK 900

ELQDQLEAEQ YFSTLYKTQV RELKEECQEK TKLCKEMQQK NQELQDERDS LAAQLEITLT 960

KADSEQLARS IAEEQYSDLE KEKIMKELEI KEMMARHKQE LVEKDATIAS LEEANRTLTS 1020

DVANLANEKE ELNNKVKEVQ EQISRLKDEE TNISVIKSQF EKQLLNERTL KTQAVNKLAE 1080

IMNRKEPPKR GADTDVRRKE KENRKLHMEL KSEREKLTQQ MIKYQKELNE MQAQIAEESQ 1140

IRIELQMTLD SKDSDIEQLR SQLQALHIGL DSSSIGSGPG EAEADDGFPE SRLEGWLSLP 1200

VRNNTKKFGW VKKYVIVSSK KILFYDSEQD KEQSNPYMVL DIDKLFHVRP VTQTDVYRAD 1260

SKEIPRIFQI LYANEGESKK EQEFPVEPVG EKSNCICHKG HEFIPTLYHF PTNCEACMKP 1320

LWHMFKPPPA LECRRCHIKC HKDHMDKKEE IIAPCKVYYD ISSAKNLLLL ANSTEDQQKW 1380

VSRLVKKIPK KPPAPDPFAR SSPRTSMKVQ PNQSIRRPSR QLPPSKP 1427

Nucleotide Sequence
(FASTA)

AGAGGAGGGG CGGGGCGGGA CGGGGAGGGG CCTGGAGCGG GAGGCTCGGG CAGCCCTCCC 60

GCCCCCAGGG AGCGGGGCCC CGAGCGGGAC GAGCCCGGGA TTGTCTCGGG CGGGAGCAGG 120

ATGAGCCAAC CGCGGGTCGA GAAAATGTCT GGCGCCCCAG AGACAGAACC GTGGAACTGG 180

GCCTTCGCGA GCCGCCAGAG GCAGCTGGAG GCCATGATCC GGGACCCCCG CTCCCCAATC 240

TACGTGGAGA GTCTCTTGGA TGGTTTGAAT TCCTTGGTCC TTGATCTGGA TTTTCCTGCT 300

CTGAGGAAAA ATAAGAATAT AGATAATTTC TTAATTAGAT ATGAGAAAAT TGTGACAAAA 360

ATTAGATGCC TACAGATGAA GGCAGAAGAT TTTGATGTTG TTAAAGTGAT TGGAAGAGGT 420

GCTTTTGGTG AAGTTCAGTT GGTTCGTCAT AAAGCATCAC AGAATGTTTA TGCCATGAAG 480

CTTCTTAGTA AATTTGAAAT GATAAAAAGA TCAGATTCTG CCTTTTTTTG GGAAGAACGA 540

GATATCATGG CCTTTGCCAA TAGTCCCTGG GTTGTTCAGC TCTTTTGTGC CTTTCAAGAT 600

GATAGATATC TTTATATGGT AATGGAATAC ATGCCTGGTG GAGATCTTGT AAACCTTATG 660

AGCAACTATG ATGTACCTGA AAAATGGGCC AAATTTTACA CAGCCGAAGT TGTTCTGGCT 720

TTGGATGCAA TACACTCCAT GGGCTTAATA CACAGAGATG TGAAGCCAGA CAACATGCTT 780

TTGGATAAAA ATGGACATTT GAAATTAGCA GATTTTGGCA CTTGTATGAA AATGGATGAA 840

ACAGGTATGG TGCATTGTGA TACAGCAGTT GGAACACCTG ATTACATATC ACCTGAAGTT 900

TTGAAGTCAC AGGGTGGTGA TGGCTATTAT GGACGAGAGT GTGATTGGTG GTCTGTAGGT 960

GTTTTCCTTT TTGAGATGCT GGTTGGAGAT ACTCCTTTTT ATGCAGATTC ACTTGTGGGA 1020

ACATACAGTA AAATTATGGA TCATAAAAAT TCATTAAATT TCCCAGAAGA TGCAGAAATA 1080

TCGAAGCATG CAAAGAATCT CATATGTGCC TTCTTAACTG ACAGGGAGGT GCGACTTGGG 1140

AGAAATGGGG TAGAAGAAAT CAAACAGCAT TCTTTCTTTA AAAGTGATCA ATGGAATTGG 1200

GATAACATAA GAGAGACCGC AGCTCCAGTA GTACCTGAAC TCAGCAGTGA CATAGATAGC 1260

AGCAATTTTG ATGACATTGA AGATGATAAA GGAGATGTGG AAACCTTTCC AATTCCTAAA 1320

GCCTTTGTGG GAAACCAGCT GCCTTTTATA GGTTTTACCT ACTATAGAGA AAATTTGTTG 1380

TTAAGTGATT CTTCTTCATC TTGTACAGAA AATGATTCAG TACAATCAAG GAAAAATGAG 1440

CAATCTGTAC AGATTCAGAA AAAACTATTC TTATTAGAAG AACACCTCAA CAATGAGATA 1500

CAAGCCAAAG AGGACCTGGA CCAGAAGTGC AAATTGGTTA GCACTCGACT AGAGAAGATA 1560

ACAAAAGAAC TAGAAGAAGA GGTTACCTCA AGAAAGAATG TAGAATCTAC ATTAAGACAA 1620

TTAGAAAGAG AAAAAGCTCT TCTTCAACAC AAAAATACAG AATACCAGCG GAAAGCAGAA 1680

TATGAAGCAG ACAAAAAACG GAATCTGGAA AATGATGTTA ACAGCTTGAA AGATCAGCTT 1740

GAAGATTTGA AGAAAAGAAA TCAAAACTCA CAAATATCTA ATGAAAAAGT CAATCAGCTT 1800

CAGAGACAAC TGGATGAAGC CAATGCTTTG CTGCGAACTG AATCTGATAC TGCAGCCAGG 1860

TTACGGAAAA ACCAGACAGA AAGTTCAAAA CAAATTCAGC AGCTGGAATG TAATAATAGG 1920

GAGCTACAAG ACAAAAACTG CATGTTAGAG AATGCTAAAC TGAAACTTGA AAAGGACTTC 1980

ATCAATCTTC AGTCAGCTCT AGAATCTGAA AGGAGAGATA AAACGCATGG ATCTGAAATA 2040

ATTAATGATT TACAAGGTAG AATATCTGGT TTGGAAGAAG ATATTAAAAA TGGTAAAATT 2100

TCATTAACAA AAATGGAGTT AGAGAAGAGA CAACTACAGG AGAGATTTAC AGATTTAGAA 2160

AAGGAAAAAA GTAACATGGA AATAGATATG ACATACAAAT TGAAAGTTAT ACAACAAAGC 2220

TTGGAACAGG AAGAAGCGGA ACATAAAACT ACAAAAGCAC GGTTAGCAGA TAAGAATAAG 2280

ATTTATGAAT CTATTGAAGA GGCCAAATCA GAAGCAATGA AAGAAATGGA GAAGAAACTC 2340

CTAGAGGAAA GAACTTTAAA ACAAAAGGTG GAAAACCTTC TGTTGGAAGC TGAAAAAAGA 2400

TGTTCAATGT TAGATTGTGA CCTCAAACAA TCACAACAGA AAGTCAATGA ACTCTTGAAA 2460

CAGAAGGACA AACTAAATGA GGATGTCAGA AATTTGACCT TAAAAATAGA ACAAGAAACA 2520

CAAAAACGCT GCCTCACACA AAATGACCTG AAGATGCAAA CACAACAAGT TAATACATTG 2580

AAAATGTCTG AAAAACAAAT GAAACAAGAA AATAATCATC TCATGGAAAT CAAAATGAGT 2640

CTGGAAAAGC AAAATATCGA GCTTCGCAAA GAAAGGCAAG ATGCAGATGG GCAAATGAAA 2700

GAGCTCCAGG ATCAGCTTGA AGCAGAACAA TATTTCTCGA CTCTCTATAA AACACAAGTT 2760

CGAGAGCTTA AAGAAGAATG TCAAGAGAAG ACTAAACTTT GCAAAGAAAT GCAGCAGAAG 2820

AACCAGGAAT TACAGGATGA AAGGGATTCC TTGGCTGCAC AACTTGAGAT CACTTTGACA 2880

AAAGCTGATT CAGAGCAGCT TGCCCGTTCT ATTGCTGAAG AACAGTACTC TGATTTGGAG 2940

AAAGAGAAGA TCATGAAAGA GCTGGAAATT AAAGAGATGA TGGCTCGACA CAAGCAAGAA 3000

CTTGTAGAAA AAGATGCTAC GATAGCGTCT CTTGAGGAGG CTAATAGGAC ACTAACTAGT 3060

GATGTGGCTA ATCTTGCAAA TGAGAAGGAA GAACTGAATA ATAAAGTCAA AGAAGTCCAA 3120

GAACAAATAT CAAGGTTGAA AGATGAAGAA ACAAATATAT CAGTTATTAA ATCACAGTTT 3180

GAGAAACAGC TTTTAAATGA GAGAACACTA AAAACTCAGG CTGTAAATAA ATTGGCTGAG 3240

ATTATGAATC GAAAAGAACC TCCCAAGCGT GGTGCCGACA CAGATGTGAG GAGGAAAGAG 3300

AAAGAGAACA GAAAGCTACA TATGGAACTT AAATCAGAAC GTGAAAAGTT AACTCAACAG 3360

ATGATCAAAT ATCAAAAAGA ACTGAATGAA ATGCAAGCTC AAATAGCTGA AGAAAGTCAA 3420

ATTCGAATTG AACTGCAAAT GACTCTGGAC AGTAAAGATA GTGATATTGA ACAGCTTCGA 3480

TCACAGCTCC AAGCCTTACA TATTGGTTTG GATAGTTCCA GTATAGGCAG TGGACCAGGG 3540

GAAGCTGAGG CAGATGATGG GTTCCCAGAA TCAAGATTAG AAGGATGGCT TTCGTTGCCT 3600

GTACGAAACA ACACTAAGAA GTTTGGATGG GTTAAAAAGT ATGTGATTGT AAGCAGTAAG 3660

AAGATTCTTT TCTATGACAG TGAACAAGAT AAAGAACAGT CTAATCCTTA CATGGTGTTA 3720

GATATAGACA AGTTGTTCCA TGTCCGGCCA GTCACCCAGA CAGATGTTTA TAGAGCTGAT 3780

TCCAAAGAGA TTCCAAGGAT ATTTCAGATT TTGTATGCTA ATGAAGGTGA AAGCAAAAAA 3840

GAACAAGAAT TTCCTGTGGA ACCTGTAGGA GAAAAGTCAA ACTGCATTTG CCACAAAGGA 3900

CATGAATTTA TTCCCACCCT TTATCATTTC CCAACTAACT GTGAGGCCTG TATGAAGCCA 3960

CTTTGGCATA TGTTTAAACC TCCACCTGCT CTTGAATGTC GTCGCTGCCA TATCAAATGC 4020

CATAAAGACC ATATGGACAA AAAGGAGGAA ATCATAGCAC CTTGCAAAGT ATACTATGAC 4080

ATTTCATCGG CAAAGAATCT GCTGTTATTA GCTAATTCTA CAGAAGACCA GCAGAAGTGG 4140

GTGAGTCGGT TGGTAAAAAA GATACCTAAA AAGCCTCCAG CACCAGACCC TTTTGCACGG 4200

TCATCTCCTA GAACTTCTAT GAAGGTACAG CCCAACCAAT CTATAAGACG TCCAAGTCGA 4260

CAGCTTCCTC CAAGCAAACC A 4281

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         f+++kviGrGafgev++vr+ka+++vyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 131   FDVVKVIGRGAFGEVQLVRHKASQNVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  190

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql++afqd++yly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g

Q: 191   VVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  248

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldk+Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+

Q: 249   LIHRDVKPDNMLLDKNGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GD  307

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl+fped+++s++ak+l

Q: 308   GYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPEDAEISKHAKNL  367

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h+ff

Q: 368   ICAFLTDREVRLGRNGVEEIKQHSFF  393

         *************************9

Domain Sequence
(FASTA)

FDVVKVIGRG AFGEVQLVRH KASQNVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFCAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120

HRDVKPDNML LDKNGHLKLA DFGTCMKMDE TGMVHCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLNFPEDAEI SKHAKNLICA 240

FLTDREVRLG RNGVEEIKQH SFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031616	; C:spindle pole centrosome
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0051298	; P:centrosome duplication
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction
GO:0016525	; P:negative regulation of angiogenesis
GO:0001843	; P:neural tube closure
GO:0010825	; P:positive regulation of centrosome duplication
GO:0045616	; P:regulation of keratinocyte differentiation

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013