EKS-MOD-00360
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00360
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src426.14.4E-128238486249
StatusUnreviewed
Ensembl ProteinENSMODP00000015019
UniProt AccessionF7B9H2;
Protein Name
Protein Synonyms/Alias
Gene NameBLK
Gene Synonyms/Alias BLK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000011985ENSMODP00000015019ENSMODT00000015294
OrganismMonodelphis domestica
Functional Description
Protein Length501
Protein Sequence
(FASTA)
MGVVSSKKLA KEKGKNQWNF KEPHIVFPKT PPPPLPPLVV FNHLTTPTPV LKPDQEEHYA 60
VALWDYEATN DRDLKVVKGE KLQILMKTGD WWLARSLVTK REGYVPSNFV TQVETLEVEK 120
WFFKTISRRE AERELLAPVN KTGAFLIRES ETIKGAYSLT VKDTTSAGNV IKHYKIRALD 180
DGGYYISPRV TFPSLRELVQ HYSKKGDGLC QKLTMPCMIL APQTQWAQDE WEVPRHSLKL 240
VRKLGAGQFG EVWMGYYKNN IKVAIKTLKE GSMSPEAFLA EANLMKTLQH DKLVRLYAVV 300
TQEPIYIVTE YMAKGSLLDF LKSEEGCKLP FSRLIDIMAQ IAEGMAYIEQ RNSIHRDLRA 360
ANVLVSESLG CKIADFGLAR IVDSEYTAHE GAKFPIKWTA PEAINFGVFS IKSDVWSFGI 420
LLMEIVTYGR IPYPGMTNPE VIRNLERGYR MPCPEMCPAE LYSIISKCWR NRPEERPTFE 480
YLQSVLEDFY IATEQQYELQ P 501
Nucleotide Sequence
(FASTA)
ATGGGAGTAG TGAGCAGCAA GAAACTGGCT AAGGAGAAAG GGAAGAATCA GTGGAATTTT 60
AAGGAGCCTC ATATCGTCTT CCCAAAGACG CCTCCCCCAC CTCTGCCTCC ATTGGTTGTC 120
TTCAATCACC TTACTACACC AACTCCTGTT CTAAAACCTG ATCAAGAAGA GCACTATGCA 180
GTTGCCTTGT GGGATTATGA AGCCACGAAT GACCGGGACC TGAAGGTGGT GAAGGGAGAG 240
AAGCTGCAAA TCTTGATGAA AACTGGAGAC TGGTGGTTGG CCAGATCGCT TGTCACTAAA 300
AGGGAAGGCT ATGTCCCTAG CAACTTTGTT ACTCAAGTAG AGACTCTGGA AGTTGAAAAG 360
TGGTTCTTCA AAACAATCAG TCGGAGAGAA GCTGAAAGGG AACTCCTGGC TCCTGTCAAC 420
AAGACTGGTG CATTCCTAAT CAGAGAGAGT GAAACAATTA AAGGTGCCTA TTCCCTGACT 480
GTGAAGGACA CCACCTCTGC GGGAAATGTT ATCAAACACT ACAAGATCCG GGCCCTAGAT 540
GATGGAGGAT ATTATATTTC TCCCAGGGTC ACCTTCCCTT CACTAAGAGA ACTGGTCCAA 600
CATTATTCTA AGAAAGGGGA CGGTTTATGC CAGAAGCTGA CTATGCCCTG TATGATTCTG 660
GCTCCTCAGA CCCAATGGGC CCAGGATGAA TGGGAAGTAC CCCGGCATTC TCTGAAACTG 720
GTGAGGAAAC TTGGTGCTGG ACAGTTTGGA GAAGTCTGGA TGGGTTATTA TAAAAACAAC 780
ATAAAGGTGG CCATCAAGAC CCTGAAGGAG GGCAGCATGT CTCCTGAAGC CTTCCTTGCT 840
GAGGCCAATC TAATGAAAAC CCTCCAGCAT GACAAATTGG TCCGTCTCTA TGCAGTGGTA 900
ACCCAGGAAC CCATCTATAT TGTCACAGAG TACATGGCCA AAGGGTCCTT ATTGGATTTC 960
CTAAAGTCAG AAGAAGGTTG CAAGCTGCCA TTCTCAAGAC TGATTGACAT AATGGCCCAG 1020
ATTGCTGAAG GGATGGCCTA CATCGAGCAA AGAAATTCAA TCCATCGAGA CTTGAGAGCA 1080
GCCAATGTCC TGGTGTCTGA GAGTCTGGGC TGCAAGATTG CTGACTTTGG CTTGGCAAGA 1140
ATTGTAGACA GTGAATATAC AGCCCATGAA GGTGCCAAGT TCCCCATCAA GTGGACAGCC 1200
CCAGAAGCCA TTAATTTTGG CGTGTTCTCC ATCAAATCTG ATGTTTGGTC CTTCGGAATT 1260
CTCCTGATGG AAATTGTTAC CTATGGGCGG ATTCCTTACC CAGGCATGAC CAACCCAGAG 1320
GTCATTCGGA ATCTAGAACG AGGCTATCGA ATGCCTTGCC CTGAAATGTG CCCAGCGGAG 1380
CTCTACAGCA TCATCAGCAA GTGTTGGCGC AACCGGCCAG AGGAGCGGCC CACCTTTGAA 1440
TACTTACAGT CTGTACTGGA GGACTTCTAC ATAGCCACAG AGCAACAGTA TGAACTGCAG 1500
CCCTAG 1506
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv+klG+GqfGevw+g++k+++kva+ktlkeg++speafl+ea+++k+l+h+klv+ly
Q: 238   LKLVRKLGAGQFGEVWMGYYKNNIKVAIKTLKEGSMSPEAFLAEANLMKTLQHDKLVRLY  297
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyivte+makGslldflk+eeg kl++++l+d+ aq+aeGmay+e++n ihr
Q: 298   AVVTQ-EPIYIVTEYMAKGSLLDFLKSEEGCKLPFSRLIDIMAQIAEGMAYIEQRNSIHR  356
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+nvlv+esl +k+adfGlar++ d+eyta+egak+PikWtaPeai++g+f+iksdv
Q: 357   DLRAANVLVSESLGCKIADFGLARIV-DSEYTAHEGAKFPIKWTAPEAINFGVFSIKSDV  415
         ************************99.899******************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGmtn ev++++ergyr+p+pe cp+ely+++ +cw+++pee
Q: 416   WSFGILLMEIVTYGRIPYPGMTNPEVIRNLERGYRMPCPEMCPAELYSIISKCWRNRPEE  475
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq+vl
Q: 476   RPTFEYLQSVL  486
         ********986
Domain Sequence
(FASTA)
LKLVRKLGAG QFGEVWMGYY KNNIKVAIKT LKEGSMSPEA FLAEANLMKT LQHDKLVRLY 60
AVVTQEPIYI VTEYMAKGSL LDFLKSEEGC KLPFSRLIDI MAQIAEGMAY IEQRNSIHRD 120
LRAANVLVSE SLGCKIADFG LARIVDSEYT AHEGAKFPIK WTAPEAINFG VFSIKSDVWS 180
FGILLMEIVT YGRIPYPGMT NPEVIRNLER GYRMPCPEMC PAELYSIISK CWRNRPEERP 240
TFEYLQSVL 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>
EKS-AIM-00345
EKS-ANC-00360
EKS-BOT-00372
EKS-CAJ-00377
EKS-CAF-00372
EKS-CAP-00405
EKS-DAR-00751
EKS-EQC-00363
EKS-FEC-00359
EKS-GAG-00314
EKS-GOG-00363
EKS-HOS-00379
EKS-ICT-00353
EKS-LAC-00386
EKS-LOA-00381
EKS-MAM-00373
EKS-MEG-00304
EKS-MUM-00404
EKS-MUP-00366
EKS-NOL-00339
EKS-ORN-00479
EKS-ORC-00351
EKS-OTG-00375
EKS-PAT-00352
EKS-PES-00329
EKS-POA-00361
EKS-PTV-00095
EKS-RAN-00386
EKS-SAH-00342
EKS-SUS-00325
EKS-TAG-00443
EKS-TUT-00099
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0032024; P:positive regulation of insulin secretion
KEGG
mdo:100032697;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013