EKS-MOD-00450

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00450

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	475.0	7.5E-143	13	287	275

Status

Unreviewed

Ensembl Protein

ENSMODP00000015056

UniProt Accession

F7AM83;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000012017	ENSMODP00000015056	ENSMODT00000015334

Organism

Monodelphis domestica

Functional Description

Protein Length

1339

Protein Sequence
(FASTA)

MILNMGGFWG DPIFKVARAK HREGLVVVKV FAIQDPTLPL TSYKQELEEL KIRLNSAQNC 60

LPFQRATEKT SEKAALLFRQ YVRDNLYDRI STRPFLNNIE KRWIAFQILT AVDQAHKSGV 120

RHGDIKTENV MVTSWNWVLL TDFASFKPTY LPEDNPADFN YFFDTSRRRT CYIAPERFVD 180

GGMFATELEC MKDPSTPLVD LTNSNQRTRG ELKRAMDIFS AGCVIAELFT EGVPLFDLSQ 240

LLAYRNGHFF PEQVLSKIED RSIRELVTQM IHCEPEKRLE AEDYLKQQRG NAFPEIFYTF 300

LQPYMAQFAK ETFLSADERI LVIRKDLDNI VHNLCGHDRT EKAEGETKEN GLVILVSVIT 360

SCLQTLKSCD SKLAALELIL HLAPRLSVEI LLDRITPYLL HFSNDSVPRV RAEAVRTLTK 420

VLALVKEVPR NDINIYPEYI LPGIAHLAQD EATIVRLAYA ENIALLAETA LRFLELVQLK 480

NLNMENDPNS EELDEVSHPS ENYDTELQAL HEMVQQKVVT LLSDPENIVK QTLMENGITR 540

LCVFFGRQKA NDVLLSHMIT FLNDKNDWHL RGAFFDSIVG VAAYVGWQSS SILKPLLQQG 600

LSDAEEFVIF KALNALTCMC QLGLLQKPHI YEFACDIAPF LCHPNLWIRY GAVGFITVVA 660

HHLNIADVYC KLMPYLHPFI TQPIIQIDKE IVLLSVLQEP VSRSIFDYAL RSKDIASLFR 720

HLQMRQKKRN GSLPDCPPPE DPAIAQLLKK LLSQGMTEEE EDKLLALKDF MMKSNKAKAN 780

IVDQSHLHDS SQKGVIDLAA LGITGRQVDL VKTKQEPDDK RARKHVKQDS NVNEEWKSMF 840

GSLEPAPIPQ ALPKGHGPPS DQEAIQTGKP LRSEPSAGLG ITLSSSPQAP EVSAVQTRKP 900

TIQVPSSTVL PSTYQIRITT CKTELQQLVQ QKREQCHAER IAKQMMENAE WESKPPPPGW 960

RPKGLLVAHL HEHKSAVNRI RVSDEHSLFA TCSNDGTVKI WNSQKMEGKT TTTRSILTYT 1020

RIGGRVKTLT FCQGSHYLAI ASDNGAVQLL GIEASKLPKS PKIHPLQSRI LDQKEDGCVV 1080

DMHHFNSGAQ LVLAYATVNG SLVGWDLRSS SNAWTLKHDL KSGLITSFAV DIHQCWLCIG 1140

TSNGTMACWD MRFQLPISSH CHPSRARIRR LLMHPLYQSW VIAAVQGNNE VSMWDMETGD 1200

RRFTLWASSA PPLSELQPSS HSVHGIYCSP ADGNPILLTA GSDMKIRFWD LAYPERSYIV 1260

AGGSSSPSVS YYRKIIEGTE VVQEIQNKQK IGPTDDTPRR GPESLPVGHH DIITDIATFQ 1320

TTQGFIVTAS RDGIVKVWK 1339

Nucleotide Sequence
(FASTA)

ATGATTTTGA ATATGGGTGG ATTCTGGGGA GACCCGATTT TTAAAGTTGC TCGAGCCAAG 60

CACAGAGAAG GCTTGGTGGT AGTGAAGGTC TTTGCAATTC AGGATCCAAC CTTACCTTTA 120

ACTAGCTACA AACAGGAACT GGAAGAGCTG AAGATCAGGC TTAATTCAGC ACAGAACTGT 180

CTACCATTCC AGAGAGCCAC AGAAAAAACA TCGGAAAAAG CGGCTCTGCT CTTCAGGCAA 240

TATGTCCGAG ACAACCTCTA TGATCGGATC AGCACCCGTC CATTCTTAAA CAATATAGAA 300

AAGCGGTGGA TTGCTTTCCA GATCTTGACT GCAGTGGACC AAGCTCACAA ATCTGGAGTC 360

CGACATGGGG ACATCAAAAC TGAAAATGTC ATGGTAACCA GTTGGAATTG GGTTCTCCTA 420

ACAGACTTTG CCAGTTTTAA ACCTACTTAC CTTCCAGAAG ACAACCCTGC TGATTTCAAT 480

TATTTCTTTG ACACATCACG GAGGAGAACT TGCTATATTG CTCCCGAGCG CTTTGTGGAT 540

GGTGGCATGT TTGCCACAGA GTTAGAGTGC ATGAAAGATC CTTCTACCCC ATTGGTAGAT 600

TTGACAAACA GCAACCAGAG AACAAGAGGG GAACTGAAGC GTGCAATGGA CATCTTTTCT 660

GCGGGTTGTG TAATAGCTGA GCTATTTACA GAAGGGGTCC CACTATTTGA CTTGTCCCAG 720

CTTTTGGCCT ATAGAAATGG ACACTTTTTC CCTGAACAAG TGCTAAGCAA AATTGAGGAC 780

CGTAGCATCA GAGAATTGGT GACCCAAATG ATCCATTGTG AACCTGAGAA ACGTTTAGAG 840

GCTGAAGATT ACTTAAAGCA ACAGCGTGGC AATGCCTTCC CTGAAATATT TTACACGTTC 900

CTCCAGCCTT ACATGGCCCA ATTTGCTAAG GAGACATTCC TCTCTGCCGA TGAGCGTATC 960

CTGGTCATAA GGAAGGATTT GGATAACATC GTCCACAATC TCTGTGGACA TGATCGAACA 1020

GAAAAAGCTG AGGGCGAGAC AAAAGAGAAT GGACTGGTGA TTCTGGTGTC TGTTATCACT 1080

TCTTGTCTGC AGACCCTTAA GTCTTGTGAC TCCAAACTGG CCGCTTTGGA GCTCATACTA 1140

CACTTGGCCC CAAGGTTAAG TGTAGAAATT CTTCTGGATC GCATCACACC TTATCTTTTG 1200

CATTTTAGCA ATGACTCTGT GCCCAGGGTG AGGGCAGAAG CTGTGAGGAC ACTCACCAAG 1260

GTTCTGGCTC TTGTCAAAGA GGTGCCCCGA AATGATATCA ATATCTATCC GGAGTATATT 1320

TTGCCAGGAA TAGCGCATCT GGCTCAAGAT GAAGCCACTA TTGTCAGGCT TGCTTATGCT 1380

GAAAACATAG CATTACTGGC AGAAACTGCC TTGAGATTCC TGGAGTTGGT ACAGCTGAAA 1440

AATCTCAATA TGGAAAATGA CCCAAATAGT GAAGAATTAG ATGAAGTTTC ACACCCCAGT 1500

GAAAATTATG ACACAGAGCT CCAAGCCTTA CATGAAATGG TCCAGCAGAA AGTTGTTACC 1560

TTACTGAGTG ACCCAGAAAA TATCGTGAAG CAAACCCTAA TGGAAAATGG AATCACTCGG 1620

TTATGTGTCT TTTTTGGACG TCAGAAGGCC AATGATGTCT TACTGTCTCA CATGATCACT 1680

TTCCTAAATG ATAAGAATGA TTGGCATCTC CGTGGAGCTT TTTTTGACAG CATTGTTGGT 1740

GTTGCTGCTT ATGTTGGCTG GCAGAGTTCT TCTATCCTTA AGCCTCTGCT ACAACAAGGC 1800

CTCAGTGATG CAGAAGAATT TGTTATCTTC AAGGCTCTCA ATGCCCTCAC CTGTATGTGC 1860

CAGTTAGGCC TGTTGCAGAA ACCTCACATC TATGAATTTG CTTGTGATAT TGCACCCTTT 1920

CTATGTCATC CCAATCTCTG GATACGCTAT GGTGCAGTGG GATTTATAAC AGTGGTGGCC 1980

CATCATTTAA ACATTGCTGA TGTCTACTGC AAACTAATGC CTTACCTTCA TCCATTTATC 2040

ACCCAGCCAA TAATACAGAT TGATAAGGAA ATTGTTCTCC TCAGTGTTCT TCAAGAGCCA 2100

GTGAGCCGCT CCATCTTTGA TTATGCCTTG AGGTCCAAAG ATATTGCTAG TCTTTTCAGA 2160

CATCTGCAGA TGCGGCAGAA GAAACGGAAT GGCTCTCTCC CTGACTGCCC ACCGCCAGAG 2220

GACCCTGCTA TTGCACAGCT TTTGAAGAAA TTGCTTTCAC AGGGAATGAC TGAGGAAGAA 2280

GAAGACAAGC TTTTAGCACT GAAGGACTTC ATGATGAAAT CCAATAAAGC TAAGGCCAAT 2340

ATAGTGGATC AGAGTCACCT TCATGATAGC AGCCAGAAAG GAGTCATTGA TTTGGCTGCT 2400

CTTGGCATCA CTGGGAGGCA AGTTGATCTT GTTAAAACCA AACAGGAGCC AGATGACAAA 2460

CGAGCCAGGA AACATGTAAA ACAGGATTCC AATGTAAATG AAGAATGGAA GAGCATGTTC 2520

GGGTCCCTGG AGCCAGCGCC CATCCCCCAG GCCCTCCCTA AAGGACACGG GCCACCGAGT 2580

GACCAGGAGG CCATTCAGAC AGGCAAACCT CTTCGCTCTG AGCCTTCGGC TGGCCTTGGA 2640

ATAACCCTGT CTTCCTCTCC CCAGGCTCCT GAAGTGTCAG CTGTCCAAAC TCGGAAGCCA 2700

ACAATACAGG TTCCAAGCAG TACCGTTTTA CCATCCACCT ACCAAATACG AATCACAACT 2760

TGTAAGACGG AGCTTCAGCA GCTAGTCCAA CAGAAGCGAG AGCAATGCCA TGCTGAAAGA 2820

ATAGCCAAGC AGATGATGGA GAATGCAGAG TGGGAGAGCA AGCCACCACC ACCAGGGTGG 2880

AGGCCTAAAG GCCTGCTGGT GGCTCATCTT CATGAACACA AGTCTGCAGT GAACCGCATC 2940

AGAGTCTCTG ATGAGCATTC CCTCTTTGCC ACTTGTTCAA ATGATGGCAC AGTGAAAATC 3000

TGGAACAGTC AGAAAATGGA AGGGAAAACA ACAACCACAA GGTCAATTCT GACGTACACA 3060

CGTATTGGAG GACGGGTTAA GACACTCACG TTTTGCCAAG GCTCCCATTA CCTGGCCATT 3120

GCTTCTGATA ATGGTGCTGT GCAGCTTCTT GGAATTGAGG CTTCCAAGTT ACCCAAATCT 3180

CCCAAAATAC ATCCCCTTCA AAGCAGGATT TTAGATCAGA AGGAGGATGG GTGCGTTGTA 3240

GATATGCATC ACTTCAACTC AGGGGCACAG TTAGTTCTGG CCTATGCCAC TGTGAATGGC 3300

TCATTGGTTG GTTGGGACCT CAGATCTTCG AGTAATGCCT GGACATTGAA GCATGATTTG 3360

AAGTCAGGTC TCATTACCTC CTTTGCTGTG GATATCCACC AGTGCTGGCT GTGTATCGGT 3420

ACAAGCAATG GGACTATGGC TTGCTGGGAC ATGAGGTTCC AGTTGCCAAT TTCTAGTCAT 3480

TGTCATCCTT CAAGGGCCCG AATTAGACGC CTGTTAATGC ATCCTCTGTA CCAGTCATGG 3540

GTAATTGCAG CTGTTCAAGG CAACAATGAG GTGTCCATGT GGGACATGGA AACTGGGGAC 3600

AGACGCTTCA CTCTCTGGGC CAGCAGCGCG CCGCCTCTGT CCGAATTACA GCCTTCCTCA 3660

CACAGTGTTC ATGGGATCTA CTGCAGCCCT GCAGATGGAA ACCCTATCCT TTTAACAGCA 3720

GGATCAGACA TGAAGATAAG ATTTTGGGAT CTGGCTTACC CAGAGAGGTC CTATATTGTT 3780

GCCGGAGGTA GCAGTTCCCC ATCTGTGTCC TACTATAGGA AAATCATTGA AGGCACAGAA 3840

GTTGTCCAGG AAATTCAAAA CAAACAGAAG ATTGGACCCA CGGATGATAC CCCTCGGAGG 3900

GGCCCAGAAT CTCTTCCTGT GGGCCATCAT GATATCATCA CAGATATCGC AACTTTCCAG 3960

ACTACACAAG GCTTTATAGT AACTGCTTCG AGAGATGGGA TTGTGAAAGT GTGGAAATAG 4020

Domain Profile

S: 12    flkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqnclpfqkvlek..e  69

          +kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqnclpfq+++ek  e

Q: 13    IFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQRATEKtsE  72

         59*****************************************************9999*

S: 70    kaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvvhGdiktenvlv  129

         kaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+hGdiktenv+v

Q: 73    KAALLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMV  132

         ************************************************************

S: 130   tswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsalasdekl...r  186

         tswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++++++++l   +

Q: 133   TSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELecmK  192

         *******************************************************99999

S: 187   dgstelvdl.dsiqrlrgelkkamdifsaGcvilelftegrplfelsqllayrsgeflve  245

         d+st+lvdl +s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqllayr+g+f++e

Q: 193   DPSTPLVDLtNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPE  252

         *******9549*************************************************

S: 246   kvlekiededlrnlvlqliqlepekrksaedllkk  280

         +vl+kied+++r+lv+q+i+ epekr++aed+lk+

Q: 253   QVLSKIEDRSIRELVTQMIHCEPEKRLEAEDYLKQ  287

         *********************************97

Domain Sequence
(FASTA)

IFKVARAKHR EGLVVVKVFA IQDPTLPLTS YKQELEELKI RLNSAQNCLP FQRATEKTSE 60

KAALLFRQYV RDNLYDRIST RPFLNNIEKR WIAFQILTAV DQAHKSGVRH GDIKTENVMV 120

TSWNWVLLTD FASFKPTYLP EDNPADFNYF FDTSRRRTCY IAPERFVDGG MFATELECMK 180

DPSTPLVDLT NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL AYRNGHFFPE 240

QVLSKIEDRS IRELVTQMIH CEPEKRLEAE DYLKQ 275

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 5.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013