EKS-MOD-00121

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00121

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	453.7	2.0E-136	1091	1348	258

Status

Unreviewed

Ensembl Protein

ENSMODP00000015454

UniProt Accession

F7E2F2;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000012335	ENSMODP00000015454	ENSMODT00000015740

Organism

Monodelphis domestica

Functional Description

Protein Length

1433

Protein Sequence
(FASTA)

MLKKDAAWHP CPLAQLTVSP AMGFFSFFLL VLFLAQGSPS PRDTWQCTHI PYASSRNFSV 60

EYVVPSFEAD APIQRVVTYD EGPGGGRAIF VATRNHLHVL NHSLGLLQSL ITGPAGHPSC 120

QSCAECKSSD PPLPGEDTDN VVLVLDPEFP SLYSCGSSLL GRCFVHELES DGGTVRLGST 180

SCLWTPSANS PQDCPDCLAS PLGTQVTVVE LSHTSYFYVA STLNRKVASR YSPQSVSIRR 240

LKSDWQGFAS SPPALAVLPR YLATYPIEYI YTFRSESFVY FLTVQPESLK DSSAFHTRLV 300

RLSAQDTDLG EYRELVLDCR FSYKRRRRRS QVASMEEETY NVLQAAHVAP VGSSLAVDLG 360

ILEGQKVLFG AFAVSQEGSR VPRHKSAVCA FPITKLNEFI DSGMERCCES QANQERVERG 420

VEFFQPQSYC PDPPTLGSNV SCWNYPTMIP TNHPRVDLLN GHLDSVLLTA IHVIHQGNAT 480

VAHMGTADGR ILQVKLFRSL NYLLYVSNFS LGSSQPVHRD VSRLGDHLLF SSGNKVFKVP 540

IRGPGCRHFL TCKRCLRAEL FMGCGWCGDV CARQEECPST WQQKSCPPHI TEFHPKSGPT 600

EGSTKLTICG SNFHSHFQDM TPKDHWKVTV GQSPCQGQSM ATSQQSSKKG YVEQLECLLV 660

ASSSQAAGPA NVTLTVSATT SKYPFQVNGS SVLSGFSFVV PVVTSIFPLF GPKAGGTQLT 720

IKGQNLKVGS SHRVLVNGTE CHLIPTEEEH LLCSTPPGGA EANVSISLYI GGAEIHTLWP 780

FQYRNNPNIS SISPNCSYSG SRITIQGQNL DAMWQMVTIF EDEHKTVKKL ECNNATLPTE 840

RVCLAPAYAN LPGRGPVWGD LSIRGDDSIL YFQSKFPFYP KPHLHSRLGP LKIEQGSVEV 900

KISGLSAVAS CMDVNMTVGG QSCQTNLKNN PVICNVPPTL SIPLGGVPLQ ICINGECQNV 960

GIVAQSSSQL LHISIGVFSI IVILAACVLA LLLFRFWRRK IKRQNRLGSL ERSHPAISLP 1020

LLRSDSDYRN GTVLSPTVGP GHIQVSSSKG SSSGSRVSLL RVKSICMGDL NSELLAEVKD 1080

VLIPPEWIIT HDDQVIGKGH FGIVYHGEYV DSSQNRIHCA IKSLNRITEI EEVEEFLREG 1140

LLMRSFCHPH VLSLIGILLP PEGLPRVVLP YMKHGDLRHF IRSPERNPTV KDLIGFGLQV 1200

ARGMAYLAEK KFVHRDLAAR NCMLDETFTV KVADFGLARD ILDKEYYSVR RHRHARLPVK 1260

WMALESLQTH KFTTKSDVWS FGVLLWELLT RGASPYPNID PFDIAHFLAK GRRLPQPEYC 1320

PDALYEVMLQ CWNAVPTERP TFGVLVREVE CVAASLRGEH YVNLHSGYVN LECGPILPPC 1380

PSSEDELDRS EEEEEEPEDP GEKAEAKEAC KQRGGPRPLS APPLTFPTLE NST 1433

Nucleotide Sequence
(FASTA)

ATGCTCAAAA AGGATGCTGC CTGGCACCCC TGCCCCTTGG CCCAGCTGAC AGTCTCCCCT 60

GCCATGGGGT TCTTCTCATT CTTCCTGCTG GTGCTCTTCC TGGCCCAGGG GTCCCCTTCC 120

CCACGGGATA CCTGGCAGTG CACCCACATC CCGTATGCCT CCTCCCGGAA CTTCAGCGTG 180

GAGTACGTGG TGCCCAGTTT TGAGGCTGAT GCCCCCATCC AAAGAGTGGT AACCTATGAC 240

GAGGGTCCAG GCGGTGGCCG GGCCATCTTT GTAGCCACTA GGAACCATCT GCATGTGCTG 300

AATCACAGCC TGGGGCTACT CCAGAGCCTG ATCACCGGGC CTGCGGGCCA CCCCAGCTGC 360

CAGTCCTGTG CGGAATGTAA GTCGTCAGAC CCTCCGCTGC CCGGGGAAGA CACAGACAAC 420

GTGGTGCTGG TCCTGGACCC TGAGTTTCCC TCCCTCTACA GCTGTGGCTC TTCCTTGCTG 480

GGCCGCTGTT TTGTGCACGA GCTGGAGTCT GACGGCGGGA CGGTCCGCTT GGGTTCCACG 540

TCCTGCCTCT GGACCCCCTC TGCCAATAGT CCTCAAGACT GCCCTGACTG CCTAGCTAGC 600

CCCCTGGGCA CCCAGGTGAC TGTGGTCGAG CTGAGCCATA CTTCCTACTT TTATGTAGCC 660

TCTACCCTGA ACCGGAAGGT GGCCTCCCGC TATAGTCCCC AGTCTGTATC GATCCGCAGG 720

CTCAAATCCG ACTGGCAGGG CTTTGCTTCC AGTCCCCCAG CCTTGGCCGT GCTGCCCAGA 780

TACCTGGCCA CCTATCCCAT CGAGTACATC TACACCTTCC GCTCGGAGAG CTTTGTCTAT 840

TTCCTCACTG TCCAACCAGA GTCCTTGAAG GATTCCAGCG CTTTCCATAC TCGACTAGTG 900

CGACTTAGCG CCCAAGACAC TGATCTGGGG GAGTACCGGG AGCTGGTCCT CGACTGCCGA 960

TTTTCATACA AGAGGCGGCG TCGGAGAAGC CAGGTGGCCA GCATGGAGGA GGAAACCTAC 1020

AACGTGCTTC AAGCGGCCCA CGTGGCCCCA GTGGGGTCTT CGCTGGCAGT GGATCTAGGG 1080

ATCCTCGAGG GCCAGAAGGT GCTATTTGGG GCCTTTGCCG TGAGCCAGGA GGGTAGTCGA 1140

GTCCCTCGTC ACAAATCGGC TGTGTGCGCC TTTCCCATAA CCAAGCTGAA TGAGTTCATT 1200

GATAGTGGCA TGGAGAGATG CTGTGAGTCT CAGGCCAACC AGGAGCGGGT GGAACGTGGA 1260

GTGGAGTTCT TTCAGCCTCA GAGCTACTGC CCAGATCCGC CTACCCTGGG CTCCAATGTC 1320

AGCTGCTGGA ACTACCCCAC CATGATCCCC ACCAACCACC CCCGAGTGGA CCTTCTCAAT 1380

GGGCACCTGG ACAGTGTTCT CCTTACGGCC ATCCACGTTA TCCATCAGGG CAATGCTACT 1440

GTGGCACACA TGGGCACTGC TGATGGGCGC ATCCTACAGG TGAAGTTGTT CAGATCGCTC 1500

AACTACCTGC TCTACGTGTC CAACTTTTCC CTGGGCTCCT CCCAGCCTGT GCATCGAGAT 1560

GTCAGCCGCC TTGGGGACCA CCTGCTTTTC AGCTCTGGGA ATAAAGTCTT CAAGGTGCCA 1620

ATTCGGGGCC CTGGCTGCCG CCACTTCCTG ACCTGTAAAA GATGCCTGAG AGCTGAGCTC 1680

TTCATGGGCT GTGGTTGGTG TGGGGATGTC TGTGCCCGGC AAGAGGAATG TCCAAGTACT 1740

TGGCAGCAGA AGTCCTGCCC ACCCCATATT ACTGAGTTCC ACCCCAAAAG CGGACCCACG 1800

GAGGGCAGTA CGAAGCTGAC AATATGTGGC TCTAACTTCC ACAGCCACTT CCAGGATATG 1860

ACCCCAAAGG ACCACTGGAA AGTCACTGTG GGCCAGAGTC CCTGCCAGGG GCAGTCTATG 1920

GCCACCTCCC AACAGAGCTC CAAGAAGGGC TACGTGGAAC AGTTGGAATG TCTACTGGTG 1980

GCATCAAGTT CACAGGCTGC TGGTCCTGCA AATGTCACCC TCACTGTCTC GGCAACAACG 2040

TCCAAATATC CGTTTCAGGT GAATGGCTCT TCAGTCCTGA GTGGTTTCTC CTTTGTGGTG 2100

CCAGTGGTGA CATCCATTTT CCCCCTGTTT GGCCCTAAGG CCGGTGGCAC TCAGCTCACC 2160

ATCAAAGGAC AGAACCTGAA GGTGGGCTCC AGTCATCGGG TGTTGGTTAA TGGAACCGAA 2220

TGCCACCTTA TTCCAACCGA AGAAGAGCAC CTTCTGTGTA GCACACCACC AGGAGGGGCT 2280

GAGGCCAATG TCTCCATCAG CTTGTACATT GGGGGTGCTG AGATCCATAC TCTTTGGCCT 2340

TTCCAATATC GGAACAATCC CAATATCTCC AGCATCTCCC CCAATTGCAG TTATTCCGGC 2400

TCCCGTATTA CCATCCAGGG CCAGAATCTG GATGCCATGT GGCAGATGGT TACCATCTTC 2460

GAGGATGAGC ACAAGACAGT GAAGAAACTG GAATGCAACA ATGCAACGCT CCCCACTGAA 2520

CGTGTGTGCC TGGCTCCTGC CTATGCCAAC CTGCCAGGCC GGGGACCAGT ATGGGGCGAT 2580

CTGAGCATCC GTGGGGATGA CTCCATCCTC TACTTCCAGT CCAAATTTCC ATTCTACCCC 2640

AAGCCCCACC TCCATTCCCG TCTGGGTCCT CTGAAGATTG AGCAGGGCTC TGTGGAAGTG 2700

AAGATTTCGG GACTAAGCGC CGTGGCCTCC TGCATGGACG TGAACATGAC TGTGGGTGGC 2760

CAAAGCTGTC AGACCAACCT GAAGAATAAT CCTGTGATCT GCAATGTTCC TCCCACCCTG 2820

TCCATCCCCC TTGGTGGAGT TCCCCTGCAG ATCTGCATTA ATGGGGAATG TCAGAACGTT 2880

GGTATCGTGG CGCAGAGCTC CTCACAGCTC CTACACATCT CCATCGGAGT GTTCTCCATC 2940

ATCGTCATCC TGGCAGCCTG CGTCCTAGCC TTACTGCTTT TCAGGTTCTG GAGAAGGAAG 3000

ATTAAGAGGC AAAACCGACT AGGTTCTCTA GAGAGGAGCC ATCCAGCCAT CTCTCTGCCC 3060

CTGCTTCGCT CAGACTCTGA TTACCGGAAT GGTACTGTCC TCAGTCCCAC AGTAGGACCT 3120

GGCCACATTC AAGTTTCATC ATCCAAGGGC AGCAGCAGTG GCTCTAGGGT CTCCCTCCTT 3180

CGGGTAAAGT CCATCTGTAT GGGAGACCTG AATTCTGAGC TCCTGGCTGA GGTGAAGGAT 3240

GTCCTCATCC CCCCTGAATG GATCATCACA CATGATGATC AAGTCATCGG CAAAGGCCAT 3300

TTTGGAATTG TCTACCATGG GGAATATGTG GACTCTTCCC AGAATCGAAT CCACTGTGCC 3360

ATCAAGTCAC TGAATCGCAT CACAGAGATA GAAGAAGTGG AAGAGTTCCT GAGGGAGGGA 3420

CTGCTCATGC GTAGCTTCTG TCACCCCCAT GTCCTGTCAC TCATTGGCAT CCTGCTGCCT 3480

CCTGAAGGGC TCCCTCGAGT GGTGCTTCCT TACATGAAAC ATGGGGACCT ACGGCATTTC 3540

ATCCGCTCCC CAGAAAGGAA CCCCACGGTG AAGGACCTCA TTGGCTTCGG GCTGCAGGTG 3600

GCCCGGGGGA TGGCCTACCT GGCCGAGAAG AAATTTGTTC ACAGGGACCT TGCAGCTCGG 3660

AATTGCATGC TGGACGAGAC GTTTACCGTA AAGGTGGCTG ACTTCGGCCT CGCCAGGGAT 3720

ATCCTAGACA AGGAATACTA CAGCGTCAGG AGGCACCGGC ATGCCCGGTT ACCGGTCAAA 3780

TGGATGGCCC TGGAGAGTTT GCAGACACAC AAGTTCACGA CCAAATCAGA TGTGTGGTCC 3840

TTTGGCGTCC TCCTTTGGGA GCTGCTGACT CGAGGGGCGT CCCCATATCC CAACATCGAC 3900

CCCTTTGACA TTGCCCATTT CCTGGCAAAG GGCCGACGTC TGCCTCAGCC CGAGTACTGC 3960

CCTGATGCCC TGTATGAAGT GATGCTCCAG TGCTGGAATG CTGTCCCCAC AGAGCGGCCA 4020

ACCTTTGGGG TGCTGGTGAG GGAGGTGGAG TGTGTCGCAG CCTCCCTGCG GGGGGAACAT 4080

TATGTCAACT TGCACAGTGG CTATGTGAAC TTGGAGTGTG GCCCCATCCT GCCCCCCTGC 4140

CCCAGCTCTG AAGATGAATT GGATCGGAGT GAGGAGGAAG AGGAAGAGCC TGAGGACCCA 4200

GGGGAAAAGG CTGAGGCAAA GGAGGCCTGC AAGCAAAGGG GGGGACCCCG GCCCCTCTCA 4260

GCCCCTCCAC TCACTTTCCC CACACTAGAG AACTCTACAT GA 4302

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         + ++viGkGhfG+vy+ge++ds++++i++a+ksl+rit+ie+veeflregl+m+ + hp+

Q: 1091  HDDQVIGKGHFGIVYHGEYVDSSQNRIHCAIKSLNRITEIEEVEEFLREGLLMRSFCHPH  1150

         7899********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vlsl+Gi l++eglp vvlpymk+Gdl++fir++ern+tvkdl++f+lqva+gm yla+k

Q: 1151  VLSLIGILLPPEGLPRVVLPYMKHGDLRHFIRSPERNPTVKDLIGFGLQVARGMAYLAEK  1210

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlard+ldke+y+v+++r+arlpvkw+aleslqt+

Q: 1211  KFVHRDLAARNCMLDETFTVKVADFGLARDILDKEYYSVRRHRHARLPVKWMALESLQTH  1270

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         k fttksdvwsfGvllwelltrga+py+++++fd+ ++l++grrl++peycpd+ly+vml

Q: 1271  K-FTTKSDVWSFGVLLWELLTRGASPYPNIDPFDIAHFLAKGRRLPQPEYCPDALYEVML  1329

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsi  260

         +cw+a p erp+f  lv

Q: 1330  QCWNAVPTERPTFGVLVRE  1348

         *************988865

Domain Sequence
(FASTA)

HDDQVIGKGH FGIVYHGEYV DSSQNRIHCA IKSLNRITEI EEVEEFLREG LLMRSFCHPH 60

VLSLIGILLP PEGLPRVVLP YMKHGDLRHF IRSPERNPTV KDLIGFGLQV ARGMAYLAEK 120

KFVHRDLAAR NCMLDETFTV KVADFGLARD ILDKEYYSVR RHRHARLPVK WMALESLQTH 180

KFTTKSDVWS FGVLLWELLT RGASPYPNID PFDIAHFLAK GRRLPQPEYC PDALYEVMLQ 240

CWNAVPTERP TFGVLVRE 258

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013