EKS-MOD-00072

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00072

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	212.5	8.1E-63	470	634	165

Status

Unreviewed

Ensembl Protein

ENSMODP00000015834

UniProt Accession

F6VYH1;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK13

Gene Synonyms/Alias

CDK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000012657	ENSMODP00000015834	ENSMODT00000016125

Organism

Monodelphis domestica

Functional Description

Protein Length

1268

Protein Sequence
(FASTA)

RSKERHREHR RRDAQRAGTG EASAKARGRH GHGDDRASEA SAKGSGSGGS SGRRKSASGS 60

SGRKERDSKA HRSRTKAVKE PPSAYKEPPR AYRDDKSEPK AYRRRPRSPS PPGSRDDAAS 120

RGRNPYSRRG PRSPSPYSRR RSPSYSRHSS YERGGDVSPS PYGSSSWRRS RSPYSPAVSR 180

RSAKSRSRSP YSSRHSRSRS RHRLSRSRSR HSSISPSTLT LKSSLAAELN KNKKARAAEA 240

AKAHAKASNT STPTKVGSTD PAGVGSTPQA NHVKELKKLK AEHTPSPTSG GTLKNDKAKV 300

KPALQVAKVE NNLIVDKATK KGTVVGKESQ PATAAAVKEE PGVLKEKSKP RTPSLGSTKE 360

KEHHGPLVTS TLPPLPFPPL LPEDKEADSL RGNISVKAVK KEVEKKLRCL LADLPLPPEL 420

PGGEDFSTSP EEKKASAPTH SKRRPKICGP RYGEIKEKDI DWGKRCVDKF DIIGIIGEGT 480

YGQVYKARDK DTGEMVALKK VRLDNEKEGF PITAIREIKI LRQLTHQSII NMKEIVTDKE 540

DALDFKKDKG AFYLVFEYMD HDLMGLLESG LVHFNENHIK SFMRQLMEGL DYCHKKNFLH 600

RDIKCSNILL NNRGQIKLAD FGLARLYSSE ERTTDLESTS PIITPSNHVT KQLFSFGIFP 660

PTVFPLNVDS VLSRRFLQLF RITALPLMEK SITFDCATMY PSVYDVLLTS EMGRKKKEEM 720

KMRRGWPFGQ GCREDLASRP GLLRGSRVPH AAPLVSFQGG GQSQDSESSE PLSPAASDSR 780

RAWAVQMAAL REQEEPRLGR PRRGQAGLSM RSLVSSTSRL PRGAGGGAHA ADETCGTGRR 840

AAGLSSSSSE LTSQRGPLEL DLGWPLPNAP GGRLGGVVRV PLTQPHLLAG ILATGDKATD 900

PPTPQQESSK QPGAGMLPAS GQPGPPKVET DAAQAAVQSA FAVLLSQLIK AQQSKQKDAA 960

AAMEEKENGA GHELSLQLRQ PPEPSPPLLG QDEHVKHTEM RMLELSPEPE RPRILPPDQR 1020

PPEPPEPPPS SEEDLDYRTE NQHVPTPSSS LTDPHAGVKA ALLQLLAQHQ TQDDPKMETS 1080

MDYQAGDTYV PSSDYKDNFA SSSFSYVNDG LGSGSVPALE RRSFIGNSDI QSLETYSTAS 1140

SHSGGPPQPP AFSESFSSSV AGYGDIYLNT GSMLFSGDKD HRFEYSHGPI AVLANSSDPA 1200

TGPESTHSLP AKMHSYNYGG NLQESPVGPG LLHGQTWPSP AQGPGYSQGY RGHISTSTSR 1260

GRGRGLPY 1268

Nucleotide Sequence
(FASTA)

CGCAGCAAGG AACGGCACCG CGAGCACCGG CGCCGGGACG CGCAGCGCGC CGGGACCGGG 60

GAGGCCTCGG CCAAGGCCCG CGGCCGCCAC GGCCACGGCG ACGACCGCGC GTCCGAGGCC 120

TCTGCCAAGG GCAGCGGCAG TGGGGGCAGC AGCGGGCGCC GCAAGAGCGC TTCGGGCTCG 180

TCGGGCCGCA AGGAGCGGGA CTCGAAGGCG CATCGCAGCC GGACTAAGGC GGTCAAGGAG 240

CCGCCTTCGG CCTACAAGGA GCCGCCGCGG GCCTACCGCG ACGACAAGAG CGAGCCCAAG 300

GCCTACCGGC GCCGCCCGCG CTCGCCAAGC CCGCCTGGCT CCCGAGACGA CGCCGCCTCG 360

CGCGGCCGCA ACCCATACTC GCGGCGCGGC CCGCGCTCAC CTAGTCCCTA TAGCCGCCGC 420

CGCTCGCCCA GTTACAGCCG CCACAGCTCC TATGAGCGCG GCGGAGACGT GTCACCCAGC 480

CCGTATGGCA GCAGCAGCTG GCGCCGCTCC AGAAGCCCCT ACAGTCCGGC TGTCAGCAGA 540

CGATCTGCCA AGTCTCGAAG CAGAAGCCCT TACTCATCTA GGCATTCGAG GTCCCGCAGC 600

AGGCATAGAT TATCTAGGTC CCGGAGTCGG CACTCTAGTA TTTCTCCTAG TACCCTGACT 660

CTCAAGAGTA GCCTGGCTGC TGAGCTGAAC AAGAACAAGA AAGCCAGGGC TGCAGAAGCA 720

GCCAAAGCTC ACGCCAAAGC ATCCAACACC TCGACTCCAA CCAAAGTGGG GAGCACAGAT 780

CCTGCAGGTG TGGGCAGCAC GCCTCAAGCC AACCATGTGA AGGAGTTGAA AAAGCTCAAG 840

GCTGAACACA CACCGTCTCC CACCAGTGGT GGGACTCTGA AAAATGACAA GGCAAAAGTG 900

AAGCCTGCTC TGCAGGTGGC AAAGGTGGAA AATAACTTGA TTGTGGACAA AGCCACCAAG 960

AAAGGCACTG TGGTGGGCAA GGAGAGTCAG CCAGCTACTG CTGCTGCTGT GAAGGAGGAG 1020

CCTGGGGTGC TGAAAGAGAA AAGCAAACCT CGCACTCCGA GCTTAGGCAG CACCAAGGAG 1080

AAGGAGCATC ATGGGCCACT GGTGACTTCC ACCTTACCCC CTTTGCCTTT TCCTCCCCTA 1140

CTGCCTGAAG ACAAAGAGGC GGACAGTTTA CGAGGGAATA TTTCAGTAAA GGCGGTGAAA 1200

AAAGAAGTTG AGAAGAAACT TCGCTGTCTG CTTGCAGACC TGCCTCTGCC CCCTGAGCTC 1260

CCAGGAGGGG AGGACTTCTC CACGAGCCCT GAGGAGAAGA AAGCCTCTGC TCCTACGCAC 1320

AGTAAGAGAA GGCCCAAAAT ATGTGGGCCT CGCTATGGTG AAATAAAAGA AAAGGATATT 1380

GACTGGGGAA AGCGCTGCGT GGATAAATTT GATATCATTG GAATTATTGG AGAAGGCACC 1440

TATGGGCAAG TTTACAAAGC CAGGGATAAA GATACAGGAG AAATGGTGGC CTTAAAAAAA 1500

GTCCGGCTGG ATAACGAAAA GGAAGGCTTC CCCATCACAG CCATCAGAGA GATTAAGATT 1560

CTCCGGCAGC TTACCCACCA GAGTATTATC AACATGAAGG AAATTGTGAC TGACAAAGAA 1620

GATGCTTTAG ATTTTAAGAA GGACAAAGGT GCATTTTATT TGGTGTTTGA ATACATGGAC 1680

CATGACCTGA TGGGACTCCT TGAATCAGGC CTGGTTCATT TTAACGAAAA TCACATAAAG 1740

TCATTCATGA GACAACTGAT GGAGGGTTTG GATTATTGCC ATAAGAAGAA CTTTTTACAT 1800

AGAGATATTA AGTGTTCAAA TATTCTGCTA AACAATAGAG GGCAGATAAA GCTAGCAGAT 1860

TTTGGACTTG CTCGATTATA TAGCTCAGAA GAAAGAACCA CTGATTTAGA GTCTACATCC 1920

CCAATCATAA CCCCATCAAA CCATGTGACC AAGCAGTTGT TTTCCTTTGG CATTTTTCCT 1980

CCCACAGTGT TTCCTCTGAA TGTGGATAGT GTTCTTTCTC GTAGATTCCT CCAGTTGTTC 2040

AGGATCACTG CATTGCCGCT AATGGAGAAG TCCATTACAT TCGATTGTGC TACAATGTAT 2100

CCATCTGTGT ACGATGTTCT CCTGACAAGT GAGATGGGAA GGAAAAAAAA GGAAGAAATG 2160

AAGATGAGAA GGGGCTGGCC CTTTGGCCAG GGCTGCAGAG AGGACCTCGC CAGCCGGCCA 2220

GGCTTGTTGA GGGGTTCCCG TGTGCCCCAC GCCGCTCCCC TTGTCTCGTT CCAGGGTGGA 2280

GGGCAGAGCC AGGACTCAGA GAGCAGTGAG CCTTTGAGTC CGGCCGCCAG CGACTCCCGC 2340

CGGGCATGGG CCGTGCAGAT GGCTGCCCTG AGGGAGCAGG AGGAGCCCAG GCTGGGGCGC 2400

CCTCGGAGGG GACAGGCGGG CCTGTCCATG CGGAGTTTAG TCAGCTCCAC CTCGAGGCTC 2460

CCTCGGGGCG CCGGTGGCGG CGCTCACGCC GCTGACGAGA CTTGTGGGAC AGGCAGGCGG 2520

GCGGCGGGGC TGTCCTCCTC CTCCTCAGAA TTGACCTCCC AGCGGGGCCC GTTAGAGCTC 2580

GACCTCGGCT GGCCTCTCCC CAACGCTCCG GGAGGCCGAC TTGGGGGCGT CGTCCGGGTG 2640

CCGCTCACTC AACCCCACCT TCTCGCTGGC ATTTTGGCAA CAGGTGACAA AGCGACCGAC 2700

CCGCCCACCC CCCAGCAGGA GTCTTCCAAG CAGCCCGGAG CCGGGATGCT GCCGGCGTCC 2760

GGCCAGCCCG GGCCGCCCAA GGTGGAGACG GATGCGGCCC AGGCCGCCGT GCAGAGCGCC 2820

TTTGCAGTCT TGCTGTCCCA GCTCATAAAG GCGCAGCAGT CCAAGCAGAA GGACGCCGCG 2880

GCGGCCATGG AAGAGAAGGA GAACGGAGCC GGCCACGAGC TCTCTCTGCA GCTGCGGCAG 2940

CCCCCCGAGC CCAGCCCTCC TCTCCTCGGG CAAGACGAAC ATGTCAAACA CACAGAGATG 3000

AGGATGCTGG AACTAAGCCC AGAACCAGAG CGCCCACGAA TCCTGCCTCC AGACCAGCGC 3060

CCCCCCGAAC CCCCTGAGCC ACCACCCTCT TCGGAAGAAG ATCTAGATTA TCGGACAGAA 3120

AACCAGCATG TGCCCACGCC TAGTTCTTCA TTGACTGACC CTCATGCTGG AGTGAAGGCT 3180

GCTTTGTTGC AGCTCCTTGC CCAACATCAG ACCCAGGATG ACCCCAAAAT GGAAACAAGT 3240

ATGGATTACC AAGCAGGAGA TACCTATGTT CCAAGTTCAG ACTACAAGGA TAATTTTGCA 3300

TCTTCTTCTT TCTCTTACGT TAACGACGGT TTAGGAAGTG GATCTGTTCC AGCCCTAGAA 3360

AGACGAAGCT TCATTGGCAA CTCAGATATA CAGTCTCTGG AGACCTACAG CACGGCTTCA 3420

TCTCATTCTG GGGGCCCCCC TCAGCCGCCT GCCTTTTCAG AATCCTTCTC CAGCTCAGTA 3480

GCTGGGTATG GAGACATTTA CCTCAACACT GGTTCCATGT TGTTTAGTGG AGATAAGGAC 3540

CATAGATTTG AGTATAGTCA TGGCCCAATC GCAGTTCTGG CCAATAGTAG TGACCCTGCT 3600

ACAGGGCCTG AGAGCACTCA CTCTTTGCCA GCCAAGATGC ACAGCTACAA CTATGGGGGC 3660

AATTTGCAGG AAAGCCCAGT GGGCCCTGGC CTTCTGCATG GACAGACTTG GCCTTCCCCT 3720

GCCCAGGGCC CTGGCTATTC CCAAGGATAC AGGGGACACA TTAGCACATC TACAAGCAGA 3780

GGGCGAGGCA GAGGGTTGCC ATACTGA 3807

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vyka+dk+tge+vAlKk+rl++ekeg+pita+rEi++l++l+h+ i

Q: 470   FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSI  529

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         ++++e+v+         kdk  +yLvfe++++dL+ ll++    +++++++ks+++ql+e

Q: 530   INMKEIVTdkedaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFNENHIKSFMRQLME  588

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplkty  157

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++t

Q: 589   GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEERTT  634

         ***************************************9998853

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKARD KDTGEMVALK KVRLDNEKEG FPITAIREIK ILRQLTHQSI 60

INMKEIVTDK EDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFNENHI KSFMRQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYSS EERTT 165

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0019908	; C:nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0016607	; C:nuclear speck
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0000380	; P:alternative mRNA splicing, via spliceosome
GO:0030097	; P:hemopoiesis
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013