EKS-MOD-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	466.8	2.7E-140	254	541	288

Status

Unreviewed

Ensembl Protein

ENSMODP00000015863

UniProt Accession

F6VGC3;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000012679	ENSMODP00000015863	ENSMODT00000016155

Organism

Monodelphis domestica

Functional Description

Protein Length

552

Protein Sequence
(FASTA)

MEGPPSSSYK GAERGRGARL GSVVPRGGGT ETRPRPLERT GRGRGTMEAP AAVTGKITVP 60

PRYQMFLLLA ATGLVPGAAG LQCFCHLCIK ENYTCVTDGL CFVAATQSAD KVIYNSMCIP 120

EADLVPRDRP FICAPSLKDG FLMSPFCCAK DHCNKIEFPT GTPVKPSPNL GPVELAAVIA 180

GPVCLVCISL MLMIYICHNR TVIHHRVPNE EDPSLDRPFI SEGTTLKDLI YDMTTSGSGS 240

GLPLLVQRTI ARTIVLQESI GKGRFGEVWR GKWRGEEVAV KIFSSREERS WFREAEIYQT 300

VMLRHENILG FIAADNKDNG TWTQLWLVSD YHEHGSLFDY LNRYTVTVEG MIKLALSTAS 360

GLAHLHMEIV GTQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVRHDSA TDTIDIAPNH 420

RVGTKRYMAP EVLDDSINMK HFESFKRADI YAMGLVFWEI ARRCSIGGIH EDYQLPYYDL 480

VPSDPSVEEM RKVVCEQKLR PNIPNRWQSC EALRVMAKIM RECWYANGAA RLTALRIKKT 540

LSQLSQQEGI KM 552

Nucleotide Sequence
(FASTA)

ATGGAAGGGC CACCCTCGAG CAGTTACAAA GGGGCCGAAC GAGGCCGCGG CGCGAGGCTC 60

GGCTCGGTGG TTCCTCGGGG CGGGGGCACC GAGACGCGGC CCCGGCCCCT TGAACGGACC 120

GGACGGGGAC GCGGGACCAT GGAGGCGCCC GCGGCCGTCA CAGGGAAGAT AACCGTCCCT 180

CCTCGCTACC AGATGTTTCT CCTTCTGGCA GCCACGGGGC TGGTCCCAGG GGCCGCGGGT 240

TTGCAGTGTT TCTGCCACCT CTGTATTAAA GAAAATTACA CATGTGTGAC AGATGGACTT 300

TGCTTTGTTG CTGCAACACA AAGTGCAGAT AAAGTTATAT ATAATAGCAT GTGTATACCA 360

GAAGCTGATT TAGTTCCTCG AGATAGGCCA TTTATATGTG CCCCCTCTTT AAAAGATGGA 420

TTTTTGATGT CACCTTTCTG TTGTGCCAAA GACCACTGCA ATAAAATAGA ATTCCCAACA 480

GGTACCCCAG TGAAACCATC TCCTAATCTT GGTCCTGTGG AATTGGCAGC TGTTATTGCC 540

GGACCTGTCT GCCTTGTCTG TATTTCATTG ATGTTGATGA TCTATATTTG CCACAATCGT 600

ACTGTTATAC ATCATCGTGT TCCAAATGAA GAAGATCCCT CTTTGGATCG CCCTTTTATT 660

TCAGAGGGTA CAACGTTAAA GGACCTAATT TATGACATGA CAACATCTGG ATCTGGGTCA 720

GGATTACCAT TACTTGTTCA AAGAACTATT GCAAGAACTA TCGTATTGCA AGAAAGCATA 780

GGGAAAGGTC GATTTGGAGA AGTCTGGAGA GGAAAATGGA GAGGAGAAGA AGTTGCAGTC 840

AAAATATTTT CCTCAAGAGA AGAACGTTCT TGGTTCCGTG AGGCAGAGAT TTATCAAACT 900

GTAATGTTAC GTCATGAAAA CATTCTGGGA TTTATAGCAG CTGACAATAA AGACAATGGT 960

ACGTGGACTC AGTTGTGGTT GGTTTCAGAT TATCATGAGC ATGGGTCCCT TTTTGATTAC 1020

TTAAACAGAT ACACGGTTAC TGTGGAAGGA ATGATCAAAC TAGCTTTATC TACTGCTAGT 1080

GGACTTGCAC ATCTTCACAT GGAGATTGTG GGCACTCAAG GCAAACCAGC AATTGCTCAT 1140

AGAGACCTGA AATCAAAGAA TATTTTAGTA AAGAAGAATG GAACATGCTG TATTGCAGAC 1200

TTAGGACTTG CAGTAAGACA TGATTCAGCC ACAGACACAA TTGATATAGC TCCAAACCAC 1260

AGAGTGGGAA CAAAAAGGTA CATGGCCCCT GAAGTTCTCG ATGATTCCAT AAACATGAAA 1320

CACTTTGAAT CATTCAAACG TGCTGACATC TATGCAATGG GATTAGTTTT TTGGGAAATA 1380

GCTCGGAGAT GTTCGATTGG TGGAATTCAT GAAGACTACC AGCTGCCTTA TTATGATCTT 1440

GTACCTTCTG ATCCATCAGT AGAAGAAATG CGGAAAGTAG TTTGTGAACA GAAGTTACGG 1500

CCAAATATTC CAAATCGATG GCAGAGTTGT GAAGCTTTGA GAGTGATGGC CAAAATTATG 1560

CGAGAATGTT GGTATGCCAA TGGAGCAGCT AGGCTTACAG CTTTACGTAT TAAGAAGACA 1620

TTATCACAGC TCAGTCAACA AGAGGGCATA AAAATGTAG 1659

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 254   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  313

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 314   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  373

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 374   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  431

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 432   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  490

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 491   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  541

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013