EKS-MOD-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	536.0	1.5E-161	998	1265	268

Status

Unreviewed

Ensembl Protein

ENSMODP00000015969

UniProt Accession

F6SJA3;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R

Gene Synonyms/Alias

IGF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000012761	ENSMODP00000015969	ENSMODT00000016263

Organism

Monodelphis domestica

Functional Description

Protein Length

1361

Protein Sequence
(FASTA)

AGRGSPTSLW GLLFLFSTLC LWPTNGEICG PHIDIRNEIQ ELKRLENCTV IEGYLRILLI 60

SKAEDYRNFR FPKLTVITDY LLLFRVAGLE SLSDLFPNLT VIRGKNLFYN YALVIFEMTN 120

LKEIGLYNLR NITRGAIRIE KNSELCYLST VDWSLILDAV SNNYIVGNKN PKECGDLCPG 180

TMEEKPLCEK TTINNEYSFR CWTTNHCQKM CPSSCGKRAC TDQNECCHPE CLGSCSAPDN 240

NTACVACRHY YYAGTCVPTC PPNTYKFEGW RCVDKDFCAS VLSAETSEFE KFVIHNDECM 300

QECPSGFIRN GSQSMYCSPC EGPCPKVCEG EKKTKTIDSV TSAQMLQGCT VFKGNLLINI 360

RRGNNIASEL ENFMGLIETV TGYVKIRHSH ALVSLSFLKN LRYILGEEQL EGNYSFYVLD 420

NQNLQQLWDW NLHNLTIKEG KMYFAFNPKL CVSEIYRMEE VSGTKGRQSK GDINTRNNGE 480

RASCESDVLH FISNTTMKNR IKLTWQRYRP PDYRDLISFT VYFKEAPFKN VTEYDGQDAC 540

GSNSWNMVDV DLPPNKDVKP GILLQGLKPW TQYAIYVKAV TLTMVENDHI RGAKSEIVYI 600

RTKAAVPSIP LDVISASNSS SQLIVKWNPP SLPNGNLSYY IVRWQRQPQD SYLYRHNYCS 660

KDKVPIRKYA DGTIDVEEVT ENPKTEVCGG EKGPCCACPK TEAEKQAEKE EAEYRKVFEN 720

FLHNSIFVPR PERRRRDVFQ IANSTMPSRN RNTTVADHFT NMSDAEEIET EYPFFESRVD 780

NKERTLISHL RPFTLYRIDI HSCNHEADTL GCSASNFVFA RTMPAEGADN IPGPVLWEER 840

PDNTVHLKWP EPENPNGLIL MYEIKYGQQV EDQRECISRQ EYRKFGGAKL TRLNPGNYSA 900

RVQATSLSGN GSWTDPVFFY VPPKTGQDYE NFLHLMIALP IAGLFIVGGL LIMWYVFNKK 960

RNSDRLGNGV LYASVNPEYF SAADVYVPDE WEVPREKITM SRELGQGSFG MVYEGTAKGV 1020

VKDEPETRVA IKTVNEAASM RERIEFLNEA SVMKEFNCHH VVRLLGVVSQ GQPTLVIMEL 1080

MTRGDLKSYL RSLRPETENN PCQMLPTLKK MIQMAGEIAD GMAYLNANKF VHRDLAARNC 1140

MVAEDFTVKI GDFGMTRDIY ETDYYRKGGK GLLPVRWMSP ESLKDGVFTT HSDVWSFGVV 1200

LWEIATLAEQ PYQGMSNEQV LRFVMEGGLL EKPDNCPDML FELMRMCWQY NPKMRPSFLE 1260

IIGSIKDELD PGFKEVSFFY SEENKPPDTE ELDLETENME SIPLDPSSTL QPADKHSGHK 1320

AENGPGVVVL RASFDERQPY AHMNGGRKNE RALPLPQSSA C 1361

Nucleotide Sequence
(FASTA)

GCCGGAAGAG GGTCCCCGAC CTCACTTTGG GGGCTTCTGT TTCTCTTTTC CACACTTTGC 60

CTTTGGCCAA CAAATGGAGA AATTTGTGGG CCACACATTG ACATTCGTAA TGAAATCCAG 120

GAGTTGAAGC GACTAGAAAA CTGCACAGTG ATTGAGGGCT ACCTCCGAAT TCTACTGATC 180

TCTAAGGCAG AGGACTACCG GAACTTCCGT TTTCCAAAGC TCACGGTCAT CACCGACTAC 240

TTGCTGCTTT TTCGCGTGGC AGGCTTGGAG AGCCTTAGTG ACCTCTTCCC TAACCTTACA 300

GTCATCCGAG GGAAAAACCT TTTTTATAAC TATGCCTTGG TGATCTTTGA AATGACAAAT 360

CTCAAAGAGA TCGGGCTCTA TAACCTTAGG AATATCACTC GGGGGGCCAT CAGGATTGAG 420

AAGAATTCAG AACTCTGTTA CCTCTCCACT GTGGACTGGT CTTTGATTCT GGATGCTGTT 480

TCTAACAACT ATATTGTGGG AAATAAAAAC CCAAAGGAGT GTGGGGACCT TTGTCCGGGG 540

ACAATGGAAG AGAAGCCATT GTGTGAAAAG ACAACCATTA ATAATGAGTA CAGCTTCCGC 600

TGCTGGACCA CAAACCACTG TCAGAAAATG TGTCCTAGCT CATGTGGAAA GCGGGCTTGC 660

ACAGACCAGA ATGAATGCTG CCACCCCGAG TGCTTGGGAA GCTGTAGTGC CCCAGACAAC 720

AACACAGCCT GTGTGGCTTG CCGCCATTAC TACTACGCGG GCACTTGTGT GCCCACCTGC 780

CCTCCTAACA CTTACAAGTT TGAGGGTTGG CGGTGTGTTG ACAAAGACTT CTGTGCCAGC 840

GTTCTCAGTG CTGAAACCAG CGAATTTGAA AAGTTTGTGA TCCACAATGA TGAGTGCATG 900

CAGGAGTGTC CCTCTGGGTT CATACGGAAT GGGAGCCAAA GTATGTACTG CAGCCCCTGT 960

GAAGGCCCTT GCCCTAAAGT CTGTGAGGGG GAAAAGAAGA CGAAGACAAT TGATTCTGTA 1020

ACTTCAGCAC AAATGCTGCA GGGATGCACT GTCTTCAAAG GCAATTTGCT CATTAATATC 1080

CGACGAGGCA ATAACATAGC CTCTGAACTG GAGAATTTCA TGGGCTTGAT TGAGACTGTT 1140

ACAGGATATG TGAAGATTCG CCATTCACAT GCCTTAGTCT CTCTGTCTTT CTTGAAAAAT 1200

CTACGCTATA TTTTAGGAGA AGAACAGCTG GAAGGGAATT ACTCTTTCTA CGTCCTTGAT 1260

AACCAGAATT TGCAGCAGTT ATGGGACTGG AACCTCCATA ATCTGACAAT CAAAGAAGGG 1320

AAAATGTACT TTGCTTTTAA TCCCAAATTG TGTGTTTCTG AAATTTATCG AATGGAGGAA 1380

GTGTCAGGAA CTAAAGGTCG CCAGAGCAAA GGGGACATAA ACACTAGGAA CAATGGAGAA 1440

AGAGCCTCTT GTGAAAGTGA CGTTTTGCAT TTCATTTCCA ACACTACAAT GAAGAACCGG 1500

ATTAAGCTAA CATGGCAACG GTATCGTCCT CCTGATTACA GGGATCTTAT TAGCTTTACT 1560

GTTTACTTCA AAGAGGCACC ATTCAAGAAT GTCACTGAGT ATGACGGACA AGATGCATGT 1620

GGCTCTAATA GCTGGAATAT GGTTGATGTG GACCTCCCTC CAAATAAAGA TGTCAAACCT 1680

GGAATTTTAC TGCAGGGATT GAAACCTTGG ACCCAGTATG CTATCTACGT CAAAGCAGTT 1740

ACTCTCACAA TGGTGGAGAA TGACCACATC CGGGGAGCAA AAAGTGAAAT TGTGTATATT 1800

CGTACCAAAG CTGCAGTTCC TTCTATTCCC TTGGATGTTA TTTCAGCATC TAATTCGTCC 1860

TCCCAGCTCA TTGTGAAGTG GAATCCTCCT TCCCTCCCAA ATGGTAACTT GTCTTACTAC 1920

ATAGTAAGAT GGCAGCGACA GCCTCAAGAT AGTTACCTCT ACCGACACAA TTATTGTTCC 1980

AAAGACAAAG TCCCTATTAG AAAATACGCT GATGGGACCA TTGACGTTGA AGAGGTTACT 2040

GAAAATCCTA AAACCGAAGT CTGTGGTGGG GAGAAAGGAC CTTGCTGTGC TTGTCCTAAG 2100

ACGGAGGCCG AGAAGCAGGC AGAAAAAGAA GAGGCCGAGT ACAGAAAAGT CTTCGAGAAT 2160

TTTCTGCACA ATTCTATCTT TGTACCCAGA CCTGAAAGGA GGCGGAGGGA TGTCTTCCAA 2220

ATTGCCAATT CTACGATGCC CAGTCGGAAC AGGAACACTA CAGTGGCTGA TCACTTCACC 2280

AACATGTCAG ACGCAGAAGA GATTGAAACA GAATACCCAT TCTTTGAGAG CCGAGTGGAT 2340

AATAAAGAGA GGACTTTAAT TTCTCATCTC AGGCCTTTTA CTTTGTACCG AATTGATATT 2400

CATAGTTGCA ACCATGAAGC TGACACTCTT GGCTGCAGTG CTTCTAACTT TGTCTTTGCC 2460

AGGACCATGC CAGCAGAAGG GGCAGATAAT ATTCCTGGGC CCGTGCTGTG GGAAGAAAGG 2520

CCAGATAATA CTGTCCACTT GAAGTGGCCA GAACCTGAAA ATCCCAATGG ACTGATATTA 2580

ATGTATGAAA TAAAGTATGG TCAGCAAGTA GAGGATCAGC GGGAATGTAT TTCCAGACAG 2640

GAATACAGGA AATTTGGAGG GGCCAAGCTT ACACGGCTGA ACCCTGGGAA CTATTCAGCC 2700

CGTGTTCAGG CCACCTCTCT TTCTGGGAAT GGATCATGGA CTGACCCTGT ATTCTTCTAT 2760

GTCCCACCCA AAACAGGACA AGACTATGAA AACTTCCTTC ACTTAATGAT TGCTCTCCCT 2820

ATCGCAGGAT TATTTATAGT TGGTGGGTTG CTGATAATGT GGTATGTCTT CAATAAAAAA 2880

AGAAACAGTG ACAGATTAGG GAATGGAGTT CTATATGCAT CTGTCAATCC AGAGTACTTC 2940

AGTGCTGCAG ATGTATATGT TCCAGATGAA TGGGAGGTAC CTCGAGAGAA GATCACCATG 3000

AGCCGAGAAC TTGGGCAGGG TTCATTTGGG ATGGTATATG AGGGAACTGC TAAAGGAGTG 3060

GTGAAAGATG AGCCTGAAAC CAGGGTTGCC ATCAAAACAG TCAATGAGGC AGCAAGCATG 3120

CGAGAGAGAA TTGAATTTCT CAATGAAGCT TCAGTAATGA AAGAATTCAA TTGTCATCAT 3180

GTGGTGCGGT TGCTTGGGGT AGTGTCCCAG GGACAGCCAA CGTTGGTCAT CATGGAATTG 3240

ATGACAAGAG GGGATCTCAA AAGTTACCTC CGATCTCTGA GGCCAGAGAC AGAGAATAAT 3300

CCATGCCAGA TGCTTCCAAC CTTAAAGAAG ATGATTCAGA TGGCTGGAGA GATTGCTGAT 3360

GGCATGGCAT ATCTCAATGC CAACAAGTTT GTCCACAGGG ATCTGGCTGC AAGGAATTGC 3420

ATGGTTGCCG AAGATTTCAC AGTCAAAATC GGAGATTTTG GTATGACAAG AGATATCTAT 3480

GAGACAGATT ACTACCGAAA AGGAGGTAAA GGATTATTAC CTGTTCGATG GATGTCTCCA 3540

GAGTCACTTA AGGATGGAGT CTTCACAACC CATTCTGATG TTTGGTCCTT TGGTGTTGTC 3600

CTCTGGGAGA TTGCAACATT AGCAGAGCAG CCCTATCAGG GCATGTCTAA TGAACAAGTT 3660

CTCCGGTTTG TTATGGAGGG TGGCCTTCTA GAGAAACCAG ACAACTGCCC CGATATGCTG 3720

TTTGAATTGA TGCGTATGTG TTGGCAGTAC AATCCCAAAA TGAGACCTTC TTTTCTGGAG 3780

ATCATTGGCA GCATCAAAGA TGAGCTGGAC CCAGGCTTCA AGGAGGTCTC CTTCTTCTAC 3840

AGTGAAGAGA ACAAGCCTCC AGACACGGAA GAGTTGGACC TAGAGACTGA GAACATGGAG 3900

AGCATTCCCT TAGACCCTTC CTCCACCCTC CAGCCGGCTG ACAAACACTC AGGACATAAA 3960

GCCGAGAATG GGCCTGGTGT GGTGGTCCTC AGGGCCAGCT TTGATGAAAG GCAGCCTTAT 4020

GCGCACATGA ATGGAGGACG CAAGAACGAA AGGGCCTTAC CTTTGCCCCA GTCTTCAGCC 4080

TGC 4083

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeG+ak+vvk+e etrvaiktvneaas+reriefl+easvmkef+

Q: 998   ITMSRELGQGSFGMVYEGTAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFN  1057

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrpe+en++    p+l+k+iqma+e

Q: 1058  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPETENNPCQMLPTLKKMIQMAGE  1117

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1118  IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1177

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqG+sneqvl+fv++gg+lekp+ncp

Q: 1178  MSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLEKPDNCP  1237

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rpsflei+ ++

Q: 1238  DMLFELMRMCWQYNPKMRPSFLEIIGSI  1265

         ************************9875

Domain Sequence
(FASTA)

ITMSRELGQG SFGMVYEGTA KGVVKDEPET RVAIKTVNEA ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPET ENNPCQMLPT LKKMIQMAGE 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTHSDVWSF GVVLWEIATL AEQPYQGMSN EQVLRFVMEG GLLEKPDNCP 240

DMLFELMRMC WQYNPKMRPS FLEIIGSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0043559	; F:insulin binding
GO:0005010	; F:insulin-like growth factor-activated receptor activity
GO:0007420	; P:brain development
GO:0031017	; P:exocrine pancreas development
GO:0006955	; P:immune response
GO:0051389	; P:inactivation of MAPKK activity
GO:0048009	; P:insulin-like growth factor receptor signaling pathway
GO:0030238	; P:male sex determination
GO:0030879	; P:mammary gland development
GO:0043066	; P:negative regulation of apoptotic process
GO:0051898	; P:negative regulation of protein kinase B signaling cascade
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0030335	; P:positive regulation of cell migration
GO:0045740	; P:positive regulation of DNA replication
GO:0043410	; P:positive regulation of MAPK cascade
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060740	; P:prostate gland epithelium morphogenesis
GO:0046777	; P:protein autophosphorylation
GO:0051262	; P:protein tetramerization
GO:0046328	; P:regulation of JNK cascade

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013