EKS-MOD-00061

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00061

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	372.2	1.7E-111	736	1029	294

Status

Unreviewed

Ensembl Protein

ENSMODP00000015980

UniProt Accession

F6S1K8;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100017594

Gene Synonyms/Alias

LOC100017594;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000012772	ENSMODP00000015980	ENSMODT00000016274

Organism

Monodelphis domestica

Functional Description

Protein Length

1395

Protein Sequence
(FASTA)

MPNPERHGGK KDGGGGSSGA MQPSSLGGGG SSNSRERHRL VSKHKRHKSK HSKDIGSLAP 60

EAAPLSTMIK PLVEYDDISS DSDTFSDDMA FKLERRDNDD RRGTDRSDRL HKHRHHQHRR 120

IRELLKTKQI EKEKKVEKNQ EVSSKSMSTK DRVSGTSKRL NEENDEYGKA LVSKSSSNKE 180

SRSAKFHKEK TRKERELKSG HKDRSKSHRK RDPPKSYKSI DSPKRRSRSP HRKWSDSPKQ 240

DDSPSGASYS QEYDVSPPRS HTSSNYDSYK KSPGGSSRRQ SISPPYREPS AYQSSTRSPS 300

PYSRRQRSVS PYNRRRSSSY ERGSGSYSGR SPSPYSRRRS SSPFVTKRSV SRSPLPRKSV 360

KSRSRSPVYS RHSSSHSKKK RSGSRSRHSS ISPTRLPLNS SLGAELSRKK KERAAAAAAA 420

KVDGKEVKGS PVILPKKENI SGETKESSLE SKKLSRVLKS EKSASDTELV NLAHLNTEMK 480

TSLDPGKVKL DENSEKKHLV PTKDLKSQGS KDSKPIALKE EIVAPKESET MEKEVPPPLP 540

TITSPPPLPT TTPPPQTPPL PPLPPLPAVP HQPPLPPLQP TFSQVTTSVT PTLSSSTHPR 600

TSALSSQANS QPLVQVSLKT QVSLTAAIPH LKTSTLPPLP LPPLLLGEDD LDSPKESLPP 660

KPMKKEKEQR TRHLLMDLPL PPELPGGDPS PPDSPEPKAA TPPQQPYKKR PKICCPRYGE 720

RRQTESDWGK RCVDKFDIIG IIGEGTYGQV YKAKDKDTGE LVALKKVRLD NEKEGFPITA 780

IREIKILRQL IHRSVVNMKE IVTDKQDALD FKKDKGAFYL VFEYMDHDLM GLLESGLVHF 840

SEDHIKSFMK QLMEGLDYCH KKNFLHRDIK CSNILLNNSG QIKLADFGLA RLYSSEESRP 900

YTNKVITLWY RPPELLLGEE RYTPAIDVWS CGCILGELFT KKPIFQANLE LAQLELISRL 960

CGSPCPAVWP DVIKLPYFNT MKPKKQYRRR LREEFSFIPL AALDLLDHML TLDPNKRCTA 1020

EQALQSDFLR DVELSKMAPP DLPHWQDCHE LWSKKRRRQR QSGIVVEEPP LSKTSRKETT 1080

SGANVEPVKN NSPAPPQPAP VKVEPGAGDA IGLGDITQQL NQSELAVLLN LLQSQTDLSI 1140

PQMAQLLNVH SNPEMQQQLE ALNQSINALN EATSQHQDSE HVALEETVKE PPPAMVVQPS 1200

TEQTTPEASG TPGDMQNVLA VLLSQLMKTQ EPTGSLEESN GEKSSGPQGP RRTPTIPQEE 1260

AAEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAMTAA LLQLLSQPET EPSGHLPHEH 1320

QALRPMEYST RPHSSRTYGS TEGPETGFSA TDTDERNSGP TLSEPLAQTL AKSRTFSGSV 1380

SHLGESSSYQ GTGTS 1395

Nucleotide Sequence
(FASTA)

ATGCCCAATC CAGAGAGACA TGGGGGCAAG AAGGATGGGG GTGGAGGGAG TTCTGGGGCC 60

ATGCAGCCAT CATCCCTGGG TGGTGGTGGC AGCTCCAACA GCAGAGAGCG GCATAGACTG 120

GTGTCCAAAC ACAAGAGGCA CAAGTCCAAG CACTCCAAAG ACATAGGCTC TCTGGCTCCT 180

GAAGCAGCCC CATTGAGCAC CATGATCAAG CCCCTGGTGG AATACGACGA CATCAGCTCT 240

GATTCAGACA CCTTCTCTGA TGACATGGCC TTCAAGCTAG AGAGAAGAGA TAATGATGAT 300

CGTCGGGGTA CTGATAGGAG TGATCGGCTC CACAAACATC GCCATCACCA GCACAGGAGA 360

ATCAGAGAGC TATTGAAAAC TAAGCAGATA GAGAAGGAAA AGAAAGTAGA AAAAAACCAA 420

GAAGTCTCCA GTAAGTCAAT GTCCACGAAA GACCGAGTAT CTGGGACTTC AAAACGACTG 480

AACGAAGAGA ATGACGAATA TGGAAAGGCA CTGGTATCCA AGAGTAGCAG TAACAAGGAA 540

TCCAGGTCAG CCAAATTCCA TAAGGAGAAA ACTCGAAAAG AACGAGAGTT AAAGTCTGGG 600

CACAAAGACC GTTCTAAAAG TCATCGGAAA AGAGACCCAC CCAAAAGCTA CAAATCCATA 660

GATAGCCCAA AAAGGAGATC CAGGAGCCCT CACAGGAAGT GGTCTGACAG CCCTAAGCAG 720

GATGATAGCC CTTCAGGAGC ATCATACAGC CAGGAATATG ATGTTAGTCC TCCAAGGTCT 780

CATACCTCCA GCAACTATGA CTCCTACAAG AAGAGCCCAG GTGGGTCTTC TCGAAGACAG 840

TCAATTAGCC CACCTTACAG AGAGCCATCG GCCTACCAGT CTAGCACCCG TTCACCTAGT 900

CCATACAGTA GGCGGCAGAG ATCAGTGAGT CCATACAATA GGAGGCGGTC ATCCAGCTAT 960

GAGAGGGGAA GTGGTTCATA CAGTGGGCGA TCGCCTAGTC CCTACAGCCG AAGACGCTCT 1020

AGCAGCCCAT TTGTGACCAA GCGCTCTGTG AGTCGGAGTC CTCTTCCCAG GAAATCAGTG 1080

AAGTCTAGAA GCAGAAGTCC TGTATATTCT AGACATTCAT CTTCCCACAG CAAAAAGAAG 1140

CGATCAGGTT CACGAAGTCG ACATTCTAGT ATTTCACCTA CCAGACTCCC ATTAAACTCC 1200

AGCTTGGGAG CTGAACTCAG CAGGAAGAAA AAGGAAAGGG CAGCTGCAGC AGCTGCTGCA 1260

AAAGTGGATG GAAAGGAGGT GAAGGGGTCA CCTGTAATTT TGCCTAAAAA AGAAAACATC 1320

TCAGGGGAGA CCAAAGAGTC AAGCCTTGAG TCTAAAAAAT TATCTAGAGT TTTAAAATCT 1380

GAAAAATCTG CTTCAGATAC TGAACTGGTA AACTTAGCAC ATCTGAATAC AGAGATGAAA 1440

ACTTCTTTAG ATCCAGGAAA AGTAAAATTG GATGAGAACT CTGAGAAGAA GCATCTTGTT 1500

CCTACTAAAG ACTTGAAATC ACAGGGATCA AAGGACTCTA AACCCATAGC ATTGAAAGAG 1560

GAGATTGTGG CCCCAAAGGA ATCAGAGACA ATGGAAAAGG AGGTTCCTCC ACCTCTCCCC 1620

ACAATTACTT CTCCACCCCC TCTACCAACC ACCACCCCTC CACCTCAGAC GCCCCCTTTG 1680

CCACCTTTAC CTCCGTTACC AGCTGTTCCA CATCAACCAC CTCTGCCACC TCTCCAACCA 1740

ACTTTTAGTC AGGTCACTAC TTCTGTCACC CCAACTTTAT CATCTTCTAC TCACCCGAGG 1800

ACATCTGCTC TATCTTCTCA GGCAAACTCT CAGCCCCTTG TACAGGTTTC TTTGAAGACC 1860

CAGGTGTCAT TGACAGCTGC TATTCCACAC CTGAAAACTT CAACTTTGCC TCCCCTGCCA 1920

CTTCCACCCT TATTACTTGG GGAGGATGAC TTGGATAGTC CAAAGGAGAG TCTTCCTCCA 1980

AAACCTATGA AGAAGGAAAA GGAACAAAGA ACTCGGCATT TGCTCATGGA CCTCCCTCTT 2040

CCTCCAGAGC TCCCCGGTGG TGATCCCTCT CCCCCAGACT CTCCAGAACC AAAGGCTGCC 2100

ACCCCACCTC AACAACCATA TAAAAAGAGA CCAAAAATCT GTTGCCCACG TTATGGGGAA 2160

AGGAGACAAA CAGAAAGTGA TTGGGGGAAG CGCTGTGTGG ACAAGTTTGA CATAATTGGA 2220

ATTATTGGGG AGGGAACATA TGGACAAGTA TACAAAGCCA AGGACAAAGA CACAGGAGAG 2280

CTAGTAGCCC TAAAGAAGGT TCGACTAGAC AACGAGAAAG AAGGCTTCCC AATCACAGCC 2340

ATTCGTGAGA TCAAAATTCT TCGACAGCTG ATCCACAGGA GTGTTGTTAA TATGAAGGAA 2400

ATTGTCACAG ATAAACAAGA TGCACTGGAT TTCAAAAAGG ACAAAGGTGC CTTTTACCTT 2460

GTATTTGAAT ACATGGACCA TGACTTAATG GGGCTGCTAG AGTCTGGATT AGTACATTTT 2520

TCTGAGGACC ACATCAAATC TTTCATGAAA CAGCTAATGG AAGGCTTGGA TTACTGCCAC 2580

AAAAAGAACT TCCTACATCG GGATATTAAA TGTTCCAACA TTTTACTGAA CAACAGTGGA 2640

CAGATCAAGC TGGCAGATTT TGGACTTGCT CGACTCTATA GCTCTGAAGA GAGTCGTCCT 2700

TATACAAATA AAGTCATTAC ATTATGGTAT CGACCACCAG AACTGCTGTT AGGAGAGGAG 2760

CGCTACACAC CAGCCATAGA TGTTTGGAGT TGTGGTTGCA TCCTTGGGGA ACTGTTTACA 2820

AAGAAGCCTA TTTTTCAAGC TAATCTGGAA CTGGCTCAGC TTGAACTAAT CAGTCGGCTC 2880

TGTGGCAGCC CCTGTCCAGC TGTGTGGCCC GATGTTATTA AGCTACCTTA CTTCAACACA 2940

ATGAAACCGA AAAAGCAATA TCGGAGACGT TTGCGTGAGG AATTCTCTTT TATTCCTCTG 3000

GCTGCTCTAG ACTTGCTTGA CCACATGCTG ACACTGGATC CTAACAAGCG CTGCACCGCT 3060

GAGCAGGCCC TGCAGAGTGA CTTTCTTAGA GATGTTGAGC TCAGCAAAAT GGCTCCTCCA 3120

GACCTCCCCC ATTGGCAGGA TTGCCATGAA CTGTGGAGCA AGAAACGGCG ACGGCAGAGG 3180

CAGAGTGGCA TTGTGGTAGA GGAACCACCT TTGTCCAAAA CTTCTCGAAA AGAAACTACC 3240

TCAGGAGCAA ATGTGGAGCC TGTGAAGAAC AACAGCCCAG CACCACCCCA GCCTGCTCCT 3300

GTCAAGGTGG AACCTGGGGC TGGGGATGCA ATAGGCCTTG GTGACATCAC ACAGCAGCTG 3360

AATCAAAGTG AATTGGCAGT GTTACTGAAC CTGCTGCAGA GCCAGACTGA CCTGAGCATC 3420

CCTCAGATGG CACAGCTGCT CAATGTCCAT TCCAACCCAG AGATGCAACA GCAGCTGGAG 3480

GCCCTGAACC AATCCATCAA TGCCCTCAAT GAAGCCACTT CCCAGCATCA GGACTCTGAG 3540

CATGTGGCCC TGGAGGAGAC TGTGAAGGAG CCCCCCCCTG CCATGGTAGT CCAACCCTCA 3600

ACAGAGCAGA CAACCCCGGA AGCATCTGGC ACACCAGGTG ACATGCAGAA TGTGCTGGCA 3660

GTCCTCCTGA GTCAGCTGAT GAAAACCCAG GAACCAACAG GCAGCCTGGA GGAAAGCAAT 3720

GGAGAAAAGA GCAGTGGGCC ACAGGGGCCC CGAAGAACTC CCACAATACC ACAGGAGGAG 3780

GCAGCAGAGA AGAGACCCCC TGAACCCCCT GGACCTCCAC CGCCGCCACC TCCACCCCCT 3840

CTGGTTGAAG GCGATCTTTC CAGCGCCCCC CAAGAGTTGA ACCCAGCTAT GACGGCCGCT 3900

CTGCTGCAGC TTTTGTCCCA GCCTGAAACG GAACCTTCTG GCCATCTGCC ACATGAGCAC 3960

CAGGCATTGA GACCTATGGA ATATTCTACC AGACCCCATT CAAGCAGGAC TTATGGAAGC 4020

ACTGAGGGGC CTGAAACAGG GTTCAGTGCT ACTGACACTG ATGAGCGCAA TTCCGGCCCA 4080

ACCTTGTCAG AACCTTTGGC CCAGACCCTG GCGAAGAGCA GGACTTTCTC AGGCTCTGTG 4140

AGCCATCTTG GGGAGTCAAG CAGTTACCAG GGCACAGGAA CAAGTTAA 4188

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 736   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  795

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 796   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  854

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 855   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  914

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k

Q: 915   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  974

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ +  +aldll+++l+ldp+kR++a++alq++++

Q: 975   LPYFNTMKPKKQYRrRLREEFSFIPLAALDLLDHMLTLDPNKRCTAEQALQSDFL  1029

         *****7777777777******999999************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFIPLAALDL LDHMLTLDPN KRCTAEQALQ SDFL 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013