EKS-MOD-00293

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00293

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	486.6	1.7E-146	721	978	258

Status

Unreviewed

Ensembl Protein

ENSMODP00000016093

UniProt Accession

F7C962;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB2

Gene Synonyms/Alias

ERBB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000012858	ENSMODP00000016093	ENSMODT00000016390

Organism

Monodelphis domestica

Functional Description

Protein Length

1257

Protein Sequence
(FASTA)

MDLSGCCCWG LLLVLLPPAV WGTQVCTGTD MKLQYPASIE NHLETLSHLY QGCQVVQGNL 60

ELTYLPAEAN LSFLQDIQEV QGYVLIAQSL VKTFPLQRLR IIRGTQLFED KYALVVLDNG 120

IPLPNPPPRP EATPGLRELQ FRSLTEILKG GVMIQKNPQL CHQDMVLWSD IFHKNNHLGT 180

TDIDTNRSRT CSPCSSSCKF SYCWGEGPDN CQSLTSTICA SGCARCKGPL STDCCHEQCA 240

AGCTGPKYSD CLACLHFNHS GICEQHCPPL VIYNSDTFES MPNPDGRYTF GSSCVKSCPY 300

NYLATDVGST SCTLVCPHHS QEVTAEDGTH RCEKCSKACP KVCYGLGMGH LRSVRAVNST 360

NIQDFAGCRK IFGSLAFLPE TFAGDLATNT SPLMPEELKV FENLEEITGY LYISAWPASL 420

PDLSIFQNLR VIRGRVLHNG VYSLTLEQLG IGWLGLRSLK ELGSGLALIH HNAHLCFVHT 480

VPWNQLFRNP RQALLHSANR PAHECAREGR ACYSLCAQGH CWGPGPTQCL NCSQFLRGEE 540

CVEECRVMQG YPREYIKDRR CFPCHEECQP QNGTETCYGS EADKCIACAH FKDPPACVAR 600

CPSGVKLDLS FIPVWKYSDD DGICQTCPTN CTHSCTVLDD KGCPAEQKPS PVTSIIAGVV 660

GVLLALIIGL IIGILIKRRK QKERKHTMRR LLQETELVEP LTPSGALPNQ AQMRILKETE 720

LRKVKVLGSG AFGTVYKGIW IPDGESVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 780

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VRENRGRLCS QDLLNWCVQI AKGMNYLEEV 840

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILCRRF 900

THQSDVWSYG VTVWELMTFG AKPYEGIPAR EIPDLLEKGD RLPQPPVCTI DVYMIMVKCW 960

MIDSECRPRF RELVTEFSRM ARDPQRFVVI QNEDSGPASP LDSTFYRSLL EEDDMGDLVD 1020

AEEYLVPQQG FFCPDPPGPG GTAHRRHRSS STRSGGELPG GLEGSEDDPP QASSEPWEGT 1080

GSDVFDGEDP WRSPGGSPKA LQGLPPRDLS PLQRYSEDPT RPLSPEMDGY VAPPACGPLP 1140

EYVNQPEVHL PPPSPLEGPL TPSHLSSSTL EHPKLPPPGK NGMVKDTFTF GAAVENPEYL 1200

APHGGGPLHL SPTAFSPAFD NLYYWNQDPP DRGAAPNGFA GTPTAENPEY LGLDMTV 1257

Nucleotide Sequence
(FASTA)

ATGGACCTGT CGGGCTGCTG CTGTTGGGGG CTCCTTCTGG TCCTTCTGCC CCCAGCAGTC 60

TGGGGGACCC AAGTGTGTAC AGGCACAGAC ATGAAGCTTC AGTATCCTGC CAGCATCGAG 120

AACCACCTGG AAACCCTGAG CCACCTGTAC CAAGGATGCC AGGTTGTACA GGGCAACCTG 180

GAGCTCACTT ACCTGCCTGC GGAGGCCAAC CTTTCCTTCC TTCAGGACAT CCAGGAAGTG 240

CAGGGCTACG TGCTGATTGC CCAGAGCCTA GTGAAGACTT TCCCCCTGCA GAGACTCCGC 300

ATCATTAGAG GCACGCAGCT CTTTGAGGAC AAATATGCCC TGGTCGTTCT GGACAACGGG 360

ATCCCCTTGC CTAACCCCCC TCCCCGGCCA GAGGCCACCC CCGGCCTCCG GGAGCTGCAA 420

TTTCGGAGCC TCACAGAGAT TCTAAAAGGC GGGGTCATGA TCCAGAAGAA CCCCCAGCTG 480

TGTCACCAAG ACATGGTGCT GTGGTCCGAC ATCTTCCATA AGAACAACCA CTTGGGCACC 540

ACCGACATTG ATACAAACCG CAGCCGAACT TGCAGCCCTT GTTCTTCATC ATGTAAATTC 600

AGCTATTGCT GGGGGGAAGG ACCTGACAAC TGTCAGAGCT TGACCAGCAC AATCTGTGCC 660

AGTGGCTGTG CCCGCTGCAA GGGGCCTTTA TCCACAGACT GCTGCCATGA GCAGTGTGCT 720

GCTGGCTGCA CTGGCCCCAA GTATTCTGAT TGCCTGGCCT GCCTCCACTT CAACCACAGT 780

GGCATCTGTG AGCAGCATTG CCCACCGCTG GTCATCTACA ACTCAGACAC CTTTGAGTCA 840

ATGCCTAATC CTGATGGGCG ATACACCTTT GGGTCTAGTT GTGTGAAATC ATGTCCCTAT 900

AACTACCTGG CTACAGATGT GGGGTCCACA TCCTGCACTC TTGTGTGTCC CCATCACAGC 960

CAAGAGGTGA CTGCTGAGGA TGGGACCCAC CGCTGTGAGA AATGTAGCAA GGCCTGCCCC 1020

AAAGTGTGTT ATGGGCTGGG CATGGGGCAC TTGCGATCCG TGAGAGCGGT CAACAGTACC 1080

AACATCCAGG ACTTTGCTGG CTGCAGGAAG ATCTTTGGAA GCCTGGCCTT CCTGCCCGAG 1140

ACCTTCGCAG GGGACTTAGC CACCAACACT TCCCCACTAA TGCCTGAAGA ACTCAAGGTG 1200

TTTGAGAACC TGGAGGAGAT CACAGGCTAC CTGTATATCT CAGCCTGGCC TGCCAGCCTC 1260

CCTGACCTCA GCATCTTTCA GAACCTAAGG GTGATCAGAG GAAGGGTGTT ACACAATGGT 1320

GTCTACTCCT TGACTCTGGA GCAACTGGGT ATTGGCTGGT TGGGGCTGCG GTCACTGAAA 1380

GAGCTGGGCA GTGGGTTGGC ACTCATCCAT CACAATGCCC ACCTATGCTT CGTCCACACG 1440

GTGCCTTGGA ATCAGCTCTT CCGCAACCCC CGCCAGGCTC TGCTCCATAG TGCCAACCGA 1500

CCTGCCCATG AGTGTGCAAG AGAGGGACGT GCATGTTACT CCCTGTGTGC TCAGGGGCAC 1560

TGCTGGGGCC CTGGACCAAC CCAGTGTCTC AACTGCAGCC AGTTTCTCCG AGGAGAAGAG 1620

TGTGTGGAGG AGTGTCGGGT CATGCAGGGG TACCCCCGAG AATATATAAA GGACAGGCGC 1680

TGCTTCCCTT GCCATGAGGA GTGCCAGCCA CAGAATGGCA CTGAGACCTG CTATGGATCG 1740

GAGGCTGACA AGTGTATAGC CTGTGCACAC TTCAAGGACC CTCCTGCCTG TGTGGCCCGA 1800

TGCCCTAGTG GGGTGAAGCT CGACCTCTCC TTCATACCTG TCTGGAAGTA CTCAGATGAT 1860

GATGGCATTT GCCAGACCTG CCCCACCAAC TGTACTCACT CATGTACTGT ATTGGATGAC 1920

AAAGGCTGTC CTGCTGAACA GAAGCCCAGC CCAGTGACCT CCATCATTGC TGGGGTGGTT 1980

GGTGTCCTCC TGGCCCTCAT CATAGGCCTC ATCATAGGCA TCTTGATCAA GCGTCGGAAA 2040

CAGAAGGAGC GGAAACACAC TATGAGAAGG CTGCTCCAGG AGACAGAGCT AGTGGAGCCC 2100

CTGACGCCCA GTGGAGCACT GCCCAACCAA GCTCAGATGC GCATCCTGAA AGAGACCGAG 2160

CTCAGAAAAG TGAAGGTTCT CGGTTCTGGG GCTTTCGGCA CAGTCTACAA GGGTATTTGG 2220

ATCCCTGATG GTGAAAGTGT GAAGATCCCA GTGGCTATCA AGGTGTTAAG GGAAAACACA 2280

TCCCCCAAAG CCAACAAGGA GATCTTGGAT GAAGCATACG TGATGGCAGG TGTTGGCTCT 2340

CCATATGTAT CTCGACTTCT GGGCATCTGC CTGACATCCA CGGTGCAGTT GGTGACCCAG 2400

CTTATGCCTT ATGGCTGCCT CCTGGACCAC GTGCGTGAAA ACCGAGGGAG GCTTTGCTCC 2460

CAGGACCTTC TCAATTGGTG TGTGCAGATT GCCAAGGGCA TGAACTACTT GGAGGAGGTT 2520

CGGCTAGTAC ATAGAGATCT GGCTGCCAGA AATGTGCTGG TCAAAAGTCC CAACCACGTC 2580

AAGATCACCG ACTTTGGACT CGCCAGGCTC CTGGACATTG ATGAGACTGA GTACCACGCA 2640

GATGGGGGCA AGGTCCCCAT CAAGTGGATG GCACTGGAGT CCATTCTGTG CCGAAGATTC 2700

ACCCATCAGA GTGATGTGTG GAGCTATGGG GTGACAGTGT GGGAACTGAT GACCTTTGGG 2760

GCTAAACCAT ATGAAGGTAT TCCTGCCCGA GAGATTCCTG ACCTGCTGGA GAAAGGAGAC 2820

CGGCTACCAC AGCCCCCTGT CTGCACTATT GATGTCTACA TGATCATGGT CAAATGTTGG 2880

ATGATTGACT CCGAGTGTCG GCCTCGGTTC CGGGAGCTAG TTACTGAATT CTCACGGATG 2940

GCCCGAGACC CTCAGCGCTT TGTGGTCATT CAGAATGAGG ATTCTGGTCC AGCCAGCCCC 3000

CTAGACAGCA CCTTTTACCG ATCACTACTG GAGGAAGATG ACATGGGCGA TTTGGTGGAT 3060

GCAGAAGAGT ACCTGGTGCC CCAGCAAGGC TTCTTCTGCC CTGATCCTCC AGGCCCTGGC 3120

GGTACTGCCC ACCGAAGACA TAGAAGTTCT TCTACAAGGA GTGGTGGGGA GCTCCCAGGA 3180

GGACTGGAAG GCTCAGAAGA TGACCCTCCC CAGGCTTCAT CAGAACCCTG GGAAGGGACT 3240

GGTTCAGATG TGTTTGATGG GGAGGACCCC TGGAGGTCTC CTGGAGGGAG CCCTAAGGCA 3300

CTACAGGGAC TCCCCCCTCG AGATCTCAGT CCCCTACAGC GCTACAGTGA AGATCCCACA 3360

AGACCACTGT CCCCTGAGAT GGATGGCTAT GTTGCCCCAC CTGCCTGTGG CCCTCTGCCT 3420

GAATATGTAA ACCAGCCAGA GGTACACCTC CCACCCCCTT CACCCCTGGA GGGGCCTCTG 3480

ACTCCTTCTC ACCTATCCAG CTCCACCCTG GAACACCCCA AGTTGCCTCC TCCAGGGAAG 3540

AATGGAATGG TGAAGGACAC ATTTACCTTT GGTGCAGCTG TGGAGAACCC TGAGTACTTG 3600

GCCCCCCATG GAGGGGGTCC CCTTCATCTT TCCCCAACTG CCTTCAGTCC AGCCTTTGAC 3660

AACCTTTACT ACTGGAACCA GGATCCCCCT GATCGAGGGG CTGCCCCAAA TGGTTTTGCA 3720

GGGACCCCCA CAGCTGAGAA CCCTGAGTAC CTGGGTTTGG ATATGACTGT GTGA 3774

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k+kvlGsGafGtvykGiwip+ge+vkipvaikvl+e+t++kanke+ldea+v+a + +

Q: 721   LRKVKVLGSGAFGTVYKGIWIPDGESVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  780

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclld+vre++++l sq+llnwcvqiakGm+ylee

Q: 781   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLCSQDLLNWCVQIAKGMNYLEEV  840

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil r++

Q: 841   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILCRRF  900

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGakpy+gipa+eipdllekG+rl+qpp+ctidvym++vkcw

Q: 901   THQSDVWSYGVTVWELMTFGAKPYEGIPAREIPDLLEKGDRLPQPPVCTIDVYMIMVKCW  960

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mid+e+rp+f+el++efs

Q: 961   MIDSECRPRFRELVTEFS  978

         ****************96

Domain Sequence
(FASTA)

LRKVKVLGSG AFGTVYKGIW IPDGESVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VRENRGRLCS QDLLNWCVQI AKGMNYLEEV 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILCRRF 180

THQSDVWSYG VTVWELMTFG AKPYEGIPAR EIPDLLEKGD RLPQPPVCTI DVYMIMVKCW 240

MIDSECRPRF RELVTEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013