EKS-MOD-00429

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00429

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	496.4	2.0E-149	76	342	267

Status

Unreviewed

Ensembl Protein

ENSMODP00000016766

UniProt Accession

F7CNZ6;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000013407	ENSMODP00000016766	ENSMODT00000017078

Organism

Monodelphis domestica

Functional Description

Protein Length

1712

Protein Sequence
(FASTA)

MSAKVRLKKL EQLLLDGPWR NESSLSVEAL LDVLICLYTE CSQSALRRDK YVAEFLEWAK 60

PFTQLVKEMQ LHRDDFEIIK VIGRGAFGEV AVVKMKNTER IYAMKILNKW EMLKRAETAC 120

FREERDVLVN GDCQWITTLH YAFQDENYLY LVMDYYVGGD LLTLLSKFED KLPEDMARFY 180

IGEMVLAIHS IHQLHYVHRD IKPDNVLLDM NGHIRLADFG SCLKMNDDGT VQSSVAVGTP 240

DYISPEILQA MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF 300

QFPSHVTDVS EEAKDLIQRL ICSRERRLGQ NGIEDFKRHA FFEGINWEDI RNLEAPYIPD 360

VSSPSDTSNF DVDDDVLRNP EIVPPGSHTG FSGLHLPFIG FTFTTESCFS DRGSLKSVMQ 420

SNAITKDEEV QRDLENSLQI EAYERRIRRL EQEKLELSRK LQESTQTVQS FHSSARSTGN 480

SNRDKEIKRL NEEIERLKNK ITDSNRLERR LEDAVTLRQE HEDSTHRLKA LEKQLRVLRQ 540

EKEDMQKQMI EASERLKSQT KELKDAHQQR KLAMQEFSEL NERMADLRSQ KQKISRQLRD 600

KEEEMEVIMQ KIDSMRQEIR KSEKARKELE SRLDDAIAEA SKERKLREHS ESFSKQVESE 660

LEALKIKQGI RGSGVTLEHQ QEISKIKSEL EKKVLFYEEE LVRREASHVL EVKNVKKEVH 720

DSESHQLALQ KEILMLKDKL EKSKRERHNE MEEAVGTVKD KYERERAMLF EENKKLTTET 780

ERLCSFVDKL TAQNRQLEDE LQDLAAKKDS VAHWEAQIAE IIQWVSDEKD ARGYLQALAS 840

KMTEELESLR SSSLGSRTLD PLWKVRRSQK LDMSARLELQ SALDAEIRAK QLIQEELRKV 900

KETNLAFESK LKESEAKNRE LLEEMENLRK KIEEKFKADT GLKLPDFQES IFEYFNTSPL 960

PHDLTFRTSS TSDQETQVPK AEVSPSTTVS INTEQQEETT RPQQRGPAIS SPTIQSLSLA 1020

VPKPKAHQFS VKSFSSPTQC SHCTSLMVGL IRQGYACEVC SFSCHVSCKD SAPQVCPIPP 1080

EQSKRPLGVD VQRGIGTAYK GYVKIPKPTG VKKGWQRAYA IVCDCKLFLY DLPEGKSTQP 1140

GVVASQVIDL RDEEFSVSCV LASDVIHATR RDIPCIFRVT ASLLGTPAKT SSLLILTENE 1200

NEKRKWVGIL EGLQSILHKN RLKNQVVHIP QEAYDSTLPL IKTMLTAAIV DRDRIAIGLE 1260

EGLYVIELTR DVIVRAADCK KVYQIELAPK EKIIILICGR NHHVHLYPWS SLDGSEGNFD 1320

IKLPETKGCQ LIVAATLKKS SSTCLFVAVK RLILCYEIHR TKPFHKKFNE IVAPGSVQWM 1380

TVFKDRLCVG YPSGFYLLNI QGDGQSLNLV NPNDPSLMFL SQQSFDALCA VELTNEEYLL 1440

CFSHMGLYVD SQGRRSRMQE LMWPATPVAC SCNSSYITVY SEYGVDVFDV YTMEWVQTIG 1500

LRKIRPLNME GTLNLLNWEP PRLIYFKNKF SGAVLSVPET SDNSKKQMLR TRSKKRFVFK 1560

VPEEERLQQR REMLRDPELR SKMISNPTNF NHVAHMGPGD GMQVLMDLPL SVLPSSQEEK 1620

AGPSSANLSR QPQSRSKTYV SWPSSGGGDL GVTIPLRSMS DPDQDFDKEP DSDSTKHSTP 1680

SNSSNPSGPP SPNSPHRNQL TLDGLDQSTC DA 1712

Nucleotide Sequence
(FASTA)

ATGTCGGCCA AGGTGCGGCT GAAGAAGCTG GAGCAACTGC TCCTGGACGG GCCGTGGCGC 60

AACGAGAGCT CGCTGAGCGT GGAGGCCCTG CTGGACGTGC TCATCTGCCT TTACACTGAG 120

TGTAGCCAGT CGGCCCTGCG TAGGGACAAG TATGTGGCCG AGTTCCTCGA GTGGGCAAAG 180

CCATTTACCC AACTGGTGAA GGAAATGCAG CTTCATCGAG ATGACTTTGA AATAATTAAA 240

GTAATTGGAA GAGGTGCATT TGGTGAGGTT GCTGTGGTTA AAATGAAGAA TACTGAACGC 300

ATTTATGCAA TGAAGATCCT AAATAAGTGG GAAATGCTAA AAAGAGCTGA GACTGCCTGT 360

TTTAGAGAAG AAAGAGATGT ATTGGTGAAT GGTGATTGTC AGTGGATCAC AACCTTACAT 420

TATGCCTTTC AAGATGAAAA CTATTTGTAC TTAGTAATGG ACTACTATGT TGGTGGTGAT 480

TTACTGACAC TCCTCAGTAA GTTTGAAGAC AAACTTCCTG AAGATATGGC AAGATTTTAC 540

ATCGGTGAAA TGGTGCTGGC CATACATTCC ATTCATCAGT TGCATTACGT ACACAGAGAT 600

ATTAAGCCTG ACAATGTTCT TTTGGATATG AATGGTCACA TTCGCTTGGC AGACTTTGGA 660

TCATGTTTGA AGATGAATGA CGATGGAACT GTCCAGTCTT CTGTGGCAGT GGGCACACCT 720

GACTACATTT CACCTGAGAT TCTACAAGCA ATGGAGGATG GAATGGGAAA ATATGGCCCA 780

GAATGTGATT GGTGGTCTCT AGGTGTTTGC ATGTATGAAA TGCTATATGG TGAAACACCT 840

TTTTATGCAG AATCATTAGT GGAAACTTAT GGAAAGATTA TGAATCATGA AGAGCGATTT 900

CAGTTTCCTT CTCATGTCAC TGATGTATCT GAAGAGGCAA AAGACCTCAT TCAAAGGCTC 960

ATCTGTAGTA GAGAACGACG ATTAGGGCAG AATGGAATAG AAGATTTCAA AAGGCACGCA 1020

TTTTTTGAAG GAATTAATTG GGAAGACATA AGAAATCTAG AAGCGCCTTA TATTCCAGAT 1080

GTTAGCAGTC CTTCAGACAC ATCAAATTTT GATGTAGATG ATGATGTGTT GAGAAATCCG 1140

GAAATAGTAC CTCCCGGTTC TCATACTGGT TTTTCTGGAT TACACTTGCC CTTCATTGGT 1200

TTTACATTTA CAACTGAAAG CTGTTTTTCT GATCGAGGCT CTCTAAAAAG TGTAATGCAG 1260

TCTAATGCTA TCACCAAAGA TGAGGAAGTG CAGCGAGATC TAGAGAACAG CTTGCAAATT 1320

GAAGCATATG AACGAAGAAT TCGAAGACTA GAACAAGAAA AGCTGGAATT GAGCAGAAAA 1380

TTACAAGAAT CAACCCAAAC TGTACAGTCC TTTCATAGTT CAGCTCGCTC TACAGGAAAC 1440

TCAAATAGAG ATAAAGAAAT CAAAAGGTTA AATGAGGAAA TTGAACGGCT GAAAAATAAA 1500

ATAACAGATT CAAATAGGCT GGAGCGGAGA CTTGAAGATG CAGTAACACT TCGCCAGGAA 1560

CATGAAGATT CCACACACAG ATTGAAAGCC CTAGAAAAGC AGCTCCGTGT GCTACGGCAA 1620

GAAAAGGAGG ATATGCAAAA GCAAATGATT GAAGCTTCAG AAAGATTAAA ATCTCAGACC 1680

AAAGAACTCA AAGATGCTCA TCAGCAGAGA AAGTTGGCCA TGCAGGAGTT TTCAGAGCTC 1740

AATGAACGGA TGGCAGATCT TCGCTCACAA AAGCAAAAGA TATCTCGACA GCTTCGTGAC 1800

AAAGAAGAGG AGATGGAAGT TATCATGCAG AAAATTGATT CAATGAGACA AGAAATACGT 1860

AAATCTGAGA AGGCCAGAAA GGAGCTGGAA TCTCGACTTG ATGATGCAAT TGCAGAAGCA 1920

TCAAAGGAAC GCAAGCTTCG TGAACATAGT GAGAGCTTCT CTAAGCAAGT GGAAAGTGAA 1980

CTGGAAGCTC TTAAGATAAA GCAAGGAATC CGTGGATCAG GTGTTACTTT AGAACACCAG 2040

CAGGAAATTT CCAAAATAAA ATCTGAACTT GAAAAGAAAG TTTTGTTTTA TGAAGAAGAA 2100

CTGGTCAGGC GAGAGGCCTC TCATGTCTTA GAAGTTAAAA ATGTGAAAAA GGAAGTCCAT 2160

GATTCAGAAA GCCATCAGTT AGCACTTCAA AAAGAGATCT TAATGTTAAA AGATAAATTG 2220

GAAAAGTCAA AAAGGGAAAG ACATAATGAG ATGGAGGAGG CAGTAGGCAC AGTAAAAGAT 2280

AAATATGAGA GAGAACGAGC AATGCTATTT GAAGAGAACA AGAAATTAAC AACAGAAACT 2340

GAAAGGCTGT GTTCATTTGT GGATAAACTA ACAGCTCAAA ACAGGCAACT GGAAGATGAA 2400

CTTCAAGATT TGGCAGCTAA GAAGGATTCG GTTGCCCATT GGGAAGCCCA GATTGCAGAA 2460

ATTATTCAGT GGGTAAGTGA CGAAAAGGAT GCCCGTGGAT ATCTTCAAGC ATTAGCTTCC 2520

AAGATGACAG AAGAACTCGA ATCATTGAGA AGCTCTAGTT TAGGATCAAG GACACTGGAT 2580

CCACTTTGGA AAGTGCGTCG TAGTCAAAAA CTAGATATGT CTGCCCGCTT GGAACTGCAA 2640

TCAGCTCTTG ATGCAGAGAT ACGTGCCAAA CAGCTCATTC AGGAAGAGCT AAGGAAAGTC 2700

AAAGAAACAA ATCTAGCCTT TGAAAGCAAA CTAAAAGAAT CTGAAGCAAA AAATAGAGAA 2760

TTATTAGAAG AAATGGAGAA TTTGAGGAAG AAAATAGAAG AAAAATTTAA GGCCGATACA 2820

GGCCTCAAGC TTCCTGATTT TCAAGAATCA ATTTTTGAGT ATTTTAACAC TTCACCTCTT 2880

CCACATGATC TGACATTTAG AACTAGCTCA ACTAGTGATC AAGAAACACA AGTTCCCAAA 2940

GCAGAAGTTT CACCATCTAC TACAGTTTCC ATAAACACAG AACAGCAAGA AGAAACAACT 3000

CGTCCTCAAC AGAGAGGACC TGCCATTTCT TCTCCCACCA TCCAGTCCCT TTCTCTAGCC 3060

GTACCAAAGC CTAAAGCTCA CCAGTTCAGT GTCAAATCCT TTTCAAGTCC TACACAGTGC 3120

AGCCACTGCA CTTCTCTTAT GGTTGGATTA ATTCGACAAG GCTATGCTTG TGAGGTGTGT 3180

TCCTTCTCAT GCCATGTTTC ATGCAAAGAC AGTGCTCCTC AGGTTTGTCC AATTCCCCCT 3240

GAGCAATCAA AAAGGCCTCT TGGAGTAGAT GTACAGAGAG GGATAGGAAC TGCTTACAAA 3300

GGCTATGTCA AGATTCCAAA GCCCACGGGG GTGAAGAAAG GATGGCAAAG AGCATATGCA 3360

ATTGTCTGTG ACTGTAAACT ATTTTTGTAT GATTTGCCTG AAGGAAAATC CACCCAGCCT 3420

GGTGTTGTTG CAAGTCAGGT CATAGATCTC AGAGATGAAG AATTTTCTGT GAGCTGTGTC 3480

TTAGCATCAG ATGTTATACA TGCTACCCGC AGAGACATTC CTTGTATATT TAGGGTGACA 3540

GCTTCTCTCT TAGGCACACC TGCTAAGACC AGTTCACTGC TAATTCTAAC AGAGAATGAA 3600

AATGAGAAGA GGAAATGGGT TGGGATCCTA GAAGGACTAC AGTCTATTCT ACATAAAAAC 3660

AGACTTAAAA ATCAAGTTGT ACATATTCCA CAGGAAGCTT ATGACAGCAC ACTGCCTCTT 3720

ATTAAAACCA TGTTAACAGC TGCAATAGTA GATCGGGATA GGATAGCCAT TGGTTTAGAA 3780

GAAGGACTGT ATGTAATAGA GTTAACTCGT GATGTGATTG TTCGAGCTGC TGATTGTAAG 3840

AAGGTGTACC AGATTGAACT TGCTCCCAAA GAGAAAATTA TCATCCTCAT CTGTGGCAGG 3900

AACCACCATG TTCATCTATA TCCATGGTCA TCTCTTGATG GTTCAGAAGG CAATTTTGAC 3960

ATCAAACTCC CAGAAACTAA AGGCTGCCAA CTTATAGTAG CTGCCACTCT AAAGAAGAGC 4020

TCCTCAACTT GCTTGTTTGT GGCTGTGAAA CGACTGATTC TTTGTTATGA AATTCATAGA 4080

ACTAAGCCTT TCCACAAAAA ATTCAATGAA ATTGTGGCTC CAGGAAGTGT ACAATGGATG 4140

ACAGTATTCA AAGACAGACT CTGTGTTGGC TACCCTTCTG GGTTCTATCT GTTGAACATC 4200

CAGGGAGATG GACAGTCTCT AAACCTGGTA AATCCTAATG ATCCCTCACT TATGTTCCTC 4260

TCACAGCAGT CTTTTGATGC CCTTTGTGCT GTGGAACTCA CTAATGAGGA ATACCTGCTT 4320

TGCTTCAGCC ATATGGGATT GTACGTGGAT TCACAAGGTC GAAGGTCACG CATGCAGGAG 4380

CTAATGTGGC CTGCAACTCC TGTTGCCTGT AGTTGTAATT CTTCTTACAT CACAGTATAT 4440

AGTGAATATG GTGTGGATGT CTTTGATGTT TATACTATGG AATGGGTCCA GACGATAGGC 4500

CTGAGGAAGA TCAGACCACT TAATATGGAA GGAACGCTTA ATCTCCTTAA CTGGGAACCT 4560

CCACGATTAA TATACTTCAA GAATAAATTT TCAGGAGCTG TACTCAGTGT GCCAGAAACT 4620

TCTGATAACA GTAAAAAACA AATGCTTCGG ACCAGAAGTA AAAAGCGATT TGTCTTTAAG 4680

GTTCCTGAGG AAGAGAGATT ACAGCAGAGG CGAGAGATGC TTAGAGACCC AGAATTGAGA 4740

TCAAAGATGA TATCAAACCC AACCAATTTC AATCACGTTG CTCATATGGG CCCAGGAGAT 4800

GGAATGCAAG TACTCATGGA CCTCCCTCTG AGCGTATTAC CTTCCTCACA AGAAGAAAAG 4860

GCTGGCCCTT CCTCAGCCAA CCTCTCTCGG CAACCACAGT CAAGGAGTAA GACCTACGTT 4920

TCATGGCCCT CTTCAGGTGG AGGTGACCTG GGAGTGACCA TACCTCTAAG AAGTATGTCT 4980

GATCCTGACC AGGATTTTGA CAAAGAGCCG GATTCTGATT CCACCAAACA CTCTACTCCA 5040

TCTAACAGCT CCAATCCAAG TGGTCCTCCC AGTCCCAATT CTCCACATAG AAATCAGCTT 5100

ACGCTTGATG GACTAGATCA ATCAACCTGC GATGCCTAA 5139

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 76    FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla++s+h+l+

Q: 136   ITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIHSIHQLH  195

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdn+lld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+g+

Q: 196   YVHRDIKPDNVLLDMNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGM  255

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseeakd

Q: 256   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEAKD  315

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+k+h+ff

Q: 316   LIQRLICSRERRLGQNGIEDFKRHAFF  342

         **************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KNTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIHSIHQLH 120

YVHRDIKPDN VLLDMNGHIR LADFGSCLKM NDDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH VTDVSEEAKD 240

LIQRLICSRE RRLGQNGIED FKRHAFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013