EKS-MOD-00454

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00454

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	427.7	2.0E-128	25	308	284

Status

Unreviewed

Ensembl Protein

ENSMODP00000017094

UniProt Accession

F6TXC2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000013669	ENSMODP00000017094	ENSMODT00000017410

Organism

Monodelphis domestica

Functional Description

Protein Length

366

Protein Sequence
(FASTA)

MSFIRKRGFY KQEVNKTAWE LPKTYVTLTH VGNGAYGAVC SAIDKKSGEK VAIKKLSRPF 60

QSEIFAKRAY RELMLLKHMQ HENVIGLLDV FTSATSLHNF HDFYLVMPFM QTDLQKIMGM 120

EFSEDKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHTDAEMT 180

GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG 240

VPGADFVQKL QDKAAKSYIQ SLPQSPKKDF SQLFPRASPQ AIDLLEKMLE LDVDIRLTAT 300

QALAHPFFDQ FRDPEEETVA QQPFDDSMEH EKLKVDEWKS HIYKEVSNFS PVARKDSRRR 360

SVMKLQ 366

Nucleotide Sequence
(FASTA)

ATGAGCTTCA TCCGGAAAAG GGGCTTCTAC AAGCAAGAAG TGAACAAGAC GGCCTGGGAG 60

CTGCCCAAGA CCTATGTGAC CCTGACCCAC GTGGGCAACG GGGCCTATGG CGCTGTGTGT 120

TCAGCCATCG ATAAGAAATC AGGAGAGAAG GTGGCAATCA AGAAACTGAG CCGACCTTTC 180

CAGTCAGAGA TCTTCGCCAA GAGGGCCTAT CGAGAGTTGA TGCTATTGAA ACATATGCAG 240

CATGAGAATG TTATTGGACT GTTGGATGTT TTCACTTCTG CTACATCTCT GCACAACTTC 300

CATGATTTCT ATCTGGTGAT GCCATTCATG CAGACAGATC TCCAAAAGAT CATGGGCATG 360

GAATTCAGTG AGGATAAGAT CCAGTACCTT GTCTATCAAA TGCTGAAAGG GCTCAAGTAT 420

ATCCATTCTG CTGGGGTCGT CCACAGGGAT TTGAAACCAG GAAACTTGGC TGTGAATGAA 480

GACTGTGAAT TAAAGATCCT AGATTTCGGG CTGGCCAGGC ACACGGATGC TGAGATGACG 540

GGCTACGTGG TGACTCGTTG GTACCGGGCT CCAGAAGTCA TTCTCAGCTG GATGCACTAT 600

AATCAGACTG TGGACATCTG GTCTGTTGGC TGCATCATGG CGGAGATGTT GACTGGGAAA 660

ACTCTGTTCA AAGGGAAAGA CTACTTGGAC CAACTGACCC AGATCCTGAA AGTGACTGGG 720

GTTCCTGGAG CTGATTTTGT ACAGAAGCTA CAGGACAAAG CAGCCAAATC CTATATCCAG 780

TCCCTGCCTC AGAGTCCCAA GAAGGATTTC TCACAACTTT TCCCTCGTGC CAGCCCCCAG 840

GCAATAGACC TATTAGAGAA GATGCTTGAG CTGGATGTGG ACATACGCTT GACTGCCACG 900

CAGGCTCTTG CCCATCCCTT CTTTGACCAG TTCCGAGACC CAGAAGAGGA AACAGTAGCC 960

CAACAGCCTT TTGATGATTC CATGGAACAT GAGAAGCTCA AAGTGGATGA ATGGAAGAGT 1020

CACATCTACA AAGAGGTTTC AAACTTCAGT CCTGTTGCAC GGAAGGATTC CAGGAGAAGG 1080

AGTGTCATGA AACTACAATA A 1101

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y +l+++g+Gayg v+sa+dk+++e+vaikklsrpfq+e+ akr++REl+llk+++heN+

Q: 25    YVTLTHVGNGAYGAVCSAIDKKSGEKVAIKKLSRPFQSEIFAKRAYRELMLLKHMQHENV  84

         677899******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvft++++l++++d+Ylv+ +m+tdL+k++ ++ +s+++i++l+yq+l+glky+Hs

Q: 85    IGLLDVFTSATSLHNFHDFYLVMPFMQTDLQKIMGME-FSEDKIQYLVYQMLKGLKYIHS  143

         ***********************************99.9*********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a+v+HrDlKP+Nl+vnedcelkildFGlar++d+e    +t+yv+trwYraPe++ls+++

Q: 144   AGVVHRDLKPGNLAVNEDCELKILDFGLARHTDAE----MTGYVVTRWYRAPEVILSWMH  199

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI+aE+ltgk+lf+gkd++dql++il+v+g p ++f++k++++ a++yi

Q: 200   YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGADFVQKLQDKAAKSYI  259

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +slp+ +kkdf++lfp+as++a+dLlek+L+ld d R+++++aL+hp++

Q: 260   QSLPQSPKKDFSQLFPRASPQAIDLLEKMLELDVDIRLTATQALAHPFF  308

         ***********************************************95

Domain Sequence
(FASTA)

YVTLTHVGNG AYGAVCSAID KKSGEKVAIK KLSRPFQSEI FAKRAYRELM LLKHMQHENV 60

IGLLDVFTSA TSLHNFHDFY LVMPFMQTDL QKIMGMEFSE DKIQYLVYQM LKGLKYIHSA 120

GVVHRDLKPG NLAVNEDCEL KILDFGLARH TDAEMTGYVV TRWYRAPEVI LSWMHYNQTV 180

DIWSVGCIMA EMLTGKTLFK GKDYLDQLTQ ILKVTGVPGA DFVQKLQDKA AKSYIQSLPQ 240

SPKKDFSQLF PRASPQAIDL LEKMLELDVD IRLTATQALA HPFF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032755	; P:positive regulation of interleukin-6 production
GO:0006970	; P:response to osmotic stress

KEGG

mdo:100028821

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013