EKS-MOD-00137
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00137
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/Akt506.02.3E-152150408259
StatusUnreviewed
Ensembl ProteinENSMODP00000017125
UniProt AccessionF6QP11;
Protein Name
Protein Synonyms/Alias
Gene NameAKT1
Gene Synonyms/Alias AKT1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000013693ENSMODP00000017125ENSMODT00000017442
OrganismMonodelphis domestica
Functional Description
Protein Length480
Protein Sequence
(FASTA)
MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK SDGTFIGYKE RPQDVDQRES PLNNFSVAQC 60
QLMKTERPKP NTFIIRCLQW TTVIERTFHV ETPEEREEWT KAIQTVADSL KKQEEELMDF 120
QSGSPSDNSG AEEMEVSTTK PKHKVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI 180
LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS 240
RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 300
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL 360
ILMEEIRFPR TLSPDAKSLL SGLLKKDPKQ RLGGGPDDAK EIMQHKFFAG IVWQDVYEKK 420
LVPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDNMEC VDNERRPHFP QFSYSASGTA 480
Nucleotide Sequence
(FASTA)
ATGAACGACG TCGCGATTGT CAAGGAGGGC TGGCTGCATA AGCGAGGAGA ATACATCAAA 60
ACATGGCGGC CACGCTACTT CTTGCTAAAG AGTGATGGGA CCTTCATTGG CTACAAGGAA 120
CGGCCACAGG ATGTGGACCA GCGGGAGTCA CCCCTCAACA ACTTCTCAGT TGCACAATGC 180
CAGCTGATGA AGACAGAGCG ACCCAAACCC AATACATTCA TCATCCGCTG CCTGCAGTGG 240
ACCACGGTAA TTGAGAGAAC GTTTCACGTG GAGACCCCCG AGGAGCGGGA AGAATGGACC 300
AAAGCCATAC AGACGGTGGC CGACAGCCTG AAAAAGCAAG AGGAAGAACT GATGGATTTC 360
CAATCAGGCT CTCCTAGTGA CAATTCTGGG GCTGAGGAGA TGGAGGTGTC AACGACCAAG 420
CCCAAGCACA AAGTGACAAT GAATGAGTTT GAATACCTGA AGCTGCTGGG CAAAGGCACC 480
TTCGGGAAGG TGATCCTGGT GAAGGAGAAA GCCACCGGGC GATACTATGC CATGAAGATC 540
CTCAAGAAGG AAGTGATTGT GGCCAAGGAT GAGGTGGCAC ATACGCTTAC GGAGAACCGG 600
GTCTTGCAGA ACTCAAGGCA CCCCTTCCTG ACAGCACTGA AGTACTCGTT CCAGACGCAT 660
GACCGCCTTT GCTTTGTGAT GGAGTACGCC AACGGAGGAG AGCTGTTTTT CCATCTCTCC 720
CGAGAGCGGG TATTCTCCGA AGACCGAGCC AGGTTCTATG GGGCAGAAAT TGTGTCTGCG 780
CTGGATTACT TGCATTCTGA GAAGAATGTG GTATACAGAG ACCTCAAGTT GGAAAACCTA 840
ATGCTGGACA AAGATGGTCA CATCAAAATT ACCGACTTTG GCCTGTGCAA GGAGGGGATC 900
AAGGATGGTG CTACCATGAA GACCTTTTGT GGGACTCCAG AATATCTGGC CCCTGAGGTG 960
CTTGAGGACA ATGACTATGG ACGGGCAGTG GACTGGTGGG GCCTGGGAGT GGTGATGTAT 1020
GAAATGATGT GTGGCAGGCT GCCCTTCTAC AACCAGGACC ACGAGAAATT GTTTGAGCTG 1080
ATACTCATGG AGGAGATCCG ATTTCCCCGA ACACTCTCCC CAGATGCCAA GTCTCTCCTG 1140
TCAGGGTTGC TGAAAAAGGA CCCTAAGCAG AGGTTAGGTG GGGGACCAGA CGATGCAAAA 1200
GAGATTATGC AGCACAAGTT TTTTGCTGGC ATTGTATGGC AAGATGTCTA TGAAAAAAAG 1260
CTGGTGCCTC CCTTTAAGCC ACAAGTCACA TCGGAGACAG ACACCAGGTA TTTTGATGAG 1320
GAGTTTACAG CCCAAATGAT CACCATCACC CCTCCTGACC AAGATGACAA CATGGAATGT 1380
GTAGATAACG AGAGACGGCC CCACTTTCCT CAGTTCTCAT ACTCTGCCAG TGGGACAGCT 1440
TGA 1443
Domain Profile
S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60
         f++lkllGkGtfGkvilv+ekat+++ya+kilkkevivakdevahtlte+rvl++++hpf
Q: 150   FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF  209
         9***********************************************************
S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhs.kd  119
         l+alkysfqt+++lc+v+ey+nGGelffhls+ervfsedrarfygaeivsaldylhs k+
Q: 210   LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSeKN  269
         ********************************************************9789
S: 120   vvyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygka  179
         vvyrdlklenl+ldkdGhikitdfGlcke+ikdg+++ktfcGtpeylapevled+dyg+a
Q: 270   VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA  329
         ************************************************************
S: 180   vdwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpk  239
         vdwwglGvv+yem+cGrlpfyn+dheklfelil+ee++fpr+ls++aksllsGllkkdpk
Q: 330   VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLSPDAKSLLSGLLKKDPK  389
         ************************************************************
S: 240   krlGggkddakeireheff  258
         +rlGgg+ddakei++h+ff
Q: 390   QRLGGGPDDAKEIMQHKFF  408
         ******************9
Domain Sequence
(FASTA)
FEYLKLLGKG TFGKVILVKE KATGRYYAMK ILKKEVIVAK DEVAHTLTEN RVLQNSRHPF 60
LTALKYSFQT HDRLCFVMEY ANGGELFFHL SRERVFSEDR ARFYGAEIVS ALDYLHSEKN 120
VVYRDLKLEN LMLDKDGHIK ITDFGLCKEG IKDGATMKTF CGTPEYLAPE VLEDNDYGRA 180
VDWWGLGVVM YEMMCGRLPF YNQDHEKLFE LILMEEIRFP RTLSPDAKSL LSGLLKKDPK 240
QRLGGGPDDA KEIMQHKFF 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00133
EKS-BOT-00141
EKS-CAE-00113
EKS-CAF-00147
EKS-CAP-00138
EKS-CII-00086
EKS-CIS-00177
EKS-EQC-00138
EKS-FEC-00131
EKS-GAM-00069
EKS-GAG-00116
EKS-GAA-00163
EKS-GOG-00140
EKS-HOS-00143
EKS-ICT-00132
EKS-LAC-00148
EKS-LOA-00138
EKS-MAM-00138
EKS-MEG-00106
EKS-MUM-00143
EKS-MUP-00144
EKS-NOL-00134
EKS-ORN-00171
EKS-ORL-00160
EKS-OTG-00144
EKS-PES-00123
EKS-PEM-00075
EKS-PRC-00020
EKS-PTV-00131
EKS-RAN-00136
EKS-SAH-00133
EKS-TAG-00168
EKS-TAR-00183
EKS-TEN-00171
EKS-XET-00127
EKS-XIM-00166
Gene Ontology
GO:0005737; C:cytoplasm
GO:0030027; C:lamellipodium
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0030235; F:nitric-oxide synthase regulator activity
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006924; P:activation-induced cell death of T cells
GO:0042640; P:anagen
GO:0008637; P:apoptotic mitochondrial changes
GO:0071364; P:cellular response to epidermal growth factor stimulus
GO:0032869; P:cellular response to insulin stimulus
GO:0007281; P:germ cell development
GO:0042593; P:glucose homeostasis
GO:0006006; P:glucose metabolic process
GO:0015758; P:glucose transport
GO:0060709; P:glycogen cell differentiation involved in embryonic placenta development
GO:0005977; P:glycogen metabolic process
GO:0006954; P:inflammatory response
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0060716; P:labyrinthine layer blood vessel development
GO:0001893; P:maternal placenta development
GO:0043066; P:negative regulation of apoptotic process
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0031999; P:negative regulation of fatty acid beta-oxidation
GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria
GO:0001649; P:osteoblast differentiation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0032287; P:peripheral nervous system myelin maintenance
GO:0043536; P:positive regulation of blood vessel endothelial cell migration
GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0045600; P:positive regulation of fat cell differentiation
GO:0046326; P:positive regulation of glucose import
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0046889; P:positive regulation of lipid biosynthetic process
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051000; P:positive regulation of nitric-oxide synthase activity
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0010765; P:positive regulation of sodium ion transport
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0030163; P:protein catabolic process
GO:0000060; P:protein import into nucleus, translocation
GO:0043491; P:protein kinase B signaling cascade
GO:0016567; P:protein ubiquitination
GO:0010975; P:regulation of neuron projection development
GO:0034405; P:response to fluid shear stress
GO:0032094; P:response to food
GO:0070141; P:response to UV-A
GO:0051146; P:striated muscle cell differentiation
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013