EKS-MOD-00268

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00268

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	436.6	6.3E-131	172	492	321

Status

Unreviewed

Ensembl Protein

ENSMODP00000017124

UniProt Accession

F6QP22;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1B

Gene Synonyms/Alias

DYRK1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000013694	ENSMODP00000017124	ENSMODT00000017441

Organism

Monodelphis domestica

Functional Description

Protein Length

661

Protein Sequence
(FASTA)

MLTARLPDWG PRRPPARGSR QPPSVGPGGG GGSSCGAGCE KSPPSRAPAP GLASLRPSEP 60

AMAAPPSHGP FSGFPAPQEH TQVVPDVRLL QRRLPLAFRD ATSAPLRKLS VDLIKTYKHI 120

NEVYYAKKKR RAQQGPPEDA STKKERKVLN HGYDDDNHDY IVRSGERWLE RYEIDSLIGK 180

GSFGQVVKAY DHQAQELVAI KIIKNKKAFL NQAQIELRLL ELMNQHDTEM KYYIVHLKRH 240

FMFRNHLCLV FELLSYNLYD LLRNTHFRGV SLNLTRKLAQ QLCTALLFLA TPELSIIHCD 300

LKPENILLCN PKRSAIKIVD FGSSCQLGQR IYQYIQSRFY RSPEVLLGTP YDLAIDMWSL 360

GCILVEMHTG EPLFSGSNEV DQMNRIVEVL GLPPAPMLEQ APKARKYFDR LPGGGWTLRR 420

SKDLRKEYQG PGTRRLQEVL GVQTGGPGGR RAGEPGHSTA DYLRFQDLVL RMLAYEPAAR 480

ISPLGALQHG FFRRTADEAT NTGPSGSSTS TSPSPAPDAS HSSSAASSVS SSGGSSGSSN 540

DNRSYRYSNR YCGGPGPPVT DCEMHSPQVP PSQPLRPWAG GDVAHKPPPG PAPAPASSSS 600

SFHGAQAGSS SSSSPPPPEL MDVSLGGGPL LPQPAPQDCA PLRPAPPLQH PATSAFRTRT 660

T 661

Nucleotide Sequence
(FASTA)

ATGCTGACTG CCCGCCTGCC AGACTGGGGA CCCCGCCGGC CACCTGCCCG TGGCTCCCGA 60

CAGCCCCCCA GCGTGGGTCC CGGCGGTGGT GGTGGCAGCA GCTGTGGTGC AGGATGCGAG 120

AAGTCGCCCC CCAGCCGGGC TCCTGCTCCG GGCCTTGCTT CCCTTCGGCC CTCTGAGCCG 180

GCCATGGCCG CCCCTCCCAG CCATGGTCCT TTCTCCGGCT TCCCAGCCCC CCAGGAGCAT 240

ACACAGGTGG TTCCAGATGT CAGGCTGCTA CAGCGACGGC TCCCGCTGGC CTTTCGGGAT 300

GCCACCTCCG CCCCCCTCCG AAAGCTCTCT GTGGACCTCA TCAAGACCTA CAAGCACATT 360

AATGAGGTGT ACTACGCCAA GAAAAAGCGT CGGGCCCAGC AGGGTCCCCC AGAGGACGCA 420

AGCACAAAGA AAGAGCGGAA GGTTCTGAAC CACGGCTATG ATGATGACAA CCATGACTAC 480

ATTGTGCGAA GCGGGGAACG GTGGCTGGAG CGCTATGAGA TCGACTCACT CATTGGGAAG 540

GGTTCCTTTG GGCAGGTGGT GAAGGCCTAT GACCACCAGG CCCAGGAGCT GGTGGCCATC 600

AAGATCATTA AGAACAAGAA GGCATTTCTG AACCAGGCGC AGATTGAGTT GCGGCTGCTT 660

GAGCTGATGA ACCAGCATGA CACAGAGATG AAGTACTACA TTGTGCATCT GAAACGACAT 720

TTCATGTTCC GGAACCACCT GTGCCTGGTC TTTGAGCTCC TCTCCTACAA CCTGTACGAC 780

CTGCTGAGGA ACACCCACTT TCGGGGCGTC TCACTGAACC TGACCCGGAA GCTGGCACAG 840

CAGCTCTGCA CGGCTCTGCT CTTCCTGGCC ACCCCTGAGC TCAGCATCAT CCACTGCGAC 900

CTCAAGCCCG AGAACATCCT CCTCTGTAAC CCCAAACGCA GCGCCATCAA AATCGTCGAC 960

TTTGGCAGCT CCTGCCAGCT GGGCCAGCGG ATCTATCAGT ATATCCAGAG CCGCTTCTAC 1020

CGCTCACCTG AGGTGCTCCT GGGGACCCCG TATGACCTGG CCATTGACAT GTGGTCTTTA 1080

GGCTGTATCC TTGTGGAGAT GCACACGGGA GAGCCCCTCT TCAGTGGTTC TAATGAGGTG 1140

GACCAGATGA ATAGGATTGT GGAAGTGCTG GGGCTACCCC CAGCTCCCAT GCTGGAACAG 1200

GCACCCAAGG CTAGGAAGTA CTTTGATCGG TTGCCTGGAG GGGGCTGGAC CCTCCGGAGG 1260

AGCAAAGACC TCAGGAAGGA GTACCAGGGA CCTGGCACGC GGCGGCTGCA GGAGGTGCTG 1320

GGCGTGCAGA CAGGCGGCCC TGGGGGCCGG CGGGCAGGCG AGCCAGGCCA TAGCACAGCC 1380

GACTACCTCC GCTTCCAGGA CCTGGTGCTG CGCATGCTGG CATATGAGCC GGCCGCCCGC 1440

ATCAGCCCCC TGGGGGCCCT GCAGCATGGT TTCTTCCGTC GAACCGCTGA CGAGGCGACC 1500

AACACGGGGC CCTCGGGGAG CAGCACCTCC ACCTCCCCCT CTCCAGCCCC CGACGCCTCC 1560

CACTCCTCCA GTGCAGCCAG CTCTGTCTCC AGCTCTGGTG GGTCCAGCGG ATCATCGAAT 1620

GACAACCGGA GCTACCGCTA CAGCAACCGG TACTGTGGGG GCCCAGGGCC TCCGGTGACG 1680

GACTGCGAGA TGCATAGCCC CCAGGTCCCA CCTTCCCAGC CGCTGCGCCC TTGGGCAGGG 1740

GGAGACGTGG CCCACAAGCC TCCCCCGGGC CCAGCCCCGG CCCCAGCCTC CTCTTCCTCC 1800

TCCTTCCACG GGGCCCAGGC TGGCTCTTCT TCCTCTTCCT CACCACCTCC TCCTGAGCTG 1860

ATGGACGTGA GCCTTGGAGG TGGCCCCCTG CTGCCTCAGC CTGCCCCACA GGACTGTGCC 1920

CCACTCCGCC CCGCTCCCCC TCTCCAGCAC CCGGCCACTT CGGCCTTCCG GACTCGGACC 1980

ACA 1983

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d++++e vaikiiknkk+f++qaq+E+++Le +n++d+e+k

Q: 172   YEIDSLIGKGSFGQVVKAYDHQAQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK  231

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfells+nLy+ll++++f+g+sl+l+rklaqq+++aL +L+

Q: 232   YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAt  291

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 292   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGTP  350

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq++ ivevlglpp+ +le+a ka+k+f++

Q: 351   YDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGLPPAPMLEQAPKARKYFDR  410

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

              ++l+++          ++r+ ++vl+v++ +     p+ +++ge+ ++++d+l f

Q: 411   LPGGGWTLRRSkdlrkeyqgPGTRRLQEVLGVQTGG-----PGGRRAGEPGHSTADYLrF  465

         ********9987777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         +dl+ rml ++pa+Ri+p  al+h f+

Q: 466   QDLVLRMLAYEPAARISPLGALQHGFF  492

         *************************97

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD HQAQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK 60

YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY 180

DLAIDMWSLG CILVEMHTGE PLFSGSNEVD QMNRIVEVLG LPPAPMLEQA PKARKYFDRL 240

PGGGWTLRRS KDLRKEYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSTAD YLRFQDLVLR 300

MLAYEPAARI SPLGALQHGF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0003713	; F:transcription coactivator activity
GO:0007520	; P:myoblast fusion
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013