EKS-MOD-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	450.5	2.3E-135	24	308	285

Status

Unreviewed

Ensembl Protein

ENSMODP00000017137

UniProt Accession

F6YAB9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK14

Gene Synonyms/Alias

MAPK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000013704	ENSMODP00000017137	ENSMODT00000017455

Organism

Monodelphis domestica

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MSQERPKFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDKKTGLRV AVKKLSRPFQ 60

SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPAKSLEEFN DVYLVTHLMG ADLNNIVKCQ 120

KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 180

GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG 240

TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 300

QALAHGYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES 360

Nucleotide Sequence
(FASTA)

ATGTCTCAGG AGAGGCCTAA GTTCTACCGG CAGGAGCTGA ACAAGACCAT CTGGGAGGTG 60

CCCGAGCGCT ACCAGAACCT GTCCCCAGTA GGTTCGGGCG CCTATGGGTC CGTATGTGCT 120

GCTTTTGACA AAAAAACAGG GTTACGTGTG GCAGTGAAGA AGTTATCCAG ACCATTTCAG 180

TCCATCATCC ATGCAAAAAG GACTTACAGG GAATTGCGAT TACTTAAGCA TATGAAACAT 240

GAAAATGTGA TTGGCCTGTT AGATGTTTTC ACACCTGCAA AGTCTCTGGA GGAATTCAAT 300

GATGTGTATC TGGTGACACA TCTCATGGGG GCAGATCTGA ACAATATTGT GAAATGCCAA 360

AAGCTCACCG ATGACCATGT ACAGTTCCTT ATCTACCAGA TTCTCCGAGG CTTAAAGTAT 420

ATTCATTCAG CTGACATTAT ACACAGAGAC CTGAAACCTA GTAACTTAGC TGTGAATGAA 480

GACTGTGAGC TTAAGATCCT AGATTTTGGA CTGGCCCGGC ACACAGATGA TGAAATGACA 540

GGTTATGTAG CCACCAGGTG GTATAGGGCT CCTGAGATCA TGCTGAACTG GATGCATTAC 600

AACCAAACAG TTGATATTTG GTCAGTGGGA TGCATAATGG CAGAACTGTT GACTGGAAGG 660

ACACTGTTTC CTGGTACCGA CCATATTGAT CAGTTGAAGC TCATTTTAAG ACTCGTTGGA 720

ACCCCAGGGG CTGAGCTTTT GAAGAAAATC TCTTCAGAGT CTGCAAGAAA TTATATTCAA 780

TCTTTGACCC AGATGCCGAA GATGAACTTT GCAAATGTGT TTATTGGTGC CAATCCATTA 840

GCTGTTGACC TGCTGGAGAA GATGCTTGTA TTGGACTCGG ATAAGAGAAT TACAGCAGCT 900

CAAGCCCTTG CCCATGGCTA CTTTGCCCAG TACCACGATC CTGATGATGA ACCAGTTGCA 960

GACCCCTATG ACCAGTCCTT TGAAAGCAGG GATCTCCTGA TAGATGAATG GAAAAGCCTG 1020

ACCTATGATG AAGTTATAAG TTTTGTGCCG CCACCACTTG ACCAAGAAGA GATGGAGTCC 1080

TGA 1083

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+p+g+Gayg v++a+dk+t+ rva+kklsrpfq+ ++akrt+REl+llk++kheN+

Q: 24    YQNLSPVGSGAYGSVCAAFDKKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV  83

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp+++lee++dvYlvt+lm++dL++++k qkl+d+h+++l+yqilrglky+Hs

Q: 84    IGLLDVFTPAKSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS  143

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsNl+vnedcelkildFGlar++d+e    +t+yvatrwYraPei+l++++

Q: 144   ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMH  199

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI+aElltg++lfpg+d+idql++il+++gtp +e lkki+se+arnyi

Q: 200   YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI  259

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +sl++++k++f+++f  a++ a+dLlek+Lvld+dkRi++++aL+h Y+

Q: 260   QSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHGYF  308

         **********************************************995

Domain Sequence
(FASTA)

YQNLSPVGSG AYGSVCAAFD KKTGLRVAVK KLSRPFQSII HAKRTYRELR LLKHMKHENV 60

IGLLDVFTPA KSLEEFNDVY LVTHLMGADL NNIVKCQKLT DDHVQFLIYQ ILRGLKYIHS 120

ADIIHRDLKP SNLAVNEDCE LKILDFGLAR HTDDEMTGYV ATRWYRAPEI MLNWMHYNQT 180

VDIWSVGCIM AELLTGRTLF PGTDHIDQLK LILRLVGTPG AELLKKISSE SARNYIQSLT 240

QMPKMNFANV FIGANPLAVD LLEKMLVLDS DKRITAAQAL AHGYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0000922	; C:spindle pole
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0001525	; P:angiogenesis
GO:0000902	; P:cell morphogenesis
GO:0071363	; P:cellular response to growth factor stimulus
GO:0071479	; P:cellular response to ionizing radiation
GO:0002062	; P:chondrocyte differentiation
GO:0000077	; P:DNA damage checkpoint
GO:0019395	; P:fatty acid oxidation
GO:0006006	; P:glucose metabolic process
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0030316	; P:osteoclast differentiation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032495	; P:response to muramyl dipeptide
GO:0042770	; P:signal transduction in response to DNA damage
GO:0007519	; P:skeletal muscle tissue development
GO:0090400	; P:stress-induced premature senescence
GO:0051146	; P:striated muscle cell differentiation
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

mdo:100026324

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013