EKS-MOD-00178

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00178

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/SRPK	833.1	8.7E-251	80	658	579

Status

Unreviewed

Ensembl Protein

ENSMODP00000017177

UniProt Accession

F6X887;

Protein Name

Protein Synonyms/Alias

Gene Name

SRPK1

Gene Synonyms/Alias

SRPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000013740	ENSMODP00000017177	ENSMODT00000017496

Organism

Monodelphis domestica

Functional Description

Protein Length

660

Protein Sequence
(FASTA)

MERKVLALQA RKKRTKAKKD KAQKKPETQH RGPVSHSEND LPEQEEEILG SDDDEQEDPN 60

DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI QGKKFVAMKV VKSAEHYTET 120

ALDEIRLLKS VRNTDPTDPN REMVVQLLDD FKISGVNGTH ICMVFEVLGH HLLKWIIKSN 180

YQGLPLPCVK KIIQQVLQGL DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR 240

SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESSPGQ 300

KQPGKQAESP IERVLLENPL STESQEKLEE ENVIEHEQTL IMEGNPESVS TEINCNGVVG 360

IANYVECNNE ESLRLKEDHH NANECDAQPL KEEEVSFPSS QNGESGASQE IADSCTALSS 420

GVSDTMLYQP SSSEHSVEQS FNEQEISQLQ ESIRAEIPSE DENENNGPLD NKGTQGKSSA 480

GNFLLNPLEP KNAEKLKVKI ADLGNACWVH KHFTEDIQTR QYRSLEVLIG SGYNTPADIW 540

STACMAFELA TGDYLFEPHS GEEYTRDEDH IALIIELLGK VPRKLIVAGK YSKEFFTKKG 600

DLKHITKLKP WGLFEVLVEK YEWSQEEAAG FTDFLLPMLE LIPEKRATAA ECLRHPWLNS 660

Nucleotide Sequence
(FASTA)

ATGGAGCGGA AAGTGCTTGC GCTCCAGGCC CGAAAGAAAC GGACCAAGGC CAAGAAGGAC 60

AAAGCCCAAA AGAAACCTGA AACTCAGCAC CGAGGCCCTG TCTCCCATTC TGAGAATGAT 120

CTCCCAGAAC AAGAGGAAGA AATTCTGGGA TCAGATGATG ATGAACAAGA GGATCCTAAT 180

GATTATTGTA AAGGGGGTTA TCATCTTGTG AAAATTGGAG ATCTGTTCAA TGGCAGATAC 240

CACGTGATCC GAAAACTGGG TTGGGGACAT TTTTCAACAG TATGGCTATC ATGGGACATT 300

CAGGGAAAGA AGTTTGTGGC AATGAAAGTA GTGAAGAGTG CTGAACATTA CACTGAAACA 360

GCCCTGGATG AAATCAGGCT GCTTAAATCG GTTCGCAATA CAGATCCCAC TGATCCAAAT 420

AGAGAGATGG TTGTTCAACT TTTGGATGAC TTCAAAATCT CAGGAGTGAA TGGAACCCAT 480

ATCTGTATGG TATTTGAAGT TTTGGGCCAT CACCTACTCA AGTGGATTAT CAAGTCAAAT 540

TATCAAGGAC TTCCACTTCC ATGTGTCAAA AAAATCATCC AACAAGTTCT GCAGGGACTG 600

GATTATCTAC ATACCAAGTG CCGTATCATC CACACTGACA TCAAACCAGA AAACATTCTT 660

CTTTCTGTAA ATGAACAATA TATCCGAAGA CTGGCTGCAG AAGCAACAGA ATGGCAGAGA 720

TCTGGAGCTC CCCCACCTTC TGGCTCTGCA GTCAGTACTG CTCCCCAACC TAAACCAGCA 780

GACAAAATGT CCAAGAATAA AAAGAAGAAA TTGAAAAAGA AGCAGAAACG TCAAGCTGAG 840

CTACTGGAGA AACGAATGCA AGAAATAGAG GAAATGGAAA AAGAATCAAG CCCTGGACAG 900

AAACAGCCAG GAAAACAAGC TGAGAGCCCT ATTGAGAGAG TCTTGCTAGA GAACCCTTTA 960

AGTACAGAAA GTCAAGAAAA ACTTGAAGAA GAAAATGTCA TTGAACATGA GCAGACCCTT 1020

ATAATGGAAG GCAATCCTGA GAGTGTTTCA ACAGAAATCA ATTGCAATGG AGTGGTTGGA 1080

ATTGCTAATT ATGTTGAATG CAATAATGAA GAGTCATTGA GGCTTAAGGA AGATCATCAT 1140

AATGCTAATG AATGTGATGC CCAACCTTTG AAAGAGGAAG AAGTTAGCTT CCCAAGCTCC 1200

CAAAATGGAG AGAGTGGTGC ATCTCAAGAA ATAGCAGACT CTTGTACAGC TTTAAGTTCT 1260

GGGGTATCAG ACACTATGTT ATATCAGCCA TCTTCAAGTG AACACTCAGT AGAGCAATCA 1320

TTCAATGAGC AGGAGATCAG CCAGCTGCAA GAGAGCATCC GGGCAGAGAT ACCCTCTGAA 1380

GATGAAAACG AAAATAATGG ACCATTGGAT AACAAAGGTA CCCAAGGAAA ATCTTCTGCT 1440

GGGAATTTTC TCCTTAATCC CCTTGAACCC AAAAATGCAG AAAAGCTCAA AGTGAAGATT 1500

GCTGATCTCG GGAATGCGTG CTGGGTGCAT AAGCATTTCA CTGAAGATAT TCAGACAAGG 1560

CAGTATCGAT CCCTAGAAGT ACTCATAGGA TCTGGTTATA ATACTCCTGC TGACATTTGG 1620

AGCACAGCAT GTATGGCCTT TGAATTAGCT ACTGGAGACT ATCTGTTTGA ACCTCATTCA 1680

GGAGAAGAGT ACACTCGAGA TGAAGATCAC ATTGCATTGA TCATAGAACT GCTGGGGAAG 1740

GTGCCTCGCA AGCTCATTGT GGCGGGAAAA TATTCCAAGG AGTTTTTCAC CAAAAAAGGT 1800

GACCTAAAAC ACATAACTAA ACTGAAGCCT TGGGGCCTTT TTGAAGTTCT AGTGGAGAAA 1860

TATGAGTGGT CTCAAGAAGA AGCAGCAGGC TTCACAGATT TCTTATTGCC AATGTTGGAG 1920

CTGATTCCTG AGAAACGAGC CACAGCAGCA GAGTGTCTCA GGCACCCTTG GCTTAACTCC 1980

TAA 1983

Domain Profile

S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60

         yhvirkLGWGhfstvWL+wd+q+k+fva+kvvksaehytetaldei+llksvr++dp+dp

Q: 80    YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNTDPTDP  139

         9***********************************************************

S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120

         +re+vvqllddfkisGvnG+h+c+vfevLG++Llk+iiksny+Glpl++vkkii+qvL+g

Q: 140   NREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQG  199

         ************************************************************

S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180

         Ldylh+kC+iihtdikPen+Ll+v+++yirrlaaeatewq++ga+ppsgsavstapq+k+

Q: 200   LDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKP  259

         ************************************************************

S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214

         ++k+sknkkkklkkkqkrqaellekr+qe+ee+e

Q: 260   ADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEkesspgqkqpgkqaespiervllenp  319

         ************************************************************

S: 215   ........aaeanseaedqelkedaekgele.eieadveeevanedeaseeee.......  258

                 ++e+n + ++q+l+++ + ++++ ei+++ +  +an+ e ++ee+

Q: 320   lstesqekLEEENVIEHEQTLIMEGNPESVStEINCNGVVGIANYVECNNEESlrlkedh  379

         *******999999999999999999988875379***********999998889999999

S: 259   ..............essltsssdaesksgel.seastellsesleqlacgsvls......  297

                       e s+ ss++ es ++++ ++++t l s++++++  + ++s

Q: 380   hnanecdaqplkeeEVSFPSSQNGESGASQEiADSCTALSSGVSDTMLYQPSSSehsveq  439

         999999*****998999999999999888765999999999*****99998888899***

S: 298   .............................................vnplepknadkikvk  312

                                                      +nplepkna+k+kvk

Q: 440   sfneqeisqlqesiraeipsedenenngpldnkgtqgkssagnflLNPLEPKNAEKLKVK  499

         ************************************************************

S: 313   iadLGnaCwvhkhftediqtrqyrslevliGagygtpadiWstaClafeLatGdyLfeph  372

         iadLGnaCwvhkhftediqtrqyrslevliG+gy+tpadiWstaC+afeLatGdyLfeph

Q: 500   IADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPH  559

         ************************************************************

S: 373   sgedysrdedhiakiiellGkiPrklilkGkysreffnkkgeLrhitkLkpwsLlevLve  432

         sge+y+rdedhia iiellGk+Prkli++Gkys+eff+kkg+L+hitkLkpw+L+evLve

Q: 560   SGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVE  619

         ************************************************************

S: 433   kyewskeeaaefsdfLlPmleldpekrasaaeclkhpwL  471

         kyews+eeaa f+dfLlPmlel+pekra+aaecl+hpwL

Q: 620   KYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL  658

         **************************************8

Domain Sequence
(FASTA)

YHVIRKLGWG HFSTVWLSWD IQGKKFVAMK VVKSAEHYTE TALDEIRLLK SVRNTDPTDP 60

NREMVVQLLD DFKISGVNGT HICMVFEVLG HHLLKWIIKS NYQGLPLPCV KKIIQQVLQG 120

LDYLHTKCRI IHTDIKPENI LLSVNEQYIR RLAAEATEWQ RSGAPPPSGS AVSTAPQPKP 180

ADKMSKNKKK KLKKKQKRQA ELLEKRMQEI EEMEKESSPG QKQPGKQAES PIERVLLENP 240

LSTESQEKLE EENVIEHEQT LIMEGNPESV STEINCNGVV GIANYVECNN EESLRLKEDH 300

HNANECDAQP LKEEEVSFPS SQNGESGASQ EIADSCTALS SGVSDTMLYQ PSSSEHSVEQ 360

SFNEQEISQL QESIRAEIPS EDENENNGPL DNKGTQGKSS AGNFLLNPLE PKNAEKLKVK 420

IADLGNACWV HKHFTEDIQT RQYRSLEVLI GSGYNTPADI WSTACMAFEL ATGDYLFEPH 480

SGEEYTRDED HIALIIELLG KVPRKLIVAG KYSKEFFTKK GDLKHITKLK PWGLFEVLVE 540

KYEWSQEEAA GFTDFLLPML ELIPEKRATA AECLRHPWL 579

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007059	; P:chromosome segregation
GO:0045071	; P:negative regulation of viral genome replication
GO:0045070	; P:positive regulation of viral genome replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013