EKS-MOD-00242

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00242

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	367.3	3.9E-110	109	360	252

Status

Unreviewed

Ensembl Protein

ENSMODP00000017236

UniProt Accession

F6TUU1;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK3

Gene Synonyms/Alias

SIK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000013784	ENSMODP00000017236	ENSMODT00000017555

Organism

Monodelphis domestica

Functional Description

Protein Length

1414

Protein Sequence
(FASTA)

MALGAGRRGR PASLSDVYPA SPSFPAPLPP SRLPAVPEVS LHNKMAAAAA SGAGGTAGAG 60

AGGVCPAARL LPPAAAGPPA APAPVPSTGP PRPPAPAPRG PLPARIGYYE IDRTIGKGNF 120

AVVKRATHLV TKAKVAIKII DKTQLDEENL KKIFREVQIM KMLCHPHIIR LYQVMETERM 180

IYLVTEYASG GEIFDHLVAH GRMAEKEARR KFKQIVAAVH FCHCRNIVHR DLKAENLLLD 240

ANLNIKIADF GFSNIFTPGQ LLKTWCGSPP YAAPELFEGK EYDGPKVDIW SLGVVLYVLV 300

CGALPFDGST LQNLRARVLS GKFRIPFFMS TECEHLIRHM LVLDPSKRLS MEQICKHKWM 360

KLGEADPNFE RLISECQHLK VERQMEPLNE DVLLAMVEMG LDKERTLQSL RTDAYDHYSA 420

IYSLLCDRLK RHKNLRIGAP PSVPRTMTFP APAAIQAEQA GTTVSINVPQ VQLINPENQI 480

VETDGTMNLD SDEGEEPSPE ALVRYLSMRR HTVGVADPRT EVTEDLQKLL PGFPRVSPQA 540

PFLQVAPNMN FVHNLLPMQN LQPTGQLEYK EQSLLQPPTL QLLNGMGPLG RRASDGGANI 600

QLHAQQLLKR PRGPSPLVTM TPAVPAVTPV DEESSDGEPD QEAVQRYLAN RSKRHTLAMT 660

NPTAEIPPDL QRQLGQQPFR ARVWPPHLVP DQHRSVYKDS NTLHLPTERF SPVRRFSDGA 720

ASIQAFKAHL EKMGNHSSIK QLQQECEQLQ KMYGGQIDER TLEKTQQQHM LYQQEQHHQI 780

LQQQIQDCIR PPQPSPPLQA TCENQPALLT HQLQRLRIQP SSPPPTHPNN HLFRQPSNSP 840

PPVSSAILQS HGAASPSQFQ GLPSRSAIFQ QPGNCSPPPN VTLTCMGLQQ PAQSQQVTIQ 900

VQEPPDMLSN MPGASAAGRG MSLNSCASQI QMQHRANLMA SLTYGHRPLS KQLSADSAEA 960

HSLNMNRFSP ANYDQAHLHP QLFSDQSRAS PTSYSPSAGV GFPPTQALKV PPLDQFPTFP 1020

SSAHQQQQHY TTSALQQALL SPTPPDYPRH QQVPHILQGL LSPRHSLTGH SDVRLPPAEF 1080

AQLIKRQQQR QQQQELQELF RHMNQGDAGS LASSLGGQSI SECQALSLPY QNTDSYHHHH 1140

HHHHHHHHHT SPQHLLQIRA QECISQVPSP APAHGYAHQP ALIHSESMEE DCSCEGARDC 1200

FPDSKSSNTL TKGCHESPLL LNTGGPGDPE SLLGTVSHAQ EMGVHPYRHQ PVTGFSRNKV 1260

PSRESVIGNC MDRSSAGQAM ELPDHNGLGY STRSTVNEHH RPRTLQRHHT IQNSDDAYVQ 1320

LDNLPGMSLM AGKALSSARM SDAVLSQSSL MGSQQLQDRE SEGCRETLEG QEPSDLTDGS 1380

QHLHNSCYPS TCITDILLSY KHPEVSFSME QAGV 1414

Nucleotide Sequence
(FASTA)

ATGGCGCTGG GCGCCGGGCG CCGCGGGCGC CCCGCCTCCC TGAGTGACGT ATACCCCGCT 60

TCCCCCTCCT TTCCCGCCCC CCTACCCCCC TCCCGGCTCC CCGCGGTCCC GGAGGTTTCT 120

CTGCACAACA AGATGGCGGC GGCGGCGGCA AGCGGAGCTG GTGGGACTGC GGGGGCCGGA 180

GCCGGGGGAG TTTGTCCGGC TGCCCGCCTG CTGCCCCCGG CCGCAGCCGG ACCCCCGGCC 240

GCGCCTGCCC CGGTCCCGTC GACCGGCCCC CCGCGCCCCC CAGCCCCAGC CCCCCGCGGG 300

CCGCTGCCCG CCCGCATCGG CTACTACGAG ATCGACCGCA CCATCGGCAA GGGCAACTTC 360

GCCGTGGTCA AGCGGGCCAC GCACCTCGTC ACCAAGGCTA AGGTTGCTAT AAAGATCATA 420

GATAAAACCC AGTTGGATGA AGAAAACCTC AAGAAGATTT TCCGAGAAGT TCAGATTATG 480

AAAATGCTTT GTCACCCACA CATCATCAGG CTATACCAGG TTATGGAGAC AGAGCGGATG 540

ATTTATTTAG TGACAGAATA TGCTAGTGGA GGAGAAATAT TTGATCACTT GGTTGCCCAT 600

GGTCGAATGG CAGAGAAAGA AGCTCGTCGG AAGTTCAAGC AGATTGTAGC TGCTGTCCAT 660

TTCTGCCATT GCCGGAACAT TGTTCACCGT GACTTAAAAG CAGAAAACCT GCTTTTGGAC 720

GCCAATCTGA ATATCAAGAT AGCAGATTTT GGGTTCAGTA ACATCTTTAC CCCAGGGCAA 780

TTACTGAAGA CCTGGTGTGG GAGTCCCCCA TATGCTGCCC CTGAGCTCTT TGAAGGAAAG 840

GAATATGATG GGCCTAAAGT GGACATTTGG AGCCTTGGAG TAGTCCTCTA TGTGCTCGTA 900

TGTGGTGCCC TGCCATTTGA TGGAAGCACC CTTCAGAATC TTCGGGCCCG GGTACTGAGT 960

GGAAAGTTCC GAATTCCATT TTTCATGTCC ACAGAATGTG AGCACTTGAT CCGCCACATG 1020

CTGGTGTTAG ACCCAAGTAA GCGCCTCTCA ATGGAGCAGA TCTGCAAACA CAAGTGGATG 1080

AAGCTGGGAG AGGCTGATCC CAACTTCGAA AGGTTAATAA GTGAATGCCA GCATCTGAAG 1140

GTAGAAAGAC AAATGGAGCC TCTGAATGAA GATGTATTGT TGGCCATGGT GGAAATGGGG 1200

CTGGACAAGG AGAGAACACT GCAGTCACTA AGGACAGATG CCTATGATCA CTACAGTGCA 1260

ATCTATAGCC TACTGTGTGA TCGACTTAAG AGACATAAGA ACCTGCGTAT TGGAGCACCT 1320

CCCAGTGTAC CACGGACCAT GACCTTCCCA GCACCAGCTG CTATCCAGGC GGAGCAAGCA 1380

GGTACCACTG TAAGCATCAA CGTTCCCCAG GTGCAGCTTA TCAACCCAGA AAACCAAATT 1440

GTGGAGACGG ATGGAACAAT GAACTTGGAC AGTGATGAAG GTGAAGAACC ATCCCCTGAA 1500

GCTCTGGTCA GGTACCTTTC AATGAGGAGG CACACAGTGG GCGTCGCTGA TCCCCGCACG 1560

GAAGTCACAG AAGATCTTCA GAAGCTCCTT CCTGGCTTTC CTCGGGTCAG CCCCCAGGCT 1620

CCATTCCTCC AGGTGGCCCC TAACATGAAT TTCGTGCACA ACCTACTCCC TATGCAAAAT 1680

TTGCAACCAA CTGGGCAGTT AGAGTACAAG GAGCAGTCCC TGCTACAGCC TCCCACTCTA 1740

CAGTTGCTGA ATGGAATGGG CCCCCTTGGC CGGCGGGCAT CAGATGGAGG AGCCAACATC 1800

CAGCTGCATG CCCAACAATT GCTGAAGCGC CCAAGGGGAC CCTCCCCTCT TGTCACCATG 1860

ACACCAGCAG TCCCAGCTGT TACCCCTGTG GATGAGGAAA GCTCCGATGG GGAGCCAGAT 1920

CAGGAAGCTG TACAGAGATA CTTGGCAAAT AGGTCCAAAA GACATACACT GGCCATGACC 1980

AACCCAACAG CTGAGATTCC TCCGGACCTG CAGCGGCAGC TAGGACAGCA GCCTTTCCGT 2040

GCCCGGGTCT GGCCGCCTCA CCTGGTACCC GATCAGCATC GCTCTGTCTA CAAGGACTCC 2100

AACACCCTGC ACCTTCCCAC AGAGCGTTTT TCCCCTGTGC GCCGATTTTC TGATGGGGCT 2160

GCAAGCATCC AGGCTTTCAA AGCTCACCTG GAGAAGATGG GCAACCACAG CAGCATCAAA 2220

CAGCTGCAGC AGGAGTGTGA GCAGCTGCAA AAGATGTATG GGGGGCAGAT TGATGAGAGA 2280

ACACTCGAGA AGACTCAGCA GCAACATATG TTATACCAGC AGGAGCAACA TCATCAGATT 2340

CTCCAGCAGC AAATTCAGGA TTGTATCCGT CCTCCTCAAC CTTCTCCACC TCTTCAGGCT 2400

ACATGTGAAA ACCAGCCAGC CCTTCTTACC CACCAGCTCC AGAGGTTACG GATTCAGCCC 2460

TCGAGCCCTC CCCCTACCCA CCCCAACAAC CATCTCTTCA GACAGCCCAG TAATAGCCCT 2520

CCCCCTGTCA GCAGTGCCAT TCTTCAGTCT CATGGTGCGG CCTCTCCTTC CCAGTTTCAA 2580

GGCTTGCCAT CCCGAAGTGC AATCTTCCAG CAGCCTGGGA ACTGTTCTCC TCCCCCCAAT 2640

GTGACACTGA CCTGCATGGG CCTACAGCAA CCTGCCCAGT CTCAGCAGGT GACCATCCAG 2700

GTACAAGAGC CACCTGACAT GCTGAGCAAC ATGCCAGGGG CATCAGCAGC TGGGCGGGGC 2760

ATGTCCCTCA ACTCCTGTGC CAGTCAGATT CAGATGCAGC ACCGTGCCAA CCTGATGGCC 2820

TCCCTCACCT ATGGGCACCG CCCATTATCC AAGCAACTGA GTGCCGACAG TGCAGAGGCC 2880

CACAGCTTGA ACATGAATCG GTTTTCCCCT GCTAATTATG ACCAGGCACA TTTACACCCC 2940

CAACTGTTCT CGGACCAGTC CCGGGCTTCC CCTACCAGCT ACAGCCCATC AGCAGGAGTG 3000

GGCTTTCCTC CAACCCAAGC CCTAAAAGTC CCTCCGCTCG ACCAGTTCCC TACTTTCCCT 3060

TCCAGCGCAC ATCAGCAGCA ACAGCACTAC ACCACATCGG CACTACAGCA GGCTCTGCTG 3120

TCCCCCACGC CGCCTGACTA TCCAAGACAC CAGCAGGTAC CCCACATCCT CCAAGGACTG 3180

CTATCCCCCC GGCACTCACT CACGGGCCAC TCGGACGTTC GGCTGCCTCC GGCAGAGTTT 3240

GCACAGCTCA TTAAAAGGCA GCAACAGCGA CAGCAGCAGC AGGAATTACA AGAATTGTTC 3300

AGGCATATGA ACCAGGGGGA TGCTGGGAGC CTGGCTTCCA GCTTAGGGGG ACAGAGTATA 3360

TCGGAGTGCC AGGCTTTGTC TTTGCCTTAT CAAAACACTG ACTCATATCA CCACCATCAC 3420

CACCACCACC ACCACCATCA CCACCATACC AGCCCCCAGC ATCTTTTACA AATCAGGGCA 3480

CAAGAATGTA TCTCACAGGT TCCCTCGCCC GCCCCGGCTC ATGGGTACGC ACACCAGCCA 3540

GCGCTGATCC ACTCAGAGAG CATGGAAGAG GACTGCTCGT GTGAAGGGGC CAGGGATTGC 3600

TTTCCAGACA GTAAGAGTTC AAACACTTTG ACCAAAGGTT GCCATGAGAG CCCCCTGCTA 3660

TTGAACACAG GTGGGCCTGG AGACCCTGAA TCTTTGCTAG GAACTGTAAG CCATGCACAG 3720

GAAATGGGAG TGCATCCATA TCGACATCAG CCAGTGACTG GATTCAGTAG AAATAAAGTG 3780

CCCAGCAGAG AATCTGTCAT AGGGAACTGT ATGGACAGAA GTTCTGCTGG ACAAGCTATG 3840

GAGCTACCTG ATCATAATGG GTTGGGTTAC TCAACACGCT CCACTGTCAA TGAGCATCAC 3900

AGGCCCCGGA CCCTACAGAG ACATCACACT ATCCAGAACA GCGATGATGC CTATGTGCAG 3960

CTGGATAACC TGCCTGGAAT GAGTCTCATG GCTGGAAAAG CACTGAGCTC TGCTCGAATG 4020

TCAGATGCTG TCCTCAGTCA GTCTTCGCTC ATGGGGAGCC AGCAGCTTCA GGACAGGGAG 4080

AGTGAGGGCT GTAGGGAGAC TTTGGAAGGT CAAGAGCCCT CAGACCTGAC CGACGGCAGC 4140

CAGCACTTAC ACAACTCTTG TTATCCATCT ACATGTATTA CAGACATTCT ACTGAGCTAC 4200

AAGCATCCAG AGGTCTCCTT CAGCATGGAG CAGGCTGGGG TGTAA 4245

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +t+G+g+f+ Vk a+h  tk kva+Kii+k++l+ee+l+ki+rE++i+k+l hp+i

Q: 109   YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHI  168

         999*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         i+l++v+et++++ylv+eyasgge+fd+++++gr+ ekear+ fkq+v+av+++h ++iv

Q: 169   IRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVAAVHFCHCRNIV  228

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld++ nikiaDFG++n+f++g+ll+t+cGsppYaaPel++gk+Y+gpkvD

Q: 229   HRDLKAENLLLDANLNIKIADFGFSNIFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD  288

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGvvLy+lv+g+lPfd+++l++l++++l+gk++ip+ +s+e+e+L+r++Lv dp+kR

Q: 289   IWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPSKR  348

         ************************************************************

S: 241   atieeilkhewl  252

         +++e+i kh+w+

Q: 349   LSMEQICKHKWM  360

         ***********8

Domain Sequence
(FASTA)

YEIDRTIGKG NFAVVKRATH LVTKAKVAIK IIDKTQLDEE NLKKIFREVQ IMKMLCHPHI 60

IRLYQVMETE RMIYLVTEYA SGGEIFDHLV AHGRMAEKEA RRKFKQIVAA VHFCHCRNIV 120

HRDLKAENLL LDANLNIKIA DFGFSNIFTP GQLLKTWCGS PPYAAPELFE GKEYDGPKVD 180

IWSLGVVLYV LVCGALPFDG STLQNLRARV LSGKFRIPFF MSTECEHLIR HMLVLDPSKR 240

LSMEQICKHK WM 252

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013