EPS-MOD-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	264.6	1.2E-78	104	408	305

Status

Unreviewed

Ensembl Protein

ENSMODP00000017699

UniProt Accession

F6X2X9;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1D

Gene Synonyms/Alias

PPM1D;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000014156	ENSMODP00000017699	ENSMODT00000018027

Organism

Monodelphis domestica

Functional Description

Protein Length

640

Protein Sequence
(FASTA)

SSSSKINNSW RPASALPGPR GAGLGGRAVW GRQGPGQPAM AGLYSLGVSV FSDQGGRKYM 60

EDVTQIVVEP EPPVEDESSL GQSPPLPGDE TGPGGEGPSA ASREGSREPA GGARASSPAA 120

GRSCLRRRRR SSVAFFAVCD GHGGREAAQF AREHLWGFIK KQKGFGSAEP AEVCAAIRKG 180

FLACHLAMWK KLAEWPKTMT GLPSTSGTTA SVVIIRGTKM YVAHVGDSGV VLGVQDDSKD 240

DFVRAVEVTQ DHKPELPKER ERIEGLGGSV INKSGVNRVV WKRPRLTHNG PVRRSTIIDQ 300

IPFLAVARAL GDLWSYDFYT GEFVVSPEPD TSVHTLDPRK HKYIILGSDG LWNMIPPQDA 360

IAMCQDQEEK KYLMGEHGQS CAKMLVNRAL GRWRQRMLRA DNTSAIVICI STGVDNQGNF 420

TREDELYLNL ADSPSYNSQE TYTMSPSPCS TPPVKILEED TWPRLNSKDH IPALVRSNAF 480

SEKYLELPTE RARSNVQSVA VSSKDPEALE ENYPKGLTLR IHDSLNNSLP VGLSPSNSAN 540

PSMDQKNLKK STPGQMKARE VERTPPANFK RTLEESNSGP AMKKPRRSGL SRNSGSPSEG 600

LSSTPQRKNS VKLTMRRSLR GQKKLGNPLL HQHRKTICVC 640

Nucleotide Sequence
(FASTA)

TCGTCGTCGT CGAAGATAAA CAATAGTTGG CGGCCGGCGA GCGCGCTACC AGGACCTCGC 60

GGGGCTGGGC TCGGCGGGCG GGCTGTGTGG GGCCGGCAGG GTCCCGGCCA GCCGGCCATG 120

GCGGGACTCT ACTCGCTCGG GGTGAGCGTC TTCTCCGATC AGGGCGGGAG GAAGTACATG 180

GAGGACGTGA CCCAGATCGT GGTGGAGCCA GAGCCGCCGG TCGAGGACGA GTCCTCGCTG 240

GGGCAGTCGC CGCCACTCCC CGGGGACGAG ACGGGCCCCG GGGGCGAGGG CCCCTCGGCG 300

GCGTCCCGGG AAGGATCCCG CGAGCCTGCT GGCGGCGCCC GGGCCTCGTC GCCAGCCGCG 360

GGCCGCAGCT GCCTACGGCG CCGCCGCCGC TCCTCAGTGG CCTTCTTCGC TGTGTGCGAC 420

GGACACGGCG GGCGGGAAGC GGCCCAGTTC GCCCGAGAGC ACCTGTGGGG CTTCATCAAG 480

AAGCAGAAGG GATTCGGCTC CGCAGAGCCG GCCGAGGTGT GCGCCGCCAT CCGTAAGGGC 540

TTCCTTGCCT GTCACCTGGC CATGTGGAAG AAACTGGCAG AATGGCCTAA GACTATGACT 600

GGCCTCCCCA GCACATCGGG CACAACTGCA AGTGTGGTTA TCATCCGAGG CACAAAGATG 660

TATGTAGCTC ATGTAGGAGA CTCAGGAGTG GTCCTTGGAG TTCAGGATGA CTCAAAGGAT 720

GATTTTGTCA GAGCTGTGGA AGTGACACAG GACCACAAAC CTGAACTTCC TAAAGAAAGA 780

GAAAGAATCG AAGGACTTGG TGGGAGTGTG ATCAACAAAT CTGGAGTTAA CCGTGTTGTT 840

TGGAAACGAC CTCGACTTAC TCATAATGGC CCTGTTCGAA GAAGTACAAT TATTGACCAG 900

ATCCCTTTCC TGGCAGTTGC GAGAGCACTT GGTGACTTGT GGAGCTATGA CTTTTATACT 960

GGGGAGTTTG TAGTGTCTCC AGAACCAGAT ACAAGTGTCC ACACTCTTGA TCCCCGGAAA 1020

CACAAGTATA TAATCTTGGG CAGTGATGGA CTATGGAACA TGATCCCTCC TCAGGATGCC 1080

ATTGCGATGT GCCAGGACCA AGAAGAGAAA AAATACTTGA TGGGGGAGCA TGGACAGTCT 1140

TGTGCCAAAA TGCTTGTCAA TAGAGCACTG GGTCGTTGGA GACAGCGCAT GCTCCGTGCA 1200

GATAACACTA GTGCCATAGT CATCTGCATT TCAACTGGAG TGGATAATCA AGGGAACTTT 1260

ACACGTGAAG ATGAGCTTTA TCTAAATCTG GCAGATAGTC CCTCATACAA CAGTCAGGAA 1320

ACTTATACAA TGTCTCCTTC CCCCTGTTCC ACACCACCAG TCAAGATTTT GGAAGAGGAT 1380

ACGTGGCCAC GCCTCAATTC TAAGGACCAC ATCCCTGCCC TTGTTCGCAG TAATGCCTTC 1440

TCAGAGAAGT ATTTAGAGCT ACCAACTGAG AGAGCACGGA GTAATGTCCA GTCTGTAGCA 1500

GTATCTTCAA AGGACCCAGA GGCATTAGAG GAAAACTACC CTAAAGGCCT GACTTTGAGA 1560

ATACATGACT CTTTGAATAA CAGCCTTCCA GTTGGCCTTT CCCCTTCTAA TTCAGCAAAC 1620

CCCAGCATGG ACCAAAAAAA CCTAAAGAAA TCAACTCCTG GCCAAATGAA AGCCCGAGAA 1680

GTTGAAAGGA CCCCTCCAGC TAACTTTAAA AGGACACTGG AAGAATCTAA CTCTGGCCCA 1740

GCTATGAAGA AGCCCAGACG AAGTGGCCTA AGCCGGAACA GTGGTTCTCC GTCAGAGGGT 1800

CTTTCATCAA CCCCTCAACG TAAAAACTCG GTGAAACTTA CTATGCGCCG CAGTCTTAGG 1860

GGCCAGAAGA AACTTGGAAA TCCTTTGTTG CACCAGCATC GGAAAACTAT TTGTGTTTGT 1920

TGA 1923

Domain Profile

S: 9     ngrrnemedavtsspnflkspekkdr...laffgvyDGhggsevakfcseklheilaeel  65

          g r+    a++ssp +++s+ +++r   +aff+v+DGhgg+e+a+f++e+l+ ++++++

Q: 104   EGSREPAGGARASSPAAGRSCLRRRRrssVAFFAVCDGHGGREAAQFAREHLWGFIKKQK  163

         66677777788889999998887777889*******************************

S: 66    esseseerkvkkalakaFlstdeel.....kvleeksldidksGstavvalikdsklyva  120

          +++ e ++v++a++k+Fl+++ ++     +++++++  +++sG+ta+v++i+++k+yva

Q: 164   GFGSAEPAEVCAAIRKGFLACHLAMwkklaEWPKTMTGLPSTSGTTASVVIIRGTKMYVA  223

         ************************************************************

S: 121   nvGdSravLcrngk.......avelssdHkpsredEleRieeaggsvilkdga.Rv....  168

         +vGdS++vL+ +++       ave+++dHkp+ ++E+eRie  ggsvi+k+g+ Rv

Q: 224   HVGDSGVVLGVQDDskddfvrAVEVTQDHKPELPKERERIEGLGGSVINKSGVnRVvwkr  283

         ***********774479*******************************************

S: 169   .................lGvLavsRalGdlylk......pyvtpePevtshrltsede.f  204

                          +++Lav+RalGdl+++      ++v+peP++++h+l+++++ +

Q: 284   prlthngpvrrstiidqIPFLAVARALGDLWSYdfytgeFVVSPEPDTSVHTLDPRKHkY  343

         ************************************************************

S: 205   liLasDGlwdvvsneeavslvrdvle....kkeaeqeaakkLvklalargsk.....dnv  255

         +iL+sDGlw+++++++a+++++d++e    ++e+ q++ak+Lv++al r+++     dn+

Q: 344   IILGSDGLWNMIPPQDAIAMCQDQEEkkylMGEHGQSCAKMLVNRALGRWRQrmlraDNT  403

         ************************************************************

S: 256   saivv  260

         saiv+

Q: 404   SAIVI  408

         ***97

Domain Sequence
(FASTA)

EGSREPAGGA RASSPAAGRS CLRRRRRSSV AFFAVCDGHG GREAAQFARE HLWGFIKKQK 60

GFGSAEPAEV CAAIRKGFLA CHLAMWKKLA EWPKTMTGLP STSGTTASVV IIRGTKMYVA 120

HVGDSGVVLG VQDDSKDDFV RAVEVTQDHK PELPKERERI EGLGGSVINK SGVNRVVWKR 180

PRLTHNGPVR RSTIIDQIPF LAVARALGDL WSYDFYTGEF VVSPEPDTSV HTLDPRKHKY 240

IILGSDGLWN MIPPQDAIAM CQDQEEKKYL MGEHGQSCAK MLVNRALGRW RQRMLRADNT 300

SAIVI 305

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0009617	; P:response to bacterium

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013