EKS-MOD-00483

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00483

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	379.6	8.5E-114	38	301	264

Status

Unreviewed

Ensembl Protein

ENSMODP00000017759

UniProt Accession

F6TQU7;

Protein Name

Protein Synonyms/Alias

Gene Name

ANKK1

Gene Synonyms/Alias

ANKK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000014205	ENSMODP00000017759	ENSMODT00000018087

Organism

Monodelphis domestica

Functional Description

Protein Length

781

Protein Sequence
(FASTA)

MEGSGGRTGQ ARVALMALGV EQHLGSLTIF SRDDFEGDWQ RVASGGFGQV FRVRHKRWRT 60

EYAIKCSPCL LADSSPTSSD MKCLIEEASK MEKIKFQHIV SIYGVCKQPL GIVMEFMAKG 120

SLEKMLPTHS LSWQLKFRII HETALAMNFL HSIKPPLLHL DLKPGNILLD SNMHAKISDF 180

GLSKWMEQST RMQYIERSAL RGTLSYIPPE MFLESTKAPG PKYDVYSFGI VIWEIVTQKK 240

PYPGFNMMAI IIRVAAGTRP SLQPISDDWP GEGQQMVDLM KRCWDQDPKK RPCFTDITTE 300

TDMLLSLLQN PVVDLEKESL VRKTSCKPSL HQPQEISREV SQELTESDSG ESLKQLLQLS 360

DSESLISSME ELGIFENNIT LLHFLVTEGN VEKVRLLLSQ EVDVDCQTAE GYTPLMLAVQ 420

DQLSDLCMLL LSQGANPNLV DKDGWAPLHF AAQNGDDRTA RLLLDHGAQV DAQEHEGWTA 480

LHLASQNNFE NVARLLVSRY ANPNLQEREG KAPLHVAAYF GHINLVKLLI GQGAQLNAQQ 540

RNLRTPLHLA VEQGKFRVIQ HLLKSGATTD LLDQNGYSPL HTAVAKDKYL ICRMLLKYGA 600

NTELKTEQGW TPLHLAAFQG HLEVLRLLHE SNAHLDARGG KDWTPLHLAV RQGEEAVVSF 660

LLQSGADPNK PEQSGWTPLH LAVQRGAFLS VINLLEYQAD VNASNKVGWS PAHLAALKGN 720

TAILKVLIKA GAQLDIQDAA GCTVLQLAIR NQKQNVISFL EGKDPLTPGL VGVESETMKE 780

T 781

Nucleotide Sequence
(FASTA)

ATGGAGGGCA GCGGTGGGAG GACGGGACAG GCCAGGGTGG CCCTCATGGC CCTGGGGGTG 60

GAGCAGCACC TAGGCAGCCT GACCATCTTT AGCCGGGACG ACTTCGAAGG AGACTGGCAG 120

CGCGTGGCCA GCGGGGGCTT TGGGCAGGTG TTCCGGGTGC GGCACAAACG CTGGCGGACC 180

GAATATGCCA TCAAGTGCTC TCCTTGCCTG CTGGCCGACT CCAGCCCCAC CAGCTCAGAC 240

ATGAAGTGCC TTATTGAAGA AGCATCCAAA ATGGAAAAGA TCAAATTCCA GCATATCGTC 300

TCCATCTACG GAGTGTGCAA GCAACCCTTG GGCATTGTAA TGGAGTTTAT GGCCAAAGGC 360

TCCCTAGAGA AGATGCTGCC TACTCATAGC CTCTCCTGGC AGCTTAAGTT CCGAATCATT 420

CATGAGACTG CCTTGGCCAT GAATTTCCTT CACAGCATTA AGCCACCTCT GCTCCATCTG 480

GACCTCAAAC CAGGCAACAT CTTGTTGGAC AGTAACATGC ATGCCAAGAT TTCAGACTTT 540

GGCCTATCCA AGTGGATGGA GCAGTCAACA CGGATGCAAT ATATTGAGAG GTCAGCACTT 600

CGGGGCACAC TCAGCTATAT TCCCCCTGAA ATGTTTCTGG AGAGCACCAA AGCACCTGGA 660

CCCAAATATG ATGTGTACAG CTTTGGAATT GTCATTTGGG AGATTGTTAC CCAGAAGAAG 720

CCATACCCAG GGTTCAACAT GATGGCCATC ATCATTCGTG TGGCTGCTGG TACCCGGCCC 780

TCACTGCAGC CCATCTCAGA TGACTGGCCA GGTGAGGGCC AACAGATGGT TGACTTGATG 840

AAGCGCTGCT GGGACCAGGA TCCTAAGAAG AGGCCGTGTT TCACAGATAT CACTACTGAG 900

ACAGACATGC TGCTATCCTT GCTCCAGAAC CCTGTCGTTG ATCTGGAGAA AGAGTCCTTG 960

GTCAGAAAGA CATCCTGCAA GCCTTCTCTA CACCAGCCCC AGGAGATCAG TAGAGAAGTC 1020

AGCCAGGAAC TGACAGAGAG TGACTCAGGT GAATCTCTGA AGCAGTTGCT CCAGCTGTCT 1080

GACAGTGAAA GCTTGATCTC CAGTATGGAA GAGTTGGGCA TCTTTGAGAA CAACATCACC 1140

CTCCTCCATT TCCTGGTGAC TGAGGGAAAT GTGGAGAAGG TGAGGCTGCT GTTGAGCCAG 1200

GAGGTAGATG TGGACTGCCA AACAGCTGAG GGCTACACAC CCCTCATGCT TGCTGTGCAG 1260

GATCAGTTGT CTGACCTCTG CATGCTACTG CTCAGCCAAG GAGCCAACCC CAATCTGGTT 1320

GACAAGGATG GCTGGGCTCC ACTCCACTTT GCTGCCCAGA ATGGGGATGA CCGTACTGCT 1380

CGGCTCCTCC TGGACCATGG TGCCCAGGTG GATGCCCAGG AGCATGAGGG CTGGACAGCT 1440

CTCCACCTTG CTTCTCAGAA CAACTTTGAG AACGTGGCCC GGCTTCTGGT CTCCCGCTAT 1500

GCTAACCCCA ACCTTCAAGA GAGGGAGGGA AAGGCTCCAC TGCATGTGGC TGCCTACTTT 1560

GGTCACATTA ACCTGGTTAA GTTGCTCATA GGCCAGGGGG CCCAGCTAAA TGCCCAGCAA 1620

AGGAACCTCC GGACCCCATT GCACTTGGCT GTGGAACAGG GTAAGTTCCG TGTAATCCAG 1680

CACCTGCTGA AAAGTGGGGC AACCACTGAC CTGCTTGACC AGAATGGCTA TAGCCCACTG 1740

CATACAGCTG TTGCCAAAGA CAAATACCTT ATCTGTAGGA TGCTGCTTAA GTATGGGGCC 1800

AACACTGAGT TGAAGACTGA ACAGGGCTGG ACACCTCTAC ATCTGGCAGC CTTCCAGGGT 1860

CACCTGGAGG TCCTCCGTCT GCTGCATGAG AGTAACGCCC ACCTGGATGC CCGAGGGGGC 1920

AAGGACTGGA CCCCACTTCA TTTAGCAGTA CGCCAAGGGG AGGAGGCAGT GGTTTCCTTC 1980

TTACTGCAGA GTGGAGCTGA CCCCAACAAG CCTGAGCAAT CTGGCTGGAC ACCTTTACAC 2040

TTGGCAGTTC AGCGAGGCGC ATTCTTGAGT GTCATCAACC TCTTGGAGTA CCAGGCTGAT 2100

GTTAATGCTT CCAACAAGGT AGGCTGGTCT CCTGCGCACT TGGCAGCTCT CAAGGGTAAT 2160

ACTGCTATCC TCAAAGTACT GATCAAGGCT GGTGCTCAGT TGGACATTCA GGATGCTGCT 2220

GGCTGCACTG TACTACAACT GGCCATCCGA AACCAGAAAC AGAATGTAAT CTCCTTCCTG 2280

GAGGGCAAGG ACCCCCTCAC TCCGGGTCTG GTCGGTGTTG AATCAGAAAC TATGAAGGAG 2340

ACTTGA 2346

Domain Profile

S: 3     elelvgsGgfgkvfkarhrkwrvevavk.slvlktda..ldserkelleeakkmeklrfs  59

         +++ v+sGgfg+vf++rh++wr+e+a+k s++l +d+  ++s+ k+l+eea kmek++f+

Q: 38    DWQRVASGGFGQVFRVRHKRWRTEYAIKcSPCLLADSspTSSDMKCLIEEASKMEKIKFQ  97

         7999*************************9*9988763368999****************

S: 60    yvlkllGvikeeeklglvmeymenGsLeklLkseielpwplkfRilkevvlgmnyLhslk  119

         ++++++Gv+k++  lg+vme+m++GsLek+L ++ +l+w+lkfRi++e++l+mn+Lhs+k

Q: 98    HIVSIYGVCKQP--LGIVMEFMAKGSLEKMLPTH-SLSWQLKFRIIHETALAMNFLHSIK  154

         ************..********************.*************************

S: 120   PpllhkDLkpeniLlDnelhvkiaDfGlskfmeessqskevsssaegGtlaYlaPellee  179

         Ppllh+DLkp niLlD+++h ki+DfGlsk+me+s++++++++sa++Gtl+Y++Pe++ e

Q: 155   PPLLHLDLKPGNILLDSNMHAKISDFGLSKWMEQSTRMQYIERSALRGTLSYIPPEMFLE  214

         ************************************************************

S: 180   vnkkaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseelPrev  239

         + k+++ k+DvYsf+iviW+++++k+py    n++ iii+v++g+RP+l+++s+++P e

Q: 215   STKAPGPKYDVYSFGIVIWEIVTQKKPYPG-FNMMAIIIRVAAGTRPSLQPISDDWPGEG  273

         ****************************99.9****************************

S: 240   pqlieLmkrcWeadpeeRPsFleieekt  267

         +q+++LmkrcW++dp++RP+F +i+++t

Q: 274   QQMVDLMKRCWDQDPKKRPCFTDITTET  301

         ************************9875

Domain Sequence
(FASTA)

DWQRVASGGF GQVFRVRHKR WRTEYAIKCS PCLLADSSPT SSDMKCLIEE ASKMEKIKFQ 60

HIVSIYGVCK QPLGIVMEFM AKGSLEKMLP THSLSWQLKF RIIHETALAM NFLHSIKPPL 120

LHLDLKPGNI LLDSNMHAKI SDFGLSKWME QSTRMQYIER SALRGTLSYI PPEMFLESTK 180

APGPKYDVYS FGIVIWEIVT QKKPYPGFNM MAIIIRVAAG TRPSLQPISD DWPGEGQQMV 240

DLMKRCWDQD PKKRPCFTDI TTET 264

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00023	; Ank; 2.
PF12796	; Ank_2; 4.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 12.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 11.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013