EKS-MOD-00160

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00160

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	491.3	6.3E-148	467	724	258

Status

Unreviewed

Ensembl Protein

ENSMODP00000017846

UniProt Accession

F6X0J4;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000014283	ENSMODP00000017846	ENSMODT00000018175

Organism

Monodelphis domestica

Functional Description

Protein Length

784

Protein Sequence
(FASTA)

MWLPRRQPQR WTWHRPSTLS HTYRGSKKCR KPCVGFGARG ARVGDVAAAA PARRADGTMP 60

LAQLGEPWPL TELLPLDPEN GQIPGEDTGR HASKASTDVP WTERDSASCT QKDDGIVKEI 120

SITHHVKEGS EKADPSQFEL LKVLGQGSFG KVFLVRKITR PDNGHLYAMK VLKKATLKAF 180

QTEGKLYLIL DFLRGGDLFT RLSKEVMFTE EDVKFYLAEL ALGLDHLHKL GIIYRDLKPE 240

NILLDEEGHI KLTDFGLSKE AIDHEKKAYS FCGTVEYMAP EVVNRQGHTH SADWWSYGVL 300

MFEMLTGSLP FQGKDRKETM TLILKAKLGM PQFLSTEAQS LLRALFKRNP ANRLGSGTDG 360

AEEIKRHVFY STIDWNKLFR REIKPPFKPA VAQPDDTFYF DTEFTSRTPK DSPGIPPSAG 420

AHQLFRGFSF VATGLMEDDG KVRAPQAPLH SVVQQLHGKS LVFSDGYVVK ETIGVGSYSV 480

CRRCIHKATN MEYAVKVIDK SKRDPTEEIE ILLRYGQHPN IITLKDVYDD GKYVYLVTEL 540

MRGGELLDKI LRQKFFSERE ASSVLHTICR TMEYLHSQGV VHRDLKPSNI LYVDESGNPE 600

SIRICDFGFA KQLRAENGLL MTPCYTANFV APEVLRRQGY DEGCDIWSLG ILLYTMLAGY 660

TPFANGPSDT PEEILTRIGG GKFTLSGGNW DTISETAKDL VSKMLHVDPH RRLTAKQVLQ 720

HPWVTQKDKL PQSQLSHQDV QLVKGAMAAT YSALSSSKPT PQLKPIESSI LAQRRVKKLP 780

STTL 784

Nucleotide Sequence
(FASTA)

ATGTGGCTCC CACGGCGGCA GCCACAGCGG TGGACATGGC ACCGCCCCTC CACTCTATCT 60

CATACCTACC GAGGTAGTAA GAAGTGCAGA AAACCGTGCG TGGGGTTCGG GGCGCGGGGC 120

GCGAGAGTAG GAGACGTAGC CGCAGCCGCG CCAGCCCGGA GGGCCGACGG CACGATGCCG 180

CTCGCCCAGC TCGGGGAGCC CTGGCCGCTC ACCGAGCTAC TTCCACTGGA TCCGGAGAAT 240

GGGCAAATTC CCGGAGAAGA CACTGGAAGA CATGCCTCCA AGGCTTCCAC AGATGTCCCC 300

TGGACAGAGA GAGATTCGGC CTCCTGCACC CAGAAGGATG ATGGCATCGT CAAAGAGATA 360

TCCATTACTC ACCATGTGAA GGAGGGCTCA GAAAAGGCTG ACCCCTCCCA GTTTGAGCTC 420

CTAAAGGTCC TGGGCCAGGG CTCCTTTGGC AAAGTCTTTC TGGTGAGGAA GATCACCCGC 480

CCAGACAATG GACACCTCTA TGCCATGAAG GTGCTCAAGA AAGCAACCTT GAAAGCCTTC 540

CAGACCGAGG GGAAGCTCTA TCTCATCCTG GACTTCCTCC GGGGAGGAGA CCTCTTTACA 600

CGCCTCTCCA AAGAGGTCAT GTTCACAGAA GAAGATGTGA AGTTCTATTT GGCTGAGCTG 660

GCTCTGGGCC TAGATCACCT CCACAAACTG GGGATCATTT ACCGAGACCT CAAGCCCGAG 720

AACATCCTTT TGGATGAAGA AGGTCACATT AAGCTCACAG ATTTTGGCCT GAGCAAGGAG 780

GCCATCGACC ATGAGAAGAA AGCCTATTCC TTCTGTGGGA CGGTGGAGTA CATGGCTCCT 840

GAGGTCGTCA ACCGCCAGGG CCACACGCAC AGTGCCGACT GGTGGTCCTA CGGGGTGCTG 900

ATGTTTGAGA TGTTAACGGG CTCCCTGCCC TTCCAGGGGA AAGACCGGAA GGAGACCATG 960

ACTCTGATTC TCAAGGCAAA GCTGGGCATG CCCCAGTTTC TGAGCACCGA AGCACAAAGC 1020

CTCCTTCGAG CCCTGTTCAA GAGGAATCCT GCCAACAGGC TGGGCTCTGG CACTGATGGG 1080

GCCGAAGAGA TTAAGAGGCA CGTCTTCTAC TCTACCATAG ACTGGAACAA ACTATTTCGG 1140

CGTGAGATCA AACCCCCCTT CAAGCCTGCC GTCGCCCAAC CTGACGACAC CTTCTACTTC 1200

GACACAGAGT TCACTTCCCG AACACCCAAA GACTCCCCAG GCATTCCCCC CAGTGCTGGG 1260

GCCCACCAGC TCTTCCGAGG CTTCAGCTTC GTGGCTACTG GCTTGATGGA AGATGATGGC 1320

AAGGTCCGGG CCCCACAGGC ACCACTGCAC TCGGTGGTCC AGCAACTTCA CGGGAAGAGT 1380

TTGGTTTTCA GTGATGGCTA CGTAGTGAAG GAAACCATTG GAGTTGGCTC CTACTCCGTG 1440

TGTAGGCGCT GTATCCACAA GGCCACCAAC ATGGAGTATG CAGTCAAGGT CATCGACAAG 1500

AGCAAGAGGG ACCCCACAGA GGAGATAGAG ATCCTTCTTC GCTATGGCCA ACACCCCAAT 1560

ATCATCACCC TGAAAGACGT GTATGACGAT GGCAAATATG TGTACCTGGT GACCGAGCTG 1620

ATGCGGGGTG GGGAGCTCCT GGACAAGATC CTTCGGCAGA AGTTCTTCTC GGAGCGTGAG 1680

GCAAGCTCCG TGCTACACAC CATCTGCCGG ACCATGGAGT ACCTGCACTC CCAAGGGGTG 1740

GTGCACAGAG ACCTGAAACC CAGCAACATC CTGTACGTGG ACGAGTCCGG GAACCCCGAA 1800

AGCATCCGAA TCTGTGACTT CGGCTTTGCC AAGCAGCTTC GAGCAGAGAA TGGGCTCCTC 1860

ATGACGCCCT GCTATACTGC TAACTTTGTG GCCCCAGAGG TCCTAAGGCG CCAGGGGTAC 1920

GACGAAGGCT GCGACATCTG GAGCCTGGGC ATCCTCCTCT ACACCATGCT GGCTGGATAC 1980

ACTCCCTTTG CAAATGGCCC CAGTGATACC CCAGAGGAGA TCCTGACCCG GATCGGAGGA 2040

GGAAAATTCA CTCTCAGTGG TGGAAACTGG GATACAATTT CAGAGACAGC CAAGGATCTG 2100

GTGTCCAAGA TGCTGCACGT GGACCCCCAC CGGCGCCTGA CTGCCAAGCA GGTCCTCCAG 2160

CATCCGTGGG TCACTCAGAA GGACAAGCTG CCCCAGAGCC AGCTGTCCCA TCAGGACGTG 2220

CAGCTGGTCA AGGGCGCCAT GGCTGCCACC TACTCCGCCC TGAGCAGTTC CAAGCCCACC 2280

CCCCAGCTCA AGCCAATCGA GTCCTCGATC TTGGCCCAGC GACGGGTGAA GAAGCTGCCG 2340

TCCACCACGC TGTGA 2355

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y+vke++GvGsysvc+rc+hkatn+e+avk+idkskrd++eeieillry+qhpni+tlkd

Q: 467   YVVKETIGVGSYSVCRRCIHKATNMEYAVKVIDKSKRDPTEEIEILLRYGQHPNIITLKD  526

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvylv+el++GGelld+i+++kffsereas++l+t+++++eylh+qGvvhrdlk

Q: 527   VYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHTICRTMEYLHSQGVVHRDLK  586

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevl+rqGyde+cd+

Q: 587   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLRRQGYDEGCDI  646

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG+llytmlaGy+pfangp+dt+eeil++i+ Gkf+lsG++wd++se+akdlvsk+l+

Q: 647   WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGGGKFTLSGGNWDTISETAKDLVSKMLH  706

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 707   VDPHRRLTAKQVLQHPWV  724

         *****************7

Domain Sequence
(FASTA)

YVVKETIGVG SYSVCRRCIH KATNMEYAVK VIDKSKRDPT EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYL VTELMRGGEL LDKILRQKFF SEREASSVLH TICRTMEYLH SQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLR RQGYDEGCDI 180

WSLGILLYTM LAGYTPFANG PSDTPEEILT RIGGGKFTLS GGNWDTISET AKDLVSKMLH 240

VDPHRRLTAK QVLQHPWV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013