EKS-MOD-00378

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00378

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	351.0	5.5E-105	637	893	257

Status

Unreviewed

Ensembl Protein

ENSMODP00000018096

UniProt Accession

F6ZG40;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K6

Gene Synonyms/Alias

MAP3K6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000014479	ENSMODP00000018096	ENSMODT00000018428

Organism

Monodelphis domestica

Functional Description

Protein Length

1273

Protein Sequence
(FASTA)

MAGPGQRGPE RAGSCWQDPL ATAPSPPRQP APGRGWSRSR PLSVVYVLTR EPEAEAEGEP 60

LPLRCLRDAC AQLPGPRPTP QVRTLPFGTV ALGESAALDS FYNADVVVLE VSGSLGQPSL 120

FYHLGVRESF SMMNNVLLCA QTDLPDLQAL REDVFQKNAD CVGGYTFIPY MVTGQGRVLC 180

GDAGVMKGLA DGLFQLGAGA EALLTPLVGR LVRLLEAIPT NSWYSSGYFR ETMRRDIRRA 240

RERFSGDQLR HELARLQRRL DSVELLTPDI IMTLLLSYRD VQDYGAIISL VETLQALPTC 300

DMAEQHNICF HYTFALNQRN RPGDRDKALS VLLPLVRRGA VAPDLYCMCG RIYKDLFISS 360

GFTDTRHRDQ ACRWYRQAFE TEPSLHSGIN AAVLLLAAGH QFENSDELRQ IGLKLGCLLG 420

RKGSVEKMQY YWDVGFYLGA QILANDPTQV ALAAEQLYQL NAPLWYLASV METFLLYRHF 480

SPAPQPSGPT GQRALFWLAF LLQSCQPFAA TDECPVLILE LNKVLQPARL RVQEGDPNAA 540

VTLSLLESET EAAGSGWTFP AASIRGVSIS KRDERYCFLY VLHTAQDFQL GFPSHQHCQW 600

FCRLIQAFVT QPVLPGDEGV ATKEVLEFEY EYTETGERLV LGKGTYGVVY AGRDLSTQVR 660

IAIKEIPERD SRFSQPLHEE IALHKRLRHK NIVQYLGSIS QAGFLKIFME EVPGGSLSSL 720

LRAVWGPLQD NESTISFYTR QILQGLSYLH DNHIIHRDIK GDNVLINTYS GLLKISDFGT 780

SKRLAGITPC TETFTGTLQY MAPEIIDQGP RGYGKAADIW SLGCTVIEMA TGRPPFYELG 840

SPQAAMFQVG MYKIHPPVPS AMSEEARAFI LRTFEPEPKH RASAAALLND PFLQPRRRAR 900

NPMLSHPSPH PTGIPPIGLA SPAGQSQTVP CPGTTPQTNP MPPKRCLSEG GAPNSQLRVP 960

EDSVAEQISS PEENPQRSLM RKESERRAML ERVLSQELPT IVESLQWALK QGPPGPQLSR 1020

EQIAQLVRGL QSYICSPSRR QLAQELRALQ EQLQAQGHSS ALLQGPLFAF QDAVKRVLRR 1080

HEIRPHWMFA LDGLMSRAVR AALAVLGTEL KKSAMGMPED GSEEEQEPGQ RGVPPRRSHS 1140

RVPEQDSLPL LAQLSLLRAE TGRLLGQLAE KERQFQVLAF RALQHAEETS TVTLVPGPAE 1200

IPPASPGDPE LAQWLQQLGV DSGTIQTLWS HGFTLHMLIT CASRDDLVYT RIRGGMVCRI 1260

WRAIMAQRAV PVP 1273

Nucleotide Sequence
(FASTA)

ATGGCAGGCC CGGGCCAGCG GGGGCCAGAG CGCGCTGGCA GCTGCTGGCA GGACCCGCTG 60

GCCACGGCGC CGAGCCCCCC GCGGCAGCCG GCCCCGGGCC GGGGCTGGAG CCGGAGTCGG 120

CCGCTCAGCG TGGTCTACGT GTTAACCCGA GAGCCTGAGG CTGAGGCCGA GGGTGAGCCG 180

TTGCCCCTGC GCTGCCTGCG CGACGCCTGC GCTCAGCTCC CCGGACCGCG CCCGACGCCG 240

CAAGTGCGCA CGCTGCCCTT TGGGACCGTG GCGCTAGGCG AGTCTGCGGC GCTGGACTCT 300

TTCTACAATG CTGATGTGGT TGTACTGGAA GTGAGCGGCT CCCTGGGCCA GCCCTCTCTG 360

TTCTACCACC TTGGAGTGAG GGAGAGTTTC AGCATGATGA ACAATGTGCT CCTCTGTGCC 420

CAAACAGACC TGCCTGACTT GCAGGCCCTC AGGGAAGATG TCTTCCAGAA AAACGCTGAT 480

TGCGTTGGAG GCTACACTTT CATCCCCTAC ATGGTGACAG GTCAAGGACG GGTCCTGTGT 540

GGCGATGCAG GCGTTATGAA GGGGCTGGCG GATGGACTGT TCCAGTTGGG GGCAGGCGCT 600

GAGGCCCTCC TCACCCCCCT GGTGGGCAGG CTTGTCCGCC TGCTAGAGGC TATTCCCACC 660

AACTCCTGGT ACTCCAGTGG CTACTTCCGG GAGACCATGC GAAGGGACAT CCGCCGGGCC 720

CGGGAGCGCT TCTCTGGGGA CCAGCTGCGT CACGAGTTGG CCCGGTTGCA GCGCCGACTG 780

GACAGCGTGG AGCTGCTGAC CCCTGACATC ATCATGACCC TGTTGCTCTC CTACAGGGAT 840

GTGCAGGACT ACGGGGCGAT CATCTCTCTG GTGGAGACGC TGCAGGCCTT GCCCACCTGT 900

GATATGGCTG AGCAGCACAA CATCTGCTTC CACTACACCT TTGCTCTCAA CCAAAGGAAC 960

AGGCCCGGCG ACCGCGACAA AGCCCTCTCT GTGTTGCTGC CCCTGGTGCG GCGTGGGGCC 1020

GTGGCCCCCG ACCTCTACTG CATGTGTGGC CGAATCTACA AGGACCTGTT CATCAGCTCG 1080

GGCTTCACTG ACACCCGTCA CCGGGACCAG GCCTGCCGCT GGTACCGACA GGCCTTCGAG 1140

ACAGAGCCCA GCCTCCACTC GGGCATCAAC GCGGCCGTCC TGCTCCTAGC CGCCGGGCAC 1200

CAGTTTGAGA ATTCAGACGA GCTCCGCCAG ATAGGGCTGA AGCTGGGATG CCTGCTGGGC 1260

CGCAAGGGCA GCGTGGAGAA GATGCAGTAC TACTGGGACG TGGGCTTCTA CCTGGGTGCC 1320

CAGATCCTTG CCAATGACCC TACCCAGGTG GCCCTGGCTG CTGAGCAGCT CTACCAGCTG 1380

AACGCCCCCC TGTGGTACCT GGCCTCCGTG ATGGAGACCT TCCTCCTCTA CCGGCACTTC 1440

TCCCCAGCCC CGCAGCCCTC AGGGCCCACG GGCCAGCGGG CTCTCTTCTG GCTGGCCTTC 1500

CTCCTGCAGT CCTGCCAGCC CTTTGCTGCC ACAGACGAAT GCCCGGTGCT AATCCTAGAA 1560

CTGAACAAGG TGCTGCAGCC AGCCAGGCTC CGGGTTCAGG AGGGGGACCC CAATGCGGCC 1620

GTGACTTTGA GCCTGCTAGA GTCTGAGACA GAGGCTGCCG GCTCTGGCTG GACCTTCCCC 1680

GCGGCCTCCA TCCGGGGAGT CAGCATCTCG AAGAGAGACG AGCGCTATTG CTTCCTGTAT 1740

GTGCTCCACA CGGCCCAGGA CTTCCAGCTG GGCTTTCCCA GCCACCAGCA CTGCCAGTGG 1800

TTCTGCAGAC TGATCCAGGC CTTCGTGACA CAGCCGGTGC TGCCTGGAGA TGAGGGGGTG 1860

GCCACCAAGG AGGTGCTGGA GTTTGAATAC GAGTACACAG AGACGGGAGA GCGGCTGGTC 1920

CTGGGCAAAG GTACCTATGG GGTGGTGTAT GCCGGTCGGG ACCTCAGCAC CCAGGTACGG 1980

ATCGCCATCA AGGAGATCCC TGAGAGGGAC AGCAGGTTTT CCCAACCCCT ACATGAGGAA 2040

ATTGCCCTGC ACAAACGTTT GCGCCATAAG AACATTGTCC AGTACCTGGG CTCCATCAGC 2100

CAGGCTGGTT TCCTCAAGAT TTTCATGGAG GAGGTACCTG GAGGCAGCCT GTCTTCCTTG 2160

TTGCGGGCTG TGTGGGGACC ACTTCAGGAC AATGAGAGCA CCATCAGCTT CTATACGCGG 2220

CAGATCCTGC AGGGGCTGAG CTATCTCCAT GACAACCACA TCATACACCG AGACATCAAG 2280

GGGGACAATG TACTGATCAA CACATACAGT GGGCTTCTCA AGATCTCTGA CTTTGGCACC 2340

TCCAAGAGGC TTGCAGGCAT CACTCCCTGT ACGGAGACCT TCACAGGAAC CTTACAGTAC 2400

ATGGCCCCTG AGATCATTGA CCAAGGCCCC CGGGGCTACG GAAAGGCCGC TGATATCTGG 2460

TCTCTGGGCT GCACTGTCAT TGAAATGGCC ACTGGACGAC CACCTTTCTA TGAGCTAGGT 2520

AGCCCACAGG CTGCCATGTT CCAGGTGGGC ATGTACAAGA TCCACCCCCC AGTGCCCAGT 2580

GCCATGTCTG AGGAGGCCCG AGCCTTCATC CTTCGCACCT TTGAGCCTGA ACCCAAGCAC 2640

CGGGCCAGTG CCGCTGCCTT GCTGAATGAC CCTTTCCTGC AGCCCCGGCG TAGAGCCCGA 2700

AACCCCATGT TATCCCACCC CAGCCCTCAT CCTACAGGTA TCCCACCAAT TGGTCTAGCT 2760

TCCCCAGCTG GGCAGTCACA GACGGTGCCA TGTCCGGGTA CCACTCCCCA GACCAACCCC 2820

ATGCCCCCGA AGCGCTGCCT CAGTGAAGGA GGAGCCCCCA ACAGCCAGCT TCGGGTGCCC 2880

GAGGACTCTG TCGCAGAGCA GATCTCATCA CCAGAGGAGA ACCCACAGCG GTCCCTGATG 2940

CGTAAGGAGA GCGAGCGGAG GGCCATGCTG GAGCGAGTCC TCAGCCAGGA GCTGCCCACC 3000

ATAGTGGAGA GTCTTCAATG GGCACTGAAG CAGGGCCCCC CTGGGCCACA GCTGAGCCGA 3060

GAGCAGATAG CCCAGCTGGT GAGAGGCCTC CAAAGCTACA TTTGCTCTCC CAGCCGCCGG 3120

CAGCTGGCAC AGGAGCTTCG GGCCCTGCAG GAGCAGCTCC AGGCCCAGGG ACATAGCTCA 3180

GCATTACTCC AAGGACCCCT TTTCGCTTTC CAGGATGCTG TGAAACGAGT CCTCAGAAGG 3240

CATGAAATCC GGCCCCATTG GATGTTTGCC CTGGATGGGC TGATGAGCCG GGCGGTGCGG 3300

GCAGCCCTGG CTGTGCTGGG GACAGAGCTA AAGAAGTCAG CCATGGGGAT GCCTGAAGAT 3360

GGGAGTGAGG AAGAACAGGA ACCTGGGCAA AGGGGTGTCC CACCCAGGAG GAGTCACTCA 3420

AGGGTACCTG AACAGGATTC CCTGCCCCTT TTGGCACAGC TGAGCCTCCT AAGGGCAGAG 3480

ACAGGCAGGC TCCTAGGACA GTTGGCAGAG AAGGAGAGGC AATTCCAAGT ATTAGCCTTC 3540

AGGGCACTAC AGCATGCCGA GGAGACCTCA ACTGTAACCT TAGTCCCTGG GCCTGCAGAG 3600

ATCCCACCAG CTTCTCCAGG GGACCCTGAG CTGGCCCAGT GGCTGCAGCA GCTGGGTGTA 3660

GACTCAGGCA CTATCCAGAC ACTCTGGAGT CACGGTTTCA CCTTACACAT GCTGATTACC 3720

TGTGCCAGTC GAGATGACCT TGTCTATACT CGGATCAGAG GTGGAATGGT GTGCCGAATC 3780

TGGAGAGCCA TCATGGCACA GAGGGCAGTG CCAGTGCCCT AG 3822

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++t+ ++a+Ke+   pe++s+   +++l+eEi+l+k+l+H+n

Q: 637   ERLVLGKGTYGVVYAGRDLSTQVRIAIKEI---PERDSR--FSQPLHEEIALHKRLRHKN  691

         5779**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ ++ + lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl+yLH+

Q: 692   IVQYLGSISQAGFLKIFMEEVPGGSLSSLLRaVWGPLQdnESTISFYTRQILQGLSYLHD  751

         *******************************99****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++i+HRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++

Q: 752   NHIIHRDIKGDNVLINTySGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  808

         ***************************************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc+viem+tg++Pf el++++a+mf+vg+ k++P++p+++see+++

Q: 809   GPRGYGKAADIWSLGCTVIEMATGRPPFYELGSPQAAMFQVGMYKIHPPVPSAMSEEARA  868

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+ +++e +pk+r+sa+ LL+++fl

Q: 869   FILRTFEPEPKHRASAAALLNDPFL  893

         ***********************96

Domain Sequence
(FASTA)

ERLVLGKGTY GVVYAGRDLS TQVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVQYL 60

GSISQAGFLK IFMEEVPGGS LSSLLRAVWG PLQDNESTIS FYTRQILQGL SYLHDNHIIH 120

RDIKGDNVLI NTYSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180

ADIWSLGCTV IEMATGRPPF YELGSPQAAM FQVGMYKIHP PVPSAMSEEA RAFILRTFEP 240

EPKHRASAAA LLNDPFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013