EKS-MOD-00244

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00244

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	361.5	2.3E-108	20	271	252

Status

Unreviewed

Ensembl Protein

ENSMODP00000018106

UniProt Accession

F7FKT7;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000014489	ENSMODP00000018106	ENSMODT00000018438

Organism

Monodelphis domestica

Functional Description

Protein Length

920

Protein Sequence
(FASTA)

MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60

LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK NGEIFDYLAN HGRLSESEAR 120

RKFWQILSAV DYCHSRKIVH RDLKAENLLL DNNMNIKIAD FGFGNFFKSG EPLATWCGSP 180

PYAAPEVFEG QQYEGPQLDI WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM 240

SEDCEHLIRR MLVLDPSKRL TIAQIKEHKW MLVEVPIQRP VLYPQEQENE PSLGEYNEQV 300

LRLMHSLGID QQKTMESLQN KSYNHFAAIY YLLVERLKSH RSSFPVDQRV DARQRRPSTV 360

AEQTVAKAQT VGPPMAIRSP NMRLMRSPIL PQTSNVEVFS FPNSGCQADA AFMEEERVDT 420

PKVNGCLLDP VPPIMVRKGC QSLPSNMMET SIDEGIETEG ESEEDPSHSF DAFQSTRCGQ 480

RRHTLAEVTN QLVMMPGTGK VFSVNDHPSL GSVDSEYDMG SIQRDLNFLE DNPSLKDIML 540

ANQPTHRLTP PFISIRPANP AMQVLSSQKR ETHNRSPVSF REGRRASDTS LTQGLVAFRQ 600

HLQNLARTKG ILELNKVQLL YEQMGSEAEP SLASAAPQLQ DLVSSASQEE ATQQQENASA 660

FPNTVHPQLS RRQSLETQYL QHRLQKPNLL SKAQNTCQLY CKESPRSLEQ QLQEHRLHQK 720

RLFLQKQSQL QAYFNQMQIA ESSYPRPNQQ LPLPHQEQLS SPQAQSPQPP QFSLAQSLSP 780

VLEPSSEQMQ YDPFLSQYRK LQLQPLPSSQ VPGSPPPLPS QLQQQPPQPP AAPPPLPFSY 840

QTRELPGAAP PEPDYPAPCQ YSMDPAQQSN VALPDCPRSS GPRESPSSYD PLALSELPGL 900

FDCEMVEAVD PQPSGYVLVN 920

Nucleotide Sequence
(FASTA)

ATGGTCATGG CGGATGGCCC GAGGCACTTG CAGCGCGGGC CGGTTCGGGT GGGGTTCTAC 60

GACATCGAGG GCACGCTGGG CAAGGGCAAC TTCGCTGTGG TGAAGCTGGG GCGCCACCGC 120

ATCACTAAGA CCGAGGTGGC TATAAAAATC ATAGATAAAT CTCAACTGGA TGCAGTGAAT 180

CTAGAGAAAA TCTACAGAGA AGTCCAAATA ATGAAAATGT TAGACCACCC TCACATAATA 240

AAACTCTACC AGGTGATGGA GACCAAAAGC ATGTTGTACC TTGTCACTGA ATATGCCAAA 300

AATGGAGAGA TTTTTGATTA CCTTGCAAAT CATGGCCGGT TGAGTGAGTC TGAGGCAAGG 360

CGAAAATTCT GGCAAATCCT GTCTGCAGTA GATTACTGTC ATAGTCGGAA GATTGTACAC 420

CGAGATCTCA AGGCTGAAAA TCTACTGCTA GATAACAATA TGAATATCAA AATAGCAGAT 480

TTTGGTTTTG GAAACTTCTT TAAGAGTGGT GAACCCCTGG CTACATGGTG TGGCAGCCCT 540

CCTTATGCAG CCCCAGAAGT CTTTGAAGGA CAACAGTATG AAGGACCACA ACTGGATATT 600

TGGAGCATGG GAGTAGTTCT TTACGTCCTT GTCTGTGGAG CTTTGCCTTT TGATGGACCA 660

ACTCTCCCTA TCCTGAGGCA AAGGGTACTG GAAGGAAGAT TCCGGATTCC ATATTTCATG 720

TCAGAAGATT GTGAGCATCT CATCCGAAGA ATGTTGGTTT TAGATCCATC TAAGAGGCTA 780

ACGATAGCCC AAATAAAAGA GCACAAGTGG ATGCTGGTGG AAGTTCCAAT ACAAAGACCT 840

GTTCTCTATC CACAAGAGCA AGAAAATGAG CCATCTCTTG GGGAGTATAA TGAGCAGGTC 900

CTGCGGCTAA TGCATAGCCT TGGAATAGAT CAACAGAAAA CCATGGAGTC TTTGCAAAAC 960

AAGAGTTATA ACCACTTTGC TGCTATCTAT TACTTATTGG TGGAAAGACT GAAATCTCAC 1020

CGGAGCAGCT TCCCTGTGGA TCAGAGAGTT GATGCCCGCC AACGTCGGCC CAGCACTGTT 1080

GCTGAACAAA CAGTTGCCAA GGCACAAACT GTTGGTCCCC CAATGGCCAT ACGTTCACCA 1140

AACATGAGAC TGATGAGGTC ACCCATCCTC CCTCAGACAT CAAATGTGGA GGTCTTTTCC 1200

TTTCCAAATT CTGGATGCCA GGCCGACGCA GCATTCATGG AAGAAGAACG AGTTGATACA 1260

CCAAAGGTGA ATGGTTGTCT GCTTGATCCA GTGCCCCCCA TAATGGTGAG AAAAGGATGC 1320

CAATCACTGC CTAGTAATAT GATGGAGACC TCCATTGATG AAGGAATAGA GACAGAAGGA 1380

GAGTCTGAGG AAGACCCTAG CCATTCATTC GATGCTTTCC AGTCAACACG CTGTGGACAG 1440

AGACGTCACA CACTGGCAGA AGTGACCAAC CAGCTAGTCA TGATGCCTGG CACAGGGAAA 1500

GTCTTTTCTG TGAATGACCA CCCCTCCTTG GGCAGTGTGG ATTCTGAGTA TGACATGGGA 1560

TCAATTCAGA GGGATCTGAA CTTTCTAGAG GACAACCCAT CCCTGAAGGA CATCATGTTG 1620

GCCAATCAGC CTACACACCG CTTGACACCT CCTTTCATAA GCATAAGACC TGCCAATCCA 1680

GCCATGCAGG TGCTAAGCTC ACAGAAACGG GAGACTCACA ACAGGTCCCC AGTAAGCTTC 1740

AGAGAAGGCC GTAGGGCATC AGATACCTCT CTCACACAAG GGCTTGTAGC ATTTAGACAG 1800

CACCTACAGA ATCTGGCCCG AACCAAAGGA ATTCTTGAAC TGAACAAAGT CCAGTTGCTA 1860

TATGAACAGA TGGGGTCAGA GGCAGAACCC AGCTTAGCAT CAGCTGCTCC CCAACTCCAA 1920

GACCTTGTCA GCAGTGCCTC ACAGGAGGAA GCCACTCAGC AACAGGAAAA TGCCTCTGCT 1980

TTTCCTAACA CTGTGCATCC ACAGCTTTCC AGACGACAAA GCCTAGAGAC CCAATACCTG 2040

CAGCATAGAC TCCAGAAACC CAATCTCCTT TCAAAAGCAC AGAACACCTG CCAACTGTAC 2100

TGTAAGGAAT CTCCCCGGAG CCTGGAACAG CAGCTGCAGG AGCACAGGCT TCATCAGAAA 2160

CGGCTCTTCC TCCAGAAGCA GTCCCAGCTG CAAGCATACT TTAACCAGAT GCAGATAGCA 2220

GAGAGTTCCT ACCCACGGCC AAACCAACAG CTGCCACTTC CCCACCAGGA GCAGCTCTCC 2280

AGTCCTCAGG CTCAGTCGCC GCAGCCACCC CAGTTCAGCC TGGCTCAGTC GCTAAGCCCA 2340

GTCCTAGAGC CTTCCTCAGA GCAAATGCAA TATGACCCCT TCCTCAGCCA GTACCGTAAA 2400

CTGCAGCTAC AGCCCCTGCC CTCCTCCCAG GTCCCCGGCT CTCCTCCTCC GCTGCCTTCC 2460

CAGCTGCAGC AGCAGCCGCC ACAGCCTCCA GCAGCACCCC CACCCTTACC GTTCTCCTAT 2520

CAGACTCGTG AGCTGCCAGG TGCTGCCCCC CCGGAGCCAG ACTATCCTGC CCCCTGCCAG 2580

TATTCCATGG ACCCAGCTCA GCAAAGCAAT GTAGCATTAC CAGACTGTCC CAGGAGCTCC 2640

GGGCCAAGGG AGTCCCCCTC CAGCTATGAC CCGTTAGCAC TCTCAGAGTT GCCTGGACTC 2700

TTTGATTGTG AAATGGTAGA GGCTGTTGAC CCCCAGCCCA GCGGCTATGT CCTAGTGAAT 2760

TAG 2763

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  tlG+g+f+ Vkl +h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 20    YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI  79

         89999*******************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e+ear+ f q++sav+Y+hs++iv

Q: 80    IKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLSESEARRKFWQILSAVDYCHSRKIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+fk+g+ l t+cGsppYaaPe+++g++Yegp++D

Q: 140   HRDLKAENLLLDNNMNIKIADFGFGNFFKSGEPLATWCGSPPYAAPEVFEGQQYEGPQLD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+++e+L+r++Lv dp+kR

Q: 200   IWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

         +ti +i++h+w+

Q: 260   LTIAQIKEHKWM  271

         ***********8

Domain Sequence
(FASTA)

YDIEGTLGKG NFAVVKLGRH RITKTEVAIK IIDKSQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK SMLYLVTEYA KNGEIFDYLA NHGRLSESEA RRKFWQILSA VDYCHSRKIV 120

HRDLKAENLL LDNNMNIKIA DFGFGNFFKS GEPLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPILRQRV LEGRFRIPYF MSEDCEHLIR RMLVLDPSKR 240

LTIAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017090	; Ser/Thr_kinase_SIK1/2.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013