EKS-MOD-00489

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00489

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/BRD	N/A	N/A	N/A	N/A	N/A

Status

Unreviewed

Ensembl Protein

ENSMODP00000018187

UniProt Accession

F7E8L1;

Protein Name

Protein Synonyms/Alias

Gene Name

BRD4

Gene Synonyms/Alias

BRD4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000014558	ENSMODP00000018187	ENSMODT00000018519

Organism

Monodelphis domestica

Functional Description

Protein Length

1384

Protein Sequence
(FASTA)

MQSERSRTRK TLYTETDTLW YNRRVPSEEC NGINSMSVES GPGTRLRNLP VMGDGLETTQ 60

MSTTQAQAQP QQGSTAGSNP PPPETSNPNK PKRQTNQLQY LLKVVLKTLW KHQFAWPFQQ 120

PVDAVKLNLP DYYKIIKTPM DMGTIKKRLE NNYYWNAHEC IQDFNTMFTN CYIYNKPGDD 180

IVLMAEALEK LFLQKISELP PEETEIVIVQ AKGRGRGRKE AVTSKPGASV VPNTTQASTP 240

PPTQTPQQNL PPVQTHSFPA VTPDLIIQTP VMTVVLAQTL QTPPQPPPPP PPHPGSQQIQ 300

THPPIIATAP QPVKTKKGVK RKADTTTPTT IDPIHESPSL PTEPKSTKLG PRRESSRPVK 360

PPKKDVPDSQ QHTVEKSNKV SEQLKYCTGI IKEMFAKKHA AYAWPFYKPV DVEALGLHDY 420

CDIIKHPMDL STIKSKLETR EYRDAQEFAA DVRLMFSNCY KYNPPDHEVV AMARKLQDVF 480

EMRFAKMPDE PEEPVVAVSS PVVAPPTKVV APPSSSDSSS DSSSDSDSST DDSEEERAQR 540

LAELQEQLKA VHEQLAALSQ PQQNKPKKKE KDKKEKKKEK HKKKEEVEEN KKGKAKEPPP 600

KKTKKSNSSN NNASKKEPMP VKNKPPPTYE SEEEDKCKPM SYEEKRQLSL DINKLPGEKL 660

GRVVHIIQSR EPSLKNSNPD EIEIDFETLK PSTLRELERY VTSCLRKKRK PQGRKGDISL 720

GSFKKKGFFF LRSPKNSAIS TSTMERSETE MAPKSKKKGH PGREPKKHHH HHHQQAPQQQ 780

PPPPTTQLPQ QQPPAQPQPP QQQPLPPPAP PSIPQQTAPP MKSSPPPFIP AQVPVLEHSL 840

PGSVFDPITH FAQPIIHLSQ TELPPHLPQP PEHSTPPHLN QHAVVSPPAL HNALPQQPSR 900

PSNRAAALPP KPTRPPAVSP ALSQQPLLPQ PPMPQPPQVL LEDEEPPTPP LTPMQMQIYL 960

QQLQKVQPST PLLPSVKVQS QPPPPLPPPA HPSVQQQLQQ QQQQQQHQPP PRPMHMQPMQ 1020

FPPHIQQPPP PPQQPTHPPP GQQPPPPQPA KPQQVIQHHP SPRHHKSDPY TTSHLREAPS 1080

PLMMHSPQMP AFQGLAHQSP PQQNVQPKKQ ELRAASVVQS QPLVVVKEEK IHSPIIRNEP 1140

FGPSLRQDPP KHPENIKAPV HLPQRPEIKP LDVGRPVIRP PEQSAPPAVG QDKDKQKQEP 1200

KTPVAPKKDL KIKNMGSWAS LVQKHPTTPS STAKSSSDSF EQFRRAAREK EEREKALKAQ 1260

AEHAEKEKER LRREQERMSR SREEEDALEQ ARRAHEEVRR RQEQQQQQQQ QQQRPEQQQP 1320

PVATASSAPQ AQSSQPQASQ SMLDQQRELA RKREQERRRR EAMAATIDMN FQSDLLAIFE 1380

ENLF 1384

Nucleotide Sequence
(FASTA)

ATGCAGAGCG AAAGGAGCAG AACCAGGAAA ACATTGTACA CAGAGACTGA TACATTGTGG 60

TACAATCGAA GAGTTCCTAG TGAAGAATGC AATGGGATCA ATAGCATGTC TGTGGAGAGT 120

GGCCCTGGGA CAAGACTGAG AAATTTACCA GTAATGGGGG ATGGACTAGA AACTACACAA 180

ATGTCTACAA CGCAGGCCCA GGCCCAACCC CAACAAGGCA GCACTGCAGG CAGTAATCCC 240

CCACCCCCAG AGACTTCCAA TCCCAACAAA CCCAAGAGAC AAACCAACCA ACTGCAATAT 300

CTGCTCAAAG TGGTGCTTAA GACATTATGG AAACATCAGT TTGCGTGGCC TTTTCAACAG 360

CCTGTGGATG CAGTCAAGCT GAACCTCCCT GATTATTATA AAATTATTAA AACACCTATG 420

GATATGGGAA CAATCAAGAA ACGCCTGGAG AATAACTACT ACTGGAATGC TCATGAATGT 480

ATCCAGGACT TTAACACGAT GTTTACAAAT TGTTACATCT ACAATAAGCC AGGAGATGAC 540

ATAGTCTTAA TGGCAGAAGC TCTAGAGAAG CTCTTCTTGC AGAAAATCTC TGAATTGCCC 600

CCAGAAGAAA CTGAAATCGT AATAGTCCAG GCAAAAGGAA GAGGACGTGG GAGGAAAGAA 660

GCAGTGACAT CAAAACCTGG AGCCTCAGTG GTACCAAACA CGACTCAAGC ATCAACCCCA 720

CCCCCAACAC AGACCCCTCA ACAGAATCTT CCGCCTGTAC AAACTCATTC CTTTCCTGCT 780

GTAACCCCTG ATCTTATCAT CCAGACTCCA GTAATGACAG TGGTGCTGGC CCAGACACTT 840

CAAACTCCCC CCCAACCCCC TCCCCCACCA CCCCCACACC CAGGCTCCCA GCAAATTCAG 900

ACACACCCAC CCATCATTGC AACTGCCCCA CAACCTGTGA AGACAAAAAA AGGGGTGAAG 960

AGGAAAGCAG ACACCACCAC ACCCACCACC ATTGACCCCA TTCATGAGTC ACCTTCACTG 1020

CCCACGGAAC CCAAATCTAC AAAGCTGGGC CCCCGTCGGG AAAGTAGCCG CCCAGTAAAG 1080

CCTCCAAAGA AGGATGTCCC GGATTCCCAG CAACATACAG TAGAGAAGAG TAATAAAGTG 1140

TCAGAGCAAT TAAAATATTG CACTGGCATT ATCAAGGAGA TGTTTGCCAA GAAGCATGCA 1200

GCCTATGCTT GGCCTTTCTA TAAACCTGTG GATGTGGAAG CCTTAGGCCT GCACGATTAT 1260

TGTGATATCA TCAAGCATCC AATGGATCTG AGCACAATCA AATCTAAACT GGAGACCCGA 1320

GAGTACAGAG ATGCTCAGGA ATTTGCTGCA GATGTCCGAT TGATGTTTTC CAATTGTTAC 1380

AAGTACAACC CTCCTGACCA TGAGGTAGTA GCCATGGCAC GTAAGCTGCA GGATGTGTTT 1440

GAGATGCGTT TTGCAAAGAT GCCTGATGAA CCTGAAGAGC CAGTGGTTGC TGTGTCCTCC 1500

CCAGTGGTAG CACCACCCAC CAAGGTAGTA GCTCCACCAT CATCTAGTGA TAGCAGCAGT 1560

GACAGTTCCT CAGACAGTGA CAGCTCAACT GATGACTCTG AGGAGGAGAG AGCTCAGCGA 1620

CTGGCAGAGC TTCAGGAACA GCTCAAGGCA GTACATGAGC AACTTGCTGC ACTCTCCCAG 1680

CCTCAGCAGA ACAAACCAAA GAAAAAAGAA AAAGACAAGA AAGAGAAAAA GAAAGAGAAG 1740

CACAAAAAGA AAGAGGAAGT GGAGGAAAAC AAGAAAGGCA AAGCAAAGGA ACCACCTCCC 1800

AAAAAGACAA AGAAAAGTAA CAGCAGCAAC AATAATGCCA GCAAGAAGGA ACCTATGCCT 1860

GTGAAGAACA AGCCCCCTCC CACCTATGAG TCAGAAGAAG AGGACAAATG TAAGCCAATG 1920

TCCTATGAAG AGAAGAGACA ATTGAGTTTG GACATTAACA AACTTCCTGG TGAGAAGCTG 1980

GGCCGGGTTG TCCATATCAT CCAGTCCCGA GAGCCCTCAC TGAAGAACTC TAACCCAGAT 2040

GAAATTGAAA TTGACTTTGA GACATTGAAA CCTTCTACCT TACGAGAACT AGAGCGCTAT 2100

GTCACCTCAT GTTTGCGGAA AAAGAGGAAA CCTCAAGGGA GAAAAGGGGA TATAAGTTTG 2160

GGGTCCTTTA AAAAGAAGGG GTTTTTTTTT TTGAGGTCGC CAAAGAATTC AGCTATATCA 2220

ACTAGTACAA TGGAAAGAAG TGAAACAGAG ATGGCACCAA AATCCAAAAA GAAAGGTCAT 2280

CCTGGGCGGG AACCAAAGAA GCACCACCAT CATCACCATC AGCAGGCACC ACAGCAGCAG 2340

CCTCCCCCAC CAACAACCCA ATTACCACAA CAGCAGCCCC CAGCCCAGCC TCAGCCACCA 2400

CAACAGCAGC CCTTACCACC ACCAGCCCCT CCATCTATCC CTCAACAGAC AGCCCCACCA 2460

ATGAAGTCCT CCCCACCTCC CTTCATCCCT GCCCAGGTGC CAGTTCTTGA GCACTCACTC 2520

CCAGGGAGTG TCTTTGATCC CATCACTCAC TTTGCCCAAC CGATCATACA CCTCTCCCAA 2580

ACTGAGCTGC CTCCCCACCT CCCCCAGCCG CCTGAGCACA GCACTCCACC TCATCTCAAC 2640

CAGCATGCAG TAGTTTCTCC TCCAGCTTTG CACAATGCTC TGCCCCAGCA GCCATCAAGG 2700

CCTAGCAATC GAGCTGCTGC CCTGCCCCCC AAGCCAACCC GCCCCCCAGC TGTGTCACCT 2760

GCACTCTCTC AGCAGCCCCT TCTCCCTCAG CCACCTATGC CTCAGCCACC CCAAGTCCTA 2820

TTAGAGGATG AAGAGCCGCC TACCCCCCCT CTCACTCCCA TGCAGATGCA GATATACCTA 2880

CAACAGCTAC AGAAGGTGCA GCCATCCACC CCTCTCCTCC CTTCTGTGAA GGTGCAATCC 2940

CAGCCTCCCC CTCCCCTACC ACCTCCAGCT CATCCCTCTG TGCAGCAACA GTTGCAGCAG 3000

CAGCAGCAGC AGCAGCAGCA CCAACCCCCA CCACGGCCCA TGCACATGCA GCCCATGCAA 3060

TTTCCTCCCC ATATTCAGCA ACCACCACCC CCTCCCCAGC AGCCCACCCA CCCACCTCCA 3120

GGGCAACAAC CGCCGCCACC GCAGCCAGCC AAGCCTCAGC AAGTCATCCA ACACCATCCT 3180

TCACCACGGC ACCATAAGTC TGATCCCTAC ACAACCAGTC ATCTACGAGA AGCTCCCTCC 3240

CCACTCATGA TGCATTCCCC TCAAATGCCA GCGTTCCAGG GTCTGGCTCA CCAGTCTCCA 3300

CCACAGCAAA ACGTCCAACC CAAGAAACAG GAGCTTCGAG CAGCCTCAGT AGTGCAGTCC 3360

CAACCCCTGG TAGTAGTGAA GGAGGAGAAG ATCCACTCTC CCATCATCCG AAATGAACCC 3420

TTTGGCCCTT CCCTTCGACA GGATCCCCCT AAGCACCCTG AGAACATCAA GGCCCCTGTC 3480

CATCTCCCTC AACGACCTGA AATAAAGCCG TTAGATGTTG GCAGACCTGT GATCCGACCT 3540

CCTGAACAGA GTGCACCCCC AGCAGTGGGT CAAGACAAGG ACAAGCAGAA ACAAGAACCC 3600

AAAACCCCAG TTGCTCCCAA AAAGGATCTC AAGATCAAGA ACATGGGCTC CTGGGCCAGC 3660

CTAGTCCAGA AACACCCCAC CACTCCGTCC TCTACAGCCA AGTCATCAAG TGACAGCTTC 3720

GAACAGTTTC GCCGAGCTGC TCGAGAGAAG GAGGAGCGAG AAAAGGCCCT CAAAGCCCAA 3780

GCTGAGCATG CTGAGAAGGA AAAAGAGCGA CTAAGAAGGG AACAGGAGAG GATGAGCAGG 3840

AGCAGAGAAG AGGAAGATGC CCTAGAGCAA GCTCGGAGGG CTCATGAAGA GGTTAGGAGG 3900

CGTCAGGAGC AGCAGCAGCA GCAGCAGCAG CAGCAGCAGC GACCAGAACA ACAGCAGCCA 3960

CCAGTAGCTA CAGCCTCCTC AGCTCCCCAA GCACAAAGCT CTCAGCCCCA GGCCTCCCAG 4020

TCCATGCTGG ATCAACAGAG GGAGTTGGCC AGGAAACGGG AACAAGAGCG AAGGCGCAGG 4080

GAGGCGATGG CAGCTACCAT TGACATGAAT TTTCAGAGTG ATCTTTTGGC AATATTTGAA 4140

GAGAATCTTT TCTGA 4155

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Bromodomain; Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000794	; C:condensed nuclear chromosome
GO:0005737	; C:cytoplasm
GO:0000790	; C:nuclear chromatin
GO:0003677	; F:DNA binding
GO:0007059	; P:chromosome segregation
GO:0044154	; P:histone H3-K14 acetylation
GO:0043983	; P:histone H4-K12 acetylation
GO:0001833	; P:inner cell mass cell proliferation
GO:0043388	; P:positive regulation of DNA binding
GO:0010971	; P:positive regulation of G2/M transition of mitotic cell cycle
GO:0032968	; P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0006468	; P:protein phosphorylation
GO:0000114	; P:regulation of transcription involved in G1 phase of mitotic cell cycle

KEGG

InterPros

IPR001487	; Bromodomain.
IPR018359	; Bromodomain_CS.

Pfam

PF00439

; Bromodomain; 2.

SMARTs

SM00297

; BROMO; 2.

Prosites

PS00633	; BROMODOMAIN_1; 1.
PS50014	; BROMODOMAIN_2; 2.

Prints

PR00503

; BROMODOMAIN.

Created Date

20-Feb-2013