EPS-MOD-00026

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00026

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	191.4	2.6E-56	54	307	254

Status

Unreviewed

Ensembl Protein

ENSMODP00000018288

UniProt Accession

F6YP93;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000014637	ENSMODP00000018288	ENSMODT00000018621

Organism

Monodelphis domestica

Functional Description

Protein Length

578

Protein Sequence
(FASTA)

MYYIPKETDG SEGTVEIETV KLARSVFSKL HEICCSWVKD FPLHRKPQLY YETSIHAIKN 60

MRRKMEDKHV CIPDFNMLFN LEDQEEQAYF AVFDGHGGVD AAIYASIHLH VNLVRQEMFP 120

HDPAEALCRA FRVTDERFVQ KAARESLRCG TTGVVTFIRG NMLHVAWLGD SQVMLVRKGQ 180

AVELMKPHKP DREDEKQRIE ALGGCVVWFG AWRVNGSLSV SRAIGDAEHK PYICGDADSA 240

STVLDGSEDY LILACDGFYD TVNPDEAVKV VADHLKENNG DSSMVAHKLV ASARDAGSSD 300

NITVIVVFLR DMNKAINVSE ESDWTENSFQ GGQEDGGDDK ENHGESKRPW PQHQCSAPAD 360

LGYDGRVDSF TDRTSLSTGS QINVLEDAGY LDLTKIEGSK PESAKFWSPV EMFGLTVPKK 420

ANLVNDMIME RESVRPSVHG QHDAGEYPAY LNLGPTGQQI NRMESLSPVF SGLENEQKNE 480

PLRKRGSSFS HLRHYYAKRR HGFRLKPKFH TFLFAHEPSH KSGTTSLTSL IRSGNRNRRL 540

VRSSLPWRQN SCKKYSEILM GMLRNGNCIP YADIPGSS 578

Nucleotide Sequence
(FASTA)

ATGTACTACA TACCAAAGGA AACAGATGGC TCAGAAGGGA CTGTGGAGAT TGAGACAGTG 60

AAATTGGCAC GTTCCGTCTT CAGTAAACTA CATGAGATTT GCTGCAGTTG GGTGAAGGAT 120

TTCCCTCTCC ACAGGAAACC CCAATTGTAT TATGAGACGT CAATCCATGC CATCAAAAAC 180

ATGCGCAGGA AAATGGAGGA CAAACACGTC TGCATTCCCG ATTTTAATAT GCTCTTCAAT 240

CTAGAGGACC AAGAAGAACA AGCTTACTTT GCAGTGTTCG ATGGGCATGG CGGAGTCGAT 300

GCTGCCATTT ATGCCTCTAT CCACCTCCAC GTGAATTTAG TACGGCAGGA AATGTTCCCC 360

CATGACCCTG CTGAGGCCCT GTGCCGGGCC TTCCGGGTGA CTGATGAGCG TTTTGTGCAG 420

AAAGCAGCCC GGGAGAGCTT GCGATGTGGG ACCACCGGAG TGGTAACCTT TATCAGAGGC 480

AACATGCTCC ACGTAGCCTG GCTGGGCGAC TCTCAGGTCA TGCTGGTGAG GAAGGGCCAA 540

GCCGTTGAAC TGATGAAGCC ACATAAGCCG GATAGAGAGG ATGAGAAGCA GCGCATTGAG 600

GCCCTCGGGG GCTGCGTGGT CTGGTTTGGG GCCTGGAGAG TAAATGGAAG TCTGTCTGTC 660

TCCAGAGCTA TAGGAGATGC TGAGCATAAG CCATACATTT GTGGGGACGC AGACTCTGCC 720

TCCACTGTTT TGGATGGGTC TGAAGACTAC CTCATTTTAG CTTGTGACGG CTTCTACGAC 780

ACCGTGAACC CCGATGAGGC AGTGAAGGTG GTGGCCGACC ACCTGAAGGA AAATAATGGT 840

GACAGCAGCA TGGTGGCCCA CAAATTAGTA GCATCAGCTC GTGATGCGGG GTCAAGTGAT 900

AATATCACTG TCATTGTGGT ATTCCTGAGG GATATGAACA AAGCTATAAA TGTTAGTGAG 960

GAATCAGACT GGACAGAGAA CTCTTTTCAA GGAGGTCAAG AAGATGGCGG GGATGATAAG 1020

GAAAATCATG GAGAGAGCAA ACGGCCCTGG CCTCAGCACC AGTGCTCAGC GCCCGCAGAT 1080

CTAGGGTATG ATGGGCGAGT GGATTCATTC ACTGATAGAA CTAGCTTGAG CACAGGGTCC 1140

CAAATCAATG TGCTTGAAGA TGCAGGCTAC CTAGATCTCA CAAAAATAGA AGGAAGCAAA 1200

CCCGAGAGTG CCAAATTTTG GTCACCAGTT GAAATGTTTG GTCTTACAGT ACCAAAGAAA 1260

GCAAATCTTG TTAATGATAT GATAATGGAG AGAGAATCAG TCCGGCCTTC AGTGCATGGA 1320

CAGCATGATG CTGGAGAATA CCCTGCTTAT CTTAATTTGG GTCCAACAGG GCAGCAGATA 1380

AACAGAATGG AGAGCTTGTC TCCCGTCTTT TCTGGGTTGG AAAATGAACA GAAAAATGAA 1440

CCCCTGAGAA AGAGAGGTTC TAGTTTCTCT CATTTACGCC ACTATTATGC AAAGAGACGG 1500

CATGGATTCA GGCTCAAACC AAAGTTTCAT ACGTTTCTCT TTGCTCACGA GCCTTCCCAT 1560

AAATCAGGCA CAACCAGTCT GACTTCACTT ATTCGAAGTG GGAATAGAAA TAGGAGGTTG 1620

GTAAGAAGTT CTCTGCCATG GAGACAAAAT AGTTGCAAAA AGTACAGTGA GATTCTGATG 1680

GGGATGCTTA GAAACGGTAA TTGTATACCA TACGCAGACA TTCCTGGGAG CAGTTAA 1737

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  l

Q: 54    SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNL  113

         567899**************99766555544459************************99

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++         +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 114   VRQEM----FPHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  167

         99955....6788888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         +GdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 168   LGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  226

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+ ++++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 227   AEHKPYICGDADSASTVLDGSEDYLILACDGFYDTVNPDEAVKVVADHLKeNNGDSSMVA  286

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 287   HKLVASARDAGSSDNITVIVV  307

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNL 60

VRQEMFPHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWLGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKQRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGSEDYLIL ACDGFYDTVN PDEAVKVVAD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013