EKS-MOD-00229

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00229

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	366.0	1.2E-109	120	380	261

Status

Unreviewed

Ensembl Protein

ENSMODP00000032081

UniProt Accession

F7D0A6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K7

Gene Synonyms/Alias

MAP2K7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000014960	ENSMODP00000032081	ENSMODT00000033657
ENSMODG00000014960	ENSMODP00000018708	ENSMODT00000019045

Organism

Monodelphis domestica

Functional Description

Protein Length

419

Protein Sequence
(FASTA)

MAASSLEQKL SRLEAKLKQE NREARRRIDL ILEISPHRPR PTLQLPLAND GGSRSPSSDS 60

SPQQPTPPAR PRHMLGLPPP LFMPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL 120

ENLGEMGSGT CGQVWKMRFK KTGHILAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV 180

QCFGTFITNT DVFIAMELMG TCAEKLKKRI QGPIPERILG KMTVAIVKAL YYLKEKHGVI 240

HRDVKPSNIL LDDRGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD 300

IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPSNMGFS VDFQSFVKDC 360

LTKDHRKRPK YNKLLEHSFI KRYEMLEVDV ASWFKDVMAK TESPRTSSIL SQHHLPFFR 419

Nucleotide Sequence
(FASTA)

ATGGCGGCGT CCTCCCTGGA ACAGAAGCTA TCCCGCCTGG AGGCGAAGCT GAAGCAGGAA 60

AACCGCGAGG CCCGGCGGAG GATCGACCTC ATCCTGGAGA TCAGTCCGCA TCGGCCCAGG 120

CCGACTCTGC AGCTCCCTCT GGCCAATGAT GGGGGTAGCC GATCGCCATC CTCTGACAGC 180

TCCCCTCAGC AACCCACCCC ACCAGCTCGT CCCCGGCATA TGTTGGGGCT CCCACCACCA 240

CTGTTCATGC CACGTAGCAT GGAGAGCATA GAAATTGACC AGAAACTACA GGAAATCATG 300

AAACAGACAG GATACCTGAC CATTGGAGGC CAGAGGTACC AGGCAGAGAT TAATGACCTG 360

GAGAACCTGG GTGAGATGGG CAGTGGCACA TGTGGCCAGG TCTGGAAGAT GCGATTCAAG 420

AAGACAGGCC ACATCCTTGC TGTCAAGCAA ATGCGACGCT CTGGAAACAA GGAAGAGAAC 480

AAACGAATTC TCATGGACCT GGATGTGGTG CTCAAGAGCC ATGACTGTCC ATACATTGTT 540

CAATGCTTTG GGACGTTCAT CACAAATACA GACGTCTTCA TTGCCATGGA ACTTATGGGC 600

ACCTGTGCTG AAAAACTAAA GAAGAGAATT CAAGGGCCCA TCCCAGAGCG GATCTTAGGC 660

AAGATGACTG TGGCTATTGT TAAGGCGCTC TATTACCTGA AGGAGAAGCA TGGTGTGATC 720

CACAGAGATG TGAAGCCCTC CAACATCCTA CTTGATGATC GGGGCCAGAT CAAGCTCTGT 780

GACTTTGGTA TCAGTGGCCG TCTGGTAGAC TCCAAAGCCA AGACGAGAAG TGCTGGCTGT 840

GCAGCTTACA TGGCGCCGGA GCGGATAGAC CCTCCAGATC CTACCAAGCC TGATTATGAC 900

ATCCGAGCAG ATGTATGGAG CCTGGGAATC TCACTGGTGG AGCTGGCAAC TGGGCAGTTC 960

CCCTACAAGA ACTGCAAGAC TGATTTTGAG GTCCTCACCA AGGTCCTGCA GGAAGAACCA 1020

CCCCTTCTGC CCAGTAATAT GGGCTTCTCG GTGGACTTTC AGTCCTTTGT TAAAGACTGC 1080

CTTACTAAAG ATCACAGGAA GAGACCAAAG TACAATAAGC TACTTGAACA CAGCTTCATC 1140

AAACGATACG AAATGTTGGA AGTGGATGTG GCATCCTGGT TCAAGGATGT CATGGCGAAG 1200

ACAGAGTCCC CCCGGACTAG CAGCATCTTG AGCCAACATC ACCTTCCCTT CTTCAGGTAG 1260

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         le+l+e+G+G++g+V+k+++kk+g+ilavK++r++ +kee+k+il++l+v+ ks+++pyi

Q: 120   LENLGEMGSGTCGQVWKMRFKKTGHILAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYI  179

         7899********************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120

         v+++G+f++++dv+i+melm  t+ +k+ k++   ++ ipe++lgk++va+vkal ylke

Q: 180   VQCFGTFITNTDVFIAMELMG-TCAEKLKKRI---QGPIPERILGKMTVAIVKALYYLKE  235

         *********************.*****99996...9************************

S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg....  175

         k+ +iHRDvKPsNiL++++G++KlCDFG+sg+lvds Ak++ +G+++YmaPEri++

Q: 236   KHGVIHRDVKPSNILLDDRGQIKLCDFGISGRLVDSKAKTRsAGCAAYMAPERIDPpdpt  295

         *******************************************************99999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee.efseefqe  234

         k++Y++++dvWslG++lvelatg++py+++k+++e+l+++++eepp lp++  fs +fq+

Q: 296   KPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPSNmGFSVDFQS  355

         9*************************************************999*******

S: 235   fvskClkkdekeRpklkellkhafi  259

         fv++Cl+kd+++Rpk+++ll+h+fi

Q: 356   FVKDCLTKDHRKRPKYNKLLEHSFI  380

         ************************7

Domain Sequence
(FASTA)

LENLGEMGSG TCGQVWKMRF KKTGHILAVK QMRRSGNKEE NKRILMDLDV VLKSHDCPYI 60

VQCFGTFITN TDVFIAMELM GTCAEKLKKR IQGPIPERIL GKMTVAIVKA LYYLKEKHGV 120

IHRDVKPSNI LLDDRGQIKL CDFGISGRLV DSKAKTRSAG CAAYMAPERI DPPDPTKPDY 180

DIRADVWSLG ISLVELATGQ FPYKNCKTDF EVLTKVLQEE PPLLPSNMGF SVDFQSFVKD 240

CLTKDHRKRP KYNKLLEHSF I 261

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007257	; P:activation of JUN kinase activity

KEGG

mdo:100026752

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013